Article
Biochemistry & Molecular Biology
Joanna M. Wieronska, Paulina Cieslik, Grzegorz Burnat, Leszek Kalinowski
Summary: The Morris water maze (MWM) is a popular test for spatial memory in rodents. Activators for muscarinic and metabotropic glutamate receptors can prevent cognitive disorders induced by MK-801 in the MWM. MWM learning increases cGMP synthesis in the cortex and hippocampi, which can be reversed by high doses of the investigated compounds.
Article
Neurosciences
Joe R. Hilton, Susannah R. Simpson, Emily R. Sherman, Will Raby-Smith, Keemia Azvine, Maite Arribas, Jiaqi Zhou, Serena Deiana, Bastian Hengerer, Emma N. Cahill
Summary: This study investigated whether recalling unpleasant memories in different contextual, olfactory, or auditory conditions would enhance anxiety-like behavior in the elevated plus maze. However, the data did not support the idea that memory recall could influence behavior in the elevated plus maze.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Chemistry, Medicinal
Mehreen Arif, Khalid Rauf, Naeem Ur Rehman, Ahmed Tokhi, Muhammad Ikram, Robert Sewell
Summary: This study found that 6-MOF and donepezil have neuroprotective effects in chronic ethanol-induced cognitive impairment, improving cognitive performance and neurochemical markers in animals.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Multidisciplinary Sciences
Mariah Mesquita de Figueiredo Cerqueira, Micaele Maria Lopes Castro, Amanda Almeida Vieira, Juliana Ayumi Azevedo Kurosawa, Fabio Leite do Amaral Junior, Fabiola de Carvalho Chaves de Siqueira Mendes, Marcia Consentino Kronka Sosthenes
Summary: Anxiety is increasingly being diagnosed in the elderly, and it is associated with cognitive decline, morbidity, and even mortality. The environment and age have an impact on anxiety-like behavior in mice, as assessed by the Elevated Plus Maze (EPM) and Open Field (OF) tests. The results from these tests suggest the need for a better evaluation of the parameters analyzed in each test.
Article
Behavioral Sciences
Parker Knight, Ranjithkumar Chellian, Ryann Wilson, Azin Behnood-Rod, Stefany Panunzio, Adriaan W. Bruijnzeel
Summary: Female rats exhibit less anxiety-like behavior in the EPM and LOF tests, with sex differences present in almost all behavioral parameters. Additionally, there is a moderate positive correlation between parameters in the EPM and LOF tests.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Neurosciences
Raquel Cardoso Brito, Thairyne Olivato, Takae Tamy Kitabatake, Kelly Zhang, Elaine Caldeira de Oliveira Guirro, Joao Eduardo de Araujo
Summary: Studies have found that psychotropic drugs can alter rat behavior in the elevated plus-maze test. This study aimed to investigate whether static magnetic fields could impact alprazolam-induced rat behavior in the same test. The results showed that the south magnetic pole of the static magnetic field blocked the effect of alprazolam on the space-time variables of the open arms and ethological anxiolytic-like behavior in the elevated plus-maze test.
NEUROSCIENCE LETTERS
(2023)
Article
Pharmacology & Pharmacy
Vandna, Shruti Ahlawat, Krishna Kant Sharma, Hari Mohan
Summary: This study found that the co-administration of ketoprofen with Yersinia enterocolitica can cause significant damage to the rat gut, leading to altered expression of gut proteins and profound effects on the NF-kB signaling pathway, immune system, dysbiosis, and gut injury. Additionally, the biochemical and histopathological analysis of treated rats showed evidence of liver enzyme activity alteration and behavioral response changes, indicating the detrimental effects of the co-administration.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Thermodynamics
M. B. Raida, G. J. Hoetmer, A. . A. . Konnov, J. A. van Oijen, L. P. H. de Goey
Summary: A new setup for burning velocity measurements using the Heat Flux method has been constructed, with improved burner design. The experimental results have high accuracy and good agreement with literature data.
COMBUSTION AND FLAME
(2021)
Article
Behavioral Sciences
Lauren Gaspar, Sydney Bartman, Giuseppe Coppotelli, Jaime M. Ross
Summary: The incidence of anxiety-like disorders in humans decreases with aging, but it is unclear whether this is also true in mice. Mouse models can be used to understand the changes in neuronal networks that regulate anxiety-like behavior in aging. The elevated plus maze (EPM) test is commonly used to assess anxiety-like behavior, but it is unknown how the construction of the apparatus affects the behavior of younger and older mice. This study found that the distance traveled during the EPM test was most affected by the apparatus characteristics, and that old mice spent more time and had more entries in the open arms compared to young mice, suggesting a decrease in anxiety-like behavior with age.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Nicolas Cordeiro, Jose Augusto Pochapski, William Sanchez Luna, Gabriel Baltazar, Rainer K. Schwarting, Roberto Andreatini, Claudio Da Cunha
Summary: Ultrasonic vocalizations play a role in conveying emotional states in both young pups and adult rats, with differences observed between genders and developmental stages. Pup vocalizations can predict adult behaviors, while adult vocalizations are influenced by stimulants.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Cell Biology
Leticia Yoshitome Queiroz, Igor Goncalves de Oliveira, Sabrina de Carvalho Cartagenes, Luanna Melo Pereira Fernandes, Savio Monteiro dos Santos, Wallax Augusto Silva Ferreira, Fernando Augusto Rodrigues Mello Junior, Leonardo Oliveira Bittencourt, Edson Bruno Campos Paiva, Rommel Mario Rodriguez Burbano, Edivaldo Herculano Correa de Oliveira, Marta Chagas Monteiro, Rafael Rodrigues Lima, Eneas Andrade Fontes-Junior, Cristiane do Socorro Ferraz Maia
Summary: This study investigates whether behavioral and cognitive changes induced by binge drinking during adolescence persist until mid and late adulthood. The results show that binge drinking in adolescence leads to anxiety, depression, and impaired short-term memory, and these changes continue to exist even after a long period of abstinence.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Psychology, Biological
Patricia Gonzalez-Gaspar, Monserrat Macias-Carballo, Teresa Cadena-Mejia, Miguel A. Landa-Jimenez, Fernando M. Montes-Gonzalez, Maria Leonor Lopez-Meraz, Luis Beltran-Parrazal, Consuelo Morgado-Valle
Summary: Analixity is a video processing software designed for the elevated plus maze test (EPM) that automatically quantifies behavioral parameters, reducing analysis time and variability issues. Comparison with manual analysis and a commercial software showed that Analixity is as reliable and effective as the latter.
BEHAVIOURAL PROCESSES
(2021)
Article
Pharmacology & Pharmacy
Natalia Bonetti Bertagna, Paulla Giovanna Cabral dos Santos, Rafaella Misael Queiroz, Gustavo Juliate Damaceno Fernandes, Fabio Cardoso Cruz, Tarciso Tadeu Miguel
Summary: This study investigated the role of the dorsal (DH) and ventral (VH) hippocampus in anxiety-like behaviors in the elevated plus maze (EPM) by inhibiting these brain regions. Results showed that VH has a stronger modulatory effect on anxiety-like behaviors in EPM, and CRF and the cAMP/PKA pathway appear to regulate these effects.
PHARMACOLOGICAL REPORTS
(2021)
Review
Pharmacology & Pharmacy
Lia P. Iglesias, Lucas Bedeschi, Daniele C. Aguiar, Laila Asth, Fabricio A. Moreira
Summary: Delta(9)-THC and related cannabinoids have complex effects on anxiety-like behavior in humans and experimental animals. This study reviews previous research and finds that cannabinoids tend to reduce anxiety-like behavior at low doses, but can increase anxiety at high doses.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Behavioral Sciences
Adriaan W. Bruijnzeel, Azin Behnood-Rod, Wendi Malphurs, Ranjithkumar Chellian, Robert M. Caudle, Marcelo Febo, Barry Setlow, John K. Neubert
Summary: This study investigated the effects of oxycodone on anxiety-like behavior in adult male and female rats. The results showed that oxycodone decreased anxiety-like behavior in rats, with a greater anxiolytic effect observed in males compared to females.
BEHAVIOURAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pawel Grochecki, Irena Smaga, Malgorzata Lopatynska-Mazurek, Ewa Gibula-Tarlowska, Ewa Kedzierska, Joanna Listos, Sylwia Talarek, Marta Marszalek-Grabska, Magdalena Hubalewska-Mazgaj, Agnieszka Korga-Plewko, Jaroslaw Dudka, Zbigniew Marzec, Malgorzata Filip, Jolanta H. Kotlinska
Summary: The study found that rats exposed to mephedrone or amphetamine during adolescence showed deficits in spatial memory and reversal learning in adulthood, potentially affecting cognitive flexibility. Changes in MMP-9 levels induced by mephedrone were associated with the negative effects on spatial memory.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Elisa Magli, Ewa Kedzierska, Agnieszka A. Kaczor, Anna Bielenica, Beatrice Severino, Ewa Gibula-Tarlowska, Jolanta H. Kotlinska, Angela Corvino, Rosa Sparaco, Giovanna Esposito, Stefania Albrizio, Elisa Perissutti, Francesco Frecentese, Anna Lesniak, Magdalena Bujalska-Zadrozny, Marta Struga, Raffaele Capasso, Vincenzo Santagada, Giuseppe Caliendo, Ferdinando Fiorino
Summary: A series of new norbornene and exo-N-hydroxy-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboximide derivatives were synthesized and evaluated for their affinities to different 5-HT receptors to identify selective ligands. Compounds with critical structural elements showed high specificity and affinity, with some selected for further in vivo assays. Molecular docking studies were conducted to rationalize the results, indicating 3e, 4j, and 4n as the most active and promising derivatives for the serotonin receptor considered in the study.
ARCHIV DER PHARMAZIE
(2021)
Article
Biochemistry & Molecular Biology
Hao-Yuan Hung, Lok-Hi Chow, Jolanta H. Kotlinska, Anna Drabik, Jerzy Silberring, Yuan-Hao Chen, Eagle Yi-Kung Huang
Summary: Chronic alcohol consumption may alter the level of LVV-H7, affecting pain sensation. Alcohol initially induces analgesia followed by hyperalgesia during withdrawal, potentially driven by changes in LVV-H7. Levels of LVV-H7 are influenced by cathepsin D activity and red blood cell/hemoglobin counts, which may be impacted by alcohol-induced anemia.
Article
Biochemistry & Molecular Biology
Malgorzata Lopatynska-Mazurek, Anna Pankowska, Ewa Gibula-Tarlowska, Radoslaw Pietura, Jolanta H. Kotlinska
Summary: The mTOR signaling pathway plays a crucial role in synaptic plasticity in mammals, and prenatal ethanol exposure can disrupt this pathway in the fetal hippocampus. Pre-treatment with rapamycin can reverse ethanol-induced memory deficits in adult rats, suggesting the involvement of mTORC1 in the deleterious effects of ethanol on the developing brain.
Article
Biochemistry & Molecular Biology
Przemyslaw Mielczarek, Tymoteusz Slowik, Jolanta Helena Kotlinska, Piotr Suder, Anna Bodzon-Kulakowska
Summary: This study investigated the derivatization of cholesterol with betaine aldehyde in tissue slices and evaluated the impact of different sample preparation methods on the signal from the derivatization product. The results demonstrated that the proposed approach could be utilized for cholesterol analysis in various tissues.
Article
Biochemistry & Molecular Biology
Malgorzata Lopatynska-Mazurek, Anna Antolak, Pawel Grochecki, Ewa Gibula-Tarlowska, Anna Bodzon-Kulakowska, Joanna Listos, Ewa Kedzierska, Piotr Suder, Jerzy Silberring, Jolanta H. Kotlinska
Summary: The study found that neonatal ethanol exposure led to deficits in spatial memory and reversal learning in adulthood, and adult rats treated with ethanol were more sensitive to the rewarding effects of ethanol. Pretreatment with rapamycin prevented the adverse effects of ethanol and normalized the expression of the NMDA receptor subunit in the brain of adult rats.
Article
Behavioral Sciences
Ewa Gibula-Tarlowska, Volker Korz, Malgorzata Lopatynska-Mazurek, Agnieszka Chlopas-Konowalek, Pawel Grochecki, Predrag Kalaba, Vladimir Dragacevic, Robert Kotlinski, Radoslaw Kujawski, Michal Szulc, Kamila Czora-Poczwardowska, Przemyslaw L. Mikolajczak, Gert Lubec, Jolanta H. Kotlinska
Summary: Perinatal alcohol exposure can result in Fetal Alcohol Spectrum Disorders (FASD) characterized by symptoms like hyperactivity and learning disabilities, with dopamine signaling being a main factor. The study found that CE-123 inhibited hyperactivity and improved reversal learning in rats exposed to alcohol, suggesting it may be a useful intervention for deficits related to neonatal ethanol exposure.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Malgorzata Lopatynska-Mazurek, Lukasz Komsta, Ewa Gibula-Tarlowska, Jolanta H. Kotlinska
Summary: Research has shown that neonatal alcohol exposure may lead to learning and memory deficits as well as depressive behavior in adult rats, associated with increased oxidative stress parameters in the hippocampus and prefrontal cortex. The complete reversal of these effects by Rapamycin suggests its effectiveness in preventive therapy for disorders related to prenatal alcohol exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Pawel Grochecki, Irena Smaga, Marta Marszalek-Grabska, Malgorzata Lopatynska-Mazurek, Tymoteusz Slowik, Ewa Gibula-Tarlowska, Ewa Kedzierska, Joanna Listos, Malgorzata Filip, Jolanta H. Kotlinska
Summary: This study suggests that prior exposure to synthetic cathinone, mephedrone, has different effects on ethanol reward in adolescent and adult rats. Adult rats with prior mephedrone administration are more sensitive to the ethanol effect in a drug-free state, and this effect is associated with upregulation of dopamine D1 receptors, NMDAR/GluN2B, MMP-9, and Cav1.2 signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Joanna Filarowska-Jurko, Lukasz Komsta, Irena Smaga, Paulina Surowka, Marta Marszalek-Grabska, Pawel Grochecki, Dorota Nizio, Malgorzata Filip, Jolanta H. Kotlinska
Summary: Adverse early life experiences, such as maternal separation, are associated with an increased risk for mental and physical health problems, including substance abuse. This study found that the NMDAR/glycine sites may be involved in vulnerability to alcohol consumption and reversal learning deficits in adolescent rats subjected to maternal separation, particularly in female rats. Targeting NMDAR/glycine sites may be a potential treatment option for alcohol abuse in adolescents with early maternal separation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Joanna Listos, Piotr Listos, Irena Baranowska-Bosiacka, Agata Karpiuk, Joanna Filarowska, Malgorzata Lupina, Tymoteusz Slowik, Sylwia Zawislak, Jolanta Kotlinska
Summary: This study demonstrates the involvement of GLP-1 receptors in morphine dependence, and suggests that linagliptin may be a valuable drug in attenuating both the physical symptoms and emotional disturbances associated with morphine withdrawal.
Review
Biochemistry & Molecular Biology
Wojciech Ziemichod, Jolanta Kotlinska, Ewa Gibula-Tarlowska, Natalia Karkoszka, Ewa Kedzierska
Summary: Cebranopadol has been evaluated as a potential solution to the side effects associated with opioids. By acting on the mu opioid receptor and the nociceptin/orphanin receptor, cebranopadol can reduce the side effects of opioids while still providing analgesia. This review examines the effects, pharmacokinetics, and clinical trials of cebranopadol to explore its promise in pain management.
Article
Biochemistry & Molecular Biology
Pawel Grochecki, Irena Smaga, Paulina Surowka, Marta Marszalek-Grabska, Predrag Kalaba, Vladimir Dragacevic, Patrycja Kotlinska, Malgorzata Filip, Gert Lubec, Jolanta H. Kotlinska
Summary: Maternal separation is a major contributor to neurodevelopmental disorders. This study suggests that dopamine signaling plays a key role in maternal separation-induced learning disabilities. The new dopamine transporter inhibitor, CE-123, can effectively counteract the spatial learning and memory deficit caused by maternal separation in rats, particularly in females. It restores cognitive impairment and dopamine signaling in adolescent rats exposed to maternal separation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rosa Sparaco, Ewa Kedzierska, Agnieszka A. Kaczor, Anna Bielenica, Elisa Magli, Beatrice Severino, Angela Corvino, Ewa Gibula-Tarlowska, Jolanta H. Kotlinska, Giorgia Andreozzi, Paolo Luciano, Elisa Perissutti, Francesco Frecentese, Marcello Casertano, Anna Lesniak, Magdalena Bujalska-Zadrozny, Malgorzata Ozieblo, Raffaele Capasso, Vincenzo Santagada, Giuseppe Caliendo, Ferdinando Fiorino
Summary: A series of new derivatives were prepared and evaluated to identify selective ligands for serotonin receptors. The most active compounds, Norbo-4 and Norbo-18, showed high specificity and affinity towards the receptors.
Article
Biochemistry & Molecular Biology
Pawel Grochecki, Irena Smaga, Karolina Wydra, Marta Marszalek-Grabska, Tymoteusz Slowik, Ewa Kedzierska, Joanna Listos, Ewa Gibula-Tarlowska, Malgorzata Filip, Jolanta H. H. Kotlinska
Summary: This study examined the complex issue of treating Post-Traumatic Stress Disorder (PTSD) when it coexists with drug use disorder. The results showed that conditioned fear, a model for PTSD, can alter the rewarding effect of mephedrone, and repeated injections of mephedrone can impact trauma-related behaviors such as fear sensitization, extinction, and recall. The study also found changes in the expression of metalloproteinase-9 (MMP-9) and GluN2A and GluN2B subunits of the N-methyl-D-aspartate (NMDA) glutamate receptor in the hippocampus and basolateral amygdala, suggesting the involvement of these brain structures in fear memory impairment and drug seeking behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
