Deimination of linker histones links neutrophil extracellular trap release with autoantibodies in systemic autoimmunity

Histone Deimination As a Response to Inflammatory Stimuli in Neutrophils

(2014) I. Neeli et al.   JOURNAL OF IMMUNOLOGY

Citrullination regulates pluripotency and histone H1 binding to chromatin

(2014) Maria A. Christophorou et al.   NATURE

Mapping of six somatic linker histone H1 variants in human breast cancer cells uncovers specific features of H1.2

(2014) Lluís Millán-Ariño et al.   NUCLEIC ACIDS RESEARCH

Antibodies from patients with rheumatoid arthritis target citrullinated histone 4 contained in neutrophils extracellular traps

(2013) Federico Pratesi et al.   ANNALS OF THE RHEUMATIC DISEASES

Citrullination of autoantigens implicates NETosis in the induction of autoimmunity

(2013) Nishant Dwivedi et al.   ANNALS OF THE RHEUMATIC DISEASES

Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus

(2013) Jason S. Knight et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel Inhibitors of Protein Arginine Deiminase with Potential Activity in Multiple Sclerosis Animal Model

(2013) Lianhu Wei et al.   JOURNAL OF MEDICINAL CHEMISTRY

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

(2013) R. Khandpur et al.   Science Translational Medicine

Neutrophil extracellular chromatin traps connect innate immune response to autoimmunity

(2013) Marko Radic et al.   Seminars in Immunopathology

Opposition between PKC isoforms regulates histone deimination and neutrophil extracellular chromatin release

(2013) Indira Neeli et al.   Frontiers in Immunology

Autoantibody Epitope Spreading in the Pre-Clinical Phase Predicts Progression to Rheumatoid Arthritis

(2012) Jeremy Sokolove et al.   PLoS One

Host-protective effect of circulating pentraxin 3 (PTX3) and complex formation with neutrophil extracellular traps

(2012) Kenji Daigo et al.   Frontiers in Immunology

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

(2012) Marc Leshner et al.   Frontiers in Immunology

Activation of PAD4 in NET formation

(2012) Amanda S. Rohrbach et al.   Frontiers in Immunology

Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps

(2011) Nishant Dwivedi et al.   ARTHRITIS AND RHEUMATISM

FoxP3 interacts with linker histone H1.5 to modulate gene expression and program Treg cell activity

(2011) S L Mackey-Cushman et al.   GENES AND IMMUNITY

N-α-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-l-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis

(2011) Van C. Willis et al.   JOURNAL OF IMMUNOLOGY

PAD4-Mediated Neutrophil Extracellular Trap Formation Is Not Required for Immunity against Influenza Infection

(2011) Saskia Hemmers et al.   PLoS One

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

Identification of citrullinated histone H3 as a potential serum protein biomarker in a lethal model of lipopolysaccharide-induced shock

(2011) Yongqing Li et al.   SURGERY

Genome-Wide Analysis Reveals PADI4 Cooperates with Elk-1 to Activate c-Fos Expression in Breast Cancer Cells

(2011) Xuesen Zhang et al.   PLoS Genetics

Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation

(2010) Felipe Andrade et al.   ARTHRITIS AND RHEUMATISM

2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

(2010) Daniel Aletaha et al.   ARTHRITIS AND RHEUMATISM

Immunological profile in primary Sjögren syndrome

(2010) A.L. Fauchais et al.   AUTOIMMUNITY REVIEWS

Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo

(2010) M. W. Munks et al.   BLOOD

Nucleosome Interaction Surface of Linker Histone H1c Is Distinct from That of H10

(2010) Eric M. George et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone H1 phosphorylation is associated with transcription by RNA polymerases I and II

(2010) Yupeng Zheng et al.   JOURNAL OF CELL BIOLOGY

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nuclease Expression by Staphylococcus aureus Facilitates Escape from Neutrophil Extracellular Traps

(2010) Evelien T.M. Berends et al.   Journal of Innate Immunity

Single-base resolution mapping of H1-nucleosome interactions and 3D organization of the nucleosome

(2010) S. H. Syed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone H2A C-Terminus Regulates Chromatin Dynamics, Remodeling, and Histone H1 Binding

(2010) Christine Vogler et al.   PLoS Genetics

Defensins in Systemic Lupus Erythematosus

(2009) Oren Froy et al.   Annals of the New York Academy of Sciences

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens

Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation

(2008) M. von Kockritz-Blickwede et al.   BLOOD

Histone H1 and its isoforms: Contribution to chromatin structure and function

(2008) Nicole Happel et al.   GENE

Isolation and Characterization of a Novel H1.2 Complex That Acts as a Repressor of p53-mediated Transcription

(2008) Kyunghwan Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti‐histones antibodies in systemic lupus erythematosus: prevalence and frequency in neuropsychiatric lupus

(2008) Xiao‐Yun Sun et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation

(2008) Paul Proost et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathogenic anti-nucleosome antibodies

(2008) S Muller et al.   LUPUS