Article
Pharmacology & Pharmacy
Shane M. Fresnoza, Giorgi Batsikadze, Lynn Elena Mueller, Constanze Rost, Michael Chamoun, Walter Paulus, Min-Fang Kuo, Michael A. Nitsche
Summary: Dopamine plays a crucial role in neuroplasticity and has dosage-dependent effects on motor cortex plasticity. Different dosages of dopamine precursor such as L-DOPA can either impair, abolish, preserve, or reverse plasticity in healthy individuals. Similarly, selective D1-like and D2-like receptor activation has excitatory and inhibitory effects on plasticity. However, the effects of nonselective dopamine agonists like apomorphine on plasticity have not been extensively explored in humans.
Article
Clinical Neurology
Mohd Faizal Mohd Zulkifly, Ornela Merkohitaj, Juergen Brockmoeller, Walter Paulus
Summary: The study investigated the impact of caffeine on brain plasticity and found that it increased motor cortex excitability in caffeine-naive subjects, enhanced PAS 25 effects, and affected alertness and motor evoked potentials under light deprivation. Time of day had no effect on tACS-induced plasticity in caffeine consumers.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Akiyoshi Matsugi, Satoru Nishishita, Kyota Bando, Yutaka Kikuchi, Keigo Tsujimoto, Yuto Tanabe, Naoki Yoshida, Hiroaki Tanaka, Shinya Douchi, Takeru Honda, Masato Odagaki, Hideki Nakano, Yohei Okada, Nobuhiko Mori, Koichi Hosomi
Summary: This study aimed to investigate abnormalities in inhibitory cortical excitability and motor control during ballistic-targeting movements in individuals with degenerative cerebellar ataxia (DCA). The results indicated that individuals with DCA showed longer cortical silent period (cSP), suggesting excessive activity in the inhibitory cortical circuit. However, this increase in inhibitory activity did not contribute to the control of ballistic-targeting movements and did not correlate with the severity of ataxia. These findings contribute to our understanding of motor control abnormalities in people with DCA and provide potential evidence for further research in this area.
SCIENTIFIC REPORTS
(2023)
Review
Psychology, Biological
Alfredo Brancucci, Davide Rivolta, Michael A. Nitsche, Valerio Manippa
Summary: The present review summarizes all papers published on transcranial random noise stimulation (tRNS) up to the end of the year 2022. tRNS is a non-invasive neuromodulation technique introduced about 15 years ago, which is increasingly being used in neuroscience. It involves applying a weak, white noise-like current over the scalp using electrodes with a surface area of several square centimeters, for a duration of seconds to minutes. Despite its low spatial and temporal resolution, tRNS has well-defined effects on central motor excitability, primarily through its impact on neuronal membrane sodium channels. These effects can last longer than the duration of stimulation itself. While the cellular-level effects in the motor cortex are becoming clearer, further studies are still needed to understand the effects of tRNS on motor behavior and performance. Initial research results, however, are promising for both basic and applied research.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Neurosciences
Tingting Zhang, Bingqi Guo, Zhentao Zuo, Xiaojing Long, Shimin Hu, Siran Li, Xin Su, Yuping Wang, Chunyan Liu
Summary: This study aimed to evaluate the modulatory effects of transcranial focus ultrasound stimulation (tFUS) on human motor cortex excitability and explore the mechanism of neurotransmitter-related intracortical circuitry and plasticity. The results showed that tFUS can significantly increase M1 excitability, decrease intracortical inhibition, and change the concentration of GABA and Glx in the brain. These findings provide new insights into how tFUS can modulate cortical excitability and plasticity.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Chemistry, Analytical
Semen Kurkin, Susanna Gordleeva, Andrey Savosenkov, Nikita Grigorev, Nikita Smirnov, Vadim V. Grubov, Anna Udoratina, Vladimir Maksimenko, Victor Kazantsev, Alexander E. Hramov
Summary: This study investigates the effects of repetitive transcranial magnetic stimulation (rTMS) on brain activity and the latency of motor imagery (MI) response by stimulating the left dorsolateral prefrontal cortex (DLPFC) and measuring the functional connectivity with the right precuneus (PrecuneusR). Results show that stimulation of the left DLPFC increases theta-band power in PrecuneusR and speeds up MI responses in 50% of participants.
Article
Anatomy & Morphology
Brenton Hordacre, Mitchell R. Goldsworthy, Lynton Graetz, Michael C. Ridding
Summary: This research investigated the impact of baseline resting state functional connectivity on responses to continuous theta burst stimulation (cTBS). The results showed that a low beta frequency band model of connectivity played a crucial role in determining responses to spaced cTBS, suggesting that M1-frontocentral networks may have an important role in the effects of cTBS on corticospinal excitability.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Physiology
Brodie J. Hand, George M. Opie, Simranjit K. Sidhu, John G. Semmler
Summary: Previous research has shown that regular exercise increases plasticity in primary motor cortex (M1) and a single session of aerobic exercise can also increase M1 plasticity in untrained individuals. This study found that the effect of acute exercise on M1 plasticity is greater in endurance-trained cyclists compared to untrained individuals. Exercise history is an important factor in exercise-induced cortical plasticity.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Neurosciences
Ryoki Sasaki, Wei-Yeh Liao, George M. Opie, John G. Semmler
Summary: Repetitive paired-pulse transcranial magnetic stimulation can enhance the plasticity of the primary motor cortex. The orientation of the TMS coil and muscle activation can affect the activity of I-waves, but their influence on M1 plasticity with iTMS is still unclear.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Review
Neurosciences
Ahmet S. Asan, James R. McIntosh, Jason B. Carmel
Summary: The central nervous system integrates sensory and motor information to acquire skilled movements. The reciprocal interaction of the sensory and motor systems is crucial for learning and performing skilled movement. Injuries to various nodes of the sensorimotor network can impair movement execution and learning. Methods that stimulate the sensorimotor system and modulate neural networks have been developed to restore movement after CNS injury. Understanding the processes and anatomical interactions responsible for sensory-motor integration is essential for improving rehabilitation strategies targeting SMI in humans after injury.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Tomoya Gyoda, Ippei Nojima, Su-Chuan Lin, Satoko Koganemaru, Tatsuya Mima, Shigeo Tanabe, Ying-Zu Huang
Summary: This study aimed to investigate the effect of GABA activity strengthening through real-time neurofeedback training on subsequent motor learning. The results showed that the NFT intervention led to enhanced GABA activity and suppressed online learning but not offline learning.
Article
Biochemistry & Molecular Biology
Sonia Turrini, Naomi Bevacqua, Antonio Cataneo, Emilio Chiappini, Francesca Fiori, Simone Battaglia, Vincenzo Romei, Alessio Avenanti
Summary: Aging is associated with a decline in motor control and neural plasticity. The plasticity in premotor-motor circuits predicts hand motor abilities in young and elderly humans. Physiological indices of PMv-M1 plasticity could provide a neurophysiological marker of fine motor control across age-groups.
Article
Clinical Neurology
Alexander D. Tang, William Bennett, Aidan D. Bindoff, Samuel Bolland, Jessica Collins, Ross C. Langley, Michael Garry, Jeffery J. Summers, Mark R. Hinder, Jennifer Rodger, Alison J. Canty
Summary: The study examined the effects of subthreshold rTMS on structural synaptic plasticity in the mouse motor cortex of young and aged mice. The results showed that subthreshold rTMS can alter the rate of dendritic spine losses and gains, and effectively drive structural synaptic plasticity in both young adult and aged mice.
Article
Multidisciplinary Sciences
Hisato Nakazono, Katsuya Ogata, Akinori Takeda, Emi Yamada, Shinichiro Oka, Shozo Tobimatsu
Summary: The study demonstrated that by modulating the phase of tACS and rPPS, the cross-synaptic efficacy induced by rPPS could be enhanced, with a stable increase in single-pulse MEPs observed particularly in the peak condition of beta tACS.
SCIENTIFIC REPORTS
(2021)
Article
Biochemical Research Methods
Sebastian Shaner, Han Lu, Maximilian Lenz, Shreyash Garg, Andreas Vlachos, Maria Asplund
Summary: We developed a microfluidic platform for precise electrical stimulation on brain tissue slices, overcoming conventional concerns with electric dosage and electrochemical reactions by utilizing precise fluidic, electrochemical, and magnetic control.
Article
Clinical Neurology
Cecile Gallea, Traian Popa, Daniel Garcia-Lorenzo, Romain Valabregue, Andre-Pierre Legrand, Lea Marais, Bertrand Degos, Cecile Hubsch, Sara Fernandez-Vidal, Eric Bardinet, Emmanuel Roze, Stephane Lehericy, Marie Vidailhet, Sabine Meunier
Article
Clinical Neurology
Cecile Hubsch, Emmanuel Roze, Traian Popa, Margherita Russo, Ammu Balachandran, Salini Pradeep, Florian Mueller, Vanessa Brochard, Angelo Quartarone, Bertrand Degos, Marie Vidailhet, Asha Kishore, Sabine Meunier
Letter
Clinical Neurology
Sabine Meunier, Traian Popa, Cecile Hubsch, Emmanuel Roze, Asha Kishore
Letter
Clinical Neurology
Cecile Gallea, Traian Popa, Sabine Meunier, Emmanuel Roze
Article
Clinical Neurology
Charlotte Rosso, R. Valabregue, C. Arbizu, S. Ferrieux, P. Vargas, F. Humbert, Y. Attal, A. Messe, C. Zavanone, S. Meunier, L. Cohen, C. Delmaire, A. Thielscher, D. M. Herz, H. R. Siebner, Y. Samson, S. Lehericy
Article
Clinical Neurology
C. Rosso, V. Perlbarg, R. Valabregue, C. Arbizu, S. Ferrieux, B. Alshawan, P. Vargas, A. Leger, C. Zavanone, J. C. Corvol, S. Meunier, S. Lehericy, Y. Samson
Article
Neurosciences
Asha Kishore, Traian Popa, Ammu Balachandran, Shyambabu Chandran, Salini Pradeep, Febina Backer, Syam Krishnan, Sabine Meunier
Article
Clinical Neurology
Malgorzata Marjanska, Stephane Lehericy, Romain Valabregue, Traian Popa, Yulia Worbe, Margherita Russo, Edward J. Auerbach, David Grabli, Cecilia Bonnet, Cecile Gallea, Mathieu Coudert, Lydia Yahia-Cherif, Marie Vidailhet, Sabine Meunier
MOVEMENT DISORDERS
(2013)
Article
Clinical Neurology
Virginie Sattler, Maya Dickler, Martin Michaud, Sabine Meunier, Marion Simonetta-Moreau
MOVEMENT DISORDERS
(2014)
Review
Clinical Neurology
Stephane Lehericy, Marina A. J. Tijssen, Marie Vidailhet, Ryuji Kaji, Sabine Meunier
MOVEMENT DISORDERS
(2013)
Article
Geriatrics & Gerontology
Asha Kishore, Traian Popa, Praveen James, Lydia Yahia-Cherif, Febina Backer, Lijo Varughese Chacko, Preetha Govind, Salini Pradeep, Sabine Meunier
NEUROBIOLOGY OF AGING
(2014)
Article
Clinical Neurology
Traian Popa, Paolo Milani, Alienor Richard, Cecile Hubsch, Vanessa Brochard, Christine Tranchant, Anna Sadnicka, John Rothwell, Marie Vidailhet, Sabine Meunier, Emmanuel Roze
Review
Clinical Neurology
Asha Kishore, Sabine Meunier, Traian Popa
FRONTIERS IN NEUROLOGY
(2014)
Meeting Abstract
Clinical Neurology
A. Kishore, T. Popa, P. James, L. Yahia-Cherif, S. Pradeep, S. Krishnan, S. Meunier
MOVEMENT DISORDERS
(2015)
Meeting Abstract
Clinical Neurology
T. Popa, F. Backer, S. Meunier, S. Pradeep, A. Balachandran, A. Kishore
MOVEMENT DISORDERS
(2013)
Article
Clinical Neurology
Jaakko Vallinoja, Timo Nurmi, Julia Jaatela, Vincent Wens, Mathieu Bourguignon, Helena Maenpaa, Harri Piitulainen
Summary: The study aimed to assess the effects of lesions related to spastic diplegic cerebral palsy on functional connectivity. Using multiple imaging modalities, the researchers found enhanced functional connectivity in the sensorimotor network of individuals with spastic diplegic cerebral palsy, which was not correlated with hand coordination performance.
CLINICAL NEUROPHYSIOLOGY
(2024)
Article
Clinical Neurology
Francesca Ginatempo, Nicola Loi, John C. Rothwell, Franca Deriu
Summary: This study comprehensively investigated sensorimotor integration in the cranial-cervical muscles of healthy adults and found that the integration of sensory inputs with motor output is profoundly influenced by the type of sensory afferent involved and the functional role played by the target muscle.
CLINICAL NEUROPHYSIOLOGY
(2024)
