Review
Biochemistry & Molecular Biology
Rim Hamze, Etienne Delangre, Stefania Tolu, Manon Moreau, Nathalie Janel, Danielle Bailbe, Jamileh Movassat
Summary: The global prevalence of diabetes mellitus and Alzheimer's disease is increasing alarmingly with the aging of the population. There is a strong association between type 2 diabetes and an increased risk of dementia. The amyloid cascade, altered glucose metabolism, and insulin signaling may play key roles in the pathophysiology of Alzheimer's disease. Impaired insulin and IGF-1 signaling, as well as GSK3 beta and DYRK1A, could be potential therapeutic targets for both diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Khaled Hameed Husain, Saud Faisal Sarhan, Haya Khaled Ali Abdulla AlKhalifa, Asal Buhasan, Abu Saleh Md Moin, Alexandra E. Butler
Summary: Hypoglycemia, a common consequence of diabetes treatment, is associated with severe morbidity and mortality and has become a major barrier to intensifying antidiabetic therapy. Dementia generally refers to the loss of memory, language, problem-solving, and other cognitive functions, which can interfere with daily life, and there is growing evidence that diabetes is associated with an increased risk of both vascular and non-vascular dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Dun Li, Hongxi Yang, Mingqian Lyu, Ju Wang, Weili Xu, Yaogang Wang
Summary: This study identified therapeutic targets and biological mechanisms of acupuncture therapy (AT) in treating dementia through integrated analysis. The results demonstrated that AT improved Alzheimer's disease (AD) and vascular dementia (VaD) by modulating synaptic function, immunity, inflammation, and apoptosis. This study provides valuable clues for complementing and combining pharmacotherapy.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Qing Yao, Xiaohao Wu, Chu Tao, Weiyuan Gong, Mingjue Chen, Minghao Qu, Yiming Zhong, Tailin He, Sheng Chen, Guozhi Xiao
Summary: Osteoarthritis (OA) is a chronic degenerative joint disorder that affects more than 500 million people worldwide. It is now recognized as a whole-joint disorder caused by biochemical and cellular alterations in the synovial joint tissues. The lack of understanding of the pathological mechanism has hindered the development of a cure for OA. Therefore, it is crucial to study the signaling pathways and key molecules involved in OA pathogenesis for the development of therapeutic strategies.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Jingqian Su, Yingsheng Luo, Shan Hu, Lu Tang, Songying Ouyang
Summary: Diabetes mellitus is a chronic disease with multiple complications and limited treatment options. The development of targeted therapies for type 2 diabetes mellitus is important due to individual variability and resistance to single-target drugs. This review provides an overview of recent therapeutic agents and discusses emerging target-based therapies for T2DM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Fidelma Dunne, Christine Newman, Alberto Alvarez-Iglesias, John Ferguson, Andrew Smyth, Marie Browne, Paula O'Shea, Declan Devane, Paddy Gillespie, Delia Bogdanet, Oratile Kgosidialwa, Aoife Egan, Yvonne Finn, Geraldine Gaffney, Aftab Khattak, Derek O'Keeffe, Aaron Liew, Martin O'Donnell
Summary: Early initiation of metformin is not superior to placebo for the primary outcome of gestational diabetes. Further investigation of metformin in larger clinical trials is supported by the prespecified secondary outcome data.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Biochemistry & Molecular Biology
Meiying Song, Xiang Fan
Summary: Elderly people over the age of 65 are most susceptible to Alzheimer's disease (AD), which is associated with apparent metabolic alterations. Currently, there is no cure for AD, and only a few drugs have been approved by the FDA to alleviate its symptoms. Numerous preclinical and clinical trials have investigated the impact of adjusting whole-body and intracellular metabolism on the development of AD. Recent evidence suggests that mitochondria play a crucial role by initiating a stress response, leading to healthy aging and neuroprotection. There is also growing awareness of the differential risk and potential targeting strategies related to metabolism and the microbiome. Mitochondrial bioenergetics, quality-control mechanisms, and mitochondrial-linked inflammatory responses are considered potential therapeutic targets for AD. This review summarizes and highlights these recent advancements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Riane Richard, Shaker Mousa
Summary: Alzheimer's disease is the sixth leading cause of death in the United States, with an estimated 20 million patients by 2050. This study examines the role of necroptosis in the development of Alzheimer's disease and finds that it plays a crucial role due to factors such as hyperglycemia, reactive oxygen species, inflammation, and insulin resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Ichiro Kawahata, Kohji Fukunaga
Summary: Parkinson's disease is a neurodegenerative disorder characterized by motor dysfunction caused by the degeneration of dopamine-producing neurons. Fatty acid-binding proteins (FABPs) play a significant role in the pathogenesis of Parkinson's disease, accumulating in cells and disrupting their normal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Lynne H. Shinto, Jacob Raber, Anusha Mishra, Natalie Roese, Lisa C. Silbert
Summary: The majority of modifiable risk factors for Alzheimer's disease and related dementia are vascular in nature. Oxylipins may have both protective and detrimental effects on brain structure, cognitive performance, and disease progression.
Review
Cell Biology
Saikat Dewanjee, Jayalakshmi Vallamkondu, Rajkumar Singh Kalra, Pratik Chakraborty, Moumita Gangopadhyay, Ranabir Sahu, Vijaykrishna Medala, Albin John, P. Hemachandra Reddy, Vincenzo De Feo, Ramesh Kandimalla
Summary: Diabetes mellitus is a major manifestation of metabolic syndrome with increasing prevalence. Chronic hyperglycemia can lead to various vascular complications, being the major cause of morbidity and mortality in diabetic patients. Histone deacetylase (HDAC) plays a crucial role in regulating molecular activities in diabetes and could serve as a potential therapeutic target for developing novel intervention strategies.
Review
Oncology
Xiang-Yuan Luo, Kong-Ming Wu, Xing-Xing He
Summary: Hepatocellular carcinoma is a deadly health burden worldwide, but recent years have seen significant breakthroughs in new drug development. The FDA has approved multiple drugs for HCC treatment, with over 1000 ongoing clinical trials globally, indicating a vibrant atmosphere in the HCC drug research field.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Geriatrics & Gerontology
Yingzi Liu, Xuewen Xiao, Hui Liu, Xinxin Liao, Yafang Zhou, Ling Weng, Lu Zhou, Xixi Liu, Xiang-yun Bi, Tianyan Xu, Yuan Zhu, Qijie Yang, Sizhe Zhang, Xiaoli Hao, Weiwei Zhang, Junling Wang, Bin Jiao, Lu Shen
Summary: Alzheimer's disease is a progressive neurodegenerative disease associated with aging, environmental, and genetic factors. Mutations in the amyloid protein precursor gene (APP) are known to be pathogenic for familial Alzheimer's disease. Although patients with APP mutations show more non-demented symptoms and neurological symptoms, their clinical phenotypes are generally consistent with typical AD. Genotype-phenotype analysis based on APP processing differences caused by mutations revealed differences in onset age, behavioral and psychological disorders of dementia, and myoclonus.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Patricia Teixeira Santana, Siane Lopes Bittencourt Rosas, Beatriz Elias Ribeiro, Ygor Marinho, Heitor S. P. de Souza
Summary: Microbe-host communication is crucial for maintaining vital functions of a healthy host. Disruption of this communication is associated with various diseases, including Crohn's disease and ulcerative colitis. Identifying microorganisms that affect disease susceptibility and phenotypes in humans is still challenging. Recent insights into the role of diet and environmental factors on the gut microbiome have direct implications for the immune response and the development of IBD. The complexity of IBD pathogenesis suggests the need for an integrative approach to identify specific therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Fu-Shun Yen, James Cheng-Chung Wei, Hei-Tung Yip, Chii-Min Hwu, Chih-Cheng Hsu
Summary: This study demonstrates that patients with type 2 diabetes and subsequent hypertension have a higher risk of all-cause dementia and vascular dementia, while patients with hypertension and subsequent type 2 diabetes have a higher risk of all-cause dementia, vascular dementia, and other dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Andleeb Khan, Sivakumar Sivagurunathan Moni, M. Ali, Syam Mohan, Huma Jan, Saiema Rasool, Mohammad A. Kamal, Saeed Alshahrani, Maryam Halawi, Hassan A. Alhazmi
Summary: Fungal infections are on the rise worldwide, particularly in immunocompromised individuals. Candida spp. is the most common disease-causing fungus, causing various infections. Understanding the morphological and developmental pathways of Candida is crucial for developing new antifungal drugs. Conventional antifungal drugs have developed resistance, necessitating the exploration of new sources such as phytochemicals and their secondary metabolites.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Review
Neurosciences
Faijan Akhtar, Parth K. Patel, Md Belal Bin Heyat, Saba Yousaf, Atif Amin Baig, Rashenda Aziz Mohona, Muhamad Malik Mutoffar, Tanima Bhattacharya, Bibi Nushrina Teelhawod, Jian Ping Li, Mohammad Amjad Kamal, Kaishun Wu
Summary: This study aims to determine the research volume conducted on students who are affected by smartphone addiction and design a database. It also provides a comprehensive image of smartphone-addicted students and highlights critical problems for future research.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Biochemistry & Molecular Biology
Fariya Khan, Salman Akhtar, Mohammad Amjad Kamal
Summary: The emerging field of nanoinformatics, combining bioinformatics and nanotechnology, offers new research opportunities for the development of personalized nanomedicine in cancer therapy. This approach has the potential to revolutionize the field of precision medicine by providing non-invasive and versatile treatment options for cancer patients.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Athanasios Alexiou, Christos Tsagkaris, Stylianos Chatzichronis, Andreas Koulouris, Ioannis Haranas, Ioannis Gkigkitzis, Georgios Zouganelis, Nobendu Mukerjee, Swastika Maitra, Niraj Kumar Jha, Gaber El-Saber Batiha, Mohammad Amjad Kamal, Michail Nikolaou, Ghulam Md Ashraf
Summary: Even though cancer therapies have improved, the number of patients has increased, making cancer the fifth deadliest disease. Efficient drug delivery systems must overcome barriers and maximize drug delivery while limiting side effects. Quantum-inspired solutions, such as using quantum tunneling phenomenon in scanning tunneling microscopes, allow for accurate mapping of tumor surfaces and efficient nanodrug design.
CURRENT MEDICINAL CHEMISTRY
(2023)
Letter
Public, Environmental & Occupational Health
Faisal Ismail, Atiya Farag, Soghra Haq, Mohammad Amjad Kamal
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2023)
Review
Endocrinology & Metabolism
Nobendu Mukerjee, Swastika Maitra, Subhradeep Roy, Shaswata Modak, Mohammad Mehedi Hasan, Biswajit Chakraborty, Arabinda Ghosh, Asmita Ghosh, Mohammad Amjad Kamal, Abhijit Dey, Ghulam Md Ashraf, Sumira Malik, Md Habibur Rahman, Badrah S. Alghamdi, Adel Mohammad Abuzenadah, Athanasios Alexiou
Summary: Glioblastoma is an aggressive tumor that hinders normal brain function, and the inability of the skull to expand results in increased pressure in the brain. Recent studies have found that SNPs play a significant role in the development and spread of glioblastoma, with many GB-related SNPs being highly abundant in the promoter region, creating genetic vulnerability to glioma.
METABOLIC BRAIN DISEASE
(2023)
Editorial Material
Neurosciences
Mohammad Amjad Kamal, Athanasios Alexiou, Asma Perveen
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Syed Mohd Danish Rizvi, Talib Hussain, Farhan Alshammari, Hana Sonbol, Nabeel Ahmad, Syed Shah Mohammed Faiyaz, Mohammad Amjad Kamal, El-Sayed Khafagy, Afrasim Moin, Amr Selim Abu Lila
Summary: Infections caused by resistant bacterial pathogens have become more complicated for clinicians worldwide. Researchers have developed gold nanoparticles (AuNPs) that efficiently deliver cephalosporin antibiotics to resistant clinical pathogens. The synthesized AuNPs showed high stability and were effective against resistant strains of E. coli and K. pneumoniae. This study suggests that investing in a nano-antibiotic strategy may be a better approach to overcome resistance.
Review
Pharmacology & Pharmacy
Syed Mohd Danish Rizvi, Amr Selim Abu Lila, Afrasim Moin, Talib Hussain, Mohammad Amjad Kamal, Hana Sonbol, El-Sayed Khafagy
Summary: The advent of new antibiotics has helped control severe bacterial infections, but inappropriate use and resistance mechanisms still pose challenges. Extended-spectrum beta-lactamases (ESBLs) genes have become one of the most common approaches for bacteria to develop resistance. Nanotechnology, specifically gold nanoparticles (AuNPs), has shown potential in converting unresponsive antibiotics into potent ones against resistant strains.
Article
Pharmacology & Pharmacy
Shailja Singhal, Utsang Kumar, Taha Alqahtani, Igor Vladimirovich Rzhepakovsky, Rekha Khandia, Megha Pandey, Saud Alqahtani, Hanan Alharbi, Mohammad Amjad Kamal
Summary: Apoptosis and autophagy are two fundamental processes involved in maintaining homeostasis, and they can be initiated by a common stimulus. Autophagy has been implicated in various diseases, including viral infections. Genetic manipulations that alter gene expression could be a strategy to control viral infection.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Review
Medicine, General & Internal
Qamar Sultana, Jill Kar, Amogh Verma, Shreya Sanghvi, Nirja Kaka, Neil Patel, Yashendra Sethi, Hitesh Chopra, Mohammad Amjad Kamal, Nigel H. H. Greig
Summary: Neuroendocrine neoplasms (NENs) are a group of heterogeneous tumors that can originate from any organ and account for 2% of all malignancies in the United States. NEN patients often experience endocrine imbalances due to increased hormone secretion, affecting their quality of life and prognosis. The past decade has seen significant advancements in the categorization, diagnosis, and treatment choices for NENs, leading to a better understanding and the possibility of targeted therapies beyond surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biology
Gnana Deepthi Medarametla, Ripudaman Singh Kahlon, Lampimukhi Mahitha, Sanobar Shariff, Naga Praneeth Vakkalagadda, Hitesh Chopra, Mohammad Amjad Kamal, Neil Patel, Yashendra Sethi, Nirja Kaka
Summary: Amyloidosis is a protein deposition disorder that damages organ function by causing the accumulation of insoluble fibrils in bodily tissues. Cardiac amyloidosis, a severe and under-reported condition, involves the accumulation of amyloid in the extracellular area of the myocardium, leading to thickening and stiffening of ventricular walls. The incidence of cardiac amyloidosis has been slowly increasing, and this study aims to provide a comprehensive understanding of its pathophysiology and clinical presentation, as well as offer up-to-date approaches for diagnosis and therapy. Genetic mutations and advancements in imaging and diagnostic methods contribute to the growing incidence of cardiac amyloidosis. Early detection can help improve treatment outcomes, and various therapeutic approaches are being explored to impede disease progression and enhance clinical outcomes.
Review
Biochemistry & Molecular Biology
Ligen Yu, Mohd Khanapi Abd Ghani, Alessio Aghemo, Debmalya Barh, Matteo Bassetti, Fausto Catena, Gaetano Gallo, Ali Gholamrezanezhad, Mohammad Amjad Kamal, Amos Lal, Kamal Kant Sahu, Shailendra K. Saxena, Ugo Elmore, Farid Rahimi, Chiara Robba, Yuanlin Song, Zhengyuan Xia, Boxuan Yu
Summary: This study analyzed keywords and found that factors such as the immune system and nutrition are related to COVID-19. It proposed that the human immune system is a complex system that employs self-destruct and rebuild strategies to fight microbial infections. Microbial infections may be self-limiting and provide essential nutrition for the patient. The study also discussed possible strategies to mitigate COVID-19, including vaccination.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Computer Science, Artificial Intelligence
Pongtep Weerapong, Kotaro Hashikura, Md Abdus Samad Kamal, Iwanori Murakami, Kou Yamada
Summary: This paper discusses a method to evaluate the prediction accuracy of a wheelchair-occupant simulation model by comparing it with real-world experimental results. Different types of seat cushions are used in the model to simulate the low-frequency vibration waves caused by the interaction between wheelchair tires and the ground. The analysis shows that the occupant's torso is most affected by the vibration, resulting in the maximum displacement of organs; and the foam-based cushion performs the best in reducing the amplitude of displacement responses.
INTERNATIONAL JOURNAL OF INNOVATIVE COMPUTING INFORMATION AND CONTROL
(2023)
Article
Computer Science, Artificial Intelligence
Sorawin Phukapak, Daisuke Koyama, Kotaro Hashikura, Md Abdus Samad Kamal, Kou Yamada
Summary: In this paper, the parameterization of all disturbance observers for periodic output disturbances is examined. Disturbance observers have been used to estimate disturbances in plants. While previous papers have clarified the parameterization of all disturbance observers for plants, none have focused on periodic output disturbances. This paper proposes a parameterization method for all disturbance observers for periodic output disturbances.
INTERNATIONAL JOURNAL OF INNOVATIVE COMPUTING INFORMATION AND CONTROL
(2023)