Article
Pediatrics
Lulu Li, Chao Jia, Yue Tang, Yuanyuan Kong, Yaofang Xia, Li Ma
Summary: This study identified rare gross deletion mutations in the NTRK1 gene associated with CIPA in two unrelated Chinese families, expanding the mutation spectrum of NTRK1 mutations in the Chinese population. The discovery of novel compound mutations highlights the importance of prenatal interventions and precision pharmacological treatments for patients. Whole exome sequencing proved to be a convenient and useful tool for clinical diagnosis of CIPA and related disorders.
FRONTIERS IN PEDIATRICS
(2021)
Article
Clinical Neurology
Shiwen Zhao, Xianwei Zhang, Mi Zhang
Summary: Based on the bibliometric analysis of research publications on CIPA, we have gained a comprehensive understanding of its global status, highlighting the need for more attention and collaboration to facilitate the study of its pathological mechanisms.
JOURNAL OF PAIN RESEARCH
(2022)
Article
Neurosciences
Lucia Lisi, Silvia Marinelli, Gabriella Maria Pia Ciotti, Michela Pizzoferrato, Federica Palmerio, Marta Chiavari, Antonino Cattaneo, Pierluigi Navarra
Summary: Previous studies have indicated that microglial cells in the brain could be a potential target for nerve growth factors. The recombinant mutated form of human nerve growth factor (hNGFp) shows similar neurotrophic properties to wild-type NGF but with lower algogenic activity. The study evaluated the expression of NGF receptors in human microglia cell lines and the effects of hNGFp and NGF on L-arginine metabolism, showing that both types of NGF inhibit iNOS expression and NO production, but only NGF stimulates urea production.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Moyim Mallick, T. R. Yoithap Prabhunath, Sonia Kumari, M. Elizabeth Sobhia
Summary: Ameloblastoma is a benign odontogenic jawbone tumor where the binding of NGF to TrkA promotes cell survival, proliferation, and differentiation. By utilizing in silico analysis and mutation on interacting residues, a hybrid peptide candidate was designed to disrupt the interaction between NGF and TrkA for potential therapeutic strategies.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Neurosciences
Yuedan Fan, Wenjuan Zou, Jia Liu, Umar Al-Sheikh, Hankui Cheng, Duo Duan, Du Chen, Siyan Liu, Luyi Chen, Jilei Xu, Firdosh Ruhomutally, Lijun Kang
Summary: The research highlights the response of C. elegans OLL sensory neurons to touch and cold, revealing the molecular mechanisms of mechanosensation and cold sensation without the involvement of specific proteins.
NEUROSCIENCE BULLETIN
(2021)
Article
Food Science & Technology
Paula Moyano, Andrea Flores, Jimena Garcia, Jose Manuel Garcia, Maria Jose Anadon, Maria Teresa Frejo, Emma Sola, Adela Pelayo, Javier del Pino
Summary: BPA induces disruption of cholinergic neurotransmission by affecting acetylcholinesterase activity and inducing apoptotic cell death, mediated partially through HDAC2 overexpression.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Neurosciences
Laura Calvo-Enrique, Silvia Lisa, Cristina Vicente-Garcia, Ruben Deogracias, Juan Carlos Arevalo
Summary: The NGF/TrkA pathway plays a crucial role in the development and function of basal forebrain cholinergic neurons, and an imbalance in TrkA signaling can lead to impaired cognitive functions.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Austin B. Keeler, Amy L. Van Deusen, Irene Cheng, Corey M. Williams, Sarah M. Goggin, Ashley K. Hirt, Shayla A. Vradenburgh, Kristen Fread, Emily A. Puleo, Lucy Jin, Christopher D. Deppmann, Eli R. Zunder, Yipkin Calhan
Summary: This study presents a single-cell, protein-level atlas of mouse dorsal root ganglia and highlights the significance of protein-level measurements in identifying functional cell states during somatosensory development.
NATURE NEUROSCIENCE
(2022)
Article
Neurosciences
Raquel Comaposada-Baro, Andrea Benito-Martinez, Juan Julian Escribano-Saiz, Maria Luisa Franco, Lorenzo Ceccarelli, Isabel Calatayud-Baselga, Helena Mira, Marcal Vilar
Summary: This study investigates the role of p75(NTR) in the basal forebrain during aging and its relationship with cholinergic neurodegeneration and dysregulated cholesterol metabolism. The findings suggest that the SAMP8-p75(exonIII-/-) mouse strain could serve as a good model for studying long-term cholinergic neurodegeneration in the central nervous system (CNS), and provide insights into the role of p75(NTR) in cholesterol biosynthesis regulation.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Diane M. Bogdan, Keith Studholme, Adriana DiBua, Chris Gordon, Martha P. Kanjiya, Mei Yu, Michelino Puopolo, Martin Kaczocha
Summary: The endocannabinoid anandamide can produce both anti-pain effects and exacerbate pain. FABP5 plays a key role in regulating the levels of endocannabinoids in nociceptors, affecting pain perception. Decreasing the expression of FABP5 can increase the levels of endocannabinoids, leading to anti-pain effects.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Balazs Sonkodi, Rita Bardoni, Laszlo Hangody, Zsolt Radak, Istvan Berkes
Summary: The authors propose a new mechanism for non-contact anterior cruciate ligament injury, suggesting that it is caused by acute compression microinjury of entrapped peripheral proprioceptive sensory axons in the proximal tibia. They highlight the importance of primary damage during strenuous exercises and secondary damage during deceleration. Elevated prostaglandin E2, nitric oxide, and glutamate may play critical roles in the neuro-modulation, leading to mechano-energetic failure and inflammatory events.
Review
Biochemistry & Molecular Biology
Jacinta N. Conroy, Elizabeth J. Coulson
Summary: Neurotrophin signaling is crucial for normal nervous system development and function. Understanding the mechanism of high-affinity receptor generation will facilitate the development of pharmaceuticals for the treatment of nervous system disorders. Despite decades of research, the modulation mechanism of the high-affinity complex remains unclear.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biology
Daniela B. Vera, Allison N. Fredes, Maritza P. Garrido, Carmen Romero
Summary: Ovarian cancer, particularly the epithelial type, is highly lethal and its treatment outcomes have not improved in recent years. Nerve growth factor and its receptor play a crucial role in cancer progression, and microRNAs regulate the expression of oncogenic proteins. Furthermore, mitochondria have been proposed as a potential therapeutic target for activating apoptosis in cancer cells.
Review
Rheumatology
Barton L. Wise, Matthias F. Seidel, Nancy E. Lane
Summary: NGF is an important neurotrophin involved in pain signal transmission, and inhibitors have shown efficacy in reducing joint pain in osteoarthritis patients, but higher doses may increase the risk of rapidly progressive osteoarthritis. Ongoing studies aim to better understand the mechanisms involved in this adverse event.
NATURE REVIEWS RHEUMATOLOGY
(2021)