Review
Immunology
Ida Pastore, Emma Assi, Moufida Ben Nasr, Andrea Mario Bolla, Anna Maestroni, Vera Usuelli, Cristian Loretelli, Andy Joe Seelam, Ahmed Abdelsalam, Gian Vincenzo Zuccotti, Francesca D'Addio, Paolo Fiorina
Summary: Although progress has been made in understanding the pathophysiological mechanisms of T1D, the quest for effective therapeutic options is ongoing. Promising results have been seen with HSC-based approaches and teplizumab, but more research is needed to establish their long-term efficacy and safety. Genetically engineered HSCs hold potential as a novel biologic therapy for T1D and other autoimmune/immune-related disorders, with studies in murine models and humanized mouse models showing accelerated translational potentials.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Dae Yoon Kim, Jae Kwon Lee
Summary: The article investigates the changes in Natural Killer (NK) cell activity under diabetic conditions. The study finds that high glucose conditions influence NK cell activity, leading to reduced cytotoxic activity against cancer cells and decreased expression of activation markers.
CELLULAR IMMUNOLOGY
(2022)
Review
Immunology
James Alexander Pearson, F. Susan Wong, Li Wen
Summary: Microbiota play a crucial role in modulating susceptibility to Type 1 diabetes, with the association of microbiota composition with genetic risk and immune responses. The role of inflammasomes in Type 1 diabetes and the development of inhibitors for therapeutically targeting inflammasomes are areas that require further study.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Ylke Bruggeman, Pieter-Jan Martens, Gabriele Sassi, Marijke Viaene, Clive H. Wasserfall, Chantal Mathieu, Conny Gysemans
Summary: This study investigates the dynamics and phenotypes of immune cells infiltrating the pancreas and their changes in peripheral blood during the development of type 1 diabetes (T1D) in non-obese diabetic (NOD) mice. The early stages of T1D are characterized by an influx of dendritic cells and neutrophils in the pancreas. CD4+ and CD8+ T cells migrate from the pancreatic draining lymph nodes to the pancreas, coinciding with increased beta cell autoimmunity and insulitis severity. These findings provide important insights into the disease process and may contribute to the development of new therapies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Emi Kawada-Horitani, Shunbun Kita, Tomonori Okita, Yuto Nakamura, Hiroyuki Nishida, Yoichi Honma, Shiro Fukuda, Yuri Tsugawa-Shimizu, Junji Kozawa, Takaaki Sakaue, Yusuke Kawachi, Yuya Fujishima, Hitoshi Nishizawa, Miyuki Azuma, Norikazu Maeda, Iichiro Shimomura
Summary: The study found that systemic administration of MSC therapy can prevent the development of type 1 diabetes. MSCs reduced the accumulation of T cells and CXCL9-positive macrophages in the islets induced by PD-1/PD-L1 blockade, thereby decreasing the occurrence of diabetes.
Article
Immunology
Qin Zeng, Jianfeng Song, Dandan Wang, Xiaoxiao Sun, Yalun Xiao, Haowei Zhang, Yang Xiao, Zhiguang Zhou, Tuo Deng
Summary: In this study, we identified sorafenib as a potential inhibitor of Th1 cell differentiation through screening an FDA-approved tyrosine kinase inhibitor drug library. Treatment with sorafenib inhibited Th1 cell population and impeded the development of type 1 diabetes in NOD mice. Mechanistically, sorafenib indirectly inhibited JAK2 activity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Xiangqian Li, Lina Wang, Gang Meng, Xiaoling Chen, Shushu Yang, Mengjun Zhang, Zhengni Zheng, Jie Zhou, Zhu Lan, Yuzhang Wu, Li Wang
Summary: This study provides evidence for the negative impact of high glucose intake as a dietary factor on the pathogenesis of type 1 diabetes. Therefore, avoiding high sugar intake may be an effective disease prevention strategy for children or adults susceptible to type 1 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
Rongjiao Liu, Qizhi Luo, Weiguang Luo, Ling Wan, Quan Zhu, Xiangli Yin, Xiaofang Lu, Zixuan Song, Leiyan Wei, Zhiqing Xiang, Yizhou Zou
Summary: In this study, a soluble NKCAR was designed to trigger NK cell cytotoxicity by binding with the ligand MICA through the NKG2D receptor expressed on NK cells. The NKCAR showed bifunctional activity, recognizing both the CD20 antigen of target cells and the NKG2D receptor of NKL cells. The soluble NKCAR mediated the killing of CD20(+) Daudi cells in vitro, indicating its potential clinical application for killing target tumor cells.
Article
Biochemistry & Molecular Biology
Kailash Singh, Orian Bricard, Jeason Haughton, Mikaela Bjorkqvist, Moa Thorstensson, Zhengkang Luo, Loriana Mascali, Emanuela Pasciuto, Chantal Mathieu, James Dooley, Adrian Liston
Summary: This article discusses the causes and mechanisms of insulin-producing beta-cell death in type 1 diabetes. Cellular stress is found to contribute to the loss of beta-cells. By enhancing the expression of the anti-apoptotic protein Manf, the robustness of beta-cells can be improved, leading to a lower incidence of type 1 diabetes.
Article
Biochemistry & Molecular Biology
Jide Tian, Blake Middleton, Victoria Seunghee Lee, Hye Won Park, Zhixuan Zhang, Bokyoung Kim, Catherine Lowe, Nancy Nguyen, Haoyuan Liu, Ryan S. Beyer, Hannah W. Chao, Ryan Chen, Davis Mai, Karen Anne O'Laco, Min Song, Daniel L. Kaufman
Summary: The expression of gamma-aminobutyric acid receptors in immune cells may have therapeutic potential in diseases like T1D, multiple sclerosis, rheumatoid arthritis, and COVID-19. Specific modulation of GABA(B)-Rs with agonists like lesogaberan shows promise in restoring normoglycemia and improving T1D remission rates in mouse models. The analysis of gene expression databases suggests a common feature of GABA receptors and production/secretion-related genes in immune cells.
Article
Multidisciplinary Sciences
Scott A. Ochsner, Rudolf T. Pillich, Deepali Rawool, Jeffrey S. Grethe, Neil J. McKenna
Summary: This article describes how investigator-generated transcriptomic datasets can be repurposed to generate hypotheses about the signaling pathways of circulating immune cells in type 1 diabetes. By computing and validating sets of differentially expressed genes, as well as inferring and validating signaling node networks, the study demonstrated the value of these datasets in understanding the pathogenesis of T1D and generating actionable hypotheses. Additionally, a federated, cloud-based web resource was developed to provide unrestricted access and re-use of the data matrix by the research community.
Article
Endocrinology & Metabolism
Ruifeng Shi, Fang Dai, Yong He, Li Sun, Min Xu, Datong Deng, Qiu Zhang
Summary: This study identified 70 DEGs between T1DM patients and healthy controls, screened out 10 hub genes, and constructed a NK cell-specific gene co-expression network. By intersection analysis, 13 overlapping genes were found between two datasets, with 7 hub genes identified. 59 target miRNAs were predicted, and 7 differentially expressed miRNAs were selected from the validation dataset GSE97123.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Beatriz Gutierrez-Miranda, Isabel Gallardo, Eleni Melliou, Isabel Cabero, Yolanda alvarez, Marta Hernandez, Prokopios Magiatis, Marita Hernandez, Maria Luisa Nieto
Summary: Multiple sclerosis (MS) is an inflammatory demyelinating disease in the central nervous system. Recent studies indicate that the gut-brain axis plays a crucial role in neurological diseases. In both MS and its preclinical model, experimental autoimmune encephalomyelitis (EAE), gastrointestinal symptoms including leaky gut have been observed. Oleacein (OLE), a phenolic compound found in olive oil or olive leaves, has therapeutic properties. This study investigated the protective effects of OLE on intestinal barrier dysfunction in EAE mice and found that it decreased inflammation and oxidative stress in the intestine, protecting against tissue injury and permeability alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Emily Chiu, Martin Felices, Frank Cichocki, Zachary Davis, Hongbo Wang, Katie Tuninga, Daniel A. Vallera, Tom Lee, Ryan Bjordahl, Karl Johan Malmberg, Bahram Valamehr, Jeffrey S. Miller
Summary: The researchers developed an immune therapy called NKG2C-KE, which directs specific types of NK cells to attack leukemia cells. This method showed promising results in experiments and could potentially become a new treatment strategy for leukemia.
Article
Immunology
Maureen Banach, Isaac T. W. Harley, Andrew Getahun, John C. Cambier
Summary: The presence of high-affinity insulin-reactive B cells is associated with the development of autoimmune type 1 diabetes. These B cells show specific phenotypes and express unmutated immunoglobulin light chains that are biased towards certain genes. The relaxation of tolerance mechanisms in NOD mice leads to the accumulation and partial activation of B cells expressing high-affinity B cell receptors, contributing to the development of autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Oncology
Michele Ardolino, David H. Raulet
Review
Immunology
Alexandre Iannello, Thornton W. Thompson, Michele Ardolino, Assaf Marcus, David H. Raulet
CURRENT OPINION IN IMMUNOLOGY
(2016)
Article
Immunology
Nataliya Tovbis Shifrin, Djem U. Kissiov, Michele Ardolino, Nathalie T. Joncker, David H. Raulet
JOURNAL OF IMMUNOLOGY
(2016)
Article
Oncology
Asaf Spiegel, Mary W. Brooks, Samin Houshyar, Ferenc Reinhardt, Michele Ardolino, Evelyn Fessler, Michelle B. Chen, Jordan A. Krall, Jasmine DeCock, Ioannis K. Zervantonakis, Alexandre Iannello, Yoshiko Iwamoto, Virna Cortez-Retamozo, Roger D. Kamm, Mikael J. Pittet, David H. Raulet, Robert A. Weinberg
Article
Oncology
Joanne Xiu, David Piccioni, Tiffany Juarez, Sandeep C. Pingle, Jethro Hu, Jeremy Rudnick, Karen Fink, David B. Spetzler, Todd Maney, Anatole Ghazalpour, Ryan Bender, Zoran Gatalica, Sandeep Reddy, Nader Sanai, Ahmed Idbaih, Michael Glantz, Santosh Kesari
Letter
Immunology
Yann M. Kerdiles, Francisca F. Almeida, Thornton Thompson, Michael Chopin, Margaux Vienne, Pierre Bruhns, Nicholas D. Huntington, David H. Raulet, Stephen L. Nutt, Gabrielle T. Belz, Eric Vivier
Review
Immunology
David H. Raulet, Assaf Marcus, Laurent Coscoy
IMMUNOLOGICAL REVIEWS
(2017)
Article
Oncology
Amanda R. Campbell, Megan C. Duggan, Lorena P. Suarez-Kelly, Neela Bhave, Kallan S. Opheim, Elizabeth L. McMichael, Prashant Trikha, Robin Parihar, Eric Luedke, Adrian Lewis, Bryant Yung, Robert Lee, David Raulet, Susheela Tridandapani, Veronika Groh, Lianbo Yu, Vedat Yildiz, John C. Byrd, Michael A. Caligiuri, William E. Carson
CANCER IMMUNOLOGY RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Beeke Wienert, Jiyung Shin, Elena Zelin, Kathleen Pestal, Jacob E. Corn
Letter
Biotechnology & Applied Microbiology
Alexandra M. Amen, Alexandra M. Amen, Kerrie W. Barry, John M. Boyle, Cara E. Brook, Seunga Choo, L. T. Cornmesser, David J. Dilworth, Jennifer A. Doudna, Alexander J. Ehrenberg, Indro Fedrigo, Skyler E. Friedline, Thomas G. W. Graham, Ralph Green, Jennifer R. Hamilton, Ariana Hirsh, Megan L. Hochstrasser, Dirk Hockemeyer, Netravathi Krishnappa, Azra Lari, Hanqin Li, Enrique Lin-Shiao, Tianlin Lu, Elijah F. Lyons, Kevin G. Mark, Lisa Argento Martell, A. Raquel O. Martins, Shana L. McDevitt, Patrick S. Mitchell, Erica A. Moehle, Christine Naca, Divya Nandakumar, Elizabeth O'Brien, Derek J. Pappas, Kathleen Pestal, Diana L. Quach, Benjamin E. Rubin, Rohan Sachdeva, Elizabeth C. Stahl, Abdullah Muhammad Syed, I-Li Tan, Amy L. Tollner, Connor A. Tsuchida, C. Kimberly Tsui, Timothy K. Turkalo, Fyodor D. Urnov, M. Bryan Warf, Oscar N. Whitney, Lea B. Witkowsky
NATURE BIOTECHNOLOGY
(2020)
Article
Multidisciplinary Sciences
Jennifer R. Hamilton, Elizabeth C. Stahl, Connor A. Tsuchida, Enrique Lin-Shiao, C. Kimberly Tsui, Kathleen Pestal, Holly K. Gildea, Lea B. Witkowsky, Erica A. Moehle, Shana L. McDevitt, Matthew McElroy, Amanda Keller, Iman Sylvain, Ariana Hirsh, Alison Ciling, Alexander J. Ehrenberg, Bradley R. Ringeisen, Garth Huberty, Fyodor D. Urnov, Petros Giannikopoulos, Jennifer A. Doudna
Summary: This study developed a robotic nucleic acid extraction method for high-throughput detection of SARS-CoV-2 RNA in saliva samples. The research identified rare positive specimens containing SARS-CoV-2 RNA during a time of low infection prevalence when testing supervised self-collected saliva samples.
Review
Oncology
James H. Park, Adrian Lopez Garcia de Lomana, Diego M. Marzese, Tiffany Juarez, Abdullah Feroze, Parvinder Hothi, Charles Cobbs, Anoop P. Patel, Santosh Kesari, Sui Huang, Nitin S. Baliga
Summary: Pronounced differences between individuals and cell-cell heterogeneity within tumors are major obstacles in effective brain tumor treatment, necessitating a personalized precision medicine approach. A systems biology approach is crucial for developing a multiscale understanding of disease mechanisms. Integrating patient tumor analysis with clinical medicine can optimize treatment strategies.
Article
Medicine, General & Internal
Terese Catherine Hammond, Raymond C. Lee, Bryan Oronsky, Tony R. Reid, Scott Caroen, Tiffany M. Juarez, Jaya Gill, Annie Heng, Santosh Kesari
Summary: This article presents the first report of RRx-001 treatment for COVID-19. Two critically ill patients with COVID-19, who had tried all available treatment options, showed improvement after receiving RRx-001. RRx-001 is a first-in-class small molecule with various properties and has been safely administered to over 300 patients in clinical trials.
INTERNATIONAL MEDICAL CASE REPORTS JOURNAL
(2022)
Review
Immunology
Nicholas A. Lind, Victoria E. Rael, Kathleen Pestal, Bo Liu, Gregory M. Barton
Summary: Activation of nucleic acid-sensing Toll-like receptors is finely tuned to distinguish between self and foreign nucleic acids. The ligands for TLRs are mostly unique to microorganisms, but a subset can recognize nucleic acids present in both host and foreign microorganisms, potentially leading to self-recognition and autoimmune diseases. Research in defining the regulatory mechanisms for proper discrimination between foreign and self-nucleic acids by TLRs has revealed a complex array of mechanisms, categorized into compartmentalization, ligand availability, receptor expression, and signal transduction.
NATURE REVIEWS IMMUNOLOGY
(2022)
Article
Immunology
Jacquelyn A. Gorman, Christian Hundhausen, John S. Errett, Amy E. Stone, Eric J. Allenspach, Yan Ge, Tanvi Arkatkar, Courtnee Clough, Xuezhi Dai, Socheath Khim, Kathleen Pestal, Denny Liggitt, Karen Cerosaletti, Daniel B. Stetson, Richard G. James, Mohamed Oukka, Patrick Concannon, Michael Gale, Jane H. Buckner, David J. Rawlings
