Article
Oncology
Claudia Augusta Di Trani, Assunta Cirella, Leire Arrizabalaga, Angela Bella, Myriam Fernandez-Sendin, Joan Salvador Russo-Cabrera, Celia Gomar, Irene Olivera, Elizabeth Bolanos, Jose Gonzalez-Gomariz, Maite Alvarez, Inaki Etxeberria, Belen Palencia, Alvaro Teijeira, Ignacio Melero, Pedro Berraondo, Fernando Aranda
Summary: Previous studies have found that local delivery of tumor antigen-specific CD8(+) T lymphocytes transiently expressing single-chain IL-12 mRNA is highly effective in treating tumors. In this study, intracavitary adoptive T cell therapy was used to treat peritoneal dissemination of B16-OVA and PANC02-OVA tumors, and it was found that intraperitoneal administration of T cells promoted homing to the omentum more effectively than intravenous administration. Transient IL-12 expression resulted in a favorable reprogramming of the tumor immune microenvironment and longer persistence of transferred T lymphocytes, leading to the development of immunity to endogenous antigens after primary tumor eradication.
Article
Biochemistry & Molecular Biology
Jiahui Zhao, Rongjun He, Hao Zhong, Shizhu Liu, Muhammad Hussain, Peilong Sun
Summary: This study aimed to determine whether the combination of a cold-water extracted polysaccharide-protein complex from Grifolia frondosa (GFG) and cyclophosphamide (CTX) could inhibit tumor growth by suppressing the expression of angiogenesis-related proteins in H22 tumor-bearing mice. The results showed that GFG combined with CTX significantly inhibited H22 tumors and increased the expression levels of angiogenesis-related proteins. Additionally, GFG treatment improved immune function and reduced the side effects of CTX. Therefore, GFG and CTX combination therapy may be a promising strategy for hepatocellular carcinoma (HCC) treatment.
Article
Biology
Abida Parveen, Sultan Zahiruddin, Nidhi Agarwal, Muhammad Akhtar Siddiqui, Shahid Husain Ansari, Sayeed Ahmad
Summary: The herbal combination of TC, PE, and PN exhibited synergistic effects in inhibiting immune cells proliferation, suppressing pro-inflammatory mediators, and showing antioxidant activity. It improved immune markers, hematogram parameters, and histological parameters with maximum protection offered by an intermediate dose, suggesting its potential as a therapeutic approach for immune modulation.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Alexander A. Pieper, Alexander L. Rakhmilevich, Daniel Spiegelman, Ravi B. Patel, Jen Birstler, Won Jong Jin, Peter M. Carlson, Deborah H. Charych, Jacquelyn A. Hank, Amy K. Erbe, Willem W. Overwijk, Zachary S. Morris, Paul M. Sondel
Summary: The combination of local RT and BEMPEG showed a cooperative antitumor effect in multiple immunologically 'cold' tumor models, along with increased IL-2 receptor expression on peripheral T cells. Adding immune checkpoint blockade to RT+BEMPEG further strengthened the antitumor response in some models.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Medicine, Research & Experimental
Shaima Salman, David J. Meyers, Elizabeth E. Wicks, Sophia N. Lee, Emmanuel Datan, Aline M. Thomas, Nicole M. Anders, Yousang Hwang, Yajing Lyu, Yongkang Yang, Walter Jackson, Dominic Dordai, Michelle A. Rudek, Gregg L. Semenza
Summary: A low-molecular-weight compound called 32-134D has been found to effectively inhibit gene expression mediated by HIF-1 and HIF-2 in hepatocellular carcinoma (HCC) cells, and blocks tumor growth. When combined with anti-PD1 therapy in a mouse model, 32-134D increased the rate of tumor eradication from 25% to 67%. This compound alters gene expression related to the tumor immune microenvironment, leading to improved immune response against the tumor.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Sareh Kamran, Ajantha Sinniah, Zamri Chik, Mohammed Abdullah Alshawsh
Summary: The combination of 5-FU and diosmetin has a synergistic effect against colorectal cancer cells, reducing the toxicity of 5-FU while enhancing its anticancer efficacy. This combination induces apoptosis and interrupts cell mitosis to achieve its anticancer effects.
Article
Nanoscience & Nanotechnology
Yoel Negrin-Montecelo, Xiang-Tian Kong, Lucas V. Besteiro, Enrique Carbo-Argibay, Zhiming M. Wang, Moises Perez-Lorenzo, Alexander O. Govorov, Miguel Comesana-Hermo, Miguel A. Correa-Duarte
Summary: This study reports a synthetic strategy that combines two main physical mechanisms driving plasmon-induced photocatalysis into an engineered system. The results show that this strategy can significantly enhance the photocatalytic response of the material and open up new possibilities for energy-efficient applications.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Pharmacology & Pharmacy
Zhao Li, Tianshan She, Hao Yang, Tao Su, Qiuxiao Shi, Ze Tao, Yanru Feng, Fen Yang, Jingqiu Cheng, Xiaofeng Lu
Summary: The fusion of tumor-targeting RGR peptide to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) enhances its antitumor effect in colorectal cancer cells with high death receptor expression. Photodynamic therapy (PDT) can increase the sensitivity of CRC cells with low death receptor expression to RGR-TRAIL. Combination therapy of RGR-TRAIL and tumor-targeted PDT shows great potential for the clinical treatment of multidrug resistant colorectal cancer.
Review
Chemistry, Multidisciplinary
Shani L. Levit, Christina Tang
Summary: Treatment of ovarian cancer is challenging due to late diagnosis, drug resistance, and chemotherapy toxicity. Combination chemotherapy, delivery sequence, dosing schedule, and nanoparticle formulations can enhance treatment efficacy. Polymer nanoparticles show promise for clinical translation of combination therapies with tunable dosing schedules.
Article
Hematology
Marianne Delville, Florence Bellier, Juliette Leon, Roman Klifa, Sabrina Lizot, Helene Vincon, Steicy Sobrino, Romane Thouenon, Armance Marchal, Alexandrine Garrigue, Juliette Olivre, Soeli Charbonnier, Chantal Lagresle-Peyrou, Mario Amendola, Axel Schambach, David Gross, Baptiste Lamarthee, Christophe Benoist, Julien Zuber, Isabelle Andre, Marina Cavazzana, Emmanuelle Six
Summary: The IPEX syndrome is caused by mutations in the FOXP3 gene, leading to loss of Treg function and early development of autoimmune symptoms. Gene transfer of FOXP3 has shown promise in treating IPEX. Using an in vivo model with scurfy mice, researchers demonstrated the potential to rescue the disease after its onset, suggesting that FOXP3 expression can convert CD4(+) T cells into functional Tregs capable of controlling severe autoimmune disease.
Article
Biochemistry & Molecular Biology
Cheng-Hsiu Lin, Yueh-Hsiung Kuo, Chun-Ching Shih
Summary: Oil-Gan extract from Phyllanthus emblica L. has therapeutic and immunoregulatory effects on type 1 diabetes and non-obese diabetes in mice. It reduces blood glucose and HbA1c levels, increases insulin levels, decreases inflammatory cytokine expression, and protects pancreatic β cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Katarzyna Wegierek-Ciura, Jagoda Mierzejewska, Agnieszka Szczygiel, Joanna Rossowska, Anna Wroblewska, Marta Switalska, Tomasz M. Goszczynski, Bozena Szermer-Olearnik, Elzbieta Pajtasz-Piasecka
Summary: This study aimed to determine whether administering HES-MTX before immunotherapy with anti-IL-10R antibodies would change the effectiveness of dendritic cell vaccines that overproduce proinflammatory cytokines IL-12, IL-15, or IL-18. The results showed that using the HES-MTX nanoconjugate created optimal conditions for the effective action of these vaccines in a murine colon carcinoma model. The treatment schedule may be promising in anticancer therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Kathyayani Sridharan, Bhowmira Rathore, Md Yousuf, Hari Krishna Reddy Rachamalla, Sudhakar Jinka, Madhan Mohan Chandra Sekhar Jaggarapu, Rajkumar Banerjee
Summary: The modified hydrocortisone molecule combined with chemotherapy drugs to form vesicles showed enhanced cancer cell killing ability. The vesicles specifically inhibited colon cancer cells while increasing their sensitivity to the drug cargo. This approach holds promise for targeted inhibition of colon tumor progression.
MOLECULAR PHARMACEUTICS
(2021)
Article
Oncology
Ghanshyam Yadav, Dana M. Roque, Stefania Bellone, Diego D. Manavella, Tobias M. P. Hartwich, Margherita Zipponi, Justin Harold, Joan Tymon-Rosario, Levent Mutlu, Gary Altwerger, Gulden Menderes, Elena Ratner, Natalia Buza, Pei Hui, Gloria S. Huang, Vaagn Andikyan, Mitchell Clark, Masoud Azodi, Peter E. Schwartz, Ludmil B. Alexandrov, Alessandro D. Santin
Summary: The efficacy of neratinib and olaparib as single agents and in combination for uterine serous carcinoma (USC) was evaluated. Neratinib was more effective than olaparib in suppressing the growth of HER2/neu overexpressing USC cell lines. The combination of olaparib and neratinib showed a stronger inhibition of USC cell lines in vitro and suppressed tumor growth in vivo.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
L. Shi, J. Wen, W. Zhang, F-D Meng, Y. Wan, L. Wang, L. Zhang, H-Y Zhu
Summary: The combination therapy of IL-15 with Met showed significant inhibitory effects on Panc02 cell proliferation, promoting apoptosis and autophagy while suppressing Akt/mTOR/STAT3 signaling transduction, leading to synergistic anti-tumor efficacy in the Panc02-bearing mouse model.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Daiana L. Vitale, Ilaria Caon, Arianna Parnigoni, Ina Sevic, Fiorella M. Spinelli, Antonella Icardi, Alberto Passi, Davide Vigetti, Laura Alaniz
Summary: The study showed that UGDH plays a critical role in epirubicin response and hyaluronan metabolism in breast cancer cells, with higher expression associated with worse prognosis. Additionally, UGDH knockdown contributes to an increase in epirubicin resistance.
Article
Biochemistry & Molecular Biology
Catalina Atorrasagasti, Flavia Piccioni, Sophia Borowski, Irene Tirado-Gonzalez, Nancy Freitag, Maria Jose Cantero, Juan Bayo, Guillermo Mazzolini, Laura D. Alaniz, Sandra M. Blois, Mariana G. Garcia
Summary: Stress may contribute to liver fibrosis, and this study identified nerve growth factor as a crucial regulator in the stress-induced fibrogenesis signaling pathway. Blocking NGF can reduce liver fibrosis, while NGF treatment can accelerate the fibrotic process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Graciela Lujan Mazzone, Atiyeh Mohammadshirazi, Jorge Benjamin Aquino, Andrea Nistri, Giuliano Taccola
Summary: Correct operation of neuronal networks depends on the interplay between synaptic excitation and inhibition processes leading to a dynamic state termed balanced network. In the spinal cord, balanced network activity is fundamental for the expression of locomotor patterns necessary for rhythmic activation of limb extensor and flexor muscles. The role of GABA A receptors at synaptic and extrasynaptic level to modulate network excitability offers a pharmacological target for symptom control.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Luciana M. Gutierrez, Matias Valenzuela Alvarez, Yuanzheng Yang, Fiorella Spinelli, Maria Jose Cantero, Laura Alaniz, Mariana G. Garcia, Eugenie S. Kleinerman, Alejandro Correa, Marcela F. Bolontrade
Summary: Osteosarcoma metastatic cells gain in angiogenic-related pathways may relate more to a prosurvival switch than to an advantage feature for lung colonization. Despite higher adhesion and gain in angiogenesis pathways, metastatic cells do not display major angiogenic potential. Antiangiogenic treatments may affect cell survival rather than angiogenesis in OS cells with different metastatic potential.
Article
Developmental Biology
Jorge B. Aquino, Romina Sierra, Laura A. Montaldo
Summary: The origin and renewal of vascular endothelial cells primarily depend on local resident cells and endothelial progenitor cells. Research shows that some cells can generate endothelial-like cells, with mesenchymal stromal progenitors being a source. Different subpopulations of bone marrow stromal cells exhibit unexpected heterogeneity.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sofia Valla, Nourhan Hassan, Daiana Lujan Vitale, Daniela Madanes, Fiorella Mercedes Spinelli, Felipe C. O. B. Teixeira, Burkhard Greve, Nancy Adriana Espinoza-Sanchez, Carolina Cristina, Laura Alaniz, Martin Goette
Summary: The study focused on the impact of Sdc-1 knockdown and HA treatment on breast cancer cell behavior, showing differential effects on HA metabolism in luminal and triple-negative breast cancer model cell lines. Sdc-1 depletion influenced cell survival, stem phenotype, and angiogenic factors through altered gene expression and signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jaspreet Kaur, Graciela L. Mazzone, Jorge B. Aquino, Andrea Nistri
Summary: The study found that high dose nicotine was neurotoxic to central and ventral spinal neurons, while low dose nicotine protected neurons and activated the Wnt1 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Maria Belen Delsouc, Rocio Ayelem Conforti, Daiana Lujan Vitale, Laura Alaniz, Pablo Pacheco, Sebastian Andujar, Sandra Silvina Vallcaneras, Marilina Casais
Summary: In this study, the chelation of copper with ammonium tetrathiomolybdate (TM) was evaluated in an experimental endometriosis model, showing that TM treatment decreased copper and estradiol levels, inhibited cell proliferation and angiogenesis in endometriotic-like lesions, and modulated oxidative stress imbalance. The findings suggest that TM is a highly effective antiproliferative and antiangiogenic agent with potential as a non-hormonal treatment for endometriosis.
Review
Oncology
Daiana L. Vitale, Antonella Icardi, Paolo Rosales, Fiorella M. Spinelli, Ina Sevic, Laura D. Alaniz
Summary: 4-Methylumbelliferone (4-MU), a natural product with antitumoral properties, inhibits tumor growth and progression by specifically inhibiting hyaluronan synthesis. It also impacts tumor cell functions, cancer stem cells, and the tumor microenvironment. However, more scientific evidence is needed to support its use in cancer therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fiorella M. Spinelli, Paolo Rosales, Stefano Pluda, Daiana L. Vitale, Antonella Icardi, Cristian Guarise, Andrea Reszegi, Ilona Kovalszky, Mariana Garcia, Ina Sevic, Devis Galesso, Laura Alaniz
Summary: sHA can regulate anti-angiogenic effects on tumor cells and monocytes/macrophages in the context of breast and lung cancer, including by modulating endothelial migration, angiogenic factors, and vessel formation.
Article
Developmental Biology
Antonella S. Rios, Ana Paula De Vincenti, Mailin Casadei, Jorge B. Aquino, Pablo R. Brumovsky, Gustavo Paratcha, Fernanda Ledda
Summary: The transcription factor Etv4 plays a crucial role in the development and function of peptidergic sensory neurons. It is regulated by NGF and is involved in the expression of genes associated with extracellular matrix remodeling. Etv4-null mice show reduced sensitivity to noxious stimuli and a decrease in the expression of the pain-transducing ion channel TRPV1.
Review
Neurosciences
Maximiliano Borda, Jorge B. Aquino, Graciela L. Mazzone
Summary: This review article discusses therapeutic strategies for inducing myelin repair and improving multiple sclerosis (MS), including the application of different cell types and new strategies combining cell-based treatment with other applications. The treatments using different cell sources yielded different results in experimental models and have their own advantages and disadvantages.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Editorial Material
Pharmacology & Pharmacy
Cecilia Veronica Nunez, Marne Carvalho de Vasconcellos, Laura Alaniz
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Carla Noemi Olivares, Analia Gabriela Ricci, Mariela Andrea Bilotas, Laura Alaniz, Rosa Ines Baranao, Gabriela Fabiana Meresman
Summary: This study aims to evaluate the effect of 4MU on the development of endometriosis. The results showed that early treatment with 4MU significantly reduced the percentage of developed lesions. In vitro experiments demonstrated that 4MU treatment inhibited cell viability and migration.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Ana Paula Giannoni, Ina Sevic, Fernanda Parenti, Laura Alaniz
Summary: Colorectal cancer is a common cancer with a hereditary basis, and Lynch syndrome is the most common cause of hereditary colorectal cancer. Mutations in mismatch repair (MMR) genes lead to microsatellite instability. Early detection of the mutation helps assess cancer risk and guide clinical management. In this report, a new mutation (c.1458dup (p.Glu487*)) is described in a 53-year-old colorectal cancer patient with Lynch syndrome, and the presence of lipomas in the patient and family may be related to the syndrome. Further investigation may identify visual clues for genetic screening.
CLINICS AND PRACTICE
(2023)