Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency

The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis

(2021) Trevor P. Fidler et al.   NATURE

A randomized, double-blind trial of three aspirin regimens to optimize antiplatelet therapy in essential thrombocythemia

(2020) Bianca Rocca et al.   BLOOD

Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death

(2019) Carlos Silvestre-Roig et al.   NATURE

Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis

(2019) Xiaoli Sun et al.   Cell Metabolism

Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease

(2019) Derek Klarin et al.   NATURE GENETICS

Effective and Rapid Generation of Functional Neutrophils from Induced Pluripotent Stem Cells Using ETV2-Modified mRNA

(2019) Vera S. Brok-Volchanskaya et al.   Stem Cell Reports

Reduction of myocardial ischaemia–reperfusion injury by inactivating oxidized phospholipids

(2018) Calvin Yeang et al.   CARDIOVASCULAR RESEARCH

Cholesterol Efflux Pathways Suppress Inflammasome Activation, NETosis and Atherogenesis

(2018) Marit Westerterp et al.   CIRCULATION

Roles of PAD4 and NETosis in Experimental Atherosclerosis and Arterial InjuryNovelty and Significance

(2018) Grégory Franck et al.   CIRCULATION RESEARCH

Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms

(2018) Ofir Wolach et al.   Science Translational Medicine

Dissecting the Contributions of Cooperating Gene Mutations to Cancer Phenotypes and Drug Responses with Patient-Derived iPSCs

(2018) Chan-Jung Chang et al.   Stem Cell Reports

Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice

(2018) Xuchu Que et al.   NATURE

Myeloid-Specific Deletion of Peptidylarginine Deiminase 4 Mitigates Atherosclerosis

(2018) Yudong Liu et al.   Frontiers in Immunology

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies

(2017) Kaosheng Lv et al.   GENES & DEVELOPMENT

Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease

(2017) Derek Klarin et al.   NATURE GENETICS

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

(2017) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

LNK mutations in familial myeloproliferative neoplasms

(2016) Elisa Rumi et al.   BLOOD

Germ line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasms

(2016) D. A. Hinds et al.   BLOOD

LNK/SH2B3 Loss of Function Promotes Atherosclerosis and ThrombosisNovelty and Significance

(2016) Wei Wang et al.   CIRCULATION RESEARCH

Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation

(2016) Deepika Awasthi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Priming of neutrophils toward NETosis promotes tumor growth

(2016) Mélanie Demers et al.   OncoImmunology

P-selectin promotes neutrophil extracellular trap formation in mice

(2015) J. Etulain et al.   BLOOD

TLR2 and neutrophils potentiate endothelial stress, apoptosis and detachment: implications for superficial erosion

(2015) Thibaut Quillard et al.   EUROPEAN HEART JOURNAL

Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells

(2015) Andriana G Kotini et al.   NATURE BIOTECHNOLOGY

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

(2015) A. Warnatsch et al.   SCIENCE

Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis

(2014) Jason S. Knight et al.   CIRCULATION RESEARCH

Platelet Lipidomics

(2014) Valerie B. O’Donnell et al.   CIRCULATION RESEARCH

Scalable Generation of Universal Platelets from Human Induced Pluripotent Stem Cells

(2014) Qiang Feng et al.   Stem Cell Reports

Elevated Levels of Circulating DNA and Chromatin Are Independently Associated With Severe Coronary Atherosclerosis and a Prothrombotic State

(2013) Julian I. Borissoff et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

(2013) K. Martinod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large-scale association analysis identifies new risk loci for coronary artery disease

(2012) Panos Deloukas et al.   NATURE GENETICS

Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms

(2010) S. T. Oh et al.   BLOOD

Physiological Jak2V617F Expression Causes a Lethal Myeloproliferative Neoplasm with Differential Effects on Hematopoietic Stem and Progenitor Cells

(2010) Ann Mullally et al.   CANCER CELL

Lnk constrains myeloproliferative diseases in mice

(2010) Alexey Bersenev et al.   JOURNAL OF CLINICAL INVESTIGATION

Thromboxane synthase expression and thromboxane A2 production in the atherosclerotic lesion

(2010) Anders Gabrielsen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Multiple common variants for celiac disease influencing immune gene expression

(2010) Patrick C A Dubois et al.   NATURE GENETICS

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F

(2009) Sigal Gery et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

(2009) Daniel F Gudbjartsson et al.   NATURE GENETICS

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS