IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential

Interleukin-6 inhibition for treatment of rheumatoid arthritis: A review of tocilizumab therapy

(2016) Aarat Patel et al.   Drug Design Development and Therapy

Cutting Edge: Th1 Cells Facilitate the Entry of Th17 Cells to the Central Nervous System during Experimental Autoimmune Encephalomyelitis

(2014) R. A. O'Connor et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NKT Cells Constitutively Express IL-23 Receptor and ROR t and Rapidly Produce IL-17 upon Receptor Ligation in an IL-6-Independent Fashion

(2014) A. V. Rachitskaya et al.   JOURNAL OF IMMUNOLOGY

Simvastatin Inhibits IL-17 Secretion by Targeting Multiple IL-17-Regulatory Cytokines and by Inhibiting the Expression of IL-17 Transcription Factor RORC in CD4+ Lymphocytes

(2014) X. Zhang et al.   JOURNAL OF IMMUNOLOGY

Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys

(2014) J. C. Crispin et al.   JOURNAL OF IMMUNOLOGY

Isoform-Specific Inhibition of ROR -Mediated Transcriptional Activation by Human FOXP3

(2014) J. Du et al.   JOURNAL OF IMMUNOLOGY

IL-17 Signaling for mRNA Stabilization Does Not Require TNF Receptor-Associated Factor 6

(2014) J. Hartupee et al.   JOURNAL OF IMMUNOLOGY

The dual nature of Ets-1: Focus to the pathogenesis of systemic lupus erythematosus

(2011) Rui-Xue Leng et al.   AUTOIMMUNITY REVIEWS

Transcription Factor Smad-Independent T Helper 17 Cell Induction by Transforming-Growth Factor-β Is Mediated by Suppression of Eomesodermin

(2011) Kenji Ichiyama et al.   IMMUNITY

Interleukin-17C Promotes Th17 Cell Responses and Autoimmune Disease via Interleukin-17 Receptor E

(2011) Seon Hee Chang et al.   IMMUNITY

Functional Specialization of Interleukin-17 Family Members

(2011) Yoichiro Iwakura et al.   IMMUNITY

IL-17-induced NF-κB Activation via CIKS/Act1

(2011) Søren Ulrik Sønder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional regulation of the Th17 immune response by IKKα

(2011) Li Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ets-1: a new player in the pathogenesis of systemic lupus erythematosus?

(2011) H-F Pan et al.   LUPUS

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

(2011) Jun R. Huh et al.   NATURE

IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens

(2011) Xinyang Song et al.   NATURE IMMUNOLOGY

The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells

(2011) Wataru Ise et al.   NATURE IMMUNOLOGY

Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF)

(2011) Dongxu Sun et al.   NATURE IMMUNOLOGY

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

IL-17C regulates the innate immune function of epithelial cells in an autocrine manner

(2011) Vladimir Ramirez-Carrozzi et al.   NATURE IMMUNOLOGY

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

(2011) Xiang-Ping Yang et al.   NATURE IMMUNOLOGY

The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation

(2011) Katarzyna Bulek et al.   NATURE IMMUNOLOGY

A CC' Loop Decoy Peptide Blocks the Interaction Between Act1 and IL-17RA to Attenuate IL-17- and IL-25-Induced Inflammation

(2011) C. Liu et al.   Science Signaling

Persistent Stimulation with Interleukin-17 Desensitizes Cells Through SCF -TrCP-Mediated Degradation of Act1

(2011) P. Shi et al.   Science Signaling

The IL-17 pathway as a major therapeutic target in autoimmune diseases

(2010) Yan Hu et al.   Annals of the New York Academy of Sciences

LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study

(2010) M. C. Genovese et al.   ARTHRITIS AND RHEUMATISM

Interleukin 17-Producing γδ T Cells Increased in Patients with Active Pulmonary Tuberculosis

(2010) Meiyu Peng et al.   Cellular & Molecular Immunology

IL-17 signaling in host defense and inflammatory diseases

(2010) Youcun Qian et al.   Cellular & Molecular Immunology

Interleukin-17 and its expanding biological functions

(2010) Sheng Xu et al.   Cellular & Molecular Immunology

The increased mucosal mRNA expressions of complement C3 and interleukin-17 in inflammatory bowel disease

(2010) T. Sugihara et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Actual status of antiinterleukin-1 therapies in rheumatic diseases

(2010) Matthias Geyer et al.   CURRENT OPINION IN RHEUMATOLOGY

Astrocyte-Restricted Ablation of Interleukin-17-Induced Act1-Mediated Signaling Ameliorates Autoimmune Encephalomyelitis

(2010) Zizhen Kang et al.   IMMUNITY

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

(2010) Hsin-Jung Wu et al.   IMMUNITY

Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease

(2010) Reiko M. Onishi et al.   IMMUNOLOGY

IL-17 in Systemic Lupus Erythematosus

(2010) José C. Crispín et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling

(2010) Shu Zhu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human NKp44+IL-22+cells and LTi-like cells constitute a stable RORC+lineage distinct from conventional natural killer cells

(2010) Natasha K. Crellin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-23-Mediated Psoriasis-Like Epidermal Hyperplasia Is Dependent on IL-17A

(2010) H. L. Rizzo et al.   JOURNAL OF IMMUNOLOGY

IL-17RC Is Required for IL-17A- and IL-17F-Dependent Signaling and the Pathogenesis of Experimental Autoimmune Encephalomyelitis

(2010) Y. Hu et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-23 Receptor Deficiency Prevents the Development of Lupus Nephritis in C57BL/6-lpr/lpr Mice

(2010) V. C. Kyttaris et al.   JOURNAL OF IMMUNOLOGY

Integrative Responses to IL-17 and TNF-α in Human Keratinocytes Account for Key Inflammatory Pathogenic Circuits in Psoriasis

(2010) Andrea Chiricozzi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IκBζ regulates TH17 development by cooperating with ROR nuclear receptors

(2010) Kazuo Okamoto et al.   NATURE

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility

(2010) Yuta Kochi et al.   NATURE GENETICS

Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2

(2010) Eva Ellinghaus et al.   NATURE GENETICS

Effector T cell plasticity: flexibility in the face of changing circumstances

(2010) Kenneth M Murphy et al.   NATURE IMMUNOLOGY

T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

(2010) Vanja Lazarevic et al.   NATURE IMMUNOLOGY

T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis

(2010) Robert C Axtell et al.   NATURE MEDICINE

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

(2010) W. Hueber et al.   Science Translational Medicine

Pathogenesis of human systemic lupus erythematosus: recent advances

(2010) José C. Crispín et al.   TRENDS IN MOLECULAR MEDICINE

Diverse Genome-wide Association Studies Associate the IL12/IL23 Pathway with Crohn Disease

(2009) Kai Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Synthetic Retinoid AM80 Inhibits Th17 Cells and Ameliorates Experimental Autoimmune Encephalomyelitis

(2009) Christian Klemann et al.   AMERICAN JOURNAL OF PATHOLOGY

Preferential recruitment of interferon-γ-expressing TH17 cells in multiple sclerosis

(2009) Hania Kebir et al.   ANNALS OF NEUROLOGY

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Th17 and natural Treg cell population dynamics in systemic lupus erythematosus

(2009) Ji Yang et al.   ARTHRITIS AND RHEUMATISM

Endogenous IL-17 contributes to reduced tumor growth and metastasis

(2009) I. Kryczek et al.   BLOOD

IL-17 stimulates the proliferation and differentiation of human mesenchymal stem cells: implications for bone remodeling

(2009) H Huang et al.   CELL DEATH AND DIFFERENTIATION

Translational Mini-Review Series on Th17 Cells: CD4+T helper cells: functional plasticity and differential sensitivity to regulatory T cell-mediated regulation

(2009) R. A. O'Connor et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Inhibition of Th17 Cells Regulates Autoimmune Diabetes in NOD Mice

(2009) J. A. Emamaullee et al.   DIABETES

A bone-protective role for IL-17 receptor signaling in ovariectomy-induced bone loss

(2009) Jaya Goswami et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Obesity predisposes to Th17 bias

(2009) Shawn Winer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cellular mechanisms of IL-17-induced blood-brain barrier disruption

(2009) Jula Huppert et al.   FASEB JOURNAL

Differential Roles of Interleukin-17A and -17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses

(2009) Harumichi Ishigame et al.   IMMUNITY

T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity

(2009) Natalia Martin-Orozco et al.   IMMUNITY

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

Randomized, double-blind, placebo-controlled trial of the oral interleukin-12/23 inhibitor apilimod mesylate for treatment of active Crohnʼs disease

(2009) Bruce E. Sands et al.   INFLAMMATORY BOWEL DISEASES

Gfi1 negatively regulates Th17 differentiation by inhibiting ROR t activity

(2009) K. Ichiyama et al.   INTERNATIONAL IMMUNOLOGY

Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice

(2009) David Bending et al.   JOURNAL OF CLINICAL INVESTIGATION

Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation

(2009) Jyoti Das et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

(2009) Heather R. Conti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Critical Role for STAT3 in IL-17A-Mediated CCL11 Expression in Human Airway Smooth Muscle Cells

(2009) A. Saleh et al.   JOURNAL OF IMMUNOLOGY

The Role of IL-23/IL-17 Axis in Lupus Nephritis

(2009) Z. Zhang et al.   JOURNAL OF IMMUNOLOGY

Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes

(2009) A. Jager et al.   JOURNAL OF IMMUNOLOGY

Skin and Peripheral Lymph Node Invariant NKT Cells Are Mainly Retinoic Acid Receptor-Related Orphan Receptor  t+ and Respond Preferentially under Inflammatory Conditions

(2009) J.-M. Doisne et al.   JOURNAL OF IMMUNOLOGY

IL-17 Induces Monocyte Migration in Rheumatoid Arthritis

(2009) S. Shahrara et al.   JOURNAL OF IMMUNOLOGY

Functional Blocking Monoclonal Antibodies against IL-12p40 Homodimer Inhibit Adoptive Transfer of Experimental Allergic Encephalomyelitis

(2009) S. Mondal et al.   JOURNAL OF IMMUNOLOGY

IL-23 Drives Pathogenic IL-17-Producing CD8+ T Cells

(2009) B. Ciric et al.   JOURNAL OF IMMUNOLOGY

Human TCR-  + CD4- CD8- T Cells Can Derive from CD8+ T Cells and Display an Inflammatory Effector Phenotype

(2009) J. C. Crispin et al.   JOURNAL OF IMMUNOLOGY

TGF-  Promotes Th17 Cell Development through Inhibition of SOCS3

(2009) H. Qin et al.   JOURNAL OF IMMUNOLOGY

IL-27 Blocks RORc Expression to Inhibit Lineage Commitment of Th17 Cells

(2009) C. Diveu et al.   JOURNAL OF IMMUNOLOGY

Th17 Cytokines Stimulate CCL20 Expression in Keratinocytes In Vitro and In Vivo: Implications for Psoriasis Pathogenesis

(2009) Erin G. Harper et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice

(2009) Maria Pini et al.   JOURNAL OF LEUKOCYTE BIOLOGY

All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis

(2009) Aiping Bai et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The primacy of CD8 T lymphocytes in type 1 diabetes and implications for therapies

(2009) Denise L. Faustman et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Changes in the serum levels of interleukin-17/interleukin-23 during acute rejection in liver transplantation

(2009) Emilio Fábrega et al.   LIVER TRANSPLANTATION

IL-17 and Th17 cells in human inflammatory diseases

(2009) Pierre Miossec   MICROBES AND INFECTION

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis

(2009) Changsheng Du et al.   NATURE IMMUNOLOGY

Structural basis of receptor sharing by interleukin 17 cytokines

(2009) Lauren K Ely et al.   NATURE IMMUNOLOGY

Interleukin 17 acts in synergy with B cell–activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus

(2009) Agnès Doreau et al.   NATURE IMMUNOLOGY

Targeted depletion of lymphotoxin-α–expressing TH1 and TH17 cells inhibits autoimmune disease

(2009) Eugene Y Chiang et al.   NATURE MEDICINE

IL-17 as a future therapeutic target for rheumatoid arthritis

(2009) Wim B. van den Berg et al.   Nature Reviews Rheumatology

Interleukin-17 and Type 17 Helper T Cells

(2009) Pierre Miossec et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-17 Receptor Signaling Inhibits C/EBP  by Sequential Phosphorylation of the Regulatory 2 Domain

(2009) F. Shen et al.   Science Signaling

Act1, a U-box E3 Ubiquitin Ligase for IL-17 Signaling

(2009) C. Liu et al.   Science Signaling

A pathogenic role of IL- 17 at the early stage of corneal allograft rejection

(2009) Haiyong Chen et al.   TRANSPLANT IMMUNOLOGY

The role of interleukin-17 in the pathogenesis of rheumatoid arthritis

(2009) Sarah L. Gaffen   Current Rheumatology Reports

Safety and Efficacy of ABT-874, a Fully Human Interleukin 12/23 Monoclonal Antibody, in the Treatment of Moderate to Severe Chronic Plaque Psoriasis

(2008) Alexa B. Kimball   ARCHIVES OF DERMATOLOGY

Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice

(2008) Reiko Ito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibitory effect of rapamycin and dexamethasone on production of IL-17 and IFN-  in Vogt-Koyanagi-Harada patients

(2008) K Yang et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: Implications for Th17-mediated inflammation in auto-immunity

(2008) Chun Kwok Wong et al.   CLINICAL IMMUNOLOGY

Structure–function relationships in the IL-17 receptor: Implications for signal transduction and therapy

(2008) Fang Shen et al.   CYTOKINE

Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjögren's syndrome

(2008) Youcun Qian et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease

(2008) William J. Sandborn et al.   GASTROENTEROLOGY

IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease

(2008) T Kobayashi et al.   GUT

The role of the novel Th17 cytokine IL-26 in intestinal inflammation

(2008) J Dambacher et al.   GUT

The Nuclear Orphan Receptor NR2F6 Suppresses Lymphocyte Activation and T Helper 17-Dependent Autoimmunity

(2008) Natascha Hermann-Kleiter et al.   IMMUNITY

Th17 Cell Differentiation: The Long and Winding Road

(2008) Mandy J. McGeachy et al.   IMMUNITY

Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction

(2008) Hideki Ogura et al.   IMMUNITY

IRF-4-Binding Protein Inhibits Interleukin-17 and Interleukin-21 Production by Controlling the Activity of IRF-4 Transcription Factor

(2008) Qinzhong Chen et al.   IMMUNITY

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

B cells flying solo

(2008) Joanna Groom et al.   IMMUNOLOGY AND CELL BIOLOGY

Distinct Cytokine Patterns Identified from Multiplex Profiles of Murine DSS and TNBS-Induced Colitis

(2008) Philip Alex et al.   INFLAMMATORY BOWEL DISEASES

Differential Regulation of the IL-17 Receptor by γc Cytokines

(2008) Matthew J. Lindemann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis

(2008) Shahla Abdollahi-Roodsaz et al.   JOURNAL OF CLINICAL INVESTIGATION

Innocuous IFNγ induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production

(2008) Renu Jain et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of inflammatory responses by IL-17F

(2008) Xuexian O. Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Deficiency of Th17 cells in hyper IgE syndrome due to mutations inSTAT3

(2008) Cindy S. Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

(2008) Craig L Leonardi et al.   LANCET

Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

(2008) Benjamin M Segal et al.   LANCET NEUROLOGY

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

IL-21 and TGF-β are required for differentiation of human TH17 cells

(2008) Li Yang et al.   NATURE

Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

(2008) Joshua D. Milner et al.   NATURE

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells

(2008) Fuping Zhang et al.   NATURE IMMUNOLOGY

Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells

(2008) Tom Cupedo et al.   NATURE IMMUNOLOGY

Resolvin E1 regulates interleukin 23, interferon-γ and lipoxin A4 to promote the resolution of allergic airway inflammation

(2008) Oliver Haworth et al.   NATURE IMMUNOLOGY

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

(2008) Elisabetta Volpe et al.   NATURE IMMUNOLOGY

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

(2008) Shean J Aujla et al.   NATURE MEDICINE

Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells

(2008) Ingunn M Stromnes et al.   NATURE MEDICINE

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY