Article
Medicine, Research & Experimental
Yelda A. Leal, Minkyo Song, Jovanny Zabaleta, Gilberto Medina-Escobedo, Patrick Caron, Aurelio Lopez-Colombo, Chantal Guillemette, M. Constanza Camargo
Summary: The study suggests that higher levels of circulating DHEA may be associated with a lower risk of noncardia gastric cancer, while estradiol and testosterone levels were not significantly linked to gastric cancer. Further longitudinal studies are needed to explore the temporality of this association and the mechanisms of disease pathogenesis.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Psychiatry
Najmeh Shahini, Zanireh Salimi, Dorsa Kiani, Ahmad Raftari, Maliheh Ziaee
Summary: This study compared the levels of estradiol and progesterone between schizophrenia patients and healthy individuals. The results showed that the progesterone level in schizophrenia patients was significantly lower than in the control group, while the estradiol level did not differ significantly. The study suggests that determining hormone levels and using complementary hormone therapies may be beneficial for the treatment of schizophrenia.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Obstetrics & Gynecology
E. Nunes, E. Gallardo, S. Morgado-Nunes, J. Fonseca-Moutinho
Summary: This study aimed to assess the association between steroid hormone levels and sexual function in postmenopausal women. The main finding was the association of androstenedione with sexual function in postmenopausal women.
Review
Psychology, Clinical
Kristen M. Culbert, Katharine N. Thakkar, Kelly L. Klump
Summary: This narrative review examines the theories behind the heightened risk for psychosis in midlife women and looks at the potential role of ovarian hormones. Studies indicate that the peak ages of midlife psychosis risk in women overlap with the age range of key menopausal stages, especially the perimenopausal transition. However, there is a lack of direct research on menopausal stage. Studies on ovarian hormone effects have mostly focused on earlier developmental stages and events, showing increases in psychotic symptoms during periods of lower estradiol levels. Future research is needed to fill the gaps in our knowledge.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Shelli Graham, David F. Archer, James A. Simon, Kathleen M. Ohleth, Brian Bernick
Summary: This document reviewed and summarized the reported outcomes of menopausal hormone therapy (MHT) containing different estrogens and progesterone. The results suggested that MHT with estradiol (E2) and progesterone (P4) may have a potentially better safety profile compared to other estrogens and progestins, but further research is needed due to limitations of some studies.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Elsa Nunes, Eugenia Gallardo, Sara Morgado-Nunes, Jose Fonseca-Moutinho
Summary: This study investigates the effect of postmenopausal bilateral oophorectomy on plasma steroid hormone levels. The results demonstrate significantly lower levels of DHEA and oestradiol in the group with bilateral salpingo-oophorectomy compared to the group with isolated hysterectomy. These findings suggest significant endocrine activity of the postmenopausal ovary.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Psychology, Clinical
Jennifer L. Gordon, Bethany Sander, Tory A. Eisenlohr-Moul, Laurie Sykes Tottenham
Summary: Individual sensitivity to estradiol is associated with the risk for perimenopausal depression, especially among women with no history of depression, reporting a low number of baseline stressful life events, and reporting fewer months since their last menstrual period.
PSYCHOLOGICAL MEDICINE
(2021)
Review
Chemistry, Medicinal
Justine Tang, Li-Ru Chen, Kuo-Hu Chen
Summary: Dehydroepiandrosterone (DHEA) and its metabolite, dehydroepiandrosterone sulfate ester (DHEAS), are circulating steroid hormones that play multiple roles in the human body. While DHEA supplementation may have benefits for postmenopausal women, such as alleviating vasomotor symptoms and preserving immune system integrity, its effects on cardiovascular disease and insulin sensitivity are still uncertain. Further research is needed to determine the physiological role, optimal dosage, and effects on women for DHEA.
Article
Obstetrics & Gynecology
Pardes Habib, Joseph Neulen, Shahin Habib, Benjamin Roesing
Summary: Neuroactive steroids such as DHEA, E2, and P4 have different distributional patterns between peripheral and central compartments in pregnant women. While DHEA levels in serum correlate strongly with those in CSF, the relationship between E2 levels in serum and CSF is weaker. Additionally, there is a significant correlation between serum DHEA levels and E2 levels in CSF, suggesting that peripheral DHEA levels may serve as an indicator for central nervous levels of neuroactive steroids DHEA and E2 in pregnant women.
REPRODUCTIVE SCIENCES
(2021)
Review
Endocrinology & Metabolism
Brendan J. Nolan, Bonnie Liang, Ada S. Cheung
Summary: The study found that micronized progesterone has a positive effect on improving sleep, especially in postmenopausal women. Although some results were inconsistent, self-reported sleep outcomes improved in most trials.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Chrisandra L. Shufelt, JoAnn E. Manson
Summary: Menopausal hormone therapy has varying effects on cardiometabolic markers and cardiovascular disease risk depending on formulation, dose, and route of delivery. Oral estrogens without progestogens have positive effects on lipoprotein levels, glycemia, insulin, and CVD risk, while adding progestogens blunts the lipid-related effects. Transdermal estrogens have less impact on coagulation, inflammation, and lipids compared to oral estrogens, potentially posing a lower risk of venous thromboembolism and stroke.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Jennifer L. Gordon, Bethany Sander
Summary: The menopause transition, a period of increased risk for depressive symptoms, is influenced by fluctuating levels of estradiol (E2), with the specific trigger for depressive mood unclear. This review summarizes research on perimenopausal depression and reproductive mood disorders, proposing four E2 sensitivity profiles with implications for timing and severity of depressive mood during menopause transition. The evidence for these profiles, potential biological mechanisms, and implications for future research are discussed.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Lukasz Nowakowski, Krzysztof Galczynski, Michal Dybowski, Rafal Typek, Andrzej Dawidowicz, Pawel Miotla, Piotr Olcha, Tomasz Rechberger
Summary: The objective of this study was to develop intravaginal vaginal suppositories containing DHEA and compare the clinical effects of vaginal topical therapy with DHEA, estradiol, or antibiotic after POP surgery. It was found that both DHEA and estradiol topical therapy improved maturation index, vaginal pH, and vaginal symptoms. Topical therapy with DHEA after pelvic organ prolapse repair brings similar results as estradiol, without potential systemic exposure to increased concentrations of sex steroids above levels observed in postmenopausal women.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2023)
Review
Biochemistry & Molecular Biology
Maria Alemany
Summary: Androgens are important steroid hormones with diverse functions including energy control, skeletal maintenance, brain development, and reproductive mechanism regulation. Testosterone plays a key role in maintaining metabolism and its insufficiency is associated with aging and metabolic disorders. T replacement therapy is effective in maintaining core metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Health Care Sciences & Services
Petra Macek, Nikolaus Molinari, Monika Sobocan, Jure Knez
Summary: The role of estrogens and progesterone in endometrial cancer is well-known, but there is limited information about the role of androgens. Five different androgens are produced in women: DHEAS, DHEA, A(4), T, and DHT. T and DHT are the most potent hormones, with DHT mainly produced from T in peripheral tissues including the endometrium. While androgens are generally considered to have anti-proliferative effects and their receptor expression is associated with a good prognosis in endometrial cancer, it is still unclear in which specific conditions androgens have carcinogenic or protective effects in endometrial cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Neurosciences
Melanie Bourque, Marc Morissette, Therese Di Paolo
Article
Endocrinology & Metabolism
Laura J. Mosher, Sean C. Godar, Marc Morissette, Kenneth M. McFarlin, Simona Scheggi, Carla Gambarana, Stephen C. Fowler, Therese Di Paolo, Marco Bortolato
PSYCHONEUROENDOCRINOLOGY
(2018)
Article
Anatomy & Morphology
Dave Gagnon, Lara Eid, Dymka Coude, Carl Whissel, Therese Di Paolo, Andre Parent, Martin Parent
FRONTIERS IN NEUROANATOMY
(2018)
Article
Clinical Neurology
Delphine Charvin, Therese Di Paolo, Erwan Bezard, Laurent Gregoire, Akihiro Takano, Guillaume Duvey, Elsa Pioli, Christer Halldin, Rossella Medori, Francois Conquet
MOVEMENT DISORDERS
(2018)
Editorial Material
Neurosciences
F. Gasparini, T. Di Paolo
Article
Endocrinology & Metabolism
Hend Jarras, Melanie Bourque, Andree-Anne Poirier, Marc Morissette, Katherine Coulombe, Therese Di Paolo, Denis Soulet
JOURNAL OF NEUROENDOCRINOLOGY
(2020)
Article
Neurosciences
Jordan Nadeau, Tara Smith, Jerome Lamontagne-Proulx, Melanie Bourque, Sara Al Sweidi, Dushmanthi Jayasinghe, Shawn Ritchie, Therese Di Paolo, Denis Soulet
Article
Immunology
Cynthia Lecours, Marie-Kim St-Pierre, Katherine Picard, Maude Bordeleau, Melanie Bourque, Ifeoluwa Oluleke Awogbindin, Amin Benadjal, Fernando Gonzalez Ibanez, Dave Gagnon, Leo Cantin, Martin Parent, Therese Di Paolo, Marie-Eve Tremblay
BRAIN BEHAVIOR AND IMMUNITY
(2020)
Review
Neurosciences
Ifeoluwa Oluleke Awogbindin, Ismail Ogunbayode Ishola, Marie-Kim St-Pierre, Micael Carrier, Julie C. Savage, Therese Di Paolo, Marie-Eve Tremblay
NEUROSCIENCE LETTERS
(2020)
Article
Neurosciences
Amandine Isenbrandt, Marc Morissette, Melanie Bourque, Jerome Lamontagne-Proulx, Katherine Coulombe, Denis Soulet, Therese Di Paolo
Summary: The study examined the effects of sex hormones on a mouse model of Parkinson's disease and the neuroprotective role of the 5 alpha-reductase inhibitor dutasteride. Results showed sex differences in mice MPTP toxicity and response to dutasteride, with implications of neuroinflammation.
Review
Neurosciences
Ifeoluwa O. Awogbindin, Benneth Ben-Azu, Babatunde A. Olusola, Elizabeth T. Akinluyi, Philip A. Adeniyi, Therese Di Paolo, Marie-Eve Tremblay
Summary: Since December 2019, humanity has been facing the devastating SARS-CoV-2 outbreak, resulting in over 3.1 million deaths globally. SARS-CoV-2 infection may lead to neurological symptoms and potentially cause chronic or permanent changes to neural tissues.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Cell Biology
Marc Morissette, Melanie Bourque, Marie-Eve Tremblay, Therese Di Paolo
Summary: Inflammatory markers were found in the brains of Parkinson's disease patients. The study showed that MPEP reduced the development of L-Dopa-induced dyskinesias (LID) in MPTP-lesioned monkeys and decreased inflammatory markers in the brain. The results demonstrated increased inflammatory markers in the basal ganglia associated with LID and revealed the potential of MPEP in reducing LID and inflammatory response.
Article
Biochemical Research Methods
Valerie Brousseau, Patrick Caron, Jocelyn Trottier, Therese Di Paolo, Piotr Milkiewicz, Olivier Barbier
Summary: This study developed a method for quantification of 24S-hydroxycholesterol and its derivatives in human plasma and validated its clinical applications. The results indicate the accumulation of cerebrosterol and its conjugates in the plasma of cholestatic patients.
JOURNAL OF MASS SPECTROMETRY
(2022)
Article
Pharmacology & Pharmacy
Andree-Anne Poirier, Melissa Cote, Hend Jarras, Nadhir Litim, Jerome Lamontagne-Proulx, Sara Al-Sweidi, Marc Morissette, Asmaa Lachhab, Martin Pelletier, Therese Di Paolo, Denis Soulet
Summary: This study demonstrates that dutasteride can prevent enteric neuronal damage in the MPTP mouse model of Parkinson's disease by anti-inflammatory and mitochondrial effects, suggesting that drug repurposing of dutasteride might be a promising avenue to treat enteric neuroinflammation in early PD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Melanie Bourque, Laurent Gregoire, Waseema Patel, David Dickens, Ralph Snodgrass, Therese Di Paolo
Summary: N-methyl-D-aspartate (NMDA) receptors have been implicated in L-Dopa-induced dyskinesias (LID) in Parkinson's disease patients. L-4-chlorokynurenine (AV-101) is a pro-drug of 7-chlorokynurenic acid, a specific antagonist of the glycine co-agonist site of NMDA receptors. This study investigated the effects of AV-101 on LID in MPTP-lesioned monkeys and found that it reduced LID and maintained the antiparkinsonian activity of L-Dopa. AV-101 showed comparable antidyskinetic activity to amantadine but without adverse effects.