Review
Endocrinology & Metabolism
Marco Di Gioia, Ivan Zanoni
Summary: Endogenous oxidized phospholipids play a key role in sustaining inflammatory responses and can affect the biology and function of phagocytes, leading to the development of chronic inflammatory diseases. Understanding the mechanisms of action of these oxidized lipids is crucial for designing interventions.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lucia Sanjurjo, Esmeralda Castelblanco, Josep Julve, Nuria Villalmanzo, Erica Tellez, Anna Ramirez-Morros, Nuria Alonso, Didac Mauricio, Maria-Rosa Sarrias
Summary: The study aimed to investigate the contribution of oxLDL to the inflammatory response of macrophages under diabetic conditions. The results showed that oxLDL promoted intracellular lipid accumulation in macrophages under high glucose (HG) conditions and enhanced the production of pro-inflammatory cytokines. Moreover, HG and oxLDL upregulated the expression of the cell surface receptor TLR4 and increased the release of sCD14, which further exacerbated the inflammation.
Review
Cardiac & Cardiovascular Systems
Marlys L. Koschinsky, Michael B. Boffa
Summary: Oxidized phospholipids (OxPL) play a crucial role in the pro-atherosclerotic effects of oxidized lipoproteins, particularly in the pathogenesis of lipoprotein(a) (Lp(a)). The OxPL on Lp(a) account for numerous harmful effects on various cells and their receptors, intracellular signaling pathways, and gene and protein expression. Despite being present at lower concentrations than LDL, the OxPL modification may explain why Lp(a) is such a potent risk factor for cardiovascular disease.
Article
Biochemistry & Molecular Biology
Maryam Darabi, Marie Lhomme, Veronica D. Dahik, Isabelle Guillas, Eric Frisdal, Emilie Tubeuf, Lucie Poupel, Mili Patel, Emmanuel L. Gautier, Thierry Huby, Maryse Guerin, Kerry-Anne Rye, Philippe Lesnik, Wilfried Le Goff, Anatol Kontush
Summary: Phosphatidylserine (PS) is a component of high-density lipoprotein (HDL) that exhibits potent anti-inflammatory activity. This study found that the incorporation of PS into reconstituted HDL enhanced its anti-inflammatory effects by modulating signaling pathways mediated by SR-BI.
Article
Biochemistry & Molecular Biology
Christina Mauerhofer, Taras Afonyushkin, Olga Oskolkova, Klara Hellauer, Bernd Gesslbauer, Jasmin Schmerda, Yunbo Ke, Andreas Zimmer, Anna A. Birukova, Konstantin G. Birukov, Valery Bochkov
Summary: Oxidized phospholipids (OxPLs) can protect endothelial cells from stress-induced damage by extracting membrane cholesterol and inducing the expression of heat shock proteins and pro-survival factors.
Review
Medicine, General & Internal
Amalia Despoina Koutsogianni, Evangelos Liberopoulos, Konstantinos Tellis, Alexandros D. Tselepis
Summary: The article summarizes the data on OxPLs and cardiovascular risk, as well as the impact of hypolipidemic medications on Lp(a) and OxPLs.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cardiac & Cardiovascular Systems
Huijuan Dou, Andriana Kotini, Wenli Liu, Trevor Fidler, Kaori Endo-Umeda, Xiaoli Sun, Malgorzata Olszewska, Tong Xiao, Sandra Abramowicz, Mustafa Yalcinkaya, Brian Hardaway, Sotirios Tsimikas, Xuchu Que, Alexander Bick, Conor Emdin, Pradeep Natarajan, Eirini P. Papapetrou, Joseph L. Witztum, Nan Wang, Alan R. Tall
Summary: Hematopoietic Lnk deficiency promotes NETosis and arterial thrombosis. Individuals carrying the JAK2(VF) mutation along with the LNK R262W allele are at increased risk of coronary artery disease.
Article
Cell Biology
Michela Palmieri, Maria Almeida, Intawat Nookaew, Horacio Gomez-Acevedo, Teenamol E. Joseph, Xuchu Que, Sotirios Tsimikas, Xiaoli Sun, Stavros C. Manolagas, Joseph L. Witztum, Elena Ambrogini
Summary: Transgenic expression of E06-scFv helps attenuate age-related bone loss in mice by increasing bone density, osteoblasts, and decreasing osteoclasts. Additionally, it increases Wnt signaling, showing promise as a therapeutic target for senile osteoporosis.
Article
Medicine, Research & Experimental
Antigona Ulndreaj, Angela Li, Yonghong Chen, Rickvinder Besla, Shaun Pacheco, Marwan G. Althagafi, Myron I. Cybulsky, Thomas Lindsay, Clinton S. Robbins, John S. Byrne
Summary: The study found that aortic macrophage accumulation in abdominal aortic aneurysm (AAA) is primarily caused by adventitial recruitment of Lyve-1(-) macrophages, with a relative depletion of Lyve-1(+) macrophages. Selective targeting of macrophage subtypes may represent a potential novel therapeutic avenue for the medical treatment of AAA.
Article
Biochemistry & Molecular Biology
Olga V. Oskolkova, Alma Hodzic, Pratap Karki, Bernd Gesslbauer, Yunbo Ke, Dina C. Hofer, Juliane G. Bogner-Strauss, Jean-Marie Galano, Camille Oger, Anna Birukova, Thierry Durand, Konstantin Birukov, Valery Bochkov
Summary: This study presents a method for synthesizing oxidized phospholipids containing oxylipins via an amide bond, which allows for high yield activation and attachment of oxylipins under mild conditions without the need for additional protection steps. The synthesized alkyl-amide oxidized phospholipids exhibit similar biological activities to di-acyl oxidized phospholipids, making them a potentially useful tool for further analysis of the structure-activity relationship of OxPLs.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Jin Kyung Seok, Eun-Hee Hong, Gabsik Yang, Hye Eun Lee, Sin-Eun Kim, Kwang-Hyeon Liu, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, Joo Young Lee
Summary: Oxidized phospholipids, such as POVPC and PGPC, are found to promote epithelial-mesenchymal transition (EMT) and autophagy in cancer cells, leading to increased migration and invasion potential. Elevated levels of these oxidized phospholipids are observed in tumor tissues and are associated with enhanced metastatic abilities.
Review
Cardiac & Cardiovascular Systems
Adele Ruder, Suzan M. W. Wetzels, Lieve Temmerman, Erik A. L. Biessen, Pieter Goossens
Summary: Monocytes differentiate into macrophages at sites of inflammation and contribute to the development of cardiovascular disease. Different subtypes of monocytes, characterized by the expression of CD14 and CD16, have been identified. The middle subtype has been found to be associated with atherosclerosis, myocardial infarction, and heart failure. However, more research is needed to understand their exact role and predictive value in cardiovascular disease.
CARDIOVASCULAR RESEARCH
(2023)
Article
Multidisciplinary Sciences
Rida Al-Rifai, Marie Vandestienne, Jean-Remi Lavillegrand, Tristan Mirault, Julie Cornebise, Johanne Poisson, Ludivine Laurans, Bruno Esposito, Chloe James, Olivier Mansier, Pierre Hirsch, Fabrizia Favale, Rayan Braik, Camille Knosp, Jose Vilar, Giuseppe Rizzo, Alma Zernecke, Antoine-Emmanuel Saliba, Alain Tedgui, Maxime Lacroix, Lionel Arrive, Ziad Mallat, Soraya Taleb, Marc Diedisheim, Clement Cochain, Pierre-Emmanuel Rautou, Hafid Ait-Oufella
Summary: JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm.
NATURE COMMUNICATIONS
(2022)
Article
Hematology
Theodoros Kelesidis, Madhav Sharma, Eashan Sharma, Isabelle Ruedisueli, Elizabeth Tran, Holly R. Middlekauff
Summary: The use of electronic cigarettes (ECIGs) may increase vulnerability to future atherosclerotic cardiovascular disease due to changes in circulating factors. Monocyte transendothelial migration and monocyte-derived foam cell formation were higher in ECIG users and tobacco cigarette (TCIG) smokers compared to nonsmokers. However, these alterations were less severe in ECIG users compared to TCIG smokers.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Alexander Sorokin, Christin G. Hong, Angel M. Aponte, Elizabeth M. Florida, Jingrong Tang, Nidhi Patel, Irina N. Baranova, Haiou Li, Philip M. Parel, Vicky Chen, Sierra R. Wilson, Emily L. Ongstad, Anna Collen, Martin P. Playford, Thomas L. Eggerman, Marcus Y. Chen, Kazuhiko Kotani, Alexander Bocharov, Alan T. Remaley
Summary: In this study, we found that oxidized apolipoprotein B and oxidized ApoA-I are associated with high-risk coronary plaque features and progression in patients with cardiovascular disease.