Article
Pharmacology & Pharmacy
Tameille Valentine, Lydia Hardowar, Jasmine Elphick-Ross, Richard P. Hulse, Mark Paul-Clark
Summary: Chemotherapy-induced neuropathies cause sensory disturbances and pain in cancer patients, and current analgesic strategies are ineffective due to a lack of understanding of the underlying causes. Research on the immune-neuronal interactions across different cancer therapy drug classes may lead to better pain management for cancer survivors.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yong-Woo Kim, Hak Jin Kim, Byung Mann Cho, Seon Hee Choi
Summary: Infusion of triolein emulsion (TE) into hepatic arteries significantly increased doxorubicin concentration in the liver approximately twofold, suggesting TE infusion may be a useful adjuvant treatment for liver cancers.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Oncology
Yusuf Mehkri, Samuel Woodford, Kevin Pierre, Abeer Dagra, Jairo Hernandez, Mohammad Reza Hosseini Siyanaki, Mohammed Azab, Brandon Lucke-Wold
Summary: Chemotherapy has not significantly improved outcomes for aggressive brain tumors due to poor blood brain barrier penetration and tumor heterogeneity. However, recent advancements in focused chemotherapies, such as nanoparticle delivery, convection-enhanced delivery, and focused ultrasound, show promising potential for improving therapeutic efficacy. Clinical trials are currently underway to study the safety and effectiveness of these methods in combination with standard of care.
Article
Nutrition & Dietetics
Sarah A. Potgens, Sophie Lecop, Violaine Havelange, Fuyong Li, Audrey M. Neyrinck, Nathalie Neveux, Johan Maertens, Jens Walter, Helene Schoemans, Nathalie M. Delzenne, Laure B. Bindels
Summary: In this study, the researchers investigated the changes in gut microbiota induced by intensive therapy in acute myeloid leukaemia (AML) patients. They found that the therapy temporarily impaired the gut barrier function and led to long-lasting alterations in the composition and metabolic activity of the gut microbiota, which were associated with weight loss.
CLINICAL NUTRITION
(2023)
Article
Instruments & Instrumentation
Fereshteh Abdi, Elham Arkan, Mojtaba Eidizadeh, Elahe Valipour, Tahereh Naseriyeh, Younes Hossainy Gamizgy, Kamran Mansouri
Summary: The encapsulation of bevacizumab in lipid-polymer nanoparticles enhances dermal absorption and significantly increases its suppressive effects on cell proliferation and angiogenesis. These findings suggest the potential therapeutic benefits of locally administering bevacizumab using lipid-polymer nanoparticles for angiogenesis-related disorders.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Editorial Material
Pharmacology & Pharmacy
Arik Dahan, Isabel Gonzalez-Alvarez
Summary: The environment and conditions of different regions in the gastrointestinal tract have a significant impact on drug absorption, leading to the importance of studying regional-dependent intestinal drug absorption and delivery. Factors such as pH, fluid composition, and transporter expression can alter drug solubility, intestinal permeability, and overall absorption.
Article
Engineering, Biomedical
Changrong Wang, Xiaoguang Shi, Huijuan Song, Chuangnian Zhang, Xiaoli Wang, Pingsheng Huang, Anjie Dong, Yumin Zhang, Deling Kong, Weiwei Wang
Summary: The combination of RNA interference and immunogenic chemotherapy shows potent antitumor immunity against melanoma. Using cationic polymer-lipid hybrid nanovesicles as a delivery system, the strategy induces immunogenic cell death and enhances antitumor immune responses effectively.
Article
Cell Biology
Yang Li, Yuling Gao, Weiling Chu, Jianjian Lv, Zhi Li, Tongxin Shi
Summary: The study revealed significant differences in overall survival rates between the chemotherapy and immunotherapy groups, with higher immune infiltration levels of immature dendritic cells in the chemotherapy group. Seven signature genes were identified, showing significant differences in overall survival and disease progression between the chemotherapy and immunotherapy groups.
Article
Oncology
Minliang Wu, Yuai Xiao, Jianguo Huang, Yuchong Wang, Yifan Zhang, Jianguo Xu, Haiying Dai, Chuan Lv, Yihui Hu, Bingdi Chen, Qingge Fu, Wenjun Le, Chunyu Xue
Summary: A preventive and therapeutic vaccine platform has been developed for in situ effective multi-model synergistic therapy. The platform utilizes liquid nitrogen frozen (LNF) cells, which preserve intact cellular structure and tumor-associated self-antigen gp100. LNF cells can also load and release doxorubicin (DOX) and induce immune response, making it a potential cancer vaccine.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Amanda Nijhuis, David Chung, Kevin London, Roger Uren, John Thompson, Omgo Nieweg
Summary: This study assessed the value of ultrasound examination in detecting additional ITMs in melanoma patients, revealing that ultrasound was able to identify extra lesions in over half of the patients and influenced management in one-third of cases.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Biochemical Research Methods
Cynthia Hajal, Giovanni S. Offeddu, Yoojin Shin, Shun Zhang, Olga Morozova, Dean Hickman, Charles G. Knutson, Roger D. Kamm
Summary: This protocol describes an in vitro model of the human blood-brain barrier, self-assembled within microfluidic devices from stem-cell-derived or primary brain endothelial cells, and primary brain pericytes and astrocytes. The model features relevant cellular organization and morphological characteristics, and can be used to assess pathophysiological molecular transport mechanisms and design targeted therapies for neurological disorders.
Review
Oncology
Ayushi Patel, Michael J. Carr, James Sun, Jonathan S. Zager
Summary: Management of in-transit melanoma involves a variety of treatment pathways based on disease characteristics and patient preferences. While surgical excision, regional perfusion, and systemic therapies are common options, some therapies can effectively treat unresectable disease. The use of systemic therapies for in-transit melanoma lacks specific data but is explored in clinical trials for synergistic benefits with other therapies.
CLINICAL & EXPERIMENTAL METASTASIS
(2022)
Article
Chemistry, Medicinal
Debby P. Chang, Shalini Burra, Eric S. Day, Joyce Chan, Laetitia Comps-Agrar, Thierry Nivaggioli, Karthikan Rajagopal
Summary: The study found that ranibizumab demonstrated superior long-term drug stability compared to bevacizumab and aflibercept, which are more prone to aggregation. However, the effects of aggregation on immunogenicity and efficacy remain unknown.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Oncology
Ying Zeng, Yong Zhang, Jing Zhang, Wei Jian, Rongqing Li, Qiaofen Fu
Summary: CNS malignant melanomas are rare tumors that arise from abnormal changes in melanocytes during embryonic development. Few cases of primary malignant melanoma in the spinal canal have been reported. This study presents a rare case of primary malignant melanoma in the thoracic spinal canal, with an incompletely resected tumor. The patient achieved disease-free survival of over 2.5 years after treatment with chemoradiotherapy and adjuvant chemotherapy.
Article
Biotechnology & Applied Microbiology
Wei Liu, Ying Han, Xin Xin, Liqing Chen, Yanhong Liu, Chao Liu, Xintong Zhang, Mingji Jin, Jingzhe Jin, Zhonggao Gao, Wei Huang
Summary: In this study, a novel double layer nanoparticles were designed to enhance the oral bioavailability of anticancer drugs. The nanoparticles can act in a temporally controlled manner via an endogenous pathway in the intestine, overcoming multiple limitations of oral delivery. The results showed that the nanoparticles had good stability and prolonged intestinal retention time, as well as enhanced active transportation. Compared to conventional oral drugs, the use of these nanoparticles significantly improved the drug bioavailability and demonstrated better antitumor efficacy and safety.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Surgery
Kristy M. Broman, Tasha C. Hughes, Brooke Bredbeck, James Sun, Dennis J. Kirichenko, Michael Carr, Avinash Sharma, Edmund Bartlett, Amanda A. G. Nijhuis, John F. Thompson, Tina J. Hieken, Lisa Kottschade, Jennifer Downs, David E. Gyorki, Emma Stahlie, Alexander van Akkooi, David Ollila, Kristin O'shea, Yun Song, Giorgos Karakousis, Marc Moncrieff, Jenny Nobes, John Vetto, Dale Han, Meghan Hotz, Jeffrey M. Farma, Jeremiah L. Deneve, Martin D. Fleming, Matthew Perez, Kirsten Baecher, Michael Lowe, Roger Olofsson Bagge, Jan Mattsson, Ann Y. Lee, Russell S. Berman, Harvey Chai, Hidde M. Kroon, Juri Teras, Roland M. Teras, Norma E. Farrow, Georgia M. Beasley, Jane Yuet Ching Hui, Lukas Been, Schelto Kruijff, Brandy Sinco, Amod A. Sarnaik, Vernon K. Sondak, Jonathan S. Zager, Lesly A. Dossett
Summary: The aim of this study was to determine trends and variation in the utilization of CLND and adjuvant systemic therapy for SLN-positive melanoma. The study found a decline in CLND and an increase in adjuvant systemic therapy. There was significant variation among treating centers, and location of care contributed significantly to the observed variation.
Letter
Dermatology
Andrew D. Tieniber, Adrienne B. Shannon, Michael J. Carr, James Sun, Karenia Landa, Kirsten M. Baecher, Kevin Lynch, Harrison G. Bartels, Robyn Panchaud, Michael C. Lowe, Craig L. Slingluff, Mark J. Jameson, Kenneth Y. Tsai, Mark B. Faries, Georgia M. Beasley, Vernon K. Sondak, Giorgos C. Karakousis, Jonathan S. Zager, John T. Miura
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Dermatology
Melissa M. Sarver, Jess D. Rames, Georgia M. Beasley, Junheng Gao, Suephy C. Chen
Summary: This study compared the tumor distributions and survival characteristics between patients with second primary melanomas and those with single primary melanomas. The findings demonstrated that patients with second primary melanomas had better survival probabilities and thinner lesions. The results support the importance of full body skin examinations, with attention to the region of initial diagnosis.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Surgery
Kristen E. Rhodin, Elizabeth M. Gaughan, Vignesh Raman, April K. Salama, Brent A. Hanks, Riddhishkumar Shah, Douglas S. Tyler, Craig L. Slingluff Jr, Georgia M. Beasley
Summary: This study aimed to evaluate the feasibility and impact of neoadjuvant therapy (NT) in patients with advanced melanoma amenable to surgical resection. Prospective data from 3 institutions showed that NT could potentially be effective in patients with advanced melanoma eligible for surgery.
Editorial Material
Oncology
Adrienne B. Shannon, Richard J. Straker, Michael J. Carr, James Sun, Karenia Landa, Kirsten Baecher, Kevin Lynch, Harrison G. Bartels, Robyn Panchaud, Luke J. Keele, Michael C. Lowe, Craig L. Slingluff, Mark J. Jameson, Kenneth Y. Tsai, Mark B. Faries, Georgia M. Beasley, Vernon K. Sondak, Giorgos C. Karakousis, Jonathan S. Zager, John T. Miura
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Optics
David Grass, Georgia M. Beasley, Martin C. Fischer, M. Angelica Selim, Yue Zhou, Warren S. Warren
Summary: Pump-probe microscopy is proposed to improve the diagnosis of malignant melanoma by analyzing the signals of melanin. The study decomposes the signals and identifies the molecular mechanisms most susceptible to melanin disaggregation, creating false-colored images to highlight these processes in biological tissue. The results demonstrate a correlation between false-colored images of melanoma tumors and clinical concern, and the approach can be applied to other samples.
Article
Oncology
Kevin T. Lynch, Yinin Hu, Norma E. Farrow, Yun Song, Max O. Meneveau, Minyoung Kwak, Michael C. Lowe, Edmund K. Bartlett, Georgia M. Beasley, Giorgos C. Karakousis, Craig L. Slingluff
Summary: This study retrospectively reviewed patients who underwent PLND and found that PLND may provide adequate regional disease control with a lower morbidity rate compared to CLND.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Cimarron E. Sharon, Georgia M. Beasley, Giorgos C. Karakousis
Summary: The current guidelines for the surgical care of cutaneous melanoma have been shaped by multiple randomized controlled clinical trials. These trials have provided important guidance for margin excision and sentinel lymph node biopsy in melanoma patients, and the development of targeted therapy and immunotherapy has offered effective adjuvant treatment options.
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA
(2023)
Letter
Oncology
Cimarron E. Sharon, Gabriella N. Tortorello, Phyllis A. Gimotty, Georgia M. Beasley, Craig L. Slingluff, John T. Miura, Giorgos C. Karakousis
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Michael C. Brown, Georgia M. Beasley, Zachary P. McKay, Yuanfan Yang, Annick Desjardins, Dina M. Randazzo, Daniel Landi, David M. Ashley, Darell D. Bigner, Smita K. Nair, Matthias Gromeier
Summary: This study reveals the contribution of pre-existing anti-polio immunity to the effectiveness of polio virotherapy for cancer treatment. Childhood vaccines such as polio and tetanus can enhance antitumor immune responses, particularly by activating CD4(+) T cells and eosinophils.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Editorial Material
Oncology
Kristen E. Rhodin, Georgia M. Beasley
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Kristen E. Rhodin, Sin-Ho Jung, Kelly Elleson, Danielle DePalo, Richard Straker, Sophia McKinley, Kate Beekman, Lily Parker, Suephy Chen, Matthew K. Iyer, April K. S. Salama, Edmund Bartlett, Giorgos Karakousis, Jonathan S. Zager, Douglas S. Tyler, Georgia M. Beasley
Summary: This study investigated the impact of the timing of adjuvant immune checkpoint inhibitor (ICI) initiation on survival in patients with stage III melanoma. The results showed that patients who initiated adjuvant ICI within 6 weeks of surgery had worse recurrence-free survival, while those who started treatment after 6 weeks had improved outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Immunology
Austin M. Eckhoff, Michael C. Brown, Karenia Landa, Ibtehaj Naqvi, Eda K. Holl, David Boczkowski, Ashley Fletcher, Kristen E. Rhodin, Minh Huy Giang, Bruce Sullenger, Georgia M. Beasley, Peter J. Allen, Smita K. Nair
Summary: This study found that monocytes in the periphery and tumor microenvironment of patients with intraductal papillary mucinous neoplasm (IPMN) and pancreatic adenocarcinoma (PDAC) undergo functional changes and are associated with immunosuppression and immune evasion. Furthermore, the study also revealed that TLR activation is positively correlated with disease progression from IPMN to PDAC. These findings suggest that innate immune reprogramming occurs as IPMNs progress to invasive disease, partly mediated by soluble mediators in sera.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Ashlyn G. Rickard, Husam Mikati, Antoine Mansourati, Daniel Stevenson, Marlee Krieger, Daniel Rocke, Ramon Esclamado, Mark W. Dewhirst, Nirmala Ramanujam, Walter T. Lee, Gregory M. Palmer
Summary: Diffuse reflectance spectroscopy (DRS) is a powerful tool for quantifying optical and physiological tissue properties. In this clinical study, a pressure-sensing and automatic self-calibration DRS was assessed and validated in patients with head and neck squamous cell carcinoma (HNSCC). The results showed that cancerous tissues have a significantly lower hemoglobin saturation compared to normal tissues, suggesting tumor hypoxia. The study also demonstrated the feasibility of conducting optical spectroscopy measurements on intact lesions prior to removal during HNSCC procedures.
Meeting Abstract
Oncology
Tarek Haykal, Georgia Beasley, April Salama, Brent Hanks
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)