Article
Immunology
Samaneh Abbasian, Mohammad Sadegh Soltani-Zangbar, Alireza Khabbazi, Rojin Farzaneh, Aida Malek Mahdavi, Roza Motavalli, Mehrzad Hajialilo, Mehdi Yousefi
Summary: Nanocurcumin supplementation in Behcet's disease patients significantly increased Treg cells frequency, elevated the expression levels of related immunologic parameters, and reduced disease activity, showing promising potential for disease improvement.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Ivo Djidrovksi, Maria Georgiou, Grant L. Hughes, Edward I. Patterson, Aitor Casas-Sanchez, Shaun H. Penington, Giancarlo A. Biagini, Marina Moya-Molina, Jelle van den Bor, Martine J. Smit, Git Chung, Majlinda Lako, Lyle Armstrong
Summary: This study developed a simplified protocol for generating airway epithelial basal-like cells from induced pluripotent stem cells, which mimic the upper airway epithelium and support viral infection and cytokine secretion. This method provides a feasible upper airway model for respiratory disease therapy development and assessment of drug toxicity on human lungs.
Article
Biochemistry & Molecular Biology
Ngan Le, Ian Luk, David Chisanga, Wei Shi, Lokman Pang, Glen Scholz, John Mariadason, Matthias Ernst, Jennifer Huynh
Summary: IL-36G induces ERK1/2 activation and promotes colony formation, migration, and invasion in gastric cancer cells. High expression of IL-36G is associated with poorer patient survival in gastric cancer.
Review
Immunology
Suheil Albert Atallah-Yunes, Michael J. Robertson
Summary: Cytokines play a regulatory role in the immune responses to cancer. While they have shown antitumor activity in preclinical models, their success as single therapeutic agents in clinical trials of cancer immunotherapy has been limited. However, combining cytokines with other immune therapeutics and advancements in genetic engineering, synthetic biology, and cellular and immune therapy have revived interest in cytokines as anticancer agents.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Plant Sciences
K. B. Megha, X. Joseph, V Akhil, P. Mohanan
Summary: Inflammatory responses are complex immune mechanisms that recruit various immune cells and chemical mediators to initiate the healing process. Cytokines play a crucial role in inflammation, with abrupt expression and hyperinflammatory responses leading to various inflammatory disorders.
Article
Dentistry, Oral Surgery & Medicine
Hisashi Goto, Takeshi Kikuchi, Yuhei Takayanagi, Yosuke Kamiya, Yuki Suzuki, Shotaro Kawamura, Noritaka Sawada, Jun-ichiro Hayashi, Akio Mitani
Summary: This study aimed to investigate the role of Ebi3-related cytokines in experimental periodontitis using Ebi3 knockout mice. The results showed that Ebi3 KO mice exhibited more severe alveolar bone resorption and higher levels of IL-17A expression, while IL-10 expression was lower. Injection of recombinant IL-35 reduced ligature-induced alveolar bone resorption in Ebi3 KO mice. These findings suggest that Th17 cells exacerbate experimental periodontitis in mice lacking Ebi3, and IL-35 may play a critical role in inhibiting periodontal tissue destruction.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Review
Immunology
Frederic Meyer, Daniel Wendling, Celine Demougeot, Clement Prati, Frank Verhoeven
Summary: This review summarizes the effects of cytokines on intestinal permeability. It was found that certain cytokines can increase intestinal permeability and lead to excessive inflammatory response. However, the effects of different cytokines may vary under different conditions.
AUTOIMMUNITY REVIEWS
(2023)
Review
Cardiac & Cardiovascular Systems
Masafumi Takahashi
Summary: NLRP3 inflammasome plays a crucial role in sterile inflammatory diseases, particularly in atherosclerosis and other vascular diseases. It is involved in disease progression by activating and assembling the NLRP3 inflammasome, leading to inflammatory cell death and interleukin secretion.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Alessandra Bettiol, Filippo Fagni, Irene Mattioli, Giacomo Bagni, Gianfranco Vitiello, Alessia Grassi, Chiara Della Bella, Marisa Benagiano, Arianna Troilo, Katarzyna Stella Holownia, David Simon, Flavia Rita Argento, Jurgen Sota, Claudia Fabiani, Matteo Becatti, Claudia Fiorillo, Georg Schett, Giuseppe Lopalco, Luca Cantarini, Domenico Prisco, Elena Silvestri, Giacomo Emmi, Mario Milco D'Elios
Summary: In this study, the ability of serum interleukin (IL)-36a concentration to differentiate Behcet's syndrome (BS) from psoriatic arthritis (PsA) was investigated. The results showed significantly lower IL-36a concentrations in BS patients compared to PsA patients, although both groups had significantly higher IL-36a levels compared to healthy controls. A cut-off of 420.6 pg/mL displayed good specificity and sensitivity in discriminating PsA from BS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Luca Liberale, Stefano Ministrini, Federico Carbone, Giovanni G. Camici, Fabrizio Montecucco
Summary: Inflammation plays a crucial role in atherosclerosis and cardiovascular diseases, with cytokines mediating the interaction between inflammatory and vascular cells in the progression of atherothrombosis. Both stimulatory and inhibitory cytokines are considered as potential markers and therapeutic targets, although cytokine inhibition may be limited by harmful side effects. Clinical trials targeting cytokines show promise for potential implications in daily clinical practice.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Review
Cell Biology
Sujata Thakur, Rishika Dhapola, Phulen Sarma, Bikash Medhi, Dibbanti HariKrishna Reddy
Summary: Alzheimer's disease is a neurodegenerative disease characterized by amyloid beta accumulation. Inflammatory cytokines play diverse roles in neurodegeneration and neuroprotection. There is a cross-link between gut microbiota and neuroinflammation in Alzheimer's disease.
Article
Immunology
Tanya Novak, Mojgan Hamedi, Lesley Ann Bergmeier, Farida Fortune, Eleni Hagi-Pavli
Summary: Behcet's disease (BD) is characterized by high levels of cytokines in saliva, especially in patients with oral ulcers. Oral ulcers in BD may indicate reactivation of systemic inflammation, and monitoring cytokine levels in saliva could provide insights into disease activity and progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Hamid Y. Dar, Daniel S. Perrien, Subhashis Pal, Andreea Stoica, Sasidhar Uppuganti, Jeffry S. Nyman, Rheinallt M. Jones, M. Neale Weitzmann, Roberto Pacifici
Summary: This study reveals that fractures can rapidly expand γδ T cells, leading to systemic inflammation and increased gut permeability. When the gut microbiota contains Th17 cell-inducing bacteria, fractures can promote the expansion of intestinal Th17 cells and their migration to the fracture callus, resulting in improved fracture repair.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Armin Mooranian, Corina Mihaela Ionescu, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Thomas Foster, Edan Johnston, Jafri Kuthubutheen, Daniel Brown, Marcus D. Atlas, Momir Mikov, Hani Al-Salami
Summary: Recent studies have shown the potential applications of bile acid-Eudragit NM30D(R) capsules in drug encapsulation and viable-cell encapsulation. These capsules can improve cell viability, insulin levels, inflammatory profile, and bioenergetics, and the stability of the capsules is associated with cellular biological activities. Changes in ratios of bile acids to Eudragit NM30D(R) can alter the microenvironment of the capsules and subsequent cellular activities.
Article
Biochemistry & Molecular Biology
Alessandra Fiorillo, Juan-Jose Gallego, Franc Casanova-Ferrer, Carla Gimenez-Garzo, Amparo Urios, Maria-Pilar Ballester, Lucia Durban, Maria-Pilar Rios, Javier Megias, Teresa San Miguel, Elena Kosenko, Desamparados Escudero-Garcia, Salvador Benlloch, Vicente Felipo, Carmina Montoliu
Summary: Patients with NAFLD may experience mild cognitive impairment (MCI), and this study identified specific alterations in the immune system that are associated with neurological changes in MCI patients with NAFLD, which may help improve and restore cognitive functions and quality of life in these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)