Elucidating the Mechanism of Action of Pregabalin

Pregabalin is a potent and selective ligand for α2δ-1 and α2δ-2 calcium channel subunits

(2011) Zheng Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anxiolytic-Like Activity of Pregabalin in the Vogel Conflict Test in  2 -1 (R217A) and  2 -2 (R279A) Mouse Mutants

(2011) S. M. Lotarski et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Switching from long-term benzodiazepine therapy to pregabalin in patients with generalized anxiety disorder: a double-blind, placebo-controlled trial

(2011) Sallie J Hadley et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Serotonergic regulation of neuronal excitability in the prefrontal cortex

(2011) Rodrigo Andrade   NEUROPHARMACOLOGY

Pregabalin Influences Insula and Amygdala Activation During Anticipation of Emotional Images

(2011) Robin L Aupperle et al.   NEUROPSYCHOPHARMACOLOGY

Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states

(2011) Amin Boroujerdi et al.   PAIN

The Neurobiology of Anxiety Disorders: Brain Imaging, Genetics, and Psychoneuroendocrinology

(2010) Elizabeth I. Martin et al.   CLINICS IN LABORATORY MEDICINE

A new look at calcium channel α2δ subunits

(2010) Claudia S Bauer et al.   CURRENT OPINION IN NEUROBIOLOGY

The pharmacological properties of antidepressants

(2010) Giorgio Racagni et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

Clinical Pharmacokinetics of Pregabalin in Healthy Volunteers

(2010) Howard N. Bockbrader et al.   JOURNAL OF CLINICAL PHARMACOLOGY

The  2  Ligand Gabapentin Inhibits the Rab11-Dependent Recycling of the Calcium Channel Subunit  2 -2

(2010) A. Tran-Van-Minh et al.   JOURNAL OF NEUROSCIENCE

The  2  subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function

(2010) A. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical Allodynia Induced by Paclitaxel, Oxaliplatin and Vincristine: Different Effectiveness of Gabapentin and Different Expression of Voltage-Dependent Calcium Channel α2δ-1 Subunit

(2009) Punam Gauchan et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Seizure susceptibility is associated with altered protein expression of voltage-gated calcium channel subunits in inferior colliculus neurons of the genetically epilepsy-prone rat

(2009) Prosper N'Gouemo et al.   BRAIN RESEARCH

Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis

(2009) Çagla Eroglu et al.   CELL

Long-term efficacy of pregabalin in generalized anxiety disorder

(2009) Douglas Feltner et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

The efficacy of pregabalin and benzodiazepines in generalized anxiety disorder presenting with high levels of insomnia

(2009) Stuart A. Montgomery et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

Impact of gastrointestinal symptoms on response to pregabalin in generalized anxiety disorder: results of a six-study combined analysis

(2009) Dan J. Stein et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

Efficacy of pregabalin and venlafaxine-XR in generalized anxiety disorder: results of a double-blind, placebo-controlled 8-week trial

(2009) Siegfried Kasper et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

Subchronic SSRI administration reduces insula response during affective anticipation in healthy volunteers

(2009) Alan N. Simmons et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Comparative efficacy of pregabalin and benzodiazepines in treating the psychic and somatic symptoms of generalized anxiety disorder

(2009) R. Bruce Lydiard et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Area-specific modulation of neural activation comparing escitalopram and citalopram revealed by pharmaco-fMRI: A randomized cross-over study

(2009) Christian Windischberger et al.   NEUROIMAGE

The Neurocircuitry of Fear, Stress and Anxiety Disorders

(2009) Lisa M Shin et al.   NEUROPSYCHOPHARMACOLOGY

Efficacy and safety of pregabalin in elderly people with generalised anxiety disorder

(2008) Stuart Montgomery et al.   BRITISH JOURNAL OF PSYCHIATRY

The influence of various glutamate receptors antagonists on anxiety-like effect of ethanol withdrawal in a plus-maze test in rats

(2008) Jolanta Kotlinska et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

JNJ16259685, a selective mGlu1 antagonist, suppresses isolation-induced aggression in male mice

(2008) José Francisco Navarro et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Efficacy and tolerability of pregabalin in partial epilepsy

(2008) Ahmad Beydoun et al.   Expert Review of Neurotherapeutics

Pharmacological Effects of the Metabotropic Glutamate Receptor 1 Antagonist Compared with Those of the Metabotropic Glutamate Receptor 5 Antagonist and Metabotropic Glutamate Receptor 2/3 Agonist in Rodents: Detailed Investigations with a Selective Allosteric Metabotropic Glutamate Receptor 1 Antagonist, FTIDC [4-[1-(2-Fluoropyridine-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide]

(2008) A. Satow et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Early onset anxiolytic efficacy after a single dose of pregabalin: double-blind, placebo- and active-comparator controlled evaluation using a dental anxiety model

(2008) D. Nutt et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Immunostaining of rat brain, spinal cord, sensory neurons and skeletal muscle for calcium channel alpha2-delta (α2-δ) type 1 protein

(2008) C.P. Taylor et al.   NEUROSCIENCE

Injury discharges regulate calcium channel alpha-2-delta-1 subunit upregulation in the dorsal horn that contributes to initiation of neuropathic pain

(2008) Amin Boroujerdi et al.   PAIN

Pharmacological disruption of calcium channel trafficking by the  2  ligand gabapentin

(2008) J. Hendrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Socioeconomic correlates of generalized anxiety disorder and major depression in primary care: The GADIS II study (Generalized Anxiety and Depression Impact Survey II)

(2007) Marc Ansseau et al.   DEPRESSION AND ANXIETY

Modulation of defensive responses and anxiety-like behaviors by group I metabotropic glutamate receptors located in the dorsolateral periaqueductal gray

(2007) Vivian C.F. Lima et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Human and economic burden of generalized anxiety disorder

(2006) Deborah L. Hoffman et al.   DEPRESSION AND ANXIETY