The PINK1-Mediated Crosstalk between Neural Cells and the Underlying Link to Parkinson’s Disease

Novel targeted therapies for Parkinson’s disease

(2021) Theodora Ntetsika et al.   MOLECULAR MEDICINE

PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency

(2020) Sheila K. Pirooznia et al.   Molecular Neurodegeneration

Cyanidin‐3‐O‐glucoside improves non‐alcoholic fatty liver disease by promoting PINK1‐mediated mitophagy in mice

(2020) Xinwei Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neuroglial transmitophagy and Parkinson's disease

(2020) Ingrid Morales et al.   GLIA

Tobacco smoking and the risk of Parkinson disease

(2020) Benjamin Mappin-Kasirer et al.   NEUROLOGY

Astrocytes rescue neuronal health after cisplatin treatment through mitochondrial transfer

(2020) Krystal English et al.   Acta Neuropathologica Communications

PINK 1 phosphorylates Drp1 S616 to regulate mitophagy‐independent mitochondrial dynamics

(2020) Hailong Han et al.   EMBO REPORTS

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

(2020) Hyuk Sung Kwon et al.   Translational Neurodegeneration

LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson’s disease

(2019) Fiona Bonello et al.   HUMAN MOLECULAR GENETICS

Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease

(2019) Angelique di Domenico et al.   Stem Cell Reports

Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease

(2019) Ludmila P. Dolgacheva et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Glial phagocytic clearance in Parkinson’s disease

(2019) Marie-Eve Tremblay et al.   Molecular Neurodegeneration

Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice

(2019) Diana Matheoud et al.   NATURE

Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease

(2019) Sonia George et al.   Molecular Neurodegeneration

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

(2019) Caroline Fecher et al.   NATURE NEUROSCIENCE

PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation

(2019) Qisheng Lin et al.   Redox Biology

Pleiotropic Mitochondria: The Influence of Mitochondria on Neuronal Development and Disease

(2019) Vidhya Rangaraju et al.   JOURNAL OF NEUROSCIENCE

Glial mitochondrial function and dysfunction in health and neurodegeneration

(2019) Kevin McAvoy et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Mitochondrial quality control pathways: PINK1 acts as a gatekeeper

(2018) Elvira P. Leites et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glia in brain energy metabolism: A perspective

(2018) L. Felipe Barros et al.   GLIA

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

(2018) Seung Pil Yun et al.   NATURE MEDICINE

New Insights into Microglia–Neuron Interactions: A Neuron’s Perspective

(2018) Balázs Pósfai et al.   NEUROSCIENCE

Phagocytic response of astrocytes to damaged neighboring cells

(2018) Nicole M. Wakida et al.   PLoS One

Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death

(2018) Liuke Sun et al.   Scientific Reports

Mitochondria-mediated damage to dopaminergic neurons in Parkinson's disease (Review)

(2017) Xiao‑Liang Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage

(2017) Veronica Lindström et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Mitochondrial dysfunction in glial cells: Implications for neuronal homeostasis and survival

(2017) Jordan Rose et al.   TOXICOLOGY

AMPKα2 Protects Against the Development of Heart Failure by Enhancing Mitophagy via PINK1 Phosphorylation

(2017) Bei Wang et al.   CIRCULATION RESEARCH

Mitochondria Dysfunction and Neurodegenerative Disorders: Cause or Consequence

(2017) Vanessa A. Morais et al.   JOURNAL OF ALZHEIMERS DISEASE

Parkinson’s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation

(2016) Diana Matheoud et al.   CELL

PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy

(2016) Kenneth R. Pryde et al.   JOURNAL OF CELL BIOLOGY

Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target

(2016) Li Du et al.   MOLECULAR NEUROBIOLOGY

Astrocyte signaling and synaptic homeostasis

(2016) Eduardo E. Benarroch   NEUROLOGY

PINK1 expression increases during brain development and stem cell differentiation, and affects the development of GFAP-positive astrocytes

(2016) Insup Choi et al.   Molecular Brain

PINK1 activation–turning on a promiscuous kinase

(2015) Liesbeth Aerts et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins

(2015) Nicol Birsa et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control

(2014) Gian-Luca McLelland et al.   EMBO JOURNAL

PINK1 Kinase Catalytic Activity Is Regulated by Phosphorylation on Serines 228 and 402

(2014) Liesbeth Aerts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Correction: PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons

(2014) Alison Wood-Kaczmar et al.   PLoS One

PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling

(2014) V. A. Morais et al.   SCIENCE

PINK1 is degraded through the N-end rule pathway

(2013) Koji Yamano et al.   Autophagy

PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage

(2013) G Arena et al.   CELL DEATH AND DIFFERENTIATION

Pink1 deficiency attenuates astrocyte proliferation through mitochondrial dysfunction, reduced akt and increased p38 mapk activation, and downregulation of egfr

(2013) Insup Choi et al.   GLIA

Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells

(2013) Junghyung Park et al.   JOURNAL OF NEUROCHEMISTRY

Rotenone Directly Induces BV2 Cell Activation via the p38 MAPK Pathway

(2013) Feng Gao et al.   PLoS One

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

PINK1 Deficiency Enhances Inflammatory Cytokine Release from Acutely Prepared Brain Slices

(2013) Jun Kim et al.   Experimental Neurobiology

Somatic mitochondrial DNA mutations in early parkinson and incidental lewy body disease

(2012) Michael T. Lin et al.   ANNALS OF NEUROLOGY

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

(2012) Andrew W Greene et al.   EMBO REPORTS

Reconstitution of Mitochondria Derived Vesicle Formation Demonstrates Selective Enrichment of Oxidized Cargo

(2012) Vincent Soubannier et al.   PLoS One

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

(2012) Kei Okatsu et al.   Nature Communications

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

(2011) Xinnan Wang et al.   CELL

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Rotenone, Paraquat, and Parkinson’s Disease

(2011) Caroline M. Tanner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Molecular mechanisms and physiologic functions of mitochondrial dynamics

(2011) H. Otera et al.   JOURNAL OF BIOCHEMISTRY

Expression of mutant alpha-synuclein modulates microglial phenotype in vitro

(2011) Lalida Rojanathammanee et al.   Journal of Neuroinflammation

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

(2010) Joo-Yong Lee et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

Increased Reactive Oxygen Species Production in the Brain After Repeated Low-Dose Pesticide Paraquat Exposure in Rats. A Comparison with Peripheral Tissues

(2010) Katarzyna Kuter et al.   NEUROCHEMICAL RESEARCH

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

(2009) Vanessa A. Morais et al.   EMBO Molecular Medicine

Protective effects of microglia in multiple sclerosis

(2009) Isabella Napoli et al.   EXPERIMENTAL NEUROLOGY

The human brain in numbers: a linearly scaled-up primate brain

(2009) Suzana Herculano-Houzel   Frontiers in Human Neuroscience

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death

(2009) Sonia Gandhi et al.   MOLECULAR CELL

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease

(2008) James B Koprich et al.   Journal of Neuroinflammation