Article
Dentistry, Oral Surgery & Medicine
Z. Wang, F. Zhou, X. Feng, H. Li, C. Duan, Y. Wu, Y. Xiong
Summary: Periodontitis, a common chronic oral disease, is highly susceptible to aging. FoxO1, a transcription factor involved in body development and senescence, was found to play a role in halting the progression of age-related alveolar bone loss in mice. Further studies revealed that FoxO1 deficiency enhanced NLRP3 inflammasome signaling in osteoblasts, and inhibiting NLRP3 inflammasome rescued osteoblast differentiation under oxidative stress. These findings provide insights into the role of FoxO1 and suggest a potential mechanism for treating age-related alveolar bone loss.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Zhanqi Wang, Wenxin Luo, Guorui Zhang, Haiyun Li, Feng Zhou, Dongyang Wang, Xuan Feng, Yi Xiong, Yingying Wu
Summary: This study demonstrated that FoxO1 knockdown inhibits osteoclastogenesis by suppressing NF-kappa B signaling and NLRP3 inflammasome activation, providing a potential therapeutic target for periodontitis treatment. The findings suggest a mechanistic link between FoxO1 and osteoclast formation in periodontitis, indicating the importance of FoxO1 in mediating bone resorption in this condition.
Review
Physiology
Renfeng Xu, Zhengchao Wang
Summary: FoxO1, a member of the FoxO transcription factor family, plays a crucial role in the pathophysiology of PCOS. Studying the involvement of FoxO1 in PCOS could offer novel insights for establishing treatment strategies.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Kaixiang Xu, Wanyun Zhu, Anyong Xu, Zhe Xiong, Di Zou, Heng Zhao, Deling Jiao, Yubo Qing, Muhammad Ameen Jamal, Hong-Jiang Wei, Hong-Ye Zhao
Summary: This study elucidated the mechanism of paclitaxel (PTX) inducing autophagy in triple-negative breast cancer (TNBC) cells, providing a potential clinical chemotherapy strategy. It was found that PTX induced both apoptosis and autophagy in MDA-MB-231 cells, and inhibition of autophagy promoted apoptotic cell death. FOXO1 was identified as a transcription factor that enhanced PTX-induced autophagy by activating several downstream target genes. Knocking down FOXO1 attenuated the survival of MDA-MB-231 cells in response to PTX treatment. These findings may improve the treatment efficacy of PTX and contribute to the development of autophagic targeted therapy for TNBC.
MOLECULAR MEDICINE REPORTS
(2022)
Review
Pharmacology & Pharmacy
Usman Sabir, Hafiz Muhammad Irfan, Alamgeer, Ihtisham Umer, Zahid Rasul Niazi, Hafiz Muhammad Mazhar Asjad
Summary: Literature evidence suggests that natural compounds have the potential to improve obesity-associated non-alcoholic fatty liver disease (NAFLD) by targeting the forkhead box O1 (FOXO1) transcription factor. Certain phytochemicals, such as polyphenols, flavonoids, alkaloids, terpenoids, and anthocyanins, can modulate FOXO1 and its associated signaling pathways, making them potential therapeutic agents for NAFLD and related complications.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Subhransu S. Sahoo, Susmita G. Ramanand, Yunpeng Gao, Ahmed Abbas, Ashwani Kumar, Ileana C. Cuevas, Hao-Dong Li, Mitzi Aguilar, Chao Xing, Ram S. Mani, Diego H. Castrillon
Summary: FOXA2 gene has a higher mutation rate in aggressive variants of endometrial cancers (ECs). It controls endometrial epithelial gene expression programs regulating cell proliferation, adhesion, and endometrial-epithelial transition. The inactivation of both Foxa2 and PI3K signaling leads to lethal ECs with complete penetrance. FOXA2 plays a role in tumor suppression through modification of enhancer activity and regulates specific target genes.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Chemistry, Medicinal
Xiaojun Zhang, Lusheng Jiang, Huimin Liu
Summary: Forkhead box protein O1 (FoXO1) is a transcription factor involved in regulating various physiological processes, with dysfunction linked to the pathophysiology of multiple diseases. Different post-translational modifications can dynamically regulate FoXO1 activity and target gene transcription.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Cell Biology
Qian Zhong, Yixin Liu, Michele Ramos Correa, Crystal Nicole Marconett, Parviz Minoo, Changgong Li, David K. Ann, Beiyun Zhou, Zea Borok
Summary: NKX2.1 and FOXO1 have significant interactions in regulating specific gene expression and cell fate in the distal lung, with FOXO1 playing a central role in alveolar epithelial cell differentiation and maintaining homeostasis.
Article
Cell Biology
Jiantao Qiu, Huaiteng Xiao, Shunchang Zhou, Weimin Du, Xiang Mu, Guangjun Shi, Xueying Tan
Summary: This study demonstrates the inhibition of cardiomyocyte hypertrophy by BMSCs, partly through the AMPK-FoxO1 signaling pathway.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Immunology
Fei Shao, Zhen Liu, Qinglin Wei, Dou Yu, Min Zhao, Xusheng Zhang, Xintong Gao, Zusen Fan, Shuo Wang
Summary: This study reveals the association between neuro-immune regulation and intestinal homeostasis. FOXO1 coordinates the immune response of ILC3s through VIP and adrenergic signaling pathways, balancing their activation under steady conditions or during colitis independently of T cells. Chronic stress increases cAMP level and downregulates FOXO1 level in ILC3s, exacerbating intestinal inflammation.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Xiaoou Li, Jie Jin, Xuefeng Long, Ruiwen Weng, Wenqian Xiong, Jiaxin Liang, Junjun Liu, Jingwen Sun, Xueqin Cai, Ling Zhang, Yi Liu
Summary: The study found that the expression of m6A and METTL3 varied in different groups of women, including normal fertile women and those with endometriosis-related infertility. The research suggests that METTL3-regulated m6A plays a role in affecting cellular decidualization and embryo implantation.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Oncology
Yu Gyung Kim, Chaeeun Seong, Kyoung-Ah Cho, Sang Min Lee, Tae-Jun Kim, Hyeon Ji Kim, Jin-Hwa Cho, Won Jung, Sungil Jang, Jae-Cheon Shin, Kyung-Ha Lee, Jin-Seok Byun, Do-Yeon Kim
Summary: Oral squamous cell carcinoma (OSCC) is a tumor with a poor prognosis and a high recurrence rate. The study found that Forkhead transcriptional factor O1 (FoxO1) can act as both a tumor suppressor and an oncogene in OSCC. FoxO1 exerts an anti-tumor effect by suppressing proliferation and migration/invasion but promoting oxidative stress-linked cell death in OSCC cells.
Article
Endocrinology & Metabolism
Wenbing Liu, Fan Sun, Xiaodong Li, Xueyun Liu, Xiaowei Wang, Qiang Liu
Summary: This study found that in lipopolysaccharide (LPS)-induced acute lung injury, the ubiquitination mediated by tripartite motif containing 37 (TRIM37) regulated the involvement of forkhead transcription factor O1 (FOXO1) and degradation of proteins.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Orthopedics
I. Kurakazu, Y. Akasaki, H. Tsushima, T. Sueishi, M. Toya, M. Kuwahara, T. Uchida, M. K. Lotz, Y. Nakashima
Summary: FOXO1, a key regulator of autophagy, is promoted by TGF-β1 to protect chondrocytes against oxidative stress. Reduced ALK5 expression with aging may lead to decreased FOXO1 expression.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Multidisciplinary Sciences
Huanqing Gao, Liang Zhou, Yiming Zhong, Zhen Ding, Sixiong Lin, Xiaoting Hou, Xiaoqian Zhou, Jie Shao, Fan Yang, Xuenong Zou, Huiling Cao, Guozhi Xiao
Summary: Increased expression of Kindlin-2 in patients with nonalcoholic fatty liver disease (NAFLD) and obese mice. Haploinsufficiency of Kindlin-2 in hepatocytes ameliorates NAFLD, while overexpression exacerbates it, by modulating Foxo1 in hepatocytes.
NATURE COMMUNICATIONS
(2022)