Article
Biochemistry & Molecular Biology
Ana Stancic, Ksenija Velickovic, Milica Markelic, Ilijana Grigorov, Tamara Saksida, Nevena Savic, Milica Vucetic, Vesna Martinovic, Andjelija Ivanovic, Vesna Otasevic
Summary: This study examines the involvement of ferroptosis in diabetes-related liver pathology. The results show that inhibition of ferroptosis can improve liver function in diabetic mice, including reducing liver fibrosis and improving hepatocyte morphology. Therefore, targeting ferroptosis may represent a promising approach in the management of diabetes-induced liver injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yunjia Li, Mengchen Qin, Weichao Zhong, Chang Liu, Guanghui Deng, Menghan Yang, Junjie Li, Haixin Ye, Hao Shi, Chaofeng Wu, Haiyan Lin, Yuyao Chen, Shaohui Huang, Chuying Zhou, Zhiping Lv, Lei Gao
Summary: The study indicates the important role of RAGE in alcoholic liver disease (ALD). Deficiency or inhibition of RAGE can alleviate hepatic inflammation and oxidative stress, as well as affect iron metabolism pathways, thereby improving liver injury.
Article
Biochemistry & Molecular Biology
Zitong Meng, Yuxiao Liao, Zhao Peng, Xiaolei Zhou, Huanhuan Zhou, Andreas K. Nuessler, Liegang Liu, Wei Yang
Summary: This study investigated the effects of rat BMSC-secreted exos on DON-induced liver damage. It was found that BMSC-exos can alleviate liver pathological changes, reduce liver function indicators and inflammatory factors, and alter oxylipin metabolism.
Article
Microbiology
Hyunna Jung, Sohyeon You, Soo-Im Choi, Chang-Ho Kang, Gun-Hee Kim
Summary: This study found that L. brevis MG5311 can alleviate ethanol-induced liver injury by inhibiting hepatic oxidative stress and promoting lipid metabolism. This suggests that L. brevis MG5311 may be a beneficial probiotic candidate for ameliorating or preventing alcoholic liver disease.
Article
Biochemistry & Molecular Biology
Aimin Wu, Bin Feng, Jie Yu, Lijun Yan, Lianqiang Che, Yong Zhuo, Yuheng Luo, Bing Yu, De Wu, Daiwen Chen
Summary: Iron overload-induced ferroptosis in hepatocytes is promoted by excessive HO-1 expression, while FGF21 protein can protect against this process by inhibiting ferroptosis and preventing liver damage. These findings suggest that activating FGF21 could be an effective strategy for potential treatment of iron overload-induced ferroptosis-related diseases like hereditary haemochromatosis.
Article
Environmental Sciences
Ahmed Abdelraouf Salem, Kira Trares, Matthias Kohl, Eugene Jansen, Hermann Brenner, Ben Schottker
Summary: The study found a significant association between current smoking and increased levels of oxidative stress biomarker D-ROM, while there was no association with TTP levels. There is a dose-response relationship between smoking amount and D-ROM concentrations, indicating long-term effects of smoking on redox balance.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Marta Martin-Fernandez, Victor Arroyo, Carmen Carnicero, Rebeca Siguenza, Reyes Busta, Natalia Mora, Beatriz Antolin, Eduardo Tamayo, Patricia Aspichueta, Irene Carnicero-Frutos, Hugo Gonzalo-Benito, Rocio Aller
Summary: This study found that elevated levels of lipid peroxidation (LPO) are significantly associated with a NASH score of >= 4 in NAFLD patients. LPO levels above 315.39 μM were identified as an independent risk factor. The model showed good discrimination ability in distinguishing NASH patients. Therefore, understanding the molecular mechanisms of basal inflammation may help identify biomarkers and therapeutic targets for NASH.
Review
Biochemistry & Molecular Biology
Heshu Chen, Chenyu Wang, Zemin Liu, Xinmiao He, Wenjie Tang, Liuqin He, Yanzhong Feng, Di Liu, Yulong Yin, Tiejun Li
Summary: Ferroptosis is a novel type of non-apoptotic cell death that can be triggered by specific modulators. It has potential implications in preventing inflammatory storms and cancer development. Ferroptosis may mediate biological processes such as oxidative stress and iron overload to treat cancer.
Review
Biochemistry & Molecular Biology
Ashley K. Putman, G. Andres Contreras, Lorraine M. Sordillo
Summary: Oxidative stress is associated with the generation of oxidized products such as IsoP, which are highly specific biomarkers of lipid peroxidation. Despite advancements in their detection and use, there is still limited knowledge about the biological activity and potential roles of IsoP in oxidative stress pathology, especially in veterinary medicine.
Article
Biochemistry & Molecular Biology
Linas Cerniauskas, Asta Mazeikiene, Egle Mazgelyte, Egle Petrylaite, Ausra Linkeviciute-Dumce, Neringa Burokiene, Dovile Karciauskaite
Summary: Cardiovascular diseases are the leading cause of mortality worldwide. This study aimed to evaluate oxidative lipid degradation biomarkers and antioxidant defense system components in healthy women and their relationships with age, anthropometric measures, and lipid metabolism biomarkers. The findings suggest that these indices could be useful biomarkers in the research of aging, obesity, and atherosclerosis pathogenesis.
Article
Biochemistry & Molecular Biology
Marlena Rademacher, Hartmut Kuhn, Astrid Borchert
Summary: GPX4, as the only enzyme capable of reducing complex lipid peroxides to the corresponding alcohols, plays a role in erythroid differentiation of mouse erythroleukemia cells, but heterozygous expression of a catalytically inactive Gpx4 is not sufficient to compromise erythropoiesis in vivo and ex vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Megha Murali, T. Shivanandappa
Summary: Endosulfan exposure causes high levels of oxidative stress in the liver and brain, leading to reduced antioxidant enzyme activity and increased ROS and lipid peroxidation. The brain is more susceptible to oxidative stress than the liver, likely due to its lower antioxidant defenses and higher oxygen consumption.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Vesna Sredoja Tisma, Stela Bulimbasic, Danica Galesic Ljubanovic, Kresimir Galesic, Jadranka Morovic-Vergles, Josko Mitrovic, Koji Uchida, Franz Tatzber, Neven Zarkovic, Morana Jaganjac
Summary: This study investigated the implication of oxidative stress in small-vessel vasculitis, focusing on acrolein immunohistochemistry in affected skin vessels and systemic stress response. It was found that systemic redox homeostasis and iron metabolism are altered in SVV patients, with possible biomarkers identified for evaluating oxidative status, disease activity, and prevalence. Furthermore, a strong correlation between the accumulation of acrolein-protein adducts in the skin and disease progression was revealed.
Article
Biochemistry & Molecular Biology
Po-Keng Cheng, Hsin-Chang Chen, Pao-Lin Kuo, Jung-Wei Chang, Wan-Ting Chang, Po-Chin Huang
Summary: This study investigated the association between oxidative and nitrosative stress and thyroid hormones, finding that an imbalance of oxidative and nitrosative stress may alter thyroid hormone homeostasis during pregnancy, which could affect embryonic and fetal development.
Review
Biochemistry & Molecular Biology
Claudia Bocca, Francesca Protopapa, Beatrice Foglia, Marina Maggiora, Stefania Cannito, Maurizio Parola, Erica Novo
Summary: This review discusses the role of hepatic myofibroblasts in the fibrogenic progression of chronic liver disease from different etiologies, highlighting the direct or indirect role of reactive oxygen species and oxidative stress in regulating myofibroblast-related phenotypic responses.
Editorial Material
Oncology
Ilhan Tasdoven, Guldeniz Karadeniz Cakmak
Article
Oncology
Ilhan Tasdoven, Guldeniz Karadeniz Cakmak, Ali Ugur Emre, Huseyin Engin, Burak Bahadir, Hakan Bekir Bakkal, Mahmut Bahadir Gulluoglu
Article
Chemistry, Medicinal
Gulay Dilek, Ishak Ozel Tekin, Burak Coban, Ali Disli, Zuhal Gercek
Summary: A series of novel artificial purine nucleosides bearing selenotetrazole pharmacophore were synthesized in this study. Although none of the compounds interacted with DNA or exhibited transcription inhibition, they significantly inhibited DNA synthesis phase and showed cytotoxic activity on cancer and proliferating cells.
MEDICINAL CHEMISTRY RESEARCH
(2021)
Review
Oncology
Maggie Banys-Paluchowski, Maria Luisa Gasparri, Jana de Boniface, Oreste Gentilini, Elmar Stickeler, Steffi Hartmann, Marc Thill, Isabel T. Rubio, Rosa Di Micco, Eduard-Alexandru Bonci, Laura Niinikoski, Michalis Kontos, Guldeniz Karadeniz Cakmak, Michael Hauptmann, Florentia Peintinger, David Pinto, Zoltan Matrai, Dawid Murawa, Geeta Kadayaprath, Lukas Dostalek, Helidon Nina, Petr Krivorotko, Jean-Marc Classe, Ellen Schlichting, Matilda Appelgren, Peter Paluchowski, Christine Solbach, Jens-Uwe Blohmer, Thorsten Kuehn
Summary: This review discusses the uncertainty surrounding the optimal axillary staging surgery for breast cancer patients with lymph node metastasis post-neoadjuvant chemotherapy. Various surgical strategies have been investigated, but questions regarding oncological safety and optimal marking techniques remain unanswered. The multinational prospective cohort study AXSANA aims to address these knowledge gaps and recruit 3000 patients in 20 countries.
Article
Surgery
Orhan Agcaoglu, Atakan Sezer, Ozer Makay, Murat Faik Erdogan, Fahri Bayram, Sibel Guldiken, Marco Raffaelli, Yusuf Alper Sonmez, Yong-Sang Lee, Kyriakos Vamvakidis, Radu Mihai, Quan-Yang Duh, Baris Akinci, Faruk Alagol, Martin Almquist, Marcin Barczynski, Taner Bayraktaroglu, Eren Berber, Yusuf Bukey, Guldeniz Karadeniz Cakmak, Nuh Zafer Canturk, Zeynep Canturk, Mehmet Celik, Ozlem Celik, Banu Ozturk Ceyhan, Sergii Cherenko, Thomas Clerici, David Scott Coombes, Orhan Demircan, Oguzhan Deyneli, Gianlorenzo Dionigi, Ali Ugur Emre, Yesim Erbil, Ali Ilker Filiz, Hulya Iliksu Gozu, Sibel Ozkan Gurdal, Gunay Gurleyik, Mehmet Haciyanli, Abut Kebudi, Seokmo Kim, Giannis Koutelidakis, Bekir Kuru, Meral Mert, Guzide Gonca Oruk, Serdar Ozbas, Fausto Palazzo, Rumen Pandev, Phillip Riss, Tevfik Sabuncu, Ibrahim Sahin, Gurhan Sakman, Fusun Saygili, Yasemin Giles Senyurek, Ilya Sleptsov, Sam Van Slycke, Serkan Teksoz, Tarik Terzioglu, Serdar Tezelman, Fatih Tunca, Mustafa Umit Ugurlu, Mehmet Uludag, Jesus Villar-del-Moral, Menno Vriens, Dilek Yazici
Summary: This study utilized the Delphi method to gather insights from 64 experienced surgeons and endocrinologists, resulting in 37 recommendations for managing endocrine surgical disorders during the COVID-19 pandemic. Unanimous agreement was reached on all recommendations, with either endorsement or rejection in two rounds of voting.
UPDATES IN SURGERY
(2022)
Article
Ophthalmology
Serpil Yazgan, Ishak Ozel Tekin, Nusret Akpolat, Ozhan Koc
Summary: In this study, bacterial cellulose membrane (BCM) showed good biocompatibility in trabeculectomy and provided better control of intraocular pressure compared to the control group. Additionally, minimal fibrosis was observed at the surgical site in BCM group.
JOURNAL OF GLAUCOMA
(2021)
Article
Optics
Gulhan Ustabas Kaya, Sefa Kocabas, Seda Kartal, Hakan Kaya, Ishak Ozel Tekin, Rahime Seda Tigli Aydin, Senol Hakan Kutoglu
Summary: This study proposes a method for imaging nano-sized particles dispersed in the air using digital holography and calculates the concentration amounts in different humidity conditions. The behavior of particulate matter in different humidity conditions is also revealed, and a deep learning algorithm is used to classify the images. The proposed system shows high accuracy in imaging and detecting the type of particulate matter.
OPTICS AND LASERS IN ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Yeliz Yalcin, Ishak Ozel Tekin, R. Seda Tigli Aydin
Summary: In this study, the researchers investigated the effects of ozonized oil nanoemulsions (OZNEs) as a radiosensitizer on B16 melanoma and OV-90 ovarian cells under X-ray irradiation in vitro. The results showed that OZNEs could enhance the sensitivity of these cells to radiation by inducing cell cycle arrest and increasing DNA damage.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Oncology
Maggie Banys-Paluchowski, Thorsten Kuehn, Yazan Masannat, Isabel Rubio, Jana de Boniface, Nina Ditsch, Gueldeniz Karadeniz Cakmak, Andreas Karakatsanis, Rajiv Dave, Markus Hahn, Shelley Potter, Ashutosh Kothari, Oreste Davide Gentilini, Bahadir M. Gulluoglu, Michael Patrick Lux, Marjolein Smidt, Walter Paul Weber, Bilge Aktas Sezen, Natalia Krawczyk, Steffi Hartmann, Rosa Di Micco, Sarah Nietz, Francois Malherbe, Neslihan Cabioglu, Nuh Zafer Canturk, Maria Luisa Gasparri, Dawid Murawa, James Harvey
Summary: Most breast cancers can be treated with breast-conserving surgery, but a localization step is required to determine which tissue needs to be removed. The traditional technique involves placing a guidewire into the tumor, but it has drawbacks. New techniques have been developed but have not been extensively studied. A review is presented to discuss available techniques and introduce the MELODY study that focuses on patient, surgeon, and radiologist preference.
Article
Infectious Diseases
Efsun Korkmaz Seven, Cumhur Aydemir, Ishak Ozel Tekin
Summary: This study aimed to evaluate the abnormalities of leukocyte surface markers CD64, CD16, CD11b, CD63, HLA-DR, and CD62L using flow cytometry for the early diagnosis of late-onset neonatal sepsis. It was found that the expression of CD16 and CD64 on monocytes and neutrophils was significantly higher in neonates with sepsis, and CD64 was identified as a diagnostic marker for neonatal sepsis. Therefore, CD64 and CD16 can be used as useful tests for the early diagnosis of late-onset neonatal sepsis.
JOURNAL OF PEDIATRIC INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Rabiye Uslu Erdemir, Ilhan Tasdoven, Taner Bayraktaroglu, Guldeniz Karadeniz Cakmak
Summary: The study demonstrates that sono-scintigraphic concordance is beneficial in improving the surgical success rates of MIP, especially in cases where intact PTH measurement is unavailable.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Surgery
Ilhan Tasdoven, Rabiye Uslu Erdemir, Guldeniz Karadeniz Cakmak
Summary: A retrospective study of 253 breast cancer patients treated with NAT found that AUS has high accuracy in identifying pathologic complete response after NAT, but caution should be exercised in its ability to detect residual small tumors and micro-metastases.
Meeting Abstract
Oncology
Neslihan Cabioglu, Hasan Karanlik, Mahmut Muslumanoglu, Guldeniz Karadeniz Cakmak, Didem Can Trablus, Mustafa Tukenmez, Yeliz E. Ersoy, Cihan Uras, Baha Zengel, Selman Emiroglu, Ayfer Kamali Polat, Levent Yeniay, Enver Ozkurt, Halil Kara, Kamuran Ibis, Adnan Aydiner, Vahit Ozmen, Abdullah Igci
Meeting Abstract
Oncology
Guldeniz Karadeniz Cakmak, Ilhan Tasdoven, Ali Emre, Figen Barut, Huseyin Engin
ANNALS OF SURGICAL ONCOLOGY
(2020)
Article
Obstetrics & Gynecology
Seyit Ahmet Erol, Gorker Sel, Mehmet Ibrahim Harma, Muge Harma, Ishak Ozel Tekin
JOURNAL OF THE TURKISH-GERMAN GYNECOLOGICAL ASSOCIATION
(2020)
