Article
Chemistry, Multidisciplinary
Jia-Ying Yang, Jun Wang, Yang Hu, Dan-Yang Shen, Guan-Li Xiao, Xiao-Yan Qin, Rongfeng Lan
Summary: This study investigated the neuroprotective effects of Paeoniflorin (PF) in a mouse model of Cd poisoning. The results showed that PF attenuated multi-organ damage and brain neurotoxicity induced by Cd, leading to improved behavioral performances in mice. Additionally, PF maintained glutamate receptor and neuronal activity, alleviated gliosis, and restored the lysosomal protein CD68 that scavenges damaged cellular components in active microglia.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Fisheries
Doaa M. M. Mokhtar, Abdelraheim Attaai, Giacomo Zaccone, Alessio Alesci, Rasha Alonaizan, Manal T. T. Hussein
Summary: This study investigated the morphology and distribution of ganglia in adult molly fish, focusing on their relation to immune cells. The results revealed direct communication between different ganglia and immune cells, which play a role in maintaining the health of ganglionic cells.
Article
Pharmacology & Pharmacy
Cynthia Kwan, Stephen G. Nuara, Jim C. Gourdon, Philippe Huot
Summary: Parkinson's disease psychosis is a complex condition affecting over half of patients and is influenced by multiple factors including dopamine replacement therapy and disease state. Studying novel stereotypical behaviors in MPTP-lesioned marmosets may provide valuable insights for interventions targeting PD psychosis symptoms.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Neurosciences
Gunasingh J. Masilamoni, Christopher G. Sinon, Brik A. Kochoian, Arun Singh, Andrew J. McRiner, Liza Leventhal, Stella M. Papa
Summary: This study assessed the effects of a selective PDE9 inhibitor (PDE9i) in a primate model of Parkinson's disease (PD). The results showed that PDE9i enhanced the antiparkinsonian effects of L-DOPA and prolonged its duration of action. This suggests that striatal PDE9 inhibition may be a strategy to improve motor responses to L-DOPA in PD.
Article
Pharmacology & Pharmacy
Mona F. Mahmoud, Samar Rezq, Amira E. Alsemeh, Mohamed A. O. Abdelfattah, Assem M. El-Shazly, Rachid Daoud, Mohamed A. El Raey, Mansour Sobeh
Summary: The extract from Potamogeton perfoliatus displayed anti-inflammatory, analgesic, and antioxidative properties in a chronic sciatic nerve constriction injury rat model. It attenuated neuro-inflammatory changes, oxidative stress, and apoptosis, while inducing the expression of neuroprotective factors in a dose-dependent manner. These findings suggest that Potamogeton perfoliatus may be a novel therapy for neuropathic pain patients, pending further clinical trials.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
M. T. Herrero, J. E. Yuste, L. Cuenca-Bermejo, P. Almela, L. Arenas-Betancur, V. De Pablos, A. Gonzalez-Cuello, E. Del Bel, J. Navarro-Zaragoza, E. Fernandez-Villalba
Summary: This study aimed to determine whether the nitric oxide synthase inhibitor, 7-nitroindazole (7-NI), can reduce L-DOPA-induced dyskinesias (LIDs) in a non-human primate model of Parkinson disease (PD). The results showed that the dyskinetic monkeys treated with 7-NI had a significant decrease in LIDs compared to their scores without 7-NI treatment. However, the anti-Parkinsonian effect of L-DOPA remained unchanged. This study suggests that 7-NI could be a promising therapy to improve the quality of life of PD patients.
Article
Chemistry, Multidisciplinary
Rima, Safri Ishmayana, Desak Made Malini, Ukun M. S. Soedjanaatmadja
Summary: Mucuna pruriens (L.) DC (Velvet beans) is a tropical bean that contains a significant amount of L-Dopa and has been widely used as a natural remedy for Parkinson's disease. This study investigated the nutritional content of M. pruriens seeds and isolated L-Dopa, and evaluated its toxicity, antibacterial activity, antioxidant activity, and anti-Parkinson's activity.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Cell Biology
Melanie Bourque, Laurent Gregoire, Waseema Patel, David Dickens, Ralph Snodgrass, Therese Di Paolo
Summary: N-methyl-D-aspartate (NMDA) receptors have been implicated in L-Dopa-induced dyskinesias (LID) in Parkinson's disease patients. L-4-chlorokynurenine (AV-101) is a pro-drug of 7-chlorokynurenic acid, a specific antagonist of the glycine co-agonist site of NMDA receptors. This study investigated the effects of AV-101 on LID in MPTP-lesioned monkeys and found that it reduced LID and maintained the antiparkinsonian activity of L-Dopa. AV-101 showed comparable antidyskinetic activity to amantadine but without adverse effects.
Article
Biochemistry & Molecular Biology
Osama F. Elabi, Jeffrey S. Davies, Emma L. Lane
Summary: GLP-1R agonists can increase graft survival and improve motor function in rats to a certain extent. However, there are differences in effects between different treatment groups that need further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Marc Deffains, Marie-Helene Canron, Margaux Teil, Qin Li, Benjamin Dehay, Erwan Bezard, Pierre-Olivier Fernagut
Summary: The study found that chronic dopamine-replacement therapy can significantly ameliorate alpha-synuclein pathology in the non-human primate model of Parkinson's disease. Therefore, patient's dopaminergic medication should be systematically considered when assessing the disease.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2021)
Review
Neurosciences
Kai Yang, Xinyue Zhao, Changcai Wang, Cheng Zeng, Yan Luo, Taolei Sun
Summary: LID is a common issue in the treatment of Parkinson's disease, involving damage to multiple brain regions, with various theoretical models proposed to explain its mechanisms, necessitating a deeper understanding.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Andrea Guerra, Francesco Asci, Alessandro Zampogna, Valentina D'Onofrio, Antonio Suppa, Giovanni Fabbrini, Alfredo Berardelli
Summary: The study demonstrates that long-term treatment with safinamide benefits SICF and M1 plasticity in PD patients, potentially preventing worsening of LID severity over time.
Article
Neurosciences
Jie Fu, Xinyu Zhao, Fugang Tian, Xin Yu
Summary: Continuous dopaminergic stimulation (CDS) reduces l-DOPA-induced dyskinesia (LID) by inhibiting the expression of neuronal NOS (nNOS) and BAX/BCL2 ratio, decreasing Ca2+ influx, and inhibiting Ca2+ signaling pathways of dopamine neurons.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Cynthia Kwan, Imane Frouni, Dominique Bedard, Adjia Hamadjida, Stephen G. Nuara, Jim C. Gourdon, Philippe Huot
Summary: Nelotanserin, a serotonin 2A and 2C inverse agonist, was tested for its anti-dyskinetic potential in MPTP-lesioned marmosets. It was found that nelotanserin significantly reduced peak dose dyskinesia and global dyskinesia severity when combined with L-DOPA without affecting its anti-parkinsonian action.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Andrea Lopez-Lopez, Rita Valenzuela, Ana Isabel Rodriguez-Perez, Maria J. Guerra, Jose Luis Labandeira-Garcia, Ana Munoz
Summary: Statins have been proposed for the treatment of L-DOPA-induced dyskinesia (LID), and their anti-dyskinetic effects may be related to the inhibition of the Ras-ERK pathway. The mechanisms responsible for the anti-LID effect are unclear, but they could involve changes in cholesterol homeostasis and oxidative stress- and inflammation-related mechanisms. Angiotensin II, cholesterol, and Rho-kinase pathways have been found to interact in LID, and their inhibition by specific drugs may attenuate the dyskinetic symptoms.
Article
Biology
Marcus Augusto-Oliveira, Gabriela P. Arrifano, Charlotte Isabelle Delage, Marie-Eve Tremblay, Maria Elena Crespo-Lopez, Alexei Verkhratsky
Summary: Microglial cells, originating from foetal macrophages, undergo phenotypic metamorphosis in response to the nervous tissue environment, displaying high plasticity and heterogeneity in gene and protein expression; their surveilling functions are crucial for maintaining homeostasis and contributing to the adaptive capacity of the central nervous system.
BIOLOGICAL REVIEWS
(2022)
Article
Neurosciences
Quentin Leyrolle, Fanny Decoeur, Cyril Dejean, Galadriel Briere, Stephane Leon, Ioannis Bakoyiannis, Emilie Baroux, Tony-Lee Sterley, Clementine Bosch-Bouju, Lydie Morel, Camille Amadieu, Cynthia Lecours, Marie-Kim St-Pierre, Maude Bordeleau, Veronique De Smedt-Peyrusse, Alexandran Sere, Leslie Schwendimann, Stephane Gregoire, Lionel Bretillon, Niyazi Acar, Corinne Joffre, Guillaume Ferreira, Raluca Uricaru, Patricia Thebault, Pierre Gressens, Marie-Eve Tremblay, Sophie Laye, Agnes Nadjar
Summary: Westernized dietary habits leading to reduced intake of n-3 PUFAs may be associated with neurodevelopmental disorders and disruptions in brain functional connectivity. Lifelong n-3 PUFA deficiency can interfere with oligodendrocyte maturation and myelination processes, resulting in long-term detrimental effects on white matter organization and hippocampus-prefrontal functional connectivity. Promoting developmental myelination through clemastine could rescue memory deficits in n-3 PUFA deficient animals.
Article
Neurosciences
Giorgio Corsi, Katherine Picard, Maria Amalia di Castro, Stefano Garofalo, Federico Tucci, Giuseppina Chece, Claudio del Percio, Maria Teresa Golia, Marcello Raspa, Ferdinando Scavizzi, Fanny Decoeur, Clotilde Lauro, Mara Rigamonti, Fabio Iannello, Davide Antonio Ragozzino, Eleonora Russo, Giovanni Bernardini, Agnes Nadjar, Marie Eve Tremblay, Claudio Babiloni, Laura Maggi, Cristina Limatola
Summary: Microglia play a crucial role in regulating sleep by adapting their cx3cr1 expression level and modulating synaptic activity in a phase-dependent manner. The findings suggest the importance of microglial cells in the homeostasis of cerebral parenchyma and the regulation of the sleep/wake cycle.
Article
Neurosciences
Fanny Decoeur, Katherine Picard, Marie-Kim St-Pierre, Andrew D. Greenhalgh, Jean-Christophe Delpech, Alexandra Sere, Sophie Laye, Marie-Eve Tremblay, Agnes Nadjar
Summary: The westernization of dietary habits has led to a decrease in the intake of n-3 polyunsaturated fatty acids (n-3 PUFAs) in pregnant and lactating women, resulting in defects in the formation of brain myelin in infants. This study found that these deficits may be related to alterations in the structure and function of microglial cells in the white matter of the brain.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Editorial Material
Neurosciences
Marie-Eve Tremblay, Charlotte Madore, Li Tian, Alexei Verkhratsky
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biology
Maude Bordeleau, Cesar H. Comin, Lourdes Fernandez de Cossio, Chloe Lacabanne, Moises Freitas-Andrade, Fernando Gonzalez Ibanez, Joanna Raman-Nair, Michael Wakem, Mallar Chakravarty, Luciano da F. Costa, Baptiste Lacoste, Marie-Eve Tremblay
Summary: This study uses a translational mouse model to investigate the effects of maternal high-fat diet (mHFD) on the cerebrovascular health of offspring. The results indicate that mHFD leads to cerebrovascular and microglial changes in the offspring, as well as behavioral alterations reminiscent of neurodevelopmental disorders.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemical Research Methods
Valerie Brousseau, Patrick Caron, Jocelyn Trottier, Therese Di Paolo, Piotr Milkiewicz, Olivier Barbier
Summary: This study developed a method for quantification of 24S-hydroxycholesterol and its derivatives in human plasma and validated its clinical applications. The results indicate the accumulation of cerebrosterol and its conjugates in the plasma of cholestatic patients.
JOURNAL OF MASS SPECTROMETRY
(2022)
Article
Pharmacology & Pharmacy
Andree-Anne Poirier, Melissa Cote, Hend Jarras, Nadhir Litim, Jerome Lamontagne-Proulx, Sara Al-Sweidi, Marc Morissette, Asmaa Lachhab, Martin Pelletier, Therese Di Paolo, Denis Soulet
Summary: This study demonstrates that dutasteride can prevent enteric neuronal damage in the MPTP mouse model of Parkinson's disease by anti-inflammatory and mitochondrial effects, suggesting that drug repurposing of dutasteride might be a promising avenue to treat enteric neuroinflammation in early PD.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Marie-Eve Tremblay, Zakaria A. Almsherqi, Yuru Deng
Summary: Fatty acids and phospholipids play essential roles in the structure and function of cell membranes. Recent research has focused on two subclasses of ether phospholipids, platelet activating factor (PAF) and its precursor plasmalogen, due to their association with several chronic inflammatory, neurodegenerative, and metabolic disorders. Inflammatory conditions often involve an excess of PAF or decreased levels of plasmalogens. The exact mechanisms of plasmalogens in inflammation are not yet fully understood. Anti-inflammatory responses are likely mediated by the plasmalogen signaling pathway, while pro-inflammatory responses involve the release of arachidonic acid from membrane phospholipids, particularly derived from the hydrolysis of plasmalogens. Changes in plasmalogen levels can affect cell membrane properties and impact signaling pathways involved in inflammatory cascades and immune responses. Plasmalogen replacement therapy shows promise as an anti-inflammatory strategy for treating chronic diseases with an inflammatory component.
Article
Cell Biology
Melanie Bourque, Laurent Gregoire, Waseema Patel, David Dickens, Ralph Snodgrass, Therese Di Paolo
Summary: N-methyl-D-aspartate (NMDA) receptors have been implicated in L-Dopa-induced dyskinesias (LID) in Parkinson's disease patients. L-4-chlorokynurenine (AV-101) is a pro-drug of 7-chlorokynurenic acid, a specific antagonist of the glycine co-agonist site of NMDA receptors. This study investigated the effects of AV-101 on LID in MPTP-lesioned monkeys and found that it reduced LID and maintained the antiparkinsonian activity of L-Dopa. AV-101 showed comparable antidyskinetic activity to amantadine but without adverse effects.
Review
Developmental Biology
Sophia M. Loewen, Adriano M. Chavesa, Colin J. Murray, Marianela E. Traetta, Sophia E. Burns, Keelin H. Pekarik, Marie-Eve Tremblay
Summary: Maternal immune activation (MIA) caused by various factors such as metabolic disorders, infections, and stress, is recognized as a major risk factor for neurodevelopmental disorders, especially with viral infections. MIA alters fetal development and triggers neurodevelopmental consequences, with microglia playing a crucial role. Animal models suggest that MIA disrupts important processes like synaptic pruning and cell proliferation/differentiation, and the COVID-19 pandemic may have implications for neurodevelopment. This review focuses on the impact of viral mimetic poly I:C-induced MIA on microglial functions and proposes approaches to prevent or mitigate MIA consequences.
DEVELOPMENTAL NEUROSCIENCE
(2023)
Editorial Material
Neurosciences
Haley A. Vecchiarelli, Marie-eve Tremblay
Summary: Vasek et al. demonstrate that microglia engage in protein translation in their processes, which plays a crucial role in the number of processes and the formation of phagocytic cups. These findings shed light on the rapid response of microglia to diverse local signals in specific cellular compartments.
NATURE NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Victor Lau, Leanne Ramer, Marie-Eve Tremblay
Summary: Alzheimer's disease primarily involves neurodegeneration and cognitive decline, with progressive memory loss. Aging and other risk factors promote the accumulation of AD pathologies and inflammation. Glial senescence, particularly senescent microglia accumulation, contributes to the perpetuation of AD pathologies, glial aging, and further senescence. Increasing glial senescence is proposed to drive individuals from healthy cognition into cognitive decline and dementia.
NATURE COMMUNICATIONS
(2023)
Editorial Material
Immunology
Haley A. Vecchiarelli, Marie-Eve Tremblay
BRAIN BEHAVIOR AND IMMUNITY
(2023)