Article
Immunology
Aina Morimune, Fuminori Kimura, Akiko Nakamura, Jun Kitazawa, Akiko Takashima, Tsukuru Amano, Shoji Kaku, Suzuko Moritani, Ryoji Kushima, Takashi Murakami
Summary: The study found that in cases of CE, the rate of miscarriage during pregnancy increased, while the rate of term birth significantly decreased. CE had an impact on variables such as miscarriage, term birth, and live birth.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Paul Pirtea, Ettore Cicinelli, Rosalba De Nola, Dominique de Ziegler, Jean Marc Ayoubi
Summary: Chronic inflammatory processes affecting the endometrium can impact endometrial receptivity, leading to early pregnancy losses and recurrent pregnancy losses. Conditions like endometriosis may increase the risk of miscarriages, but assisted reproductive technology can mitigate these risks.
FERTILITY AND STERILITY
(2021)
Review
Biochemistry & Molecular Biology
Angela Santoro, Antonio Travaglino, Frediano Inzani, Giuseppe Angelico, Antonio Raffone, Giuseppe Maria Maruotti, Patrizia Straccia, Damiano Arciuolo, Federica Castri, Nicoletta D'Alessandris, Giulia Scaglione, Michele Valente, Federica Cianfrini, Valeria Masciullo, Gian Franco Zannoni
Summary: Chronic endometritis (CE) is associated with infertility and reproductive failures. The lack of standardized methods to assess plasma cells makes the diagnosis challenging. This study suggests that a threshold of ≥5 plasma cells/10 HPF may be more appropriate for diagnosing CE, as plasma cells at lower levels (<5/10 HPF) may not predict worsened pregnancy outcomes.
Article
Obstetrics & Gynecology
Leslie Farland, Judy E. Stern, Chia-ling Liu, Howard J. Cabral, Charles C. Coddington, Hafsatou Diop, Dmitry Dukhovny, Sunah Hwang, Stacey A. Missmer
Summary: Women with a history of endometriosis or fibroids have a higher risk of pregnancy complications and preterm birth. This risk is increased when they have a history of infertility or utilize assisted reproductive technology.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Yujing Xiong, Qi Chen, Chunxiao Chen, Jinfeng Tan, Zengyan Wang, Fang Gu, Yanwen Xu
Summary: This study aimed to investigate the therapeutic effect of antibiotic treatment on pregnancy outcomes in infertile women undergoing frozen-thawed embryo transfer cycles. The results showed that CD138+/HPF <4 in the endometrium did not have a negative impact on pregnancy outcomes, while antibiotic treatment was effective in improving reproductive outcomes for women with CD138+/HPF >5. Persistent chronic endometritis was associated with poorer pregnancy outcomes.
FERTILITY AND STERILITY
(2021)
Article
Genetics & Heredity
N. S. Herlihy, A. M. Klimczak, S. Titus, C. Scott, B. M. Hanson, J. K. Kim, E. Seli, R. T. Scott
Summary: This study found that endometrial plasma cells are present in half of the general infertile population, but do not predict implantation, clinical pregnancy, clinical pregnancy loss, or live birth rates at low levels.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Public, Environmental & Occupational Health
Juan Gu, Qingqing Sun, Yujuan Qi, Fangfang Hu, Yijuan Cao
Summary: The study aimed to investigate the effect of chronic endometritis (CE) on the clinical outcome of patients with unexplained infertility. Hysteroscopy and immunohistochemical tests were performed on 145 patients with unexplained infertility and 42 patients with definite infertility causes. The incidence of CE and the clinical pregnancy outcomes were compared between different groups.
Article
Obstetrics & Gynecology
Paolo Vercellini, Paola Vigano, Veronica Bandini, Laura Buggio, Nicola Berlanda, Edgardo Somigliana
Summary: This review synthesized systematic reviews and meta-analyses published in the last 5 years to explore the association between endometriosis and adenomyosis with reproductive and obstetric outcomes. The findings suggest that women with endometriosis and adenomyosis have reduced pregnancy and live birth rates, increased miscarriage rates, and higher risks of various adverse obstetric outcomes. Women with deep infiltrating endometriosis and severe adenomyosis should be considered at high obstetric risk and referred to tertiary care centers for safe management during pregnancy and delivery. It is uncertain whether the same applies to pregnant women with minimal endometriosis and adenomyosis forms. Emerging evidence suggests that some adverse outcomes observed in women with endometriosis are associated with coexisting adenomyosis.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Dana B. McQueen, Kruti P. Maniar, Anne Hutchinson, Rafael Confino, Lia Bernardi, Mary Ellen Pavone
Summary: The study aimed to develop diagnostic criteria for chronic endometritis and compare its prevalence between women with recurrent pregnancy loss (RPL) and controls. Results showed that with strict diagnostic criteria, the prevalence of chronic endometritis was significantly higher in women with RPL, indicating an association between chronic endometritis and RPL.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Sophie Hezer, Geraldine Chauvin, Clement Klein, Valerie Bernard, Jean-Luc Brun, Marie-Veronique Launay-Savary, Claude Hocke
Summary: This study aimed to assess the pregnancy rate after surgery for colorectal endometriosis. The results showed a high postoperative pregnancy rate for patients with colorectal endometriosis, and further studies with a high level of evidence are needed to determine good candidates for this type of surgery.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Wen-juan Liu, Ju Huang, Li Sun, Li Huang, Qian-yu Zhang, Ying-qi Nong, Jia-hui Wei, Kun-he Wu, Feng-hua Liu
Summary: This study aimed to investigate the effect of chronic endometritis on infertile patients, comparing pregnancy outcomes between groups positive and negative for chronic endometritis. The results showed that doxycycline treatment and re-examination had no effect on pregnancy outcomes.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Pharmacology & Pharmacy
C. C. Vaduva, C. Constantinescu, M. Serbanescu, L. Dara, M. D. Oancea, A. Carp-Veliscu
Summary: This study found a frequent association between endometrial polyps and chronic endometritis, and the presence of endometrial polyps negatively affected the outcomes of in vitro fertilization. Treatment of these pathologies improved the outcomes of in vitro fertilization.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Jingjing Liu, Zheng Ai Liu, Yichun Liu, Lei Cheng, Lei Yan
Summary: Antibiotic treatment for chronic endometritis (CE) does not significantly affect reproductive outcomes, but it can reduce the miscarriage rate. Cured CE is associated with higher on-going pregnancy rate/live birth rate and clinical pregnancy rate compared to non-CE women. Women with cured CE have significantly higher on-going pregnancy rate/live birth rate and clinical pregnancy rate compared to those with persistent CE.
FRONTIERS IN MEDICINE
(2022)
Article
Obstetrics & Gynecology
Emily Ryan, Alisha T. Tolani, Jiaqi Zhang, Giovanna I. Cruz, Ann K. Folkins, Ruth B. Lathi
Summary: This retrospective cohort study found that the menstrual cycle phase has an impact on the detection of plasma cells. Plasma cells are more likely to be found in the follicular phase compared with the luteal phase, and in the early follicular phase compared with the late follicular phase. The density of plasma cells is also higher in the follicular phase group. Further studies are needed to determine the optimal timing of biopsy for standardized diagnosis.
FERTILITY AND STERILITY
(2022)
Article
Genetics & Heredity
Elena HogenEsch, Ronus Hojjati, Allison Komorowski, Kruti Maniar, Mary Ellen Pavone, Jennifer Bakkensen, Lia Bernardi
Summary: This study aims to determine the prevalence of chronic endometritis (CE), compare the efficacy of antibiotic regimens for CE, and examine pregnancy outcomes after treatment for CE among patients in an academic fertility clinic. Data from patients who underwent endometrial sampling for CE evaluation at a single academic institution from 2014 to 2020 were collected and analyzed. The prevalence of CE varied by indication, and clearance of CE through antibiotic treatment was associated with higher live birth rates.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Endocrinology & Metabolism
Chang Liu, Guimei Feng, Wei Huang, Qiuyi Wang, Shiyuan Yang, Jing Tan, Jing Fu, Dong Liu
GYNECOLOGICAL ENDOCRINOLOGY
(2017)
Article
Obstetrics & Gynecology
Xianghui Zhang, Dong Liu, Wei Huang, Qiushi Wang, Xue Feng, Jing Tan
REPRODUCTIVE BIOMEDICINE ONLINE
(2018)
Article
Obstetrics & Gynecology
Licong Shen, Aixiang Tan, Huili Zhu, Chun Guo, Dong Liu, Wei Huang
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2012)
Article
Integrative & Complementary Medicine
Shaomi Zhu, Dong Liu, Wei Huang, Qiushi Wang, Qiuyi Wang, Lu Zhou, Guimei Feng
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2014)
Article
Obstetrics & Gynecology
Huili Zhu, Haike Lei, Wei Huang, Jing Fu, Qiushi Wang, Licong Shen, Qiuyi Wang, Jie Ruan, Dong Liu, Hao Song, Lina Hu
Article
Obstetrics & Gynecology
Tingting Liu, Qiuyi Wang, Wei Huang, Jing Tan, Dong Liu, Tianjiao Pei, Xueying Li, Guojun Zhou
REPRODUCTIVE BIOMEDICINE ONLINE
(2019)
Article
Obstetrics & Gynecology
Lu Zhou, Jing Fu, Dong Liu, Qiuyi Wang, Hengxi Chen, Shiyuan Yang, Wei Huang
Summary: For infertile women with minimal to mild endometriosis, ovulation induction with letrozole or clomiphene citrate after laparoscopy significantly increases ovulation rate, which are comparable between them; but does not demonstrate a significant advantage on improving pregnancy rate and live-birth rate when compared to laparoscopy alone. Further research may focus on prolonging cycles of ovulation induction or choosing alternative ovarian stimulation protocols, and more RCTs are needed to compare the efficacy of letrozole with CC in ovulation induction.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Oncology
Fengqi Wan, Fulin Ma, Jiaxin Wu, Xinyu Qiao, Minxue Chen, Wenjian Li, Liang Ma
Summary: This study demonstrated that Lycium barbarum polysaccharide (LBP) has significant hypoglycemic and renal protective effects, improving renal function, relieving kidney injury, and inhibiting inflammation in diabetic nephropathy.
ANALYTICAL CELLULAR PATHOLOGY
(2022)
Article
Endocrinology & Metabolism
Tianjiao Pei, Bin Luo, Wei Huang, Dong Liu, Yujing Li, Li Xiao, Xin Huang, Yunwei Ouyang, Huili Zhu
Summary: The Hippo-YAP signaling pathway and autophagy play important roles in the pathogenesis of endometriosis. This study found that increased YAP inhibits autophagy by upregulating the mTOR signal in eutopic endometrial stromal cells, and the YAP-autophagy signal is involved in the pathogenesis of endometriosis-associated infertility.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Xin Huang, Lukanxuan Wu, Tianjiao Pei, Dong Liu, Chang Liu, Bin Luo, Li Xiao, Yujing Li, Ruiying Wang, Yunwei Ouyang, Huili Zhu, Wei Huang
Summary: We systematically investigated the immune landscape of eutopic endometrial single cells in minimal/mild endometriosis and compared it with disease-free controls. Our study sheds light on the inflammatory microenvironment and impaired endometrial receptivity in patients with endometriosis-associated infertility. The findings provide insights into the immunopathogenesis of endometriosis-associated infertility.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Xin Huang, Qiuyi Wang, Tingting Liu, Tianjiao Pei, Dong Liu, Huili Zhu, Wei Huang
Article
Medicine, General & Internal
Xiao Li, Liu Dong, Song Yong, Huang Wei
CHINESE MEDICAL JOURNAL
(2014)