Phosphate toxicity: new insights into an old problem

Therapeutic potential of klotho–FGF23 fusion polypeptides: WO2009095372

(2010) Mohammed S Razzaque   EXPERT OPINION ON THERAPEUTIC PATENTS

Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging

(2010) Mutsuko Ohnishi et al.   FASEB JOURNAL

Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule

(2010) Ming Chang Hu et al.   FASEB JOURNAL

The dualistic role of vitamin D in vascular calcifications

(2010) M. Shawkat Razzaque   KIDNEY INTERNATIONAL

A potential link between phosphate and aging—Lessons from Klotho-deficient mice

(2010) Makoto Kuro-o   MECHANISMS OF AGEING AND DEVELOPMENT

In Vivo Genetic Evidence for Suppressing Vascular and Soft-Tissue Calcification Through the Reduction of Serum Phosphate Levels, Even in the Presence of High Serum Calcium and 1,25-Dihydroxyvitamin D Levels

(2009) Mutsuko Ohnishi et al.   Circulation-Cardiovascular Genetics

Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model

(2009) Teruyo Nakatani et al.   FASEB JOURNAL

Intestinal Npt2b Plays a Major Role in Phosphate Absorption and Homeostasis

(2009) Y. Sabbagh et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1α-hydroxylase

(2009) Mutsuko Ohnishi et al.   KIDNEY INTERNATIONAL

The FGF23–Klotho axis: endocrine regulation of phosphate homeostasis

(2009) M. Shawkat Razzaque   Nature Reviews Endocrinology

Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation

(2009) R. Goetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Klotho ablation converts the biochemical and skeletal alterations in FGF23 (R176Q) transgenic mice to a Klotho-deficient phenotype

(2008) Xiuying Bai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The discovery of α-Klotho and FGF23 unveiled new insight into calcium and phosphate homeostasis

(2008) Y. Nabeshima   CELLULAR AND MOLECULAR LIFE SCIENCES

Vitamin D Deficiency and Risk of Cardiovascular Disease

(2008) Thomas J. Wang et al.   CIRCULATION

In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis

(2008) Teruyo Nakatani et al.   FASEB JOURNAL

FGF-23–Klotho signaling stimulates proliferation and prevents vitamin D–induced apoptosis

(2008) Damian Medici et al.   JOURNAL OF CELL BIOLOGY

Amelioration of the premature ageing-like features ofFgf-23knockout mice by genetically restoring the systemic actions of FGF-23

(2008) S DeLuca et al.   JOURNAL OF PATHOLOGY

FGFR3 and FGFR4 Do not Mediate Renal Effects of FGF23

(2008) S. Liu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Does FGF23 toxicity influence the outcome of chronic kidney disease?

(2008) M. S. Razzaque   NEPHROLOGY DIALYSIS TRANSPLANTATION