Article
Nanoscience & Nanotechnology
Yuzhu Wang, Lu Jia, Tingting Hu, Zhuoran Yang, Chunyu Yang, Huiming Lin, Feng Zhang, Kai Yu, Fengyu Qu, Wei Guo
Summary: Although phototherapy has been extensively studied in recent years, its efficacy in treating tumors is often unsatisfactory due to the complex and variable tumor microenvironment. In this study, we report the discovery of novel hollow carriers named CoSn(OH)6@CoOOH with oxidase properties, which can enhance the effectiveness of phototherapy. These carriers react with oxygen to generate singlet oxygen and consume glutathione, and their hollow structure allows for the delivery of drug molecules. Loading indocyanine green and AIPH onto the carriers resulted in enhanced phototherapy effects through oxidase-catalyzed reactions, generation of alkyl radicals, and glutathione consumption. Cell and mouse experiments demonstrated that these carriers, combined with near-infrared laser irradiation, significantly inhibited tumor growth. Enrichment analysis revealed the involvement of the PI3K-Akt and MAPK signaling pathways in this therapeutic system. Hollow carriers with oxidase activity like these have great potential for the design of multifunctional drug delivery vehicles for tumor therapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Letter
Oncology
Dawei Wu, Lingfeng Hu, Xin Wang, Yue Yu, Shuo-Peng Jia, Hui-Yao Huang, Zi-Wei Li, Jin-Feng Ma, Hai-Bo Zhu, Yu Tang, Ning Li
Summary: Based on a retrospective analysis of the Trialtrove database, it was found that the clinical development of mRNA therapies against solid tumors is still in its early stages. The delivery systems have evolved from dendritic cells to lipid-based platforms, and the encoding strategies have shifted from fixed tumor antigens to personalized neoantigens. Adjuvant or maintenance therapy, as well as combination treatment with checkpoint inhibitors, are the major clinical development orientations.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Nicolas Cuburu, Lukasz Bialkowski, Sergio M. Pontejo, Shiv K. Sethi, Alexander T. F. Bell, Rina Kim, Cynthia D. Thompson, Douglas R. Lowy, John T. Schiller
Summary: Tumor infiltration by T cells plays a significant role in cancer progression and immunotherapy. This study explores the use of intratumoral injection of virus-derived peptide epitopes to activate preexisting antiviral T cell responses and promote antitumor responses or antigen spreading. The results show that this approach can act as a standalone therapy to control tumor growth and induce long-term antitumor immunity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, Research & Experimental
Yizhao Chen, Zhiying Yu, Xuewen Tan, Haifeng Jiang, Zhen Xu, Yilong Fang, Dafei Han, Wenming Hong, Wei Wei, Jiajie Tu
Summary: CAR-M therapy shows potential in targeting solid tumors, but there are limitations that need further research to enhance its therapeutic efficacy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Xianjun Li, Tianchuan Zhu, Ronghao Wang, Jian Chen, Lantian Tang, Wenwen Huo, Xi Huang, Qingdong Cao
Summary: This study developed genetically programmable cellular vesicles loaded with glutamine antagonists to metabolically dismantle the immunosuppressive tumor microenvironment and enhance the efficiency of anti-mesothelin CAR-T cells in orthotopic lung cancer. The vesicles specifically targeted tumor cells and prevented the premature exhaustion of CAR-T cells by addressing the upregulation of PD-L1. Additionally, the vesicles reduced immunosuppressive cells, promoted the recruitment of inflammatory cells, and improved the infiltration and effector functions of CAR-T cells, ultimately enhancing their anti-tumor ability and long-term memory immunity.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jia-Xin An, Zi-Yi Han, You-Teng Qin, Chu-Xin Li, Jin-Lian He, Xian-Zheng Zhang
Summary: This study reports a strategy of attaching bacteria to macrophages, which sustainably stimulates the polarization of macrophages and reduces tumor progression in an immunosuppressive tumor microenvironment without any side effects. This research opens a new avenue for the development of cell therapies.
ADVANCED MATERIALS
(2023)
Article
Humanities, Multidisciplinary
Emma Dahlin
Summary: Research on artificial intelligence often focuses on separating technical and social issues, but it is important to bridge the gap between these analyses to ensure feasible and sustainable AI systems that benefit society. By exploring the connections between technical design and social implications, researchers can work towards prosperous collaborations and innovative solutions for the future of AI.
HUMANITIES & SOCIAL SCIENCES COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Ruxing Fu, Hongjun Li, Ruoxin Li, Kyle McGrath, Gianpietro Dotti, Zhen Gu
Summary: CAR T cells show promise in cancer immunotherapy, but have limited clinical success in solid tumors, leading to exploration of strategies to enhance their efficacy. Altering the tumor microenvironment is crucial, with a focus on future development directions.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Immunology
Cooper J. Sailer, Yeonsun Hong, Ankit Dahal, Allison T. Ryan, Sana Mir, Scott A. Gerber, Patrick M. Reagan, Minsoo Kim
Summary: Chimeric antigen receptor (CAR)-T cell therapy shows promise in treating hematologic cancers, but its success in solid tumors is limited due to CAR-T cell exhaustion and poor persistence. This study finds that PD-1(high) CAR-T cells perform better in multiple T cell functions compared to PD-1(low) CAR-T cells. However, adoptive transfer of PD-1(high) CAR-T cells alone is insufficient to control tumor growth, and a combination therapy with PD-1 blockade is needed for solid tumors.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jie Zhao, Yuguang Yang, Xia Xu, Hongyan Li, Jinbo Fei, Yilin Liu, Xiaoming Zhang, Junbai Li
Summary: This study introduces super light-sensitive PS nanoparticles to enhance the therapeutic effects of photodynamic therapy (PDT) in solid tumor treatment. These nanoparticles can produce a large amount of singlet oxygen under low power density light, and efficiently accumulate in tumors, exhibiting excellent antitumor efficacy when irradiated by suitable light wavelength.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Green & Sustainable Science & Technology
Swapnil Tawde, Renuka Kamath, R. V. ShabbirHusain
Summary: Why do green consumers' purchase intentions often not convert into actual green buying actions? Limited research focuses on bridging this intention-behavior gap using consumers' intrapsychic traits. This study analyzes whether implementation intentions and self-efficacy types can motivate green consumers to initiate their green actions. The findings provide practical implications for encouraging green purchases.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Cell Biology
Yue Liu, Guangna Liu, Jiasheng Wang, Zhe-Yu Zheng, Lemei Jia, Wei Rui, Daosheng Huang, Zhi-Xiao Zhou, Liqun Zhou, Xin Wu, Song Lin, Xueqiang Zhao, Xin Lin
Summary: A new double-chain chimeric receptor STAR was constructed to mediate strong and sensitive TCR-like signaling upon antigen stimulation, showing better antigen sensitivity and less risk of dysfunction compared to traditional CAR-T cells. In multiple solid tumor models, STAR-T cells outperformed BBzCAR-T cells and showed superior antitumor effects.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Engineering, Biomedical
Chunhui Wu, Yingxue Zhang, Xiaodan Wei, Ningxi Li, Honglin Huang, Zhengxin Xie, Hanxi Zhang, Geng Yang, Mengyue Li, Tingting Li, Hong Yang, Shun Li, Xiang Qin, Yiyao Liu
Summary: This study presents a novel 2D phototheranostics GMtC against hypoxic solid tumors, integrating tumor homing-penetrating and in situ oxygen-generating functions, showing outstanding performance in tumor deep penetration to hypoxia center and generating abundant oxygen in response to tumor microenvironment, thus exerting the highest efficiency of PDT against 4T1 mammary tumor.
ACTA BIOMATERIALIA
(2022)
Article
Microbiology
Ana Montalban-Arques, Egle Katkeviciute, Philipp Busenhart, Anna Bircher, Jakob Wirbel, Georg Zeller, Yasser Morsy, Lubor Borsig, Jesus F. Glaus Garzon, Anne Mueller, Isabelle C. Arnold, Mariela Artola-Boran, Michael Krauthammer, Anna Sintsova, Nicola Zamboni, Gabriel E. Leventhal, Laura Berchtold, Tomas de Wouters, Gerhard Rogler, Katharina Baebler, Marlene Schwarzfischer, Larissa Hering, Ivan Olivares-Rivas, Kirstin Atrott, Claudia Gottier, Silvia Lang, Onur Boyman, Ralph Fritsch, Markus G. Manz, Marianne R. Spalinger, Michael Scharl
Summary: Despite the overall success of T cell checkpoint inhibitors in cancer treatment, research has found that certain commensal species of gut microbiota associated with lower tumor burden and are significantly reduced in CRC patients. Oral application of specific Clostridiales strains can prevent and even treat CRC successfully in mouse models, outperforming anti-PD-1 therapy in some cases. This indicates the potential of gut bacteria as a novel stand-alone therapy against solid tumors.
CELL HOST & MICROBE
(2021)
Article
Chemistry, Multidisciplinary
Lingxiao Zhang, Jing Zhao, Xi Hu, Chenhan Wang, Yingbo Jia, Chaojie Zhu, Shangzhi Xie, Jiyoung Lee, Fangyuan Li, Daishun Ling
Summary: This study reports a Zn2+-doped layered double hydroxide (Zn-LDH) immunomodulating adjuvant, which can neutralize the acidic tumor microenvironment and promote an immune response. The Zn-LDH induces immunogenic cell death and enhances the release of antigens to stimulate cytotoxic T lymphocytes. The experiments demonstrate that the Zn-LDH adjuvant alone can significantly inhibit the growth, recurrence, and metastasis of solid tumors.
ADVANCED MATERIALS
(2022)