Article
Chemistry, Multidisciplinary
Kai-li Fu, Pan Chen, Yan-ying Zhou, Yi-ming Jiang, Yue Gao, Hui-zhen Zhang, Li-huan Guan, Cong-hui Wang, Jun-ling Liu, Min Huang, Hui-chang Bi
Summary: Hepatic deficiency of Vps33b exacerbates cholestatic liver injury, leading to abnormal serum markers and liver function, as well as altered metabolism of bile acids. Metabolomics analysis reveals that Vps33b deficiency changes the profile of bile acids, accompanied by alterations in gene expression of bile acid metabolizing enzymes and transporters.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Cell Biology
Ya Tan, Nan Zhao, Qiaoling Xie, Ziqian Xu, Jin Chai, Xiaoxun Zhang, Yan Li
Summary: Melatonin has been found to ameliorate cholestatic liver injury by inhibiting the inflammatory response. The levels of serum melatonin are significantly elevated in cholestatic patients. Mechanistic studies revealed that melatonin reduces the expression of cytokines through the ERK/Egr1 signaling pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Xueqian Zhou, Xiaoxun Zhang, Nan Zhao, Liangjun Zhang, Wen Qiu, Chunwei Song, Jin Chai, Shiying Cai, Wensheng Chen
Summary: Bile components are important in maintaining gut microbiota homeostasis. In cholestasis, impaired bile secretion leads to liver injury. However, it is unclear whether gut microbiota plays a role in cholestatic liver injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Tingting Qin, Muhammad Hasnat, Ziwei Wang, Hozeifa Mohamed Hassan, Yang Zhou, Ziqiao Yuan, Wenzhou Zhang
Summary: This study aimed to investigate the effects of geniposide (GE) on bile duct ligation (BDL)-induced liver fibrosis and the underlying mechanisms. The results showed that GE treatment protected mice from BDL-induced liver fibrosis by inhibiting NLRP3 inflammasome activation. Furthermore, the protective effect of GE was mediated through the activation of SIRT1 and subsequent deacetylation of FXR, which restored bile acid homeostasis and contributed to the observed hepaprotective effect.
Article
Medicine, General & Internal
Lars-Olav Harnisch, Sophie Baumann, Diana Mihaylov, Michael Kiehntopf, Michael Bauer, Onnen Moerer, Michael Quintel
Summary: The study found that early hypoxic liver and cholangiocyte injury in ARDS patients are not directly related to the severity of hypoxemia. GGT levels can serve as a sensitive marker for liver function, influenced significantly by total bile acid levels.
Article
Physiology
Sha Li, Chenghai Wang, Xiaxia Zhang, Wen Su
Summary: The study revealed that Cyp4a14 gene plays a role in cholestatic-induced liver fibrosis, with its deficiency exacerbating fibrosis and overexpression alleviating fibrotic symptoms. Enhancing Cyp4a14 activity may be a potential therapeutic strategy for cholestatic-related liver fibrosis.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Plant Sciences
Jingyi Cai, Jiasheng Wu, Su Fang, Shaoyong Liu, Tianming Wang, Yuanyuan Li, Juan Zou, Rong Shi, Zhengtao Wang, Li Yang, Yueming Ma
Summary: CBBP treatment alleviates ANIT-induced cholestasis and liver injury by reducing hepatocyte inflammation and apoptosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Cell Biology
Sujit K. Mohanty, Bryan Donnelly, Haley Temple, Alexander Bondoc, Monica McNeal, Greg Tiao
Summary: Biliary atresia is an obstructive neonatal cholangiopathy leading to liver cirrhosis and end stage liver disease. The transcription factor T-bet plays a critical role in the progression of BA. Analysis showed that T-bet knockout mice had decreased inflammatory response and altered immune cell profile compared to wild-type mice when infected with RRV, indicating the importance of T-bet in the disease.
Article
Biochemistry & Molecular Biology
Pin-Ho Pan, Ya-Yu Wang, Shih-Yi Lin, Su-Lan Liao, Yu-Fang Chen, Wei-Chi Huang, Chun-Jung Chen, Wen-Ying Chen
Summary: 18-β-Glycyrrhetinic acid has promising hepatoprotective effects against cholestatic liver injury, improving liver histology and reducing oxidative stress, inflammation, apoptosis, impaired autophagy, and fibrosis.
Review
Biochemistry & Molecular Biology
Jing Zeng, Jiangao Fan, Huiping Zhou
Summary: Chronic cholestatic liver diseases, such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), gradually progress to liver fibrosis, cirrhosis, and failure. Disruption of bile acid metabolism and intrahepatic circulation plays a crucial role in accelerating the progression of cholestatic liver diseases. Bile acids not only act as detergents for nutrition absorption but also function as key signaling molecules that regulate hepatic metabolism and immune responses. This review focuses on the role of bile acid-mediated signaling in cholestatic liver disease.
CELL AND BIOSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Mohammad Mehdi Ommati, Ali Mobasheri, Yanqin Ma, Dongmei Xu, Zhongwei Tang, Ram Kumar Manthari, Narges Abdoli, Negar Azarpira, Yu Lu, Issa Sadeghian, Abolghasem Mousavifaraz, Ali Nadgaran, Ahmad Nikoozadeh, Sahra Mazloomi, Pooria Sayar Mehrabani, Mohammad Rezaei, Hu Xin, Yang Mingyu, Hossein Niknahad, Reza Heidari
Summary: This study evaluated the role of taurine in cholestasis-related lung injury. The results showed that taurine could attenuate inflammation, alleviate oxidative stress, and improve lung histopathological changes.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Mark Ly, Ngee-Soon Lau, Catriona Mckenzie, James G. Kench, Doruk Seyfi, Avik Majumdar, Ken Liu, Geoffrey Mccaughan, Michael Crawford, Carlo Pulitano
Summary: Histological assessment of bile duct injury is limited in predicting post-transplant biliary strictures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Pin-Ho Pan, Ya-Yu Wang, Shih-Yi Lin, Su-Lan Liao, Yu-Fang Chen, Wei-Chi Huang, Chun-Jung Chen, Wen-Ying Chen
Summary: Plumbagin has the potential to protect the liver from cholestatic damage by regulating multiple intracellular signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Su Fang, Tianming Wang, Yuanyuan Li, Haoyu Xue, Juan Zou, Jingyi Cai, Rong Shi, Jiasheng Wu, Yueming Ma
Summary: Gardenia jasminoides Ellis polysaccharide (GPS) has a protective effect against cholestatic liver injury through modulation of gut microbiota and inhibition of the TLR4/NF-kappa B pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Ayse Basak Engin, Atilla Engin, Evren Doruk Engin, Leyla Memis
Summary: This study suggests that activation of glutamatergic receptors may play a role in liver damage caused by bile acid accumulation. The use of lithium, a NMDAR-GluN2B subunit inhibitor, can protect the liver from oxidative stress and injury induced by bile acids. These findings provide important insights into the molecular mechanisms of cholestasis-induced liver damage and potential therapeutic strategies.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Zhou Yuming, Tang Ruqi, Merrill Eric Gershwin, Ma Xiong
CLINICS IN LIVER DISEASE
(2024)
Article
Gastroenterology & Hepatology
Inbal Houri, Gideon M. Hirschfield
CLINICS IN LIVER DISEASE
(2024)
Article
Gastroenterology & Hepatology
Yasameen Muzahim, Ali Wakil, Mehak Bassi, Nikolaos Pyrsopoulos
CLINICS IN LIVER DISEASE
(2024)
Article
Gastroenterology & Hepatology
Brian H. Horwich, Douglas T. Dieterich
CLINICS IN LIVER DISEASE
(2024)
Article
Gastroenterology & Hepatology
Aparna Goel, Paul Kwo
Summary: The goal of autoimmune hepatitis treatment is achieving clinical and biochemical remission. Standard care involves induction treatment with corticosteroids and gradual tapering of steroids. Alternatives to standard therapy can be considered for patients with intolerance or inadequate response. Treatment withdrawal is achievable in less than 20% of patients after 2 years of sustained remission, and liver transplantation should be considered for patients with progressive disease or complications.
CLINICS IN LIVER DISEASE
(2024)
Article
Gastroenterology & Hepatology
Mariana Zapata, Hendrick Pagan-Torres, Marlyn J. Mayo
CLINICS IN LIVER DISEASE
(2024)
Article
Gastroenterology & Hepatology
Aalam Sohal, Sanya Kayani, Kris Kowdley
Summary: Primary sclerosing cholangitis (PSC) is an immune-mediated liver disease characterized by inflammation and fibrosis of bile ducts. It is commonly associated with inflammatory bowel disease, especially ulcerative colitis. The natural history of the disease varies among patients, but most will develop cirrhosis.
CLINICS IN LIVER DISEASE
(2024)