期刊
NEUROBIOLOGY OF AGING
卷 35, 期 11, 页码 2541-2551出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2014.05.004
关键词
Motor cortex; Aging; Plasticity; Levodopa; Cerebellum
资金
- Sree Chitra Tirunal Institute for Medical Sciences and Technology, Kerala, India [5040, 5201]
- Indian Council of Medical Research (ICMR) [INDO-INSERM/Neurol/21/2010-NCD-1]
- Institute National de la Sante et de la Recherche Medicale (INSERM) [C10-01]
The plasticity of motor cortex is integral for motor memory and skills acquisition but it declines with aging. Forty healthy volunteers, across 6 decades, were tested to examine the (a) age-dependency of motor cortex responsiveness to plasticity induction, as measured from the response to paired associative stimulation (PAS) and the (b) effect of aging on the cerebellar modulation of motor cortex response to PAS. We examined if reduced dopaminergic transmission was involved in the age-related decline of response to PAS by retesting 10 of the older subjects after a single dose of levodopa. There was a substantial decline in the motor cortex response to PAS with aging, which was restored by levodopa in the older subjects. The cerebellar modulation of motor cortex response to PAS was less vulnerable to aging and a single session of cerebellar inhibition reinstated the cortical responsiveness in older subjects. Both levodopa and cerebellar inhibition can be tested for their ability to enhance motor skills acquisition and motor performance in the elderly individuals. (C) 2014 Elsevier Inc. All rights reserved.
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