Article
Immunology
David E. Soper, Harold C. Wiesenfeld
Summary: Many women with lower genital tract infections associated with sexually transmitted pathogens may have evidence of upper genital tract inflammation, despite the absence of traditional symptoms and signs of PID. New biomarkers are needed to identify these women with clinically mild or subclinical PID, in order to initiate early treatment and alleviate the sequelae associated with upper genital tract infection and inflammation.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Immunology
Sharon L. Hillier, Kyle T. Bernstein, Sevgi Aral
Summary: PID is a global syndrome that causes significant morbidity in women. While gonococcal and chlamydial infections are commonly associated with PID, other pathogens such as Mycoplasma genitalium and respiratory pathogens also play a role. Developing noninvasive diagnostic tests and vaccines may help improve diagnosis and prevention of PID.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Obstetrics & Gynecology
Paul Pirtea, Ettore Cicinelli, Rosalba De Nola, Dominique de Ziegler, Jean Marc Ayoubi
Summary: Chronic inflammatory processes affecting the endometrium can impact endometrial receptivity, leading to early pregnancy losses and recurrent pregnancy losses. Conditions like endometriosis may increase the risk of miscarriages, but assisted reproductive technology can mitigate these risks.
FERTILITY AND STERILITY
(2021)
Review
Biochemistry & Molecular Biology
Julia Zalecka, Katarzyna Pankiewicz, Tadeusz Issat, Piotr Laudanski
Summary: Endometriosis is a common inflammatory disease that can cause chronic pelvic pain and infertility. One of its most serious complications is ectopic pregnancy, and the exact mechanism behind it is still unknown.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Anna C. Loeffelmann, Alena Hoerscher, Muhammad A. Riaz, Felix Zeppernick, Ivo Meinhold-Heerlein, Lutz Konrad
Summary: In endometriosis, the localization of claudin-10 is impaired, but the epithelial phenotype remains preserved. Claudin-10 is highly expressed in endometriosis and adenomyosis, but there are differences in its localization between the two conditions.
Article
Obstetrics & Gynecology
Xinyu Qiao, Lukanxuan Wu, Dong Liu, Tianjiao Pei, Wei Huang
Summary: This study evaluated the prevalence of chronic endometritis (CE) in women with minimal/mild endometriosis and found that it negatively affects pregnancy outcomes.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Biotechnology & Applied Microbiology
Shasha Zhu, Jiqian Zhang, Nairui Xue, Xiaoling Zhu, Fenfen Li, Qingqing Dai, Xin Qing, Dawei Chen, Xuesheng Liu, Zhaolian Wei, Yunxia Cao
Summary: This study identified two features of endometriosis and developed a glucose oxidase-loaded bovine serum albumin nanoparticle (BSA-GOx-NPs) that specifically targets ectopic lesions, depleting glucose and inducing apoptosis in the lesions. The BSA-GOx-NPs showed excellent anti-endometriosis effects in both acute and chronic inflammatory phases.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Medicine, General & Internal
Si-fan Yin, Jia-gui Chai, Run-lin Feng, Zhi-yuan Yin, Shen-zhao Zhao, Tao Zhang, Chang-xing Ke
Summary: This article reports a rare case of a rudimentary uterine horn with ovarian endometriosis and congenital renal agenesis, which can easily be misdiagnosed due to the lack of typical clinical manifestations. The patient underwent laparoscopic surgery for removal and no right adnexal or uterine abnormalities were detected during follow-up.
FRONTIERS IN MEDICINE
(2023)
Article
Immunology
Omero Benedicto Poli-Neto, Daniela Carlos, Aureo Favaretto Junior, Julio Cesar Rosa-e-Silva, Juliana Meola, Daniel Tiezzi
Summary: This study aimed to identify key similarities between eutopic endometrium of women with endometriosis and chlamydia-induced endometritis, considering tissue microenvironment heterogeneity, gene expression profiles, and enrichment pathways. Both conditions showed similar distributions of cell types in the microenvironment, downregulation of DNA repair genes, and immune response pathway evasion, with some chlamydial endometritis samples lacking enriched immune pathways.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Immunology
Stacey X. Xu, Scott D. Gray-Owen
Summary: This review examines the contribution of N. gonorrhoeae to pelvic inflammatory disease compared to other potential causes, taking into account new insights gained through molecular, immunological, and microbiome-based analyses, as well as the current epidemiological burden of infection, to highlight key areas for future study.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Barbara Andrea Mc Cormack, Carla Noemi Olivares, Daniela Madanes, Analia Gabriela Ricci, Mariela Andrea Bilotas, Rosa Ines Baranao
Summary: The study found that urolithins A and B have a beneficial effect on the growth of endometriotic-like lesions in a mouse model of endometriosis, without affecting the body weight or estrous cycle of the mice.
Article
Emergency Medicine
Marie J. Murphy, Aleksandr Gleyzer
Summary: Bilateral ectopic pregnancies are rare but may pose a risk in patients with endometriosis. Emergency physicians should be aware of this possibility, especially in pregnant patients presenting with abdominal pain or vaginal bleeding.
JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
S. Diaz-Lundahl, B. Heringstad, R. T. Garmo, P. Gillund, A. K. Krogenaes
Summary: Subclinical endometritis (SCE) is highly prevalent in dairy cows and has negative effects on reproductive outcomes and the producer economy. This study estimates the heritability of SCE in the Norwegian Red (NR) population and discusses its potential as a fertility phenotype for breeding purposes.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Obstetrics & Gynecology
Renata Voltolini Velho, Nicolette Halben, Radoslav Chekerov, Jacqueline Keye, Johanna Plendl, Jalid Sehouli, Sylvia Mechsner
Summary: The study found that in women with endometriosis, the functional activity of immune cells decreased, the cytokine profile shifted, and increased levels of certain cytokines were related to disease severity.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Review
Obstetrics & Gynecology
Kotaro Kitaya, Takako Mihara, Masaya Mihara
Summary: This study summarizes recent progress in immunological, infectious, and inflammatory aspects of endometriosis, and highlights chronic endometritis (CE) as an immunological, infectious, and inflammatory disorder characterized by unusual stromal plasmacyte infiltration. It aims to better understand the relationship between endometriosis and CE, and finds that CE may be associated with infertility, repeated implantation failure, recurrent pregnancy loss, and perinatal/neonatal complications. Further studies are needed to explore the potential relationships between these two diseases.
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
(2023)