Article
Oncology
Ana del Castillo, Susana Gomez-Modet, Jose Maria Mata, Luis Tejedor
Summary: The purpose of this study is to evaluate the feasibility of targeted axillary dissection using 99mTechnetiumlabeled macroaggregated albumin (99mTc-MAA) injected preoperatively into the clipped lymph node of patients with axillary complete clinical response (ycN0) after neoadjuvant chemotherapy (NAC) for breast cancer. A retrospective observational study has shown that the use of radioguided occult lesion localization (ROLL) technique can successfully detect the 99mTc-MAA injection and avoid axillary lymph node dissection in 62.9% of the cases.
Review
Oncology
Parinita K. Swarnkar, Salim Tayeh, Michael J. Michell, Kefah Mokbel
Summary: The study demonstrates that using Marked Lymph Node Biopsy and Targeted Axillary Dissection surgery procedures can safely replace more radical surgery in breast cancer patients, accurately assessing the lymph node status. These procedures can improve patients' quality of life and reduce complications.
Article
Medicine, Research & Experimental
Hao Zhang, Wen Cao, Lianjuan Liu, Zifan Meng, Ningning Sun, Yuanyuan Meng, Jie Fei
Summary: This study aimed to establish an optimal model to predict the response of patients with axillary lymph node positive breast cancer to neoadjuvant chemotherapy using machine learning and clinical factors combined with ultrasound-based radiomic features. The results showed that the RNWCF model, which integrates clinical factors and radiomic features, had favorable predictive efficacy in the training, validation, and external test cohorts, suggesting its potential as a noninvasive tool for predicting the response of breast cancer to neoadjuvant chemotherapy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Amparo Garcia-Tejedor, Carlos Ortega-Exposito, Sira Salinas, Ana Luzardo-Gonzalez, Catalina Falo, Evelyn Martinez-Perez, Hector Perez-Montero, M. Teresa Soler-Monso, Maria-Teresa Bajen, Ana Benitez, Raul Ortega, Anna Petit, Anna Guma, Miriam Campos, Maria J. Pla, Sonia Pernas, Judith Penafiel, Carlos Yeste, Miguel Gil-Gil, Ferran Guedea, Jordi Ponce, Maria Laplana
Summary: This study aims to evaluate whether axillary radiotherapy (ART) is non-inferior to axillary lymph node dissection (ALND) in patients with limited lymphatic involvement after neoadjuvant systemic treatment (NST), and whether it reduces surgery-related adverse effects.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Cornelis M. de Mooij, Thiemo J. A. van Nijnatten, Briete Goorts, Loes F. S. Kooreman, Isabel W. M. Raymakers, Silke P. L. van Meijl, Maaike de Boer, Kristien B. M. I. Keymeulen, Joachim E. Wildberger, Felix M. Mottaghy, Marc B. I. Lobbes, Marjolein L. Smidt
Summary: This study investigated the feasibility of sequential hybrid [18F]FDG PET/MRI in predicting the treatment response in breast cancer patients undergoing neoadjuvant chemo(targeted) therapy. The qualitative or quantitative evaluation of PET/MRI after therapy was found to be unreliable in predicting the response of the primary tumor and axillary lymph nodes. However, combining the relative decrease in PET and MR imaging variables halfway through therapy improved the diagnostic accuracy, especially for predicting the response of axillary lymph nodes. These findings suggest that sequential hybrid [18F]FDG PET/MRI may have complementary value in the early prediction of treatment response in breast cancer.
Article
Oncology
Diego Flores-Funes, Jose Aguilar-Jimenez, Maria Martinez-Galvez, Maria Jose Ibanez-Ibanez, Luis Carrasco-Gonzalez, Jose Ignacio Gil-Izquierdo, Maria Asuncion Chaves-Benito, Francisco Ayala-De La Pena, Andres Nieto-Olivares, Jose Luis Aguayo-Albasini
Summary: This study aimed to determine predictive factors of ALND results in BC patients undergoing NACT, and subsequent staging using TAD. Tumor size, number of suspected nodes in ultrasound, HER2 status, response to NACT, and positive TAD were identified as independent predictors of positive ALND. The predictive score showed good calibration and discrimination, with a sensitivity of 100% and specificity of 70% at a cut-off point of 17% risk of positive ALND.
SURGICAL ONCOLOGY-OXFORD
(2021)
Article
Medicine, General & Internal
Wenyan Wang, Xin Wang, Jiaqi Liu, Qiang Zhu, Xiang Wang, Pilin Wang
Summary: A predictive clinical model was developed to assess the pathological complete response of axillary lymph nodes in breast cancer patients after neoadjuvant chemotherapy. The model performed well in external validation and could provide information to surgeons regarding additional lymph node dissection.
CHINESE MEDICAL JOURNAL
(2022)
Review
Oncology
Vijayashree Murthy, Jessica Young, Yoshihisa Tokumaru, Marie Quinn, Stephen B. Edge, Kazuaki Takabe
Summary: This article reviews different options to identify positive lymph nodes at the time of definitive surgery, aiming to determine pathological response after neoadjuvant therapy and achieve optimal surgical outcomes with minimal complications.
Article
Oncology
Marissa L. G. Vane, Joanna Hunter-Squires, Sungjin Kim, Marjolein L. Smidt, Armando E. Giuliano
Summary: The study found that patients undergoing mastectomy are more likely to receive cALND, while those choosing BCT instead of mastectomy are more likely to avoid cALND.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Sophie H. H. Chung, Susanna W. L. de Geus, Grant Shewmaker, Kelsey S. S. Romatoski, Frederick T. T. Drake, Naomi Y. Y. Ko, Andrea L. L. Merrill, Ariel E. E. Hirsch, Jennifer F. F. Tseng, Teviah E. E. Sachs, Michael R. R. Cassidy
Summary: This study compared the survival outcomes of men with positive sentinel lymph nodes after either sentinel lymph node biopsy (SLNB) alone or complete axillary dissection (ALND) in breast cancer. The results showed that ALND was associated with superior survival compared to SLNB alone in early-stage male breast cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Jennifer L. Baker, Farnaz Haji, Amy M. Kusske, Cheryce P. Fischer, Anne C. Hoyt, Carlie K. Thompson, Minna K. Lee, Deanna Attai, Maggie L. DiNome
Summary: This study evaluated the feasibility of localizing metastatic lymph nodes with SAVI reflector prior to neoadjuvant chemotherapy for targeted removal at surgery, showing successful localization in some patients and potential advantages in lymph node detection post-surgery.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Sungchan Gwark, Woo Chul Noh, Sei Hyun Ahn, Eun Sook Lee, Yongsik Jung, Lee Su Kim, Wonshik Han, Seok Jin Nam, Gyungyub Gong, Seon-Ok Kim, Hee Jeong Kim
Summary: This study evaluated ALND rates and prognosis in ER+/HER2-, LN-positive, premenopausal breast cancer patients after NCT and NET treatment. The NCT group had a lower ALND rate, higher axillary pCR rate, but there was no significant difference in survival rates compared to the NET group.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Muayad F. Almahariq, Ronald Levitin, Thomas J. Quinn, Peter Y. Chen, Nayana Dekhne, Sayee Kiran, Amita Desai, Pamela Benitez, Maha S. Jawad, Gregory S. Gustafson, Joshua T. Dilworth
Summary: The study compared the survival outcomes of breast cancer patients with residual lymph node disease who underwent sentinel lymph node dissection (SLND) or axillary lymph node dissection (ALND) using the National Cancer Database (NCDB). The results showed that SLND was associated with lower survival rates compared to ALND in matched cohorts, suggesting that ALND may be preferred over SLND for patients with residual lymph node disease. Further prospective trials are needed to confirm the efficacy of SLND in this patient population.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Anna C. Beck, Monica Morrow
Summary: Although sentinel lymph node biopsy is the preferred method for axillary staging and therapeutic for limited nodal disease, axillary lymph node dissection is still necessary in certain cases and for maintaining local control with heavy axillary tumor burden. Knowledge of the number of involved axillary nodes, obtained through axillary lymph node dissection, is also needed for tailored systemic therapies. Ongoing trials will explore the possibility of radiotherapy as a replacement for axillary lymph node dissection in certain circumstances.
Article
Medicine, General & Internal
Hee Jun Choi, Jai Min Ryu, Jun Ho Lee, Yoonju Bang, Jongwook Oh, Byung-Joo Chae, Seok Jin Nam, Seok Won Kim, Jeong Eon Lee, Se Kyung Lee, Jonghan Yu
Summary: This study evaluated the prognostic value of the number of lymph nodes removed in breast cancer patients who underwent axillary lymph node dissection (ALND) after neoadjuvant chemotherapy (NAC). The results showed that in certain subgroups, patients with less than 10 lymph nodes removed had worse prognosis and may require closer monitoring.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Nilgun Guldogan, Gul Esen, Yasemin Kayadibi, Fusun Taskin, Aysenur Oktay Alfatli, Fatma Nur Soylu Boy, Pinar Balci, Onur Bugdayci, Fatma Tokat, Tulin Ozturk, Mehtap Tunaci, Akif Enes Arikan
Summary: The study aims to determine the most common imaging features of adenoid cystic carcinoma (ACC) of the breast and review the literature. The findings show that ACC can present with various imaging characteristics, including round or oval shape, parallel orientation, isoechoic or hyperechoic appearance, high T2 signal, restricted diffusion, and homogeneous enhancement. Radiologists should be aware of these frequent findings for early diagnosis of ACC.
ACADEMIC RADIOLOGY
(2023)
Article
Oncology
C. Mueller, V Kiver, E-F Solomayer, G. Wagenpfeil, C. Neeb, J. U. Blohmer, A. Abramian, N. Maass, F. Schuetz, C. Kolberg-Liedtke, D. J. Ralser, A-C Rambow
Summary: This study presents real-world data on the treatment of HR+/HER2- ABC patients with CDK4/6 inhibitors in four certified German university breast cancer centers. The results support the efficacy and safety of CDK4/6 inhibitors as shown in randomized controlled trials (RCTs). However, the median progression-free survival (PFS) in real-world data was lower than that in RCTs, which may be due to the inclusion of patients with more advanced disease.
Article
Biochemistry & Molecular Biology
Martin J. Raftery, Alexander Sebastian Franzen, Clarissa Radecke, Abdelhadi Boulifa, Guenther Schoenrich, Sebastian Stintzing, Jens-Uwe Blohmer, Gabriele Pecher
Summary: There is a medical need to develop new and effective therapies against triple-negative breast cancer (TNBC). We have developed a next-generation CAR targeting CD44v6 that incorporates IL-15 superagonist and checkpoint inhibitor molecules. CD44v6 CAR-NK cells demonstrated effective cytotoxicity against TNBC in 3D spheroid models and were resistant to immunosuppression by the tumor microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Mattea Reinisch, Simona Bruzas, Oleg Gluz, Beyhan Ataseven, Peter Schmid, Javier Cortes, Jens-Uwe Blohmer, Satyendra Shenoy, Mark H. Dyson, Christine Dittmer-Grabowski, Ouafaa Chiari, Hakima Harrach, Daniel Gebauer, Alexander Traut, Sherko Kuemmel
Summary: This study explored the expression of 758 genes in early breast cancer patients and identified several genes and immune markers associated with prognosis. The study also found two genes that played a role in chemotherapy efficacy and survival. Therefore, multigene expression analysis has the potential for prognosis and prediction in early breast cancer.
MOLECULAR ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Fabio Medas, Chiara Dobrinja, Ebtesam Abdullah Al-Suhaimi, Julia Altmeier, Said Anajar, Akif Enes Arikan, Irina Azaryan, Lovenish Bains, Giancarlo Basili, Hakan Bolukbasi, Marco Bononi, Farzad Borumandi, Mehmet Bugra Bozan, Gabriela Brenta, Laurent Brunaud, Maximilian Brunner, Antoine Buemi, Gian Luigi Canu, Federico Cappellacci, Burchfield Cartwright, Ignasi Castells Fuste, Beatriz Cavalheiro, Giuseppe Cavallaro, Andres Chala, Shun Yan Bryant Chan, John Chaplin, Mustafa Sajjad Cheema, Costanza Chiapponi, Maria Grazia Chiofalo, Emmanuel Chrysos, Annamaria D'Amore, Michael de Cillia, Carmela De Crea, Nicolo de Manzini, Leandro Luongo de Matos, Loredana De Pasquale, Paolo Del Rio, Marco Stefano Demarchi, Muthuswamy Dhiwakar, Gianluca Donatini, Jose Miguel Dora, Valerio D'Orazi, Viyey Kishore Doulatram Gamgaram, Vitalijus Eismontas, El Hassane Kabiri, Hadj Omar El Malki, Islam Elzahaby, Octavian Enciu, Antoine Eskander, Francesco Feroci, David Figueroa-Bohorquez, Dimitrios Filis, Gorostidi Francois, Pedro Frias-Fernandez, Armando Gamboa-Dominguez, Volkan Genc, Davide Giordano, Antonio Gomez-Pedraza, Giuseppa Graceffa, James Griffin, Sofia Cuco Guerreiro, Karan Gupta, Keshav Kumar Gupta, Angela Gurrado, Jiannis Hajiioannou, Tommi Hakala, Wirsma Arif Harahap, Lindsay Hargitai, Dana Hartl, Andrzej Hellmann, Jiri Hlozek, Van Trung Hoang, Maurizio Iacobone, Nadia Innaro, Orestis Ioannidis, J. H. Isabelle Jang, Jose Candido Xavier-Junior, Milan Jovanovic, Reto Martin Kaderli, Fahmi Kakamad, Krzysztof Kaliszewski, Martin Karamanliev, Hiroshi Katoh, Andro Kosec, Bozidar Kovacevic, Luiz Paulo Kowalski, Robert Kralik, Sanjay Kumar Yadav, Adriana Kumorova, Savvas Lampridis, Konstantinos Lasithiotakis, Jean-Christophe Leclere, Eugene Kwong Fei Leong, Melvin Khee-Shing Leow, James Y. Lim, Leonardo S. Lino-Silva, Shirley Yuk Wah Liu, Nuria Perucho Llorach, Celestino Pio Lombardi, Javier Lopez-Gomez, Eleonora Lori, Lourdes Quintanilla-Dieck, Roberta Lucchini, Amin Madani, Dimitrios Manatakis, Ivan Markovic, Gabriele Materazzi, Haggi Mazeh, Giuseppe Mercante, Goswin Yason Meyer-Rochow, Olgica Mihaljevic, Julie A. Miller, Michele Minuto, Massimo Monacelli, Francesk Mulita, Barbara Mullineris, Jose Luis Munoz-de-Nova, Fabio Muradas Girardi, Saki Nader, Tangjaturonrasme Napadon, Constantinos Nastos, Chiara Offi, Ohad Ronen, Luigi Oragano, Aida Orois, Yongqin Pan, Emmanouil Panagiotidis, Ramakanth Bhargav Panchangam, Theodosios Papavramidis, Pradipta Kumar Parida, Anna Paspala, Oscar Vidal Perez, Sabrina Petrovic, Marco Raffaelli, Constanza Fernanda Ramacciotti, Tomas Ratia Gimenez, Angel Rivo Vazquez, Jong-Lyel Roh, Leonardo Rossi, Alvaro Sanabria, Alena Santeerapharp, Arseny Semenov, Sanjeewa Seneviratne, Altinay Serdar, Patrick Sheahan, Sean C. Sheppard, Rachel L. Slotcavage, Constantin Smaxwil, Soo Young Kim, Salvatore Sorrenti, Eleftherios Spartalis, Chutintorn Sriphrapradang, Mario Testini, Yigit Turk, George Tzikos, Kristina Vabalayte, Kelly Vargas-Osorio, Rafael Sebastian, Vazquez Renteria, David Velazquez-Fernandez, Sanura Malinda Pallegoda Vithana, Levent Yucel, Erwin Danil Yulian, Petra Zahradnikova, Paul Zarogoulidis, Evgeniia Ziablitskaia, Anna Zolotoukho, Pietro Giorgio Calo
Summary: This study aimed to quantify the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic and evaluate whether delays in surgery led to an increased occurrence of aggressive tumors. The study found a significant reduction in surgeries during the pandemic and observed an increased occurrence of larger tumors, lymph node metastases, and high-risk tumors during the decrease phase. The study suggests that surgery for indeterminate thyroid nodules should not be postponed even during future pandemic escalations.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Review
Oncology
Maggie Banys-Paluchowski, Thorsten Kuehn, Yazan Masannat, Isabel Rubio, Jana de Boniface, Nina Ditsch, Gueldeniz Karadeniz Cakmak, Andreas Karakatsanis, Rajiv Dave, Markus Hahn, Shelley Potter, Ashutosh Kothari, Oreste Davide Gentilini, Bahadir M. Gulluoglu, Michael Patrick Lux, Marjolein Smidt, Walter Paul Weber, Bilge Aktas Sezen, Natalia Krawczyk, Steffi Hartmann, Rosa Di Micco, Sarah Nietz, Francois Malherbe, Neslihan Cabioglu, Nuh Zafer Canturk, Maria Luisa Gasparri, Dawid Murawa, James Harvey
Summary: Most breast cancers can be treated with breast-conserving surgery, but a localization step is required to determine which tissue needs to be removed. The traditional technique involves placing a guidewire into the tumor, but it has drawbacks. New techniques have been developed but have not been extensively studied. A review is presented to discuss available techniques and introduce the MELODY study that focuses on patient, surgeon, and radiologist preference.
Article
Oncology
Maximilian Heinz Beck, Derya Balci-Hakimeh, Florian Scheuerecker, Charlotte Wallach, Hannah Lena Guengor, Marlene Lee, Ahmed Farouk Abdel-Kawi, Jacek Glajzer, Jekaterina Vasiljeva, Karol Kubiak, Jens-Uwe Blohmer, Jalid Sehouli, Klaus Pietzner
Summary: This study highlights the poor implementation of modern optimized fasting management in clinical practice, emphasizing the need for better implementation of ERAS protocols and sensitizing clinicians to appropriate patient education about perioperative fasting.
Article
Medicine, Research & Experimental
Jonathan Nuebel, Meike Hoffmeister, Oliver Labrenz, Kerstin Jost, Stefanie Oess, Michael Hauptmann, Julika Schoen, Georg Fritz, Michael Haase, Christian Butter, Anja Haase-Fielitz
Summary: This study aimed to determine whether novel and conventional cardiorenal biomarkers in patients before transcatheter aortic valve implantation may be associated with cardiorenal syndrome (CRS) type 1. Serum NT-proBNP and urine biomarkers (hepcidin-25, NGAL, IL-6) were measured, and it was found that patients with CRS type 1 had longer hospital stay and had higher readmission rate within 6 months after discharge. The NT-proBNP/urine hepcidin-25 ratio was identified as an independent modifier of CRS type 1.
BIOMARKERS IN MEDICINE
(2023)
Review
Health Care Sciences & Services
L. Sollfrank, S. C. Linn, M. Hauptmann, K. Jozwiak
Summary: This study aimed to explore the commonly used biomarker-based tests in clinical studies, and found that most studies evaluated treatment heterogeneity by analyzing biomarker-specific treatment effects and/or multiplicative interaction. However, there is a need for more efficient statistical methods to evaluate treatment heterogeneity in clinical studies.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Article
Oncology
Halil Kara, Akif Enes Arikan, Onur Dulgeroglu, Cihan Uras
Summary: This study investigated the feasibility of sentinel lymph node biopsy (SLNB) in the early postoperative period of nipple-sparing mastectomy (NSM). The results showed that SLNB could be performed successfully by intradermal radioisotope injection in the early period after NSM. No complications or recurrence were observed. Further studies are needed to determine the feasibility of SLNB in the early postoperative period of NSM.
INDIAN JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Orit Kaidar-Person, Marilia Antunes, Jaime D. Cardoso, Oriana Ciani, Helena Cruz, Rosa Di Micco, Oreste Gentilini, Tiago Goncalves, Pedro Gouveia, Jorg Heil, Pawel Kabata, Daniela Lopes, Marta Martinho, Henrique P. Martins, Carlos Mavioso, Martin Mika, Helena Montenegro, Helder Oliveira, Andre Pfob, Nicole Rotmensz, Timo Schinkothe, Giovani Silva, Rosana Tarricone, Maria-Joao Cardoso, CINDERELLA Consortium
Summary: The CINDERELLA trial aims to evaluate the impact of an artificial-intelligence cloud-based platform on patient education prior to therapy for breast cancer. The platform will provide patients with a visual representation of their potential aesthetic outcomes and an objective evaluation. The goal is to improve patient satisfaction, enhance psychosocial well-being, and reduce the need for additional surgeries.
Article
Medicine, General & Internal
Neslihan Cabioglu, Cihan Uras, Halime Mutlu, Derya Sezgin, Selman Emiroglu, Onur Dulgeroglu, Ravza Yilmaz, Mustafa Tukenmez, Akif Enes Arikan, Halil Kara, Mahmut Muslumanoglu
Summary: This study explored the therapeutic efficacy of local steroid injections (LSI) in patients with severe idiopathic granulomatous mastitis (IGM). The results showed that LSI could be considered as the first-line treatment for severe IGM, either as a sole treatment or in combination with oral steroids. The complete response rates did not differ between the LSI group and the combined LSI with oral steroid treatment group, but systemic side effects were lower in the LSI alone group.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
Pedro F. Gouveia, Rogelio Luna, Francisco Fontes, David Pinto, Carlos Mavioso, Joao Anacleto, Rafaela Timoteo, Joao Santinha, Tiago Marques, Fatima Cardoso, Maria Joao Cardoso
Summary: Augmented reality (AR) has the potential to benefit the healthcare sector through real-time data acquisition, machine learning-aided processing, and visualization. This paper focuses on the future use of AR in breast surgery education, specifically surgical telementoring and impalpable breast cancer localization. The success of these applications depends on improvements in data transformation and infrastructures. (c) 2023 S. Karger AG, Basel
Article
Oncology
Nina Streefkerk, Jop C. Teepen, Elizabeth A. M. Feijen, Katarzyna Jozwiak, Helena J. H. van der Pal, Cecile M. Ronckers, Andrica C. H. De Vries, Margriet van der van der Loo, Nynke Hollema, Marleen van den Berg, Jacqueline Loonen, Martha A. Grootenhuis, Dorine Bresters, A. Brigitta Versluys, Eline van Dulmen-den Broeder, Marry M. van den Heuvel-eibrink, Flora E. van Leeuwen, Sebastian J. C. M. M. Neggers, Hanneke M. Van Santen, Mike Hawkins, Michael Hauptmann, Daisuke Yoneoka, Joke C. Korevaar, Wim J. E. Tissing, Leontien C. M. Kremer
Summary: This study found that childhood cancer survivors experience a high cumulative burden of clinically relevant outcomes compared to siblings. The burden mainly consists of endocrine and vascular conditions and varies by primary cancer type. However, the ranking of 30-year MCC often does not correspond with levels of care in existing risk stratifications.
Article
Oncology
Yuwei Wang, Annegien Broeks, Daniele Giardiello, Michael Hauptmann, Katarzyna Jozwiak, Esther A. Koop, Mark Opdam, Sabine Siesling, Gabe S. Sonke, Nikolas Stathonikos, Natalie D. ter Hoeve, Elsken van der Wall, Carolien H. M. van Deurzen, Paul J. van Diest, Adri C. Voogd, Willem Vreuls, Sabine C. Linn, Gwen M. H. E. Dackus, Marjanka K. Schmidt
Summary: This study validated the reliability of the PREDICT breast cancer prognostic model and assessed its clinical utility in young women with node-negative breast cancer. The results showed that PREDICT was not reliable in predicting outcomes for this patient subset and further updates are needed.
EUROPEAN JOURNAL OF CANCER
(2023)