Review
Biochemistry & Molecular Biology
Ying Chen, John Man Tak Chu, Raymond Chuen Chung Chang, Gordon Tin Chun Wong
Summary: The complement system plays a crucial role in the central nervous system beyond immunity, impacting neurodevelopment and neurodegenerative diseases. Proper activation of the complement system is essential for maintaining normal brain function, but overactivation or dysregulation may lead to synaptic dysfunction and excessive pro-inflammatory responses. Targeting complement factors shows therapeutic potential for neurodegenerative conditions.
Review
Biochemistry & Molecular Biology
Madiha Rasheed, Junhan Liang, Chaolei Wang, Yulin Deng, Zixuan Chen
Summary: Neuroinflammation plays a significant role in the initiation and progression of Parkinson's disease, activating the neuronal immune system and triggering a vicious cycle of inflammation-induced dopaminergic neuron damage. Epigenetic mechanisms are at the forefront of regulating neuroinflammatory factors, offering potential for breaking this cycle. These mechanisms do not work independently but cooperatively, impacting various neuroinflammatory pathways and potentially influencing PD development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Itzia Jimenez-Ferrer, Filip Backstrom, Alfredo Duenas-Rey, Michael Jewett, Antonio Boza-Serrano, Kelvin C. Luk, Tomas Deierborg, Maria Swanberg
Summary: The study demonstrates that Mhc2ta gene modulates aggregation, propagation, and dopaminergic pathology of alpha-synuclein in a PD model, affecting neurodegeneration and motor impairment.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Multidisciplinary Sciences
Sarmistha Mitra, Raju Dash, Amena Al Nishan, Sarmin Ummey Habiba, Il Soo Moon
Summary: This review examines the influence of the gut microbiota on neuronal development and neurodegenerative disorders, emphasizing the importance of understanding the balance between beneficial and harmful bacteria. It also highlights the potential therapeutic applications of targeting the gut microbiota population and its derivatives.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Cell Biology
Elvira Pequeno Leites, Vanessa Alexandra Morais
Summary: Mitochondrial dysfunction, particularly related to the nuclear-encoded mitochondrial kinase PINK1, plays a crucial role in the development of Parkinson's disease. Recent discoveries suggest that disruptions in overall brain homeostasis may underlie the neurodegeneration seen in PD. The involvement of astrocytes and microglia lacking PINK1 in increased neuroinflammation and deficits in physiological roles highlight the importance of these cells in the pathophysiology of PD.
Review
Cell Biology
Juan Segura-Aguilar, Bengt Mannervik, Jose Inzunza, Mukesh Varshney, Ivan Nalvarte, Patricia Munoz
Summary: Astrocytes play a vital role in protecting neurons by providing energy, defending against excitotoxicity, metabolizing fatty acids, and converting glutamate. A recent discovery suggests that astrocytes also protect dopamine neurons from neurotoxicity through the secretion of certain enzymes.
NEURAL REGENERATION RESEARCH
(2022)
Article
Immunology
Michael MacLean, Judyta Juranek, Swetha Cuddapah, Raquel Lopez-Diez, Henry H. Ruiz, Jiyuan Hu, Laura Frye, Huilin Li, Paul F. Gugger, Ann Marie Schmidt
Summary: The study demonstrates the significant role of microglia RAGE in the progression of ALS pathology, showing that microglia Ager deletion can extend survival in male SOD1(G93A) mice and ameliorate certain pathways identified in human ALS patients.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Dimitrinka Atanasova, Nikolai Lazarov, Dimo S. Stoyanov, Radoslav H. Spassov, Anton B. Tonchev, Jana Tchekalarova
Summary: Agomelatine has anti-inflammatory and antidepressant effects, which can restore abnormal neuroglia activity in the model and partially restore suppressed neurogenesis.
Review
Biochemistry & Molecular Biology
Savina Apolloni, Martina Milani, Nadia D'Ambrosi
Summary: Friedreich's ataxia (FRDA) is a rare genetic disorder caused by mutations in the frataxin gene, leading to progressive nervous system damage. In addition to neurons, alterations in glial cells and neuroinflammatory-related mechanisms may contribute to the pathogenesis of FRDA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mariana Bresque, Daniel Esteve, Mariana Pehar, Marcelo R. Vargas
Summary: NAD(+) metabolism plays a significant role in neuronal function and its dysregulation is associated with neurological disorders. Modulating NAD(+) availability could be a promising therapeutic approach for these disorders.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Neurosciences
Yujia Zhao, Yuze Qi, Qingru Li, Huihui Quan, Dan Liu, Hui Zhou
Summary: This study used an in vivo Parkinson's disease model to investigate the role of Cx43 and its underlying mechanisms. The results showed that inhibiting Cx43 may prevent neurotoxicity and dopaminergic neuronal death caused by lipopolysaccharide, possibly by reducing neuroinflammation and increasing neurotrophic factors.
NEUROSCIENCE LETTERS
(2022)
Review
Neurosciences
George Fadoul, Milos Ikonomovic, Feng Zhang, Tuo Yang
Summary: Ischemic stroke is a significant cause of mortality and disability, and Nrf2 has been investigated as a therapeutic target for reducing oxidative damage. This review comprehensively summarizes the protective effects of Nrf2 in different cell types during acute and chronic phases of stroke and highlights the importance of targeting Nrf2 in clinical settings while considering various factors.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Geriatrics & Gerontology
Leonard Radu Pinosanu, Bogdan Capitanescu, Daniela Glavan, Sanziana Godeanu, Israel Fernaundez Cadenas, Thorsten R. Doeppner, Dirk M. Hermann, Adrian-Tudor Balseanu, Catalin Bogdan, Aurel Popa-Wagner
Summary: The functions and activities of astroglia cells in brain development, aging, and neurodegenerative diseases differ. Comparing the transcriptomic activity of astroglia cells in these processes may provide new therapeutic strategies to protect the aging brain and improve clinical outcomes.
Article
Behavioral Sciences
Thuy Thi Lai, Yun Joong Kim, Phuong Thi Nguyen, Young Ho Koh, Tinh Thi Nguyen, Hyeo-il Ma, Young Eun Kim
Summary: The study found that in the PD mouse model, inflammatory response may occur before the accumulation of the pathologic form of alpha Syn, followed by neurodegeneration and motor dysfunction as alpha Syn propagation occurs, which could be helpful in establishing PD animal model and monitoring the effect of interventional therapy.
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2021)
Article
Immunology
Alexander Grotemeyer, Judith F. Fischer, James B. Koprich, Jonathan M. Brotchie, Robert Blum, Jens Volkmann, Chi Wang Ip
Summary: Inhibition of the NLRP3 inflammasome can reduce neuroinflammation and prevent the death of dopaminergic neurons in a human α-synuclein mouse model of progressive Parkinson's disease (PD). Repeat administration of the NLRP3 inhibitor MCC950 decreased the infiltration of T cells into the substantia nigra and mitigated microglial activation and α-synuclein protein aggregation in dopaminergic neurons. This treatment also resulted in less neurodegeneration of dopaminergic neurons and improved motor behavior related to PD.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Geriatrics & Gerontology
Maria Francesca Serapide, Francesca L'Episcopo, Cataldo Tirolo, Nunzio Testa, Salvatore Caniglia, Carmela Giachino, Bianca Marchetti
FRONTIERS IN AGING NEUROSCIENCE
(2020)
Review
Biochemistry & Molecular Biology
Bianca Marchetti
Review
Medicine, General & Internal
Bianca Marchetti, Loredana Leggio, Francesca L'Episcopo, Silvia Vivarelli, Cataldo Tirolo, Greta Paterno, Carmela Giachino, Salvatore Caniglia, Maria Francesca Serapide, Nunzio Iraci
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Pierpaolo Risiglione, Loredana Leggio, Salvatore A. M. Cubisino, Simona Reina, Greta Paterno, Bianca Marchetti, Andrea Magri, Nunzio Iraci, Angela Messina
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Engineering, Biomedical
Loredana Leggio, Giuseppe Arrabito, Vittorio Ferrara, Silvia Vivarelli, Greta Paterno, Bianca Marchetti, Bruno Pignataro, Nunzio Iraci
ADVANCED HEALTHCARE MATERIALS
(2020)
Review
Biochemistry & Molecular Biology
Loredana Leggio, Greta Paterno, Silvia Vivarelli, Francesca L'Episcopo, Cataldo Tirolo, Gabriele Raciti, Fabrizio Pappalardo, Carmela Giachino, Salvatore Caniglia, Maria Francesca Serapide, Bianca Marchetti, Nunzio Iraci
Review
Cell Biology
Bianca Marchetti, Carmela Giachino, Cataldo Tirolo, Maria F. Serapide
Summary: This article discusses the multifunctional role of dopamine (DA) signaling in neuroendocrine-immune modulation and its involvement in Parkinson's disease (PD). The degeneration of DA nigrostriatal pathway in PD leads to the loss of substantia nigra pars compacta (SNpc) neurons and disruption of glial inflammatory networks. The article emphasizes the reciprocal modulation between DA and glial cells, as well as the impact of gene-environment interactions on PD vulnerability. Additionally, the article introduces the role of DA as an endogenous modulator in the regulation of oxidative stress and inflammation, and explores the potential application of DA receptor agonists as immune modifiers in the clinic.
Article
Engineering, Biomedical
Loredana Leggio, Francesca L'Episcopo, Andrea Magri, Maria Jose Ulloa-Navas, Greta Paterno, Silvia Vivarelli, Carlos A. P. Bastos, Cataldo Tirolo, Nunzio Testa, Salvatore Caniglia, Pierpaolo Risiglione, Fabrizio Pappalardo, Alessandro Serra, Patricia Garcia-Tarraga, Nuno Faria, Jonathan J. Powell, Luca Peruzzotti-Jametti, Stefano Pluchino, Jose Manuel Garcia-Verdugo, Angela Messina, Bianca Marchetti, Nunzio Iraci
Summary: Extracellular vesicles released by astrocytes in the brain of Parkinson's disease patients play a significant role in cell-to-cell communication and have neuroprotective effects on dopaminergic neurons. Nigrostriatal astrocytes release the highest number of EVs, especially in response to CCL3, which promotes dopaminergic neuroprotection. These EVs specifically protect differentiated cells from oxidative stress-induced caspase-3 activation and restore impaired mitochondrial function caused by the neurotoxin MPP+. EVs from VMB-astrocytes fully restore ATP production in differentiated SH-SY5Y cells.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Environmental Sciences
Antonino Musumeci, Mirella Vinci, Francesca L'Episcopo, Alda Ragalmuto, Vincenzo Neri, Michele Roccella, Giuseppe Quatrosi, Luigi Vetri, Francesco Cali
Summary: The reliability, accuracy, and timeliness of diagnostic testing for SARS-CoV-2 infection are essential for public health management. Pooling multiple samples together can significantly improve testing efficiency and reduce costs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)