Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites

Novel and High Affinity Fluorescent Ligands for the Serotonin Transporter Based on (S)-Citalopram

(2014) Vivek Kumar et al.   ACS Medicinal Chemistry Letters

X-ray structure of dopamine transporter elucidates antidepressant mechanism

(2013) Aravind Penmatsa et al.   NATURE

Steric Hindrance Mutagenesis in the Conserved Extracellular Vestibule Impedes Allosteric Binding of Antidepressants to the Serotonin Transporter

(2012) Per Plenge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context

(2012) Hui Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Experimental conditions can obscure the second high-affinity site in LeuT

(2012) Matthias Quick et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Probing Binding Pocket of Serotonin Transporter by Single Molecular Force Spectroscopy on Living Cells

(2011) Linda Wildling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue

(2011) Yongfang Zhao et al.   NATURE

SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

(2011) A. S. Kristensen et al.   PHARMACOLOGICAL REVIEWS

Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters

(2011) J. Andersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The High-Affinity Binding Site for Tricyclic Antidepressants Resides in the Outer Vestibule of the Serotonin Transporter

(2010) S. Sarker et al.   MOLECULAR PHARMACOLOGY

Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site

(2010) Chayne L. Piscitelli et al.   NATURE

Binding and Orientation of Tricyclic Antidepressants within the Central Substrate Site of the Human Serotonin Transporter

(2009) Steffen Sinning et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: Kinetic binding studies with the ALI/VFL–SI/TT mutant

(2009) Huailing Zhong et al.   NEUROSCIENCE LETTERS

The Mechanism of a Neurotransmitter:Sodium Symporter—Inward Release of Na+ and Substrate Is Triggered by Substrate in a Second Binding Site

(2008) Lei Shi et al.   MOLECULAR CELL