Article
Nutrition & Dietetics
Juan F. Navarro-Gonzalez, Carmen Mora-Fernandez, Juan Miguel Diaz-Tocados, Milica Bozic, Marcelino Bermudez-Lopez, Marisa Martin, Jose Manuel Valdivielso
Summary: This study found that elevated serum phosphate and intact FGF23 levels were closely associated with an increased risk of anemia in patients with chronic kidney disease. Low phosphate levels amplified the effect of intact FGF23 concentration on anemia.
Review
Biochemistry & Molecular Biology
Merita Rroji, Andreja Figurek, Davide Viggiano, Giovambattista Capasso, Goce Spasovski
Summary: The nervous system and the kidneys are linked in maintaining normal body homeostasis. Chronic kidney disease can impair the central nervous system, leading to cerebrovascular disease and cognitive impairment. Recent studies suggest that controlling hyperphosphatemia in CKD may lower the risk of cognitive decline and dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Linda Hagmayer, Christina Mayer, Nadja Ebert, Kerstin Amann, Christoph Daniel
Summary: Chronic kidney disease (CKD) often leads to congestive heart failure (CHF) and left ventricular hypertrophy (LVH), contributing to increased mortality in CKD patients. This study investigated whether cardiovascular changes in CKD could be reversed by kidney transplantation. The results showed that while renal function normalized after transplantation, heart load and hypertrophy did not decrease. However, left ventricular wall thickness, fractional shortening, and ejection fraction were restored to normal levels.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Giuseppe Vergaro, Alberto Aimo, Ester Taurino, Annamaria Del Franco, Iacopo Fabiani, Concetta Prontera, Silvia Masotti, Veronica Musetti, Michele Emdin, Claudio Passino
Summary: During an episode of acute heart failure (AHF), plasma FGF23 levels increase, and patients with higher FGF23 levels at discharge have a higher risk of worse outcomes.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Physiology
Seth Bollenbecker, Brian Czaya, Orlando M. Gutierrez, Stefanie Krick
Summary: Chronic kidney disease is often accompanied by comorbidities, including cardiovascular diseases, diabetes, and lung diseases. The interaction between the lungs and kidneys is not well understood. This review summarizes the current research on kidney-pulmonary interorgan cross talk in the context of chronic kidney disease and explores the impact of lung diseases on patient care.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Review
Nutrition & Dietetics
Aleksandra Beata Juszczak, Maciej Kupczak, Tomasz Konecki
Summary: This narrative review summarizes 98 studies of chronic kidney disease (CKD) and the effects of vitamin supplementation on patients on dialysis. The findings suggest potential effectiveness of certain vitamins, such as B, D, or C, but recommendations for vitamins A and K are still unclear due to potential toxicity. Further research is needed to evaluate the effectiveness and risks of vitamin supplementation for CKD patients.
Article
Agriculture, Dairy & Animal Science
Carla Steffen, Ellen Kienzle, Britta Dobenecker
Summary: The hormone FGF23 plays important roles in regulating phosphorus homeostasis and sodium retention. High sodium chloride intake does not affect serum FGF23 concentrations in cats, but it may increase the digestibility of phosphorus.
Article
Endocrinology & Metabolism
Shilpa Sharma, Ronit Katz, Charles Ginsberg, Alexander Bullen, Volker Vallon, Scott Thomson, Orson W. Moe, Andrew N. Hoofnagle, Peter W. de Leeuw, Abraham A. Kroon, Alfons J. H. M. Houben, Joachim H. Ix
Summary: The relative abundance of fibroblast growth factor-23 (FGF23) varies depending on kidney function in humans. This study found that the kidney clearance of FGF23 is higher than that of creatinine, and the clearance of intact FGF23 is higher than that of C-terminal fragments. The reduction of FGF23 by the kidney is associated with kidney function decline.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Medicine, General & Internal
Shrikant D. Pande, Julie Morris
Summary: This study reviewed the post-stroke survival and functional outcomes following rehabilitation in patients with CKD and those on haemodialysis, finding that patients with CKD had longer hospital stays, more recurrent hospitalizations, and poorer survival outcomes.
SINGAPORE MEDICAL JOURNAL
(2021)
Article
Medicine, General & Internal
Yan Chen, Yan-Xia Chen, Chong Huang, Zhi-Bing Duan, Cheng-Yun Xu
Summary: This study aimed to investigate the clinical value of serum Klotho and FGF23 in cardiac valve calcification in patients with Chronic Kidney Disease (CKD). Findings showed that with the decrease of GFR in CKD patients, the serum levels of FGF23 increased, while the serum levels of Klotho decreased. Various factors influence FGF23 and Klotho levels, and they are negatively correlated in CKD patients. GFR, serum creatinine, FGF23, and Klotho were identified as independent risk factors for heart valve calcification in patients with CKD.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Biology
Brian Czaya, Kylie Heitman, Isaac Campos, Christopher Yanucil, Dominik Kentrup, David Westbrook, Orlando Gutierrez, Jodie L. Babitt, Grace Jung, Isidro B. Salusky, Mark Hanudel, Christian Faul
Summary: Elevated plasma phosphate concentrations can lead to complications such as inflammation, anemia, and skeletal muscle wasting in chronic kidney disease patients. This study found that these complications can also occur in mice with adenine-induced CKD or mice fed a high phosphate diet. However, a low phosphate diet was able to ameliorate anemia and skeletal muscle wasting in a genetic mouse model of CKD. Mechanistic in vitro studies revealed that phosphate elevations induce inflammatory signaling and increase hepcidin expression in hepatocytes. These findings suggest the harmful effects of high phosphate intake, supporting the need to treat hyperphosphatemia in CKD patients and limit phosphate intake in healthy individuals.
Article
Transplantation
Zhalaliddin Makhammajanov, Abduzhappar Gaipov, Askhat Myngbay, Rostislav Bukasov, Mohamad Aljofan, Mehmet Kanbay
Summary: Proteinuria is a well-recognized biomarker and driver of chronic kidney disease progression. Degraded and reabsorbed proteins in proximal tubular epithelial cells can cause toxicity. Proteinuria leads to kidney damage and inflammation by increasing reactive oxygen species and impairing autophagy function.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Food Science & Technology
Mateo Ondrussek-Sekac, Diana Navas-Carrillo, Esteban Orenes-Pinero
Summary: In chronic kidney disease, dysbiosis of intestinal microbiota can lead to uremic toxicity, inflammation and disease progression. Modulating gut microbiota through dietary changes and using probiotics, prebiotics, and low protein diets can offer therapeutic interventions to improve this imbalance and manage chronic kidney disease effectively.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Medicine, Research & Experimental
Francisco Mendoza-Carrera, Alfonso Farias-Basulto, Erika F. Gomez-Garcia, Laura Cortes-Sanabria, Alfonso Martin Cueto-Manzano, Lourdes del Carmen Rizo-de la Torre, Caridad A. Leal-Cortes
Summary: This study analyzed the association between serum levels of FGF23, two FGF23 gene variants, and metabolic and renal function parameters in Mexican patients with Type 2 Diabetes and/or essential hypertension. The results showed that CKD patients had higher levels of FGF23, as well as older age, higher systolic blood pressure, uric acid, and glucose levels compared to those without CKD. Additionally, FGF23 gene variants rs11063112 and rs7955866 were found to be associated with the probability of developing CKD.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Transplantation
Francis Verbeke, Justyna Siwy, Wim Van Biesen, Harald Mischak, Anneleen Pletinck, Eva Schepers, Nathalie Neirynck, Pedro Magalhaes, Martin Pejchinovski, Claudia Pontillo, Ralf Lichtinghagen, Korbinian Brand, Antonia Vlahou, Dirk De Bacquer, Griet Glorieux
Summary: The urinary proteomic classifier CKD273 has been found to be predictive for cardiovascular events in patients with chronic kidney disease. In patients with CKD Stages G1-G3b and without a history of cardiovascular disease, CKD273 is a strong and independent predictor of fatal or non-fatal cardiovascular events.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
