Chimeric STAR receptors using TCR machinery mediate robust responses against solid tumors

Structural understanding of T cell receptor triggering

(2020) Xinyi Xu et al.   Cellular & Molecular Immunology

4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling

(2020) Benjamin I. Philipson et al.   Science Signaling

Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response

(2019) Patrick A. Baeuerle et al.   Nature Communications

Cell Biology of T Cell Receptor Expression and Regulation

(2018) Andrés Alcover et al.   Annual Review of Immunology

IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor

(2018) Keishi Adachi et al.   NATURE BIOTECHNOLOGY

A novel chimeric antigen receptor containing a JAK–STAT signaling domain mediates superior antitumor effects

(2018) Yuki Kagoya et al.   NATURE MEDICINE

Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

(2018) A. J. Davenport et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes

(2018) Jonathan T. Sockolosky et al.   SCIENCE

Tuning ITAM multiplicity on T cell receptors can control potency and selectivity to ligand density

(2018) John R. James   Science Signaling

Tuning ITAM multiplicity on T cell receptors can control potency and selectivity to ligand density

(2018) John R. James   Science Signaling

CART cells are prone to Fas- and DR5-mediated cell death

(2018) Benjamin O. Tschumi et al.   Journal for ImmunoTherapy of Cancer

Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo

(2018) Sarwish Rafiq et al.   NATURE BIOTECHNOLOGY

The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity

(2018) Christopher W. Helsen et al.   Nature Communications

Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

(2018) Judith Feucht et al.   NATURE MEDICINE

A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta-TCR signaling to facilitate T-cell cytotoxicity with low cytokine release

(2018) Yiyang Xu et al.   Cell Discovery

Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains

(2017) Daniel T. Harris et al.   JOURNAL OF IMMUNOLOGY

CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy

(2017) Terry J Fry et al.   NATURE MEDICINE

Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent

(2017) Diogo Gomes-Silva et al.   Cell Reports

Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition

(2016) Leonid Cherkassky et al.   JOURNAL OF CLINICAL INVESTIGATION

Prospects for gene-engineered T cell immunotherapy for solid cancers

(2016) Christopher A Klebanoff et al.   NATURE MEDICINE

What Scales the T Cell Response?

(2016) Viveka Mayya et al.   TRENDS IN IMMUNOLOGY

Adoptive T Cell Therapies: A Comparison of T Cell Receptors and Chimeric Antigen Receptors

(2016) Daniel T. Harris et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity

(2015) H. G. Caruso et al.   CANCER RESEARCH

Eradication of Large Solid Tumors by Gene Therapy with a T-Cell Receptor Targeting a Single Cancer-Specific Point Mutation

(2015) M. Leisegang et al.   CLINICAL CANCER RESEARCH

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

(2015) Adrienne H Long et al.   NATURE MEDICINE

Rational development and characterization of humanized anti–EGFR variant III chimeric antigen receptor T cells for glioblastoma

(2015) Laura A. Johnson et al.   Science Translational Medicine

Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

(2015) David L. Porter et al.   Science Translational Medicine

A Pilot Trial Using Lymphocytes Genetically Engineered with an NY-ESO-1-Reactive T-cell Receptor: Long-term Follow-up and Correlates with Response

(2014) P. F. Robbins et al.   CLINICAL CANCER RESEARCH

Molecular architecture of the αβ T cell receptor–CD3 complex

(2014) Michael E. Birnbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nonsignaling Extracellular Spacer Domain of Chimeric Antigen Receptors Is Decisive for In Vivo Antitumor Activity

(2014) M. Hudecek et al.   Cancer Immunology Research

First-in-Man Phase I Study of GC33, a Novel Recombinant Humanized Antibody Against Glypican-3, in Patients with Advanced Hepatocellular Carcinoma

(2013) A. X. Zhu et al.   CLINICAL CANCER RESEARCH

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells

(2013) Clifford S Guy et al.   NATURE IMMUNOLOGY

CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia

(2013) R. J. Brentjens et al.   Science Translational Medicine

Incorporation of Transmembrane Hydrophobic Mutations in the TCR Enhance Its Surface Expression and T Cell Functional Avidity

(2012) A. Haga-Friedman et al.   JOURNAL OF IMMUNOLOGY

CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients

(2011) Barbara Savoldo et al.   JOURNAL OF CLINICAL INVESTIGATION

Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells

(2010) J. N. Kochenderfer et al.   BLOOD

T cell receptor gene therapy: strategies for optimizing transgenic TCR pairing

(2010) Coen Govers et al.   TRENDS IN MOLECULAR MEDICINE

ITAM-mediated Signaling by the T-Cell Antigen Receptor

(2010) P. E. Love et al.   Cold Spring Harbor Perspectives in Biology

Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition

(2008) S Yang et al.   GENE THERAPY