Targeting the Tumor Extracellular Matrix by the Natural Molecule 4-Methylumbelliferone: A Complementary and Alternative Cancer Therapeutic Strategy
出版年份 2021 全文链接
标题
Targeting the Tumor Extracellular Matrix by the Natural Molecule 4-Methylumbelliferone: A Complementary and Alternative Cancer Therapeutic Strategy
作者
关键词
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出版物
Frontiers in Oncology
Volume 11, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2021-10-04
DOI
10.3389/fonc.2021.710061
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- A Guide to the Composition and Functions of the Extracellular Matrix
- (2021) Nikos K. Karamanos et al. FEBS Journal
- Screening of metabolic modulators identifies new strategies to target metabolic reprogramming in melanoma
- (2021) Cecilie Abildgaard et al. Scientific Reports
- Initial Identification of UDP-Glucose Dehydrogenase as a Prognostic Marker in Breast Cancer Patients, Which Facilitates Epirubicin Resistance and Regulates Hyaluronan Synthesis in MDA-MB-231 Cells
- (2021) Daiana L. Vitale et al. Biomolecules
- Interfering with hyaluronic acid metabolism suppresses glioma cell proliferation by regulating autophagy
- (2021) Tao Yan et al. Cell Death & Disease
- 4-methylumbelliferone-mediated polarization of M1 macrophages correlate with decreased hepatocellular carcinoma aggressiveness in mice
- (2021) Marcelo M. Rodríguez et al. Scientific Reports
- 4-Methylumbelliferone administration enhances radiosensitivity of human fibrosarcoma by intercellular communication
- (2021) Ryo Saga et al. Scientific Reports
- New insights into M1/M2 macrophages: key modulators in cancer progression
- (2021) Jiuyang Liu et al. Cancer Cell International
- Advances in non-invasive assessment of hepatic fibrosis
- (2020) Rohit Loomba et al. GUT
- 4‑methylumbelliferone inhibits clonogenic potency by suppressing high molecular weight‑hyaluronan in fibrosarcoma cells
- (2020) Kazuki Hasegawa et al. Oncology Letters
- Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019
- (2020) David J. Newman et al. JOURNAL OF NATURAL PRODUCTS
- Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties
- (2020) Masaki Takasugi et al. Nature Communications
- Targeted and immunotherapies in BRAF mutant melanoma – where we are standing and what to expect
- (2020) X. Bai et al. BRITISH JOURNAL OF DERMATOLOGY
- Antiproliferative Effect of 4-Methylumbelliferone in Epithelial Ovarian Cancer Cells Is Mediated by Disruption of Intracellular Homeostasis and Regulation of PI3K/AKT and MAPK Signaling
- (2020) Garam An et al. Pharmaceutics
- Drug repurposing approach to fight COVID-19
- (2020) Thakur Uttam Singh et al. Pharmacological Reports
- Increase of Tumor Infiltrating γδ T-cells in Pancreatic Ductal Adenocarcinoma Through Remodeling of the Extracellular Matrix by a Hyaluronan Synthesis Suppressor, 4-Methylumbelliferone
- (2019) Akiko Suto et al. PANCREAS
- Regulation of radiosensitivity by 4‑methylumbelliferone via the suppression of interleukin‑1 in fibrosarcoma cells
- (2019) Ryo Saga et al. Oncology Letters
- 4-Methylumbelliferyl glucuronide contributes to hyaluronan synthesis inhibition
- (2019) Nadine Nagy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hyaluronan preconditioning of monocytes/macrophages affects their angiogenic behavior and regulation of TSG ‐6 expression in a tumor type‐specific manner
- (2019) Fiorella M. Spinelli et al. FEBS Journal
- Translational role of natural coumarins and their derivatives as anticancer agents
- (2019) José CJMDS Menezes et al. Future Medicinal Chemistry
- 4-Methylumbelliferone Inhibits Cancer Stem Cell Activation and Overcomes Chemoresistance in Ovarian Cancer
- (2019) Noor A. Lokman et al. Cancers
- 4-methylumbelliferone Prevents Liver Fibrosis by Affecting Hyaluronan Deposition, FSTL1 Expression and Cell Localization
- (2019) Irina N. Andreichenko et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Chronic myeloid leukemia: 2018 update on diagnosis, therapy and monitoring
- (2018) Elias Jabbour et al. AMERICAN JOURNAL OF HEMATOLOGY
- In vitro elucidation of the role of pericellular matrix in metastatic extravasation and invasion of breast carcinoma cells
- (2018) Marie-Elena Brett et al. Integrative Biology
- Resistance to Anti-Angiogenic Therapy in Cancer—Alterations to Anti-VEGF Pathway
- (2018) Yoshiro Itatani et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors
- (2018) Theodoros T. Karalis et al. MATRIX BIOLOGY
- 4-Methylumbelliferone inhibits enhanced hyaluronan synthesis and cell migration in pancreatic cancer cells in response to tumor-stromal interactions
- (2018) Xiao‑Bo Cheng et al. Oncology Letters
- 4Mu decreases CD47 expression on hepatic cancer stem cells and primes a potent antitumor T-cell response induced by interleukin-12
- (2018) Marcelo M. Rodríguez et al. MOLECULAR THERAPY
- 4-Methylumbelliferone Decreases the Hyaluronan-rich Extracellular Matrix and Increases the Effectiveness of 5-Fluorouracil
- (2018) ERI YOSHIDA et al. ANTICANCER RESEARCH
- Co-treatment of tumor cells with hyaluronan plus doxorubicin affects endothelial cell behavior independently of VEGF expression
- (2018) Daiana L. Vitale et al. Oncotarget
- Suppression of hyaluronan synthesis attenuates the tumorigenicity of low-grade chondrosarcoma
- (2017) Shunsuke Hamada et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- 4-Methylumbelliferone Suppresses Hyaluronan Synthesis and Tumor Progression in SCID Mice Intra-abdominally Inoculated With Pancreatic Cancer Cells
- (2017) Hayato Nagase et al. PANCREAS
- Drug repurposing in cancer
- (2017) Linda Sleire et al. PHARMACOLOGICAL RESEARCH
- Interstitial Pressure in Pancreatic Ductal Adenocarcinoma Is Dominated by a Gel-Fluid Phase
- (2016) Christopher C. DuFort et al. BIOPHYSICAL JOURNAL
- The pharmacokinetics and dosing of oral 4-methylumbelliferone for inhibition of hyaluronan synthesis in mice
- (2016) H. F. Kuipers et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Inhibition of hyaluronic acid formation sensitizes chronic myelogenous leukemia to treatment with doxorubicin
- (2016) Olga N Uchakina et al. GLYCOBIOLOGY
- 4-Methylumbelliferone Diminishes Catabolically Activated Articular Chondrocytes and Cartilage Explants via a Mechanism Independent of Hyaluronan Inhibition
- (2016) Shinya Ishizuka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Relation between hyaluronan synthesis and cell morphology in ovarian clear cell carcinomas
- (2016) Noriko Kato et al. PATHOLOGY INTERNATIONAL
- Inhibition of Hyaluronic Acid Synthesis Suppresses Angiogenesis in Developing Endometriotic Lesions
- (2016) Carla N. Olivares et al. PLoS One
- Anti-tumor and anti-invasion effects of a combination of 4-methylumbelliferone and ionizing radiation in human fibrosarcoma cells
- (2016) Ryo Saga et al. Oncology Letters
- Antitumor effects of the hyaluronan inhibitor 4-methylumbelliferone on pancreatic cancer
- (2016) Eri Yoshida et al. Oncology Letters
- Spitting out the demons: Extracellular vesicles in glioblastoma
- (2016) Gwennan André-Grégoire et al. Cell Adhesion & Migration
- Targeting hyaluronan for the treatment of pancreatic ductal adenocarcinoma
- (2016) Norihiro Sato et al. Acta Pharmaceutica Sinica B
- 4-Methylumbelliferone inhibits hepatocellular carcinoma growth by decreasing IL-6 production and angiogenesis
- (2015) Flavia Piccioni et al. GLYCOBIOLOGY
- Dietary Supplement 4-Methylumbelliferone: An Effective Chemopreventive and Therapeutic Agent for Prostate Cancer
- (2015) Travis J. Yates et al. JNCI-Journal of the National Cancer Institute
- Tumor Microenvironment Remodeling by 4-Methylumbelliferone Boosts the Antitumor Effect of Combined Immunotherapy in Murine Colorectal Carcinoma
- (2015) Mariana Malvicini et al. MOLECULAR THERAPY
- Dietary Supplement 4-Methylumbelliferone: An Effective Chemopreventive and Therapeutic Agent for Prostate Cancer
- (2015) Travis J. Yates et al. JNCI-Journal of the National Cancer Institute
- 4-Methylumbelliferone Treatment and Hyaluronan Inhibition as a Therapeutic Strategy in Inflammation, Autoimmunity, and Cancer
- (2015) Nadine Nagy et al. Frontiers in Immunology
- Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene
- (2015) Arnaldur Hall et al. Oncotarget
- Releasing Pressure in Tumors: What Do We Know So Far and Where Do We Go from Here? A Review
- (2014) A. B. Ariffin et al. CANCER RESEARCH
- Molecular Pathways: BRAF Induces Bioenergetic Adaptation by Attenuating Oxidative Phosphorylation
- (2014) R. Haq et al. CLINICAL CANCER RESEARCH
- Inhibition of Hyaluronan Synthesis Protects against Central Nervous System (CNS) Autoimmunity and Increases CXCL12 Expression in the Inflamed CNS
- (2014) Andre Michael Mueller et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CD44-Mediated Adhesion to Hyaluronic Acid Contributes to Mechanosensing and Invasive Motility
- (2014) Yushan Kim et al. MOLECULAR CANCER RESEARCH
- 4-Methylumbelliferone inhibits ovarian cancer growth by suppressing thymidine phosphorylase expression
- (2014) Ryosuke Tamura et al. Journal of Ovarian Research
- FAK and HAS Inhibition Synergistically Decrease Colon Cancer Cell Viability and Affect Expression of Critical Genes
- (2013) Melissa Heffler et al. Anti-Cancer Agents in Medicinal Chemistry
- Hyaluronan, fluid pressure and stromal resistance in pancreas cancer
- (2013) P P Provenzano et al. BRITISH JOURNAL OF CANCER
- PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress
- (2013) Francisca Vazquez et al. CANCER CELL
- Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF
- (2013) Rizwan Haq et al. CANCER CELL
- Human leukemic cell lines synthesize hyaluronan to avoid senescence and resist chemotherapy
- (2013) S. L. Lompardia et al. GLYCOBIOLOGY
- 4-Methylumbelliferone Inhibits Angiogenesis in Vitro and in Vivo
- (2013) Javier A. García-Vilas et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers
- (2013) Rakesh K. Jain JOURNAL OF CLINICAL ONCOLOGY
- Cutaneous melanoma
- (2013) Alexander MM Eggermont et al. LANCET
- Targeting hyaluronic acid production for the treatment of leukemia: Treatment with 4-methylumbelliferone leads to induction of MAPK-mediated apoptosis in K562 leukemia
- (2013) Olga N. Uchakina et al. LEUKEMIA RESEARCH
- Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma
- (2012) Paolo P. Provenzano et al. CANCER CELL
- Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
- (2012) Michael A Jacobetz et al. GUT
- Inhibition of Hyaluronan Synthesis Reduces Versican and Fibronectin Levels in Trabecular Meshwork Cells
- (2012) Kate E. Keller et al. PLoS One
- Restoration of chemosensitivity for doxorubicin and cisplatin in chondrosarcoma in vitro: BCL-2 family members cause chemoresistance
- (2011) J. G. van Oosterwijk et al. ANNALS OF ONCOLOGY
- Inhibition of hyaluronan retention by 4-methylumbelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo
- (2011) E Arai et al. BRITISH JOURNAL OF CANCER
- Hyaluronan Synthase HAS2 Promotes Tumor Progression in Bone by Stimulating the Interaction of Breast Cancer Stem-Like Cells with Macrophages and Stromal Cells
- (2011) H. Okuda et al. CANCER RESEARCH
- Synthesis and antimicrobial properties of some new thiazolyl coumarin derivatives
- (2011) Afsheen Arshad et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Antitumor effects of hyaluronic acid inhibitor 4-methylumbelliferone in an orthotopic hepatocellular carcinoma model in mice
- (2011) F. Piccioni et al. GLYCOBIOLOGY
- Inhibition of hyaluronan synthesis in breast cancer cells by 4-methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo
- (2011) Hiroshi Urakawa et al. INTERNATIONAL JOURNAL OF CANCER
- The Matrisome:In SilicoDefinition andIn VivoCharacterization by Proteomics of Normal and Tumor Extracellular Matrices
- (2011) Alexandra Naba et al. MOLECULAR & CELLULAR PROTEOMICS
- Hyaluronan as an Immune Regulator in Human Diseases
- (2011) Dianhua Jiang et al. PHYSIOLOGICAL REVIEWS
- Synthesis, anticoagulant and PIVKA-II induced by new 4-hydroxycoumarin derivatives
- (2010) Omaima M. Abdelhafez et al. BIOORGANIC & MEDICINAL CHEMISTRY
- 4-Methylumbelliferone inhibits tumour cell growth and the activation of stromal hyaluronan synthesis by melanoma cell-derived factors
- (2010) M. Edward et al. BRITISH JOURNAL OF DERMATOLOGY
- Antitumor Activity of Hyaluronic Acid Synthesis Inhibitor 4-Methylumbelliferone in Prostate Cancer Cells
- (2010) Vinata B. Lokeshwar et al. CANCER RESEARCH
- Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and Tumor Neovascularization
- (2010) N. Kobayashi et al. CANCER RESEARCH
- Inhibition of Hyaluronan Synthesis Accelerates Murine Atherosclerosis
- (2010) Nadine Nagy et al. CIRCULATION
- Down-regulation of UDP-glucose dehydrogenase affects glycosaminoglycans synthesis and motility in HCT-8 colorectal carcinoma cells
- (2010) Tsung-Pao Wang et al. EXPERIMENTAL CELL RESEARCH
- Hyaluronan in human malignancies
- (2010) R.K. Sironen et al. EXPERIMENTAL CELL RESEARCH
- Hyaluronan-CD44 Interactions in Cancer: Paradoxes and Possibilities
- (2009) B. P. Toole CLINICAL CANCER RESEARCH
- A synthetic coumarin (4-Methyl-7 hydroxy coumarin) has anti-cancer potentials against DMBA-induced skin cancer in mice
- (2009) Soumya S. Bhattacharyya et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- 4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3
- (2009) Anne Kultti et al. EXPERIMENTAL CELL RESEARCH
- Modulation of hyaluronan production by CD44 positive glioma cells
- (2009) Marzenna Wiranowska et al. INTERNATIONAL JOURNAL OF CANCER
- Molecular signatures suggest a major role for stromal cells in development of invasive breast cancer
- (2008) Theresa Casey et al. BREAST CANCER RESEARCH AND TREATMENT
- Hyaluronan receptors involved in cytokine induction in monocytes
- (2008) H. Yamawaki et al. GLYCOBIOLOGY
- Pericellular Matrix Formation Alters the Efficiency of Intracellular Uptake of Oligonucleotides in Osteosarcoma Cells
- (2008) Yoshitaka Suzuki et al. JOURNAL OF SURGICAL RESEARCH
- The Clinical Approach Towards Chondrosarcoma
- (2008) H. Gelderblom et al. ONCOLOGIST
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