Article
Rheumatology
Sara S. McCoy, Maxwell Parker, Ilya Gurevic, Rahul Das, Andrea Pennati, Jacques Galipeau
Summary: This study aimed to investigate the immunobiology of IFN-γ-exposed SG-MSCs and the role of the JAK1 and 2 inhibitor, ruxolitinib. The results showed that ruxolitinib inhibits the expression of SG-MSC immunomodulatory markers and chemokines induced by IFN-γ, and reverses IFN-γ-induced CD4(+) T cell chemotaxis. In addition, SG-MSCs were identified as a possible pathogenic cell type in Sjögren's disease due to the higher levels of IFN-γ. These findings support further research on the use of ruxolitinib to treat Sjögren's disease.
Review
Rheumatology
Mitsuhiro Akiyama, Waleed Alshehri, Keiko Yoshimoto, Yuko Kaneko
Summary: Recent technological progress has advanced our understanding of human immunology through the discovery of T follicular helper (Tfh) and T peripheral helper (Tph) cells. These cells play critical roles in B cell differentiation and maturation, with differences in their functional properties. In various rheumatic and musculoskeletal diseases, the contribution of Tfh and Tph cells varies, with Tph cells predominating in peripheral inflammatory lesions and Tfh cells predominating in affected lesions of IgG4-related disease. This review provides an overview of these novel T cell subsets and their involvement in these diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Fisheries
Alehegne Yirsaw, Cynthia L. Baldwin
Summary: Goats are significant food animals with high adaptability. Infectious diseases can impact their productivity, while gamma delta T cells play important roles in immune responses. These cells respond to various infections and may have altered representation and function due to infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Editorial Material
Immunology
David A. C. Elliman, Andrew R. Gennery
Summary: SCID is a severe primary immunodeficiency disease that presents in infancy, characterized by recurrent infections, progressive pneumonia, and failure to thrive. Newborn bloodspot screening can detect T lymphocyte receptor excision circles, which is crucial for early detection of SCID.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Immunology
Ella Bhagyaraj, Hongbin Wang, Xinghong Yang, Carol Hoffman, Ali Akgul, Zakia Goodwin, David W. Pascual
Summary: znBAZ infection induces an increase and activation of lung NK cells in mice, which play a crucial role in promoting lung DC activation, migration, and the development of protective CD8(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Tingmei Feng, Yan Chen, Jinmei Wei, Sen Tan, Guangnan Liu
Summary: Traumatic tracheal stenosis (TS) is caused by a systemic and local inflammatory immune imbalance. This study found that CD4(+) T lymphocytes are the predominant immune cells in TS and can be actively recruited by CCR4/CCL22 and CCR8/CCL1. CD4(+) T cells in untreated patients showed higher levels of TGF-β1 and increased expression of CCL22 and CCL1 compared to treated patients. In vitro experiments confirmed that blocking CCL1 and CCL22 can partially inhibit the chemoattractant effect of TS bronchoalveolar lavage (BAL) on CD4(+) T cells.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Microbiology
Chen Yuan, Lidan Sun, Ligong Chen, Haiyong Guo, Zuojun Yao, Yawen Wang, Weixia Zhu, Tanqing Li, Qinye Song, Huanrong Li
Summary: Porcine epidemic diarrhea virus (PEDV) is a re-emerging pathogen that causes severe economic loss in the pig industry. This study analyzed the expression and chemotactic effect of chemokines on key immune cells in PEDV infection using cDNA microarray and FACS analysis. The results suggest that chemokines play a role in immune cell migration during PEDV infection and provide a theoretical basis for studying the mechanism of anti-PEDV infection in piglets.
VETERINARY MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mie Kurosawa, Yosuke Shikama, Masae Furukawa, Rieko Arakaki, Naozumi Ishimaru, Kenji Matsushita
Summary: Immunosenescence and cellular senescence's role in the pathogenesis of sialadenitis remains unclear, but recent studies have shown elevated expression of chemokine CXCL13 in salivary glands of aged mice, as well as the involvement of senescence-associated T cells (SA-Ts) in inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Claudia Curci, Angela Picerno, Nada Chaoul, Alessandra Stasi, Giuseppe De Palma, Rossana Franzin, Paola Pontrelli, Giuseppe Castellano, Giovanni B. Pertosa, Luigi Macchia, Vito Francesco Di Lorenzo, Carlo Sabba, Anna Gallone, Loreto Gesualdo, Fabio Sallustio
Summary: Studies have shown that Adult Renal Stem/Progenitor Cells (ARPCs) can regulate immune responses by inducing Tregs and DN T cell modulation, which play a crucial role in maintaining immune tolerance and preventing autoimmunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Anna Maria Malfitano, Vittoria D'Esposito, Pietro De Placido, Marianna Tortora, Margaret Ottaviano, Erica Pietroluongo, Rocco Morra, Brigitta Mucci, Fabiana Napolitano, Liliana Montella, Mario Giuliano, Sabino De Placido, Daniela Terracciano, Giovannella Palmieri, Pietro Formisano
Summary: This study investigated the differences between thymic epithelial tumor (TET) patients with associated autoimmune diseases (AD) and those without AD. We found significant differences in the lymphocyte profiles, particularly a reduction in the numbers of B lymphocytes and T-regulatory cells, as well as differences in the serum levels of immune modulators.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Yuxiang Xu, Yongjie Li, Changqing Wang, Tingting Han, Haixuan Liu, Lin Sun, Jun Hong, Makoto Hashimoto, Jianshe Wei
Summary: In Parkinson's disease, neurotoxic microglia, Th1 cells, and Th17 cells are excessively activated, leading to the pathological development of pro-inflammatory molecules and the loss of dopaminergic neurons. The interactions between microglia and T cells, along with the production of cytokines and chemokines, play a crucial role in the progression of the disease. This review highlights potential targets and models for studying PD neuroinflammation, providing new directions for future research.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Oncology
Laia Gorchs, Marlies Oosthoek, Tulay Yucel-Lindberg, Carlos Fernandez Moro, Helen Kaipe
Summary: The infiltration of T cells in pancreatic tumors is associated with better overall survival. However, cancer-associated fibroblasts (CAFs) in the tumor microenvironment can prevent T cells from reaching the tumor nests. This study investigated how CAFs modulate chemokine receptors on T cells and the spatial distribution of T cells within tumors. It was found that CXCR3 ligands were associated with increased T cell numbers in tumor-rich areas, and CAFs downregulated the expression of CXCR3 on T cells. Understanding these mechanisms is crucial for developing targeted therapies.
Review
Immunology
Jang Hyun Park, In Kang, Heung Kyu Lee
Summary: gamma delta T cells, expressing gamma delta T cell receptor instead of alpha beta T cell receptor, play critical roles in multiple physiological systems and diseases. They are preferentially located at mucosal surfaces, such as the gut, and can also be found in the meninges in the central nervous system. Recent findings suggest their importance in brain function, homeostasis, and regulating inflammatory responses, particularly in neurodegenerative diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Quentin Le Hingrat, Irini Sereti, Alan L. Landay, Ivona Pandrea, Cristian Apetrei
Summary: CD4(+) T-cell depletion is a key feature of AIDS in both HIV and SIV infections, occurring early and being most significant at mucosal sites. The clinical outcome is associated with mucosal CD4(+) T-cell recovery during chronic infection, while immune activation and inflammation play critical roles in CD4(+) T-cell depletion.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Fouzia Naheed, Rabia Mumtaz, Sana Shabbir, Arshad Jamil, Akhtar Rasool Asif, Abdur Rahman, Hafiz Ishfaq Ahmad, Muhammad Essa, Hammad Akhtar, Samy F. Mahmoud, Fatimah Othman Alghamdi, Hala Abdulrahman Al Amari, Jinping Chen
Summary: Our study analyzed the evolutionary patterns and genetic changes of CXCR4 protein in various mammalian species, revealing its important role in immune system function and disease processes. We also examined the three-dimensional structure and interactions of CXCR4, providing insights into the development of treatments or prevention strategies for emerging and re-emerging diseases. These findings highlight the potential of CXCR4 as a therapeutic target in human and animal health.
Article
Economics
Laia Alsina, J. Bruno Montoro, Pedro Moral Moral, Olaf Neth, Marta Ortiz Pica, Silvia Sanchez-Ramon, Maria Presa, Itziar Oyaguez, Miguel Angel Casado, Luis Ignacio Gonzalez-Granado
Summary: A cost-minimization model compared the costs of IVIG and SCIG for patients with PID in Spain, revealing that SCIG was associated with lower total costs. The main cost-saving factors for SCIG included differences in annual IG dosage costs and reduced hospital administration costs.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2022)
Article
Genetics & Heredity
Leire Solis, Julia Nordin, Johan Prevot, Nizar Mahlaoui, Silvia Sanchez-Ramon, Adli Ali, Elodie Cassignol, John W. Seymour, Martine Pergent
Summary: This article introduces the development of the Principles of Care for Primary Immunodeficiencies (PIDs) and the PID Life Index. The PID principles set a common goal to ensure appropriate care and good quality of life for PID patients, while the PID Life Index assesses the status and implementation of these principles worldwide.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Immunology
Miriam Simon-Fuentes, Silvia Sanchez-Ramon, Lidia Fernandez-Paredes, Barbara Alonso, Kissy Guevara-Hoyer, Miguel A. Vega, Angel L. Corbi, Angeles Dominguez-Soto
Summary: Common variable immunodeficiency disorders (CVID) is a primary immune deficiency characterized by hypogammaglobulinemia and impaired antibody responses. Intravenous Immunoglobulin (IVIg), a preparation of highly purified poly-specific IgG, exerts immunoregulatory and anti-inflammatory actions on peripheral blood monocytes, leading to an acquisition of an anti-inflammatory gene profile and altered proportions of monocyte subsets. CD14+ MDSC-like cells may contribute to the immunoregulatory effects of IVIg in CVID and other inflammatory disorders.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Kissy Guevara-Hoyer, Jesus Fuentes-Antras, Eduardo de la Fuente-munoz, Miguel Fernandez-Arquero, Fernando Solano, Pedro Perez-Segura, Esmeralda Neves, Alberto Ocana, Rebeca Perez de Diego, Silvia Sanchez-Ramon
Summary: This study aims to explore the shared genomic basis between common variable immunodeficiency (CVID) and non-Hodgkin's lymphoma (NHL), in order to better understand the immunodeficiency phenotype of CVID in NHL. The study found that NHL samples harbored genetic variants associated with CVID, indicating the existence of shared pathological mechanisms and signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Mark Ballow, Silvia Sanchez-Ramon, Jolan E. Walter
Summary: Primary immunodeficiencies (PIDs) are genetic immune errors determined at birth, while secondary immunodeficiencies (SIDs) are acquired diseases with decreased immune cell counts. Distinguishing between primary and secondary antibody deficiencies is crucial in the era of immune-modulating biologicals. This article explores the crossovers between SIDs and PIDs, and discusses the challenges in diagnosis and treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Eduardo de la Fuente-munoz, Ana van den Rym, Blanca Garcia-Solis, Juliana Ochoa Grullon, Kissy Guevara-Hoyer, Miguel Fernandez-Arquero, Lucia Galan Davila, Jorge Matias-Guiu, Silvia Sanchez-Ramon, Rebeca Perez de Diego
Summary: This study describes a patient with tubular aggregate myopathy and Stormorken syndrome (TAM/STRMK) caused by a novel STIM1 mutation. In addition to typical TAM/STRMK manifestations, the patient also exhibited immunological involvement with respiratory infections, chronic cough, and chronic bronchiectasis. Dysregulation of calcium signaling in immune cells may contribute to the immune involvement observed in this patient.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Juliana Ochoa-Grullon, Kissy Guevara-Hoyer, Cristina Perez Lopez, Rebeca Perez de Diego, Ascension Pena Cortijo, Marta Polo, Marta Mateo Morales, Eduardo Anguita Mandley, Carlos Jimenez Garcia, Estefania Bolanos, Belen Inigo, Fiorella Medina, Antonia Rodriguez de la Pena, Carmen Izquierdo Delgado, Eduardo de la Fuente Munoz, Elsa Mayol, Miguel Fernandez-Arquero, Ataulfo Gonzalez-Fernandez, Celina Benavente Cuesta, Silvia Sanchez-Ramon
Summary: B-cell chronic lymphoproliferative diseases (B-CLPD) are associated with immune deficiencies, resulting in increased risk of severe infections and earlier cancer progression. This study also suggests that some patients with B-CLPD may have underlying primary immunodeficiencies.
Article
Immunology
Alejandra Comins-Boo, Lorena Valdeolivas, Fernando Perez-Pla, Ignacio Cristobal, Nabil Subhi-Issa, Angeles Dominguez-Soto, Lydia Pilar-Suarez, Pilar Gasca-Escorial, Marta Calvo-Urrutia, Miguel Fernandez-Arquero, Miguel Angel Herraiz, Angel Corbi, Silvia Sanchez-Ramon
Summary: This study aimed to evaluate the role of monocyte subsets and cytokines in RPL and RIF women. The study found that CX3CR1+ and CCR5+ intermediate monocytes were significantly higher in RPL and RIF, and there was a significant positive correlation between CX3CR1+ intermediate monocytes and IL-17A. The combination of specific monocyte subsets and cytokines could aid in identifying RPL and RIF women with a pro-inflammatory profile.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Oncology
Javier David Benitez Fuentes, Kauzar Mohamed Mohamed, Alicia de Luna Aguilar, Carlos Jimenez Garcia, Kissy Guevara-Hoyer, Miguel Fernandez-Arquero, M. Antonia Rodriguez de la Pena, Laura Garciia Bravo, Alejandro Francisco Jimenez Ortega, Paloma Flores Navarro, Jorge Bartolome Arcilla, Barbara Alonso Arenilla, Elvira Baos Munoz, Alberto Delgado-Iribarren Garcia-Campero, Maria Montealegre Sanz, Silvia Sanchez-Ramon, Pedro Perez Segura
Summary: This study investigated the long-term cellular and humoral responses to the SARS-CoV-2 mRNA vaccine in cancer patients and found the possibility of T cell exhaustion. The results suggest that an additional booster dose might be beneficial for patients with a decrease in specific IFN-γ response after vaccination.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Peng Zhang, Jeremy Manry, Yoann Seeleuthner, Yu Zhang, Alexandre Bolze, Matthieu Chaldebas, Baptiste Milisavljevic, Adrian Gervais, Paul Bastard, Takaki Asano, Lucy Bizien, Federica Barzaghi, Hassan Abolhassani, Ahmad Abou Tayoun, Alessandro Aiuti, Ilad Alavi Darazam, Luis M. Allende, Rebeca Alonso-Arias, Andres Augusto Arias, Gokhan Aytekin, Peter Bergman, Simone Bondesan, Yenan T. Bryceson, Ingrid G. Bustos, Oscar Cabrera-Marante, Sheila Carcel, Paola Carrera, Giorgio Casari, Khalil Chaibi, Roger Colobran, Antonio Condino-Neto, Laura E. Covill, Ottavia M. Delmonte, Loubna El Zein, Carlos Flores, Peter K. Gregersen, Marta Gut, Filomeen Haerynck, Rabih Halwani, Selda Hancerli, Lennart Hammarstroem, Nevin Hatipoglu, Adem Karbuz, Sevgi Keles, Christele Kyheng, Rafael Leon-Lopez, Jose Luis Franco, Davood Mansouri, Javier Martinez-Picado, Ozge Metin Akcan, Isabelle Migeotte, Pierre-Emmanuel Morange, Guillaume Morelle, Andrea Martin-Nalda, Giuseppe Novelli, Antonio Novelli, Tayfun Ozcelik, Figen Palabiyik, Qiang Pan-Hammarstroem, Rebeca Perez de Diego, Laura Planas-Serra, Daniel E. Pleguezuelo, Carolina Prando, Aurora Pujol, Luis Felipe Reyes, Jacques G. Riviere, Carlos Rodriguez-Gallego, Julian Rojas, Patrizia Rovere-Querini, Agatha Schlueter, Mohammad Shahrooei, Ali Sobh, Pere Soler-Palacin, Yacine Tandjaoui-Lambiotte, Imran Tipu, Cristina Tresoldi, Jesus Troya, Diederik van de Beek, Mayana Zatz, Pawel Zawadzki, Saleh Zaid Al-Muhsen, Mohammed Faraj Alosaimi, Fahad M. Alsohime, Hagit Baris-Feldman, Manish J. Butte, Stefan N. Constantinescu, Megan A. Cooper, Clifton L. Dalgard, Jacques Fellay, James R. Heath, Yu-Lung Lau, Richard P. Lifton, Tom Maniatis, Trine H. Mogensen, Horst von Bernuth, Alban Lermine, Michel Vidaud, Anne Boland, Jean-Francois Deleuze, Robert Nussbaum, Amanda Kahn-Kirby, France Mentre, Sarah Tubiana, Guy Gorochov, Florence Tubach, Pierre Hausfater, C. O. V. I. D. Human Genetic Effort, Isabelle Meyts, Shen-Ying Zhang, Anne Puel, Luigi D. Notarangelo, Stephanie Boisson-Dupuis, Helen C. Su, Bertrand Boisson, Emmanuelle Jouanguy, Jean-Laurent Casanova, Qian Zhang, Laurent Abel, Aurelie Cobat
Summary: Through a genome-wide rare variant burden association analysis, it was found that there is an association between at-risk variants in the TLR7 gene and rare loss-of-function variants in TLR3-dependent type I interferon immunity genes. These findings suggest that rare variants in TLR3- and TLR7-dependent type I interferon immunity genes may underlie life-threatening COVID-19 in patients under 60 years old.
Letter
Dermatology
Rosa Sacedon, M. Carmen de Arriba, Lucia Martinez-Santamaria, Rocio Maseda, Sara Herraiz-Gil, Eva Jimenez, Isabel Rosales, Lucia Quintana, Nuria Illera, Marta Garcia, Nora Butta, Ihosvany Fernandez-Bello, Su M. Lwin, Miguel Fernandez-Arquero, Carlos Leon, John A. Mcgrath, M. Angeles Vicente, Marcela del Rio, Raul de Lucas, Silvia Sanchez-Ramon, Maria Jose Escamez
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kauzar Mohamed Mohamed, Maria Paula Alvarez-Hernandez, Carlos Jimenez Garcia, Kissy Guevara-Hoyer, Dalifer Freites, Cristina Martinez Prada, Ines Perez-Sancristobal, Benjamin Fernandez Gutierrez, Gloria Mato Chain, Maria Rodero, Antonia Rodriguez de la Pena, Teresa Mulero, Cecilia Bravo, Esther Toledano, Esther Culebras Lopez, Beatriz Mediero Valeros, Pedro Perez Segura, Silvia Sanchez-Ramon, Gloria Candelas Rodriguez
Summary: This study evaluated the immune response in patients with immune-mediated rheumatic diseases (IMRDs) who received the third dose of anti-SARS-CoV-2 vaccine. The majority of patients developed cellular and humoral responses, but the specific response magnitude varied depending on the immunosuppressive therapy administered.
Meeting Abstract
Rheumatology
Ines Perez Sancristobal, Maria Paula Alvarez Hernandez, Silvia Sanchez-Ramon, Cristina Martinez, Eduardo de la Fuente, Concepcion Morado, Dalifer Freites Nunez, Benjamin Fernandez Gutierrez, Gloria Candelas
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Obstetrics & Gynecology
R. Gil Laborda, E. Carrillo de Albornoz, J. Vidal, V. Verdu, A. De la Fuente, M. Farinas, A. Garcia Segovia, D. Pintado Vera, J. L. Vicario, F. Ros Berruezo, F. M. Canadas, M. Ordenes, M. Fernandez-Arquero, S. Sanchez-Ramon
HUMAN REPRODUCTION
(2022)
Article
Immunology
Laura Garcia-Bravo, Myriam Calle-Rubio, Miguel Fernandez-Arquero, Kauzar Mohamed Mohamed, Teresa Guerra-Galan, Maria Guzman-Fulgencio, Antonia Rodriguez de la Pena, Cristina Canizares, Barbara Lopez, Cristina Vadillo, Jorge Matias-Guiu, Asuncion Nieto Barbero, Jose Luis Alvarez-Sala Walther, Silvia Sanchez-Ramon, Juliana Ochoa-Grullon
Summary: This study retrospectively investigated the global incidence of autoantibodies associated with myositis (non Jo1-RNA synthetases: antiPL7, anti-PL12, anti-EJ, anti-OJ and RNA-sensor: anti-MDA5) in a cohort of 444 patients with suspected inflammatory myopathy from 2015 to 2021. The results showed an increased incidence of anti-synthetase antibodies during the COVID-19 pandemic and SARS-CoV-2 vaccination, with differential profiles of antibody specificities observed between 2020 and 2021.
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY
(2022)