Article
Health Care Sciences & Services
Laura A. Lucaciu, Maria Ilies, Stefan C. Vesa, Radu Seicean, Shahida Din, Cristina Adela Iuga, Andrada Seicean
Summary: Interleukin (IL)-23 and fecal calprotectin levels were significantly elevated in severe inflammatory bowel disease (IBD), while IL-17 and C-reactive protein were associated with disease severity. IL-23 may serve as a promising novel biomarker for severe Crohn's disease, guiding clinical decision-making on biologic therapy. Identifying the main IL pathway involved in IBD severity could provide valuable insights for personalized treatment approaches.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Pediatrics
Maya Ruban, Adam Slavick, Achiya Amir, Amir Ben-Tov, Hadar Moran-Lev, Yael Weintraub, Adi Anafy, Shlomi Cohen, Anat Yerushalmy-Feler
Summary: The rate of a positive family history of IBD in the pediatric IBD population is increasing, and patients with a positive family history are more likely to have a severe phenotype, receive more nutritional therapy, and less corticosteroids. Patients with a negative family history may require intensified biologic therapy.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Gastroenterology & Hepatology
G. Leoncini, F. Donato, L. Reggiani-Bonetti, T. Salviato, M. Cadei, M. Daperno, M. B. Principi, A. Armuzzi, F. Caprioli, G. Canavese, V. Villanacci
Summary: The study revealed moderate interobserver agreement regarding the histopathological detection and classification of IBD-associated dysplasia. Further efforts are needed to integrate histopathological data with ancillary tests and molecular investigations.
TECHNIQUES IN COLOPROCTOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nikolas Dovrolis, Anastasia Moschoviti, Smaragdi Fessatou, George Karamanolis, George Kolios, Maria Gazouli
Summary: This study examines the role of the microbiome in the onset of pediatric inflammatory bowel disease (IBD). Through analyzing the microbiota of nine IBD families, specific patterns of microbial taxa were identified among patients and their families. The results suggest a potential role of maternal factors in the establishment and modulation of the early life microbiome.
Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Article
Pharmacology & Pharmacy
Snjezana Cuzic, Maja Antolic, Anja Ognjenovic, Darija Stupin-Polancec, Adriana Petrinic Grba, Boska Hrvacic, Miroslava Dominis Kramaric, Sanja Musladin, Lidija Pozgaj, Ivo Zlatar, Denis Polancec, Gorana Aralica, Marko Banic, Marija Urek, Brankica Mijandrusic Sincic, Aleksandar Cubranic, Ines Glojnaric, Martina Bosnar, Vesna Erakovic Haber
Summary: This study explored the expression of claudins in human disease and two different animal models of IBD. The diverse alterations in claudin expression by epithelial and inflammatory cells were recorded in IBD and both animal models. The results suggest that claudins are not exclusively expressed by epithelial cells, and changes in claudin mRNA levels should be interpreted in the context of overall tissue alterations.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Christopher Ma, Jurij Hanzel, Remo Panaccione, William J. Sandborn, Geert R. D'Haens, Vineet Ahuja, Raja Atreya, Charles N. Bernstein, Peter Bossuyt, Brian Bressler, Robert Bryant, Benjamin Cohen, Jean-Frederic Colombel, Silvio Danese, Axel Dignass, Marla C. Dubinsky, Phillip R. Fleshner, Richard B. Gearry, Stephen B. Hanauer, Ailsa Hart, Paulo Gustavo Kotze, Torsten Kucharzik, Peter L. Lakatos, Rupert W. Leong, Fernando Magro, Julian Panes, Laurent Peyrin-Biroulet, Zhihua Ran, Miguel Regueiro, Siddharth Singh, Antonino Spinelli, A. Hillary Steinhart, Simon P. Travis, C. Janneke van der Woude, Bruce Yacyshyn, Takayuki Yamamoto, Matthieu Allez, Willem A. Bemelman, Amy L. Lightner, Edouard Louis, David T. Rubin, Ellen J. Scherl, Corey A. Siegel, Mark S. Silverberg, Severine Vermeire, Claire E. Parker, Stefanie C. McFarlane, Leonardo Guizzetti, Michelle Smith, Niels Vande Casteele, Brian G. Feagan, Vipul Jairath
Summary: This study establishes a core outcome set for randomized controlled trials of CD and UC through a multidisciplinary collaboration involving patients and clinical experts. Candidate outcome domains and measures were generated from literature reviews and patient engagement. The study highlights the importance of harmonizing endpoints for drug development in inflammatory bowel disease.
Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tyler Atagozli, David E. Elliott, Mirac Nedim Ince
Summary: Helminths are multicellular invertebrates that live in the gut of vertebrate animals, including humans. They can cause pathology and require treatment, but can also have commensal or symbiotic relationships with their hosts. Epidemiological data suggests that helminth exposure may provide protection against immune disorders, such as allergies and autoimmune illnesses.
Article
Gastroenterology & Hepatology
Tatsuki Noguchi, Soichiro Ishihara, Motoi Uchino, Hiroki Ikeuchi, Koji Okabayashi, Kitaro Futami, Shinji Tanaka, Hiroki Ohge, Hisashi Nagahara, Kazuhiro Watanabe, Michio Itabashi, Kinya Okamoto, Yoshiki Okita, Tsunekazu Mizushima, Yusuke Mizuuchi, Kazutaka Yamada, Yoshifumi Shimada, Yu Sato, Hideaki Kimura, Kenichi Takahashi, Koya Hida, Yusuke Kinugasa, Junji Okuda, Koji Daito, Fumikazu Koyama, Hideki Ueno, Takayuki Yamamoto, Tsunekazu Hanai, Atsuo Maemoto, Koji Oba, Yoichi Ajioka, Kenichi Sugihara
Summary: Patients with longstanding inflammatory bowel disease, such as ulcerative colitis and Crohn's disease, are at high risk of developing intestinal cancers. This study found significant differences between intestinal cancers associated with ulcerative colitis and Crohn's disease. Crohn's disease-associated cancers were diagnosed at more advanced stages, detected less frequently by surveillance, and had a poorer prognosis compared to those associated with ulcerative colitis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Pathology
Zhiyan Fu, Michel Kmeid, Soe Htet Arker, Georgi Lukose, Edward C. Lee, Gregory Y. Lauwers, Hwajeong Lee
Summary: This study aimed to identify histologic features of diverted colon segments in IBD patients and found that severe inflammatory activity, mucosal atrophy, and transmural inflammation were significantly greater in IBD patients compared to non-IBD cases. The inflammatory activity, presence of ulcer(s), IMLAs, TMLAs, and transmural inflammation in diverted colon segments of IBD patients may reflect the severity of underlying IBD.
Article
Gastroenterology & Hepatology
Aonghus Lavelle, Stephane Nancey, Jean-Marie Reimund, David Laharie, Philippe Marteau, Xavier Treton, Matthieu Allez, Xavier Roblin, Georgia Malamut, Cyriane Oeuvray, Nathalie Rolhion, Xavier Dray, Dominique Rainteau, Antonin Lamaziere, Emilie Gauliard, Julien Kirchgesner, Laurent Beaugerie, Philippe Seksik, Laurent Peyrin-Biroulet, Harry Sokol
Summary: This study investigated the association between gut microbiota, bile acids, and colorectal cancer in IBD patients. The results found that specific bacterial taxa were associated with cancer, while bile acids were not. Additionally, clustering analysis identified microbiota clusters associated with clinical features.
Article
Biochemical Research Methods
Florent Clerc, Karli R. Reiding, Noortje de Haan, Carolien A. M. Koeleman, Agnes L. Hipgrave Ederveen, Natalia Manetti, Viktoria Dotz, Vito Annese, Manfred Wuhrer
Summary: This study investigates the associations of immunoglobulin A1 and A2 glycosylation with inflammatory bowel diseases (IBD). Differences in IgA O- and N-glycosylation between patient groups were found to be associated with the diseases, and a statistical model was constructed to predict the disease group of the patients. These findings contribute to the development of noninvasive biomarkers for IBD and improvement in patient care.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Giuseppe Biscaglia, Anna Latiano, Stefano Castellana, Rosanna Fontana, Annamaria Gentile, Tiziana Latiano, Giuseppe Corritore, Anna Panza, Marianna Nardella, Giuseppina Martino, Fabrizio Bossa, Francesco Perri, Tommaso Mazza, Angelo Andriulli, Orazio Palmieri
Summary: This study investigated germline alterations in patients with inflammatory bowel disease (IBD)-associated colorectal cancer (CRC). The results showed that a significant proportion of IBD patients with CRC had pathogenic variants in cancer-related genes. Those with pathogenic variants had earlier onset of high-grade dysplasia or CRC compared to patients with benign or unidentified variants. Screening for these genes could help identify IBD patients who require more intensive surveillance for early detection of dysplastic changes.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
E. Zittan, A. H. Steinhart, H. Aran, R. Milgrom, I. M. Gralnek, S. Zelber-Sagi, M. S. Silverberg
Summary: The TIGER score is a reliable and simple endoscopic score that can be used for both CD and UC patients and is correlated with other markers of disease activity.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Immunology
K. Takahashi, H. Imaeda, T. Fujimoto, H. Ban, S. Bamba, T. Tsujikawa, M. Sasaki, Y. Fujiyama, A. Andoh
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2013)
Article
Immunology
H. Imaeda, K. Takahashi, T. Fujimoto, E. Kasumi, H. Ban, S. Bamba, H. Sonoda, T. Shimizu, Y. Fujiyama, A. Andoh
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2013)
Article
Gastroenterology & Hepatology
Shigeki Bamba, Akira Andoh, Hiromitsu Ban, Hirotsugu Imaeda, Tomoki Aomatsu, Ayako Kobori, Yosuke Mochizuki, Makoto Shioya, Takashi Nishimura, Osamu Inatomi, Masaya Sasaki, Yasuharu Saitoh, Tomoyuki Tsujikawa, Yoshio Araki, Yoshihide Fujiyama
DIGESTIVE DISEASES AND SCIENCES
(2012)
Article
Gastroenterology & Hepatology
Yusuke Honzawa, Hiroshi Nakase, Masahiro Shiokawa, Takuya Yoshino, Hirotsugu Imaeda, Minoru Matsuura, Yuzo Kodama, Hiroki Ikeuchi, Akira Andoh, Yoshiharu Sakai, Kazuhiro Nagata, Tsutomu Chiba
Article
Medicine, Research & Experimental
Tomoki Aomatsu, Hirotsugu Imaeda, Kenichiro Takahashi, Takehide Fujimoto, Eiji Kasumi, Atsushi Yoden, Hiroshi Tamai, Yoshihide Fujiyama, Akira Andoh
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2012)
Article
Nutrition & Dietetics
Tomoki Aomatsu, Hirotsugu Imaeda, Kenichiro Takahashi, Takehide Fujimoto, Eiji Kasumi, Hiromitsu Ban, Shigeki Bamba, Atsushi Yoden, Hiroshi Tamai, Yoshihide Fujiyama, Akira Andoh
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
(2013)
Article
Immunology
Atsushi Nishida, Kiyotaka Nagahama, Hirotsugu Imaeda, Atsuhiro Ogawa, Cindy W. Lau, Taku Kobayashi, Tadakazu Hisamatsu, Frederic I. Preffer, Emiko Mizoguchi, Hiroki Ikeuchi, Toshifumi Hibi, Minoru Fukuda, Akira Andoh, Richard S. Blumberg, Atsushi Mizoguchi
JOURNAL OF EXPERIMENTAL MEDICINE
(2012)
Article
Gastroenterology & Hepatology
Hirotsugu Imaeda, Akira Andoh, Yoshihide Fujiyama
JOURNAL OF GASTROENTEROLOGY
(2012)
Article
Gastroenterology & Hepatology
Hirotsugu Imaeda, Kenichiro Takahashi, Takehide Fujimoto, Shigeki Bamba, Tomoyuki Tsujikawa, Masaya Sasaki, Yoshihide Fujiyama, Akira Andoh
JOURNAL OF GASTROENTEROLOGY
(2014)
Article
Gastroenterology & Hepatology
Hirotsugu Imaeda, Shigeki Bamba, Kenichiro Takahashi, Takehide Fujimoto, Hiromitsu Ban, Tomoyuki Tsujikawa, Masaya Sasaki, Yoshihide Fujiyama, Akira Andoh
JOURNAL OF GASTROENTEROLOGY
(2014)
Article
Gastroenterology & Hepatology
Takehide Fujimoto, Hirotsugu Imaeda, Kenichiro Takahashi, Eiji Kasumi, Shigeki Bamba, Yoshihide Fujiyama, Akira Andoh
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2013)
Article
Immunology
Motohiro Nonaka, Hirotsugu Imaeda, Shogo Matsumoto, Bruce Yong Ma, Nobuko Kawasaki, Eiji Mekata, Akira Andoh, Yasuharu Saito, Tohru Tani, Yoshihide Fujiyama, Toshisuke Kawasaki
JOURNAL OF IMMUNOLOGY
(2014)
Article
Oncology
Takashi Nishimura, Rie Osaki, Makoto Shioya, Hirotsugu Imaeda, Tomoki Aomatsu, Takayuki Takeuchi, Yoshiaki Okumura, Yoshihide Fujiyama, Akira Andoh
MOLECULAR MEDICINE REPORTS
(2012)
Article
Gastroenterology & Hepatology
Kyoko Shimizu, Kahoko Hashimoto, Junko Tahara, Hirotsugu Imaeda, Akira Andoh, Keiko Shiratori
Article
Medicine, Research & Experimental
Shigeki Bamba, Akira Andoh, Hirotsugu Imaeda, Hiromitsu Ban, Ayako Kobori, Yousuke Mochizuki, Makoto Shioya, Takashi Nishimura, Osamu Inatomi, Masaya Sasaki, Yasuharu Saitoh, Tomoyuki Tsujikawa, Yoshihide Fujiyama
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2012)