Article
Allergy
Francisca Vilchez-Sanchez, Rosa Rodriguez-Perez, Carmen Gomez-Traseira, Javier Dominguez-Ortega, Lucia Hernandez-Rivas, Itsaso Losantos Garcia, Santiago Quirce, Maria Pedrosa
Summary: This study found that 16.3% of patients were sensitised to Pru p 7, which was associated with severe reactions, upper airway symptoms, anaphylaxis, and the presence of an eliciting cofactor.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Review
Allergy
Debra de Silva, Pablo Rodriguez del Rio, Nicolette W. de Jong, Ekaterina Khaleva, Chris Singh, Anna Nowak-Wegrzyn, Antonella Muraro, Philippe Begin, Giovanni Pajno, Alessandro Fiocchi, Angel Sanchez, Carla Jones, Caroline Nilsson, Carsten Bindslev-Jensen, Gary Wong, Hugh Sampson, Kirsten Beyer, Mary-Jane Marchisotto, Montserrat Fernandez Rivas, Rosan Meyer, Susanne Lau, Ulugbek Nurmatov, Graham Roberts
Summary: Oral immunotherapy improves tolerance in patients with peanut, cow's milk, and hen's egg allergy during therapy and is likely safe. The effects of other allergies and administration routes are inconclusive and require further research.
Review
Immunology
Nishelle D'souza, Milena Weber, Eszter Sarzsinszky, Susanne Vrtala, Mirela Curin, Mirjam Schaar, Victoria Garib, Margarete Focke-Tejkl, Yanqiu Li, Richard Jones, Hao Chen, Rudolf Valenta, Baoqing Sun
Summary: Approximately 30% of the global population suffers from IgE-mediated allergy, with China having the largest population and over 400 million allergic patients. Allergy prevention and treatment strategies include allergen avoidance, vaccination, and tolerance induction, requiring a detailed understanding of relevant allergen molecules affecting specific populations.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Xinyue Chang, Lisha Zha, Alexandra Wallimann, Mona O. Mohsen, Pascal Krenger, Xuelan Liu, Monique Vogel, Martin F. Bachmann
Summary: This study found that even IgE antibodies with low affinity can activate mast cells in vitro and in vivo, triggering allergic reactions. This is because these low-affinity IgE antibodies bind allergens bivalently on the surface of mast cells, leading to high-avidity interactions.
Article
Immunology
I-Hui Lin, Ming-Chin Tsai, Jun-Peng Chen, Lin-Shien Fu
Summary: The study found that for two thirds of atopic children, a specific allergen could be identified during follow-up tests. Specific allergens could be identified through MAST tests and further assist in treatment options.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Cell Biology
Xue'an Wang, Long Zhou, Guixi Wei, Hui Zhang, Bin Yang
Summary: Identifying allergen distribution is crucial for effective diagnosis and treatment of allergic diseases. This study examined allergen sensitivity in four southern China cities, finding a decrease in sensitivity with age and higher rates in males. Aeroallergens showed significant seasonal variations, while Liuzhou had the highest rates of food and aeroallergen sensitivities.
Article
Chemistry, Applied
Jesus F. Crespo, Cristina Bueno, Mayte Villalba, Linda Monaci, Carmen Cuadrado, Natalija Novak, Beatriz Cabanillas
Summary: Epitopes of the major allergen Pin p 1 from pine nut were analyzed with a peptide library and sera from patients, revealing similarities with epitopes from allergenic 2S albumins from peanut and Brazil nut. These epitopes were found in alpha-helices and coils in the 3D protein structure, with all epitopes well-exposed on the protein surface for facile IgE-binding.
Article
Nutrition & Dietetics
Severina Terlouw, Frank E. van Boven, Monika Borsboom-van Zonneveld, Catharina de Graaf-in 't Veld, Marloes E. van Splunter, Paul L. A. van Daele, Maurits S. van Maaren, Marco W. J. Schreurs, Nicolette W. de Jong
Summary: The study compared the SPT results of homemade food allergen extracts with commercially available extracts, finding that homemade hazelnut and walnut extracts can be good alternatives in the absence of commercial extracts. The agreement between SPT results and food allergen-specific symptoms were comparable for homemade and commercial extracts, except for peach.
Article
Allergy
Josefin Ullberg, Mareike Fech-Bormann, Ulrika L. Fagerberg
Summary: In this study of 113 Swedish children, cow's milk, fish, and oat were the most common trigger foods for FPIES. Most patients reacted to a single food, and IgE sensitization was rare.
Article
Allergy
Paraskevi Xepapadaki, Georgia Christopoulou, George Stavroulakis, Raphaela Freidl, Birgit Linhart, Laurian Zuidmeer, John Lakoumentas, Ronald van Ree, Rudolf Valenta, Nikolaos G. Papadopoulos
Summary: The study investigated the natural history of immunoglobulin E-mediated fish allergy in 126 children and found that a considerable proportion of fish-allergic children develop tolerance around adolescence. Most fish-allergic children can consume tuna and swordfish, providing safe alternatives for a balanced diet.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
Tanja Kalic, Annette Kuehn, Martina Aumayr, Joan Bartra, Carsten Bindslev-Jensen, Francoise Codreanu-Morel, Olga Dominguez, Peter Forstenlechner, Wolfgang Hemmer, Sandip D. Kamath, Agnes Leung, Nicki Leung, Yuri Lifanov, Charlotte G. Mortz, Mariona Pascal, Robin Ristl, Martin Sorensen, Oyku Uzulmez, Lusine Yeghiazaryan, Gary Wong, Christine Hafner, Heimo Breiteneder
Summary: This study investigates the use of multiplex IgE testing to identify potentially tolerated fish species for fish-allergic patients. The results suggest that the presence or absence of IgE to parvalbumin and extracts from specific fish species can help determine individual tolerance to different species.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Allergy
Thimo Ruethers, Roni Nugraha, Aya C. Taki, Andrea O'Malley, Shaymaviswanathan Karnaneedi, Stephanie Zhang, A. Brenda Kapingidza, Sam Mehr, Sandip D. Kamath, Maksymilian Chruszcz, Graham Mackay, Dianne E. Campbell, Andreas L. Lopata
Summary: This study reveals the clinical relevance of IgE-binding proteins in crocodile meat for fish-allergic patients. The major fish allergen parvalbumin (PV) was found to trigger allergic reactions in fish-allergic patients when present in heated crocodile meat. Crocodile beta-PV was identified as the major IgE-binding protein, but less abundant than alpha-PV. It is recommended that fish-allergic individuals seek specialist advice before consuming crocodile meat.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Review
Immunology
Lu Qin, Lan-Fang Tang, Lei Cheng, Hui-Ying Wang
Summary: IgG4 is a subclass of antibody with unique molecular features, allowing it to bind bispecific antigens in a mono-valent manner. It exhibits non-inflammatory characteristics due to low binding affinity to certain receptors. The clinical significance of IgG4 in allergic diseases is complex and controversial, with different viewpoints describing its role.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daria Trifonova, Mirela Curin, Ksenja Riabova, Antonina Karsonova, Walter Keller, Hans Groenlund, Ulrika Kaeck, Jon R. Konradsen, Marianne van Hage, Alexander Karaulov, Rudolf Valenta, Kurt A. Jellinger
Summary: More than 10% of the world's population suffers from an IgE-mediated allergy to cats, which mainly manifests as respiratory symptoms. Several cat allergens have been identified, and Fel d 1, Fel d 4, and Fel d 7 show high allergenic activity in patients with respiratory allergies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Yang Li, Yi Yang, Yinghui Liu, Jinyuan Liu, Yunjia Yang, Jing Zhang, Yue Zou, Lin Shu, Nanyin Han, Bing Shao
Summary: A new method was developed for measuring and diagnosing total IgE in serum for food allergies. This method uses magnetic beads and ultraperformance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) to extract and quantify IgE, and combines in vitro binding experiments to evaluate its binding capacity with different allergenic proteins, thus speculating the allergen causing allergic reactions.
ANALYTICA CHIMICA ACTA
(2022)
Article
Food Science & Technology
Kunal Pratap, Marwan E. Majzoub, Aya C. Taki, Socorro Miranda Hernandez, Marie Magnusson, Christopher R. K. Glasson, Rocky de Nys, Torsten Thomas, Andreas L. Lopata, Sandip D. Kamath
Summary: The intestinal microbial community is crucial for gut health, and dietary components like algal polysaccharides and carotenoids can modulate its structure. This study found that ulvan and astaxanthin can promote significant changes in the gut microbiota of mice, highlighting their potential to improve gut health conditions.
Article
Food Science & Technology
Roni Nugraha, Thimo Ruethers, Aya C. Taki, Elecia B. Johnston, Shaymaviswanathan Karnaneedi, Sandip D. Kamath, Andreas L. Lopata
Summary: This study investigates the IgE sensitisation profiles of patients with oyster allergy to raw and heated Pacific oyster extract. Tropomyosin is identified as the major allergen responsible for oyster allergy, and the study also reveals partial cross-reactivity and/or co-sensitisation between oyster, prawn, and dust mite allergens. This research emphasizes the importance of using recombinant tropomyosin in improved diagnostics and immunotherapy.
Letter
Allergy
Sara Anvari, Shea Brunner, Karen S. Tuano, Brenda Bin Su, Shaymaviswanathan Karnaneedi, Andreas L. Lopata, Carla M. Davis
Letter
Allergy
Sandip D. Kamath, Tiange Liu, Paul Giacomin, Alex Loukas, Severine Navarro, Andreas L. Lopata
Article
Chemistry, Applied
Stefan Kabasser, Kunal Pratap, Sandip Kamath, Aya C. Taki, Thanh Dang, Jennifer Koplin, Kirsten Perrett, Karin Hummel, Christian Radauer, Heimo Breiteneder, Andreas L. Lopata, Merima Bublin
Summary: Macadamia nut is a popular choice for a healthy diet, but it is also a potent allergen. Research has identified four IgE-binding proteins in sera from individuals allergic to macadamia nut, with three of them successfully purified and characterized. These newly discovered allergens have the potential to improve molecular diagnostics for macadamia nut allergy.
Article
Biochemistry & Molecular Biology
Minh N. Nguyen, Nora L. Krutz, Vachiranee Limviphuvadh, Andreas L. Lopata, G. Frank Gerberick, Sebastian Maurer-Stroh
Summary: AllerCatPro 2.0 is a web server for predicting the allergenic potential of proteins with better accuracy than other methods, and new features to help assessors make informed decisions. It predicts protein similarity using amino acid sequences and predicted 3D structures.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Allergy
Thimo Ruethers, Roni Nugraha, Aya C. Taki, Andrea O'Malley, Shaymaviswanathan Karnaneedi, Stephanie Zhang, A. Brenda Kapingidza, Sam Mehr, Sandip D. Kamath, Maksymilian Chruszcz, Graham Mackay, Dianne E. Campbell, Andreas L. Lopata
Summary: This study reveals the clinical relevance of IgE-binding proteins in crocodile meat for fish-allergic patients. The major fish allergen parvalbumin (PV) was found to trigger allergic reactions in fish-allergic patients when present in heated crocodile meat. Crocodile beta-PV was identified as the major IgE-binding protein, but less abundant than alpha-PV. It is recommended that fish-allergic individuals seek specialist advice before consuming crocodile meat.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Caroline Lourdes Candebat, Frances Stephens, Mark A. Booth, Fernando Fernando, Andreas Lopata, Igor Pirozzi
Summary: The sulphur amino acids methionine, cysteine and taurine are important for growth and health. This study investigated their effects on yellowtail kingfish and found that adequate intake of these nutrients improved liver and intestinal function. The findings could contribute to the development of optimal aquafeed and maintenance of good health in yellowtail kingfish.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Biochemical Research Methods
Utpal Bose, James A. Broadbent, Angela Juhasz, Shaymaviswanathan Karnaneedi, Elecia B. Johnston, Sally Stockwell, Keren Byrne, Vachiranee Limviphuvadh, Sebastian Maurer-Stroh, Andreas L. Lopata, Michelle L. Colgrave
Summary: We explored the influence of protein extraction buffer selection and processing method on protein yield and allergen detection in processed and unprocessed black soldier fly (BSF) samples. We detected a total of 33 putative allergens by comparing the detected BSF proteins with sequences from public allergen protein databases. A targeted LC-MRM-MS assay was developed for tropomyosin, highlighting the importance of buffer selection and processing conditions in reducing allergenicity of BSF samples.
JOURNAL OF PROTEOMICS
(2022)
Review
Allergy
Matteo Pontone, Mattia Giovannini, Simona Barni, Francesca Mori, Elisabetta Venturini, Luisa Galli, Claudia Valleriani, Leticia De las Vecillas, Cansin Sackesen, Andreas Ludwig Lopata, Betul Buyuktiryaki
Summary: Anisakids are nematodes that cause different clinical patterns in humans. Anisakis species, such as Anisakis simplex, are well-known for infecting humans. Anisakiasis, the disease caused by Anisakis, is usually contracted by consuming raw or undercooked seafood containing Anisakis larvae. This study aims to summarize the current knowledge about Anisakis and Anisakiasis, including epidemiology, pathophysiology, clinical presentation, diagnosis, and treatment. Special attention is given to Anisakis allergens and their cross-reactivity in diagnostic methods, specifically focusing on pediatric patients due to the limited available data in the literature.
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2023)
Review
Allergy
Sandip D. Kamath, Merima Bublin, Katsumasa Kitamura, Teruaki Matsui, Komei Ito, Andreas L. Lopata
Summary: Allergenic cross-reactivity among food allergens is a complication in the diagnosis and management of food allergy. Some food groups have high rates of cross-reactivity, while others have low or variable rates. Cross-reactive carbohydrate determinants and α-Gal in red meat can lead to severe reactions. Multiple sensitizations to tree nuts complicate the diagnosis and management of patients allergic to peanut and tree nut. This review discusses cross-reactive allergens and carbohydrate determinants in major food groups and their clinical relevance.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Nutrition & Dietetics
Mattia Giovannini, Burcin Beken, Betul Buyuktiryaki, Simona Barni, Giulia Liccioli, Lucrezia Sarti, Lorenzo Lodi, Matteo Pontone, Irene Bartha, Francesca Mori, Cansin Sackesen, George du Toit, Andreas L. Lopata, Antonella Muraro
Summary: Shellfish, a key component of a healthy diet, can also cause allergic reactions. These reactions can be immunological or non-immunological in nature. Immunological reactions involve IgE-mediated allergic reactions, while non-immunological reactions include toxic reactions and food intolerance. Understanding the molecular features of shellfish allergens can improve diagnosis and immunotherapy for shellfish allergy.
Editorial Material
Food Science & Technology
Nanju Alice Lee, Andreas Ludwig Lopata, Michelle Lisa Colgrave
Letter
Allergy
Supapich Chanasit, Elecia Johnston, Chanatip Thanasarnthungcharoen, Sandip D. Kamath, Barbara Bohle, Andreas L. Lopata, Alain Jacquet
Meeting Abstract
Allergy
Thimo Ruethers, Shuai Nie, Sheik Moniruzzaman, Elecia B. Johnston, Shaymaviswanathan Karnaneedi, Roni Nugraha, Nicholas A. Williamson, Carla M. Davis, Sandip D. Kamath, Sam S. Mehr, Dianne E. Campbell, Andreas L. Lopata
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)