Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid–Mediated Troglitazone Hepatotoxicity

Linking physiology to toxicity using DILIsym®, a mechanistic mathematical model of drug-induced liver injury

(2013) Lisl K. M. Shoda et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver

(2013) X Chu et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Imaging in the Study of Membrane Transporters

(2013) H Kusuhara   CLINICAL PHARMACOLOGY & THERAPEUTICS

An updated review on drug-induced cholestasis: Mechanisms and investigation of physicochemical properties and pharmacokinetic parameters

(2013) Kyunghee Yang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A Multifactorial Approach to Hepatobiliary Transporter Assessment Enables Improved Therapeutic Compound Development

(2013) Ryan E. Morgan et al.   TOXICOLOGICAL SCIENCES

Early Identification of Clinically Relevant Drug Interactions With the Human Bile Salt Export Pump (BSEP/ABCB11)

(2013) Jenny M. Pedersen et al.   TOXICOLOGICAL SCIENCES

Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method

(2012) Juan C. García-Cañaveras et al.   JOURNAL OF LIPID RESEARCH

In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI

(2012) Brett A. Howell et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Genetic basis of susceptibility to drug-induced liver injury: what have we learned and where do we go from here?

(2012) Thomas J Urban et al.   PHARMACOGENOMICS

Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes

(2012) Tracy L. Marion et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Profile of Serum Bile Acids in Noncholestatic Volunteers: Gender-Related Differences in Response to Fenofibrate

(2011) J Trottier et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Bile salts and cholestasis

(2010) Lucas Maillette de Buy Wenniger et al.   DIGESTIVE AND LIVER DISEASE

An In Vitro Assay to Assess Transporter-Based Cholestatic Hepatotoxicity Using Sandwich-Cultured Rat Hepatocytes

(2009) J. H. Ansede et al.   DRUG METABOLISM AND DISPOSITION

Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs

(2009) Ichiro Ieiri et al.   Expert Opinion on Drug Metabolism & Toxicology

Bile-acid-induced cell injury and protection

(2009) Maria J Perez et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump

(2008) Yvonne Meier et al.   WORLD JOURNAL OF GASTROENTEROLOGY