期刊
CURRENT OPINION IN IMMUNOLOGY
卷 38, 期 -, 页码 52-58出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2015.11.001
关键词
-
类别
资金
- National Institutes of Health [R01 CA093678, R01 AI113041]
- Cancer Research Institute
- Leukemia and Lymphoma Society
Increasing evidence supports a role for innate immune effector cells in tumor surveillance. Natural killer (NK) cells and myeloid cells represent the two main subsets of innate immune cells possessing efficient but quite different tumor suppressive abilities. Here, we describe the germline-encoded NK cell receptors that play a role in suppressing tumor development and describe briefly the cellular pathways leading to the upregulation of their ligands in tumor cells. We also describe mechanisms underlying the elimination of tumor cells by macrophages and a recently characterized mechanism dedicated to sensing cytosolic DNA that is implicated in antitumor immune responses.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据