标题
NLRP3 inflammasome as a key driver of vascular disease
作者
关键词
-
出版物
CARDIOVASCULAR RESEARCH
Volume -, Issue -, Pages -
出版商
Oxford University Press (OUP)
发表日期
2021-01-16
DOI
10.1093/cvr/cvab010
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- VX-765 attenuates atherosclerosis in ApoE deficient mice by modulating VSMCs pyroptosis
- (2020) Yiyi Li et al. EXPERIMENTAL CELL RESEARCH
- Glucose regulates hypoxia‐induced NLRP3 inflammasome activation in macrophages
- (2020) Sachiko Watanabe et al. JOURNAL OF CELLULAR PHYSIOLOGY
- From CANTOS to CIRT to COLCOT to Clinic
- (2020) Paul M Ridker CIRCULATION
- Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease
- (2020) Antonio Abbate et al. CIRCULATION RESEARCH
- Kawasaki disease: pathophysiology and insights from mouse models
- (2020) Magali Noval Rivas et al. Nature Reviews Rheumatology
- SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease
- (2020) So Ra Kim et al. Nature Communications
- Targeting the NLRP3 Inflammasome With Inhibitor MCC950 Prevents Aortic Aneurysms and Dissections in Mice
- (2020) Pingping Ren et al. Journal of the American Heart Association
- Inflammasomes: a preclinical assessment of targeting in atherosclerosis
- (2020) Jeremiah Stitham et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- NLRP3 inflammasome priming: A riddle wrapped in a mystery inside an enigma
- (2020) Chloe M. McKee et al. JOURNAL OF LEUKOCYTE BIOLOGY
- GSDME-Dependent Incomplete Pyroptosis Permits Selective IL-1α Release under Caspase-1 Inhibition
- (2020) Emi Aizawa et al. iScience
- Colchicine in Patients with Chronic Coronary Disease
- (2020) Stefan M. Nidorf et al. NEW ENGLAND JOURNAL OF MEDICINE
- Interplay Between NLRP3 Inflammasome and Autophagy
- (2020) Monika Biasizzo et al. Frontiers in Immunology
- Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors
- (2019) Yang Yang et al. Cell Death & Disease
- Interleukin-18 in Health and Disease
- (2019) Koubun Yasuda et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- AIM2 levels and DNA-triggered inflammasome response are increased in peripheral leukocytes of patients with abdominal aortic aneurysm
- (2019) Markus Wortmann et al. INFLAMMATION RESEARCH
- Stage-dependent differential effects of interleukin-1 isoforms on experimental atherosclerosis
- (2019) Amélie Vromman et al. EUROPEAN HEART JOURNAL
- Cellular Mechanisms of Aortic Aneurysm Formation
- (2019) Raymundo Alain Quintana et al. CIRCULATION RESEARCH
- TNF and IL-1 Play Essential but Temporally Distinct Roles in Driving Cardiac Inflammation in a Murine Model of Kawasaki Disease
- (2019) Angus T. Stock et al. JOURNAL OF IMMUNOLOGY
- MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
- (2019) Rebecca C. Coll et al. Nature Chemical Biology
- The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
- (2019) Nathan Kelley et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cell-Specific Roles of NLRP3 Inflammasome in Myocardial Infarction
- (2019) Masafumi Takahashi JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Dectin-2–induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis
- (2019) Chie Miyabe et al. JOURNAL OF CLINICAL INVESTIGATION
- Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome
- (2019) Humayun Sharif et al. NATURE
- Novel Insights Into the NLRP3 Inflammasome in Atherosclerosis
- (2019) Ying Jin et al. Journal of the American Heart Association
- Guidelines for evaluating myocardial cell death
- (2019) Paras K Mishra et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Role of AIM2 inflammasome in inflammatory diseases, cancer and infection
- (2019) Bhesh Raj Sharma et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Pannexin‐1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation
- (2019) Kaiwen W. Chen et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Inflammasome signaling and regulation of interleukin-1 family cytokines
- (2019) Amy H. Chan et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction
- (2019) Jean-Claude Tardif et al. NEW ENGLAND JOURNAL OF MEDICINE
- Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation
- (2019) Chang Jia et al. Cell Death & Disease
- Pharmacological Inhibitors of the NLRP3 Inflammasome
- (2019) Ayesha Zahid et al. Frontiers in Immunology
- Crucial role of NLRP3 inflammasome in a murine model of Kawasaki disease
- (2019) Fumiya Anzai et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- NLRP3 Inflammasome and Mineralocorticoid Receptors Are Associated with Vascular Dysfunction in Type 2 Diabetes Mellitus
- (2019) Nathanne Santos Ferreira et al. Cells
- AIM2 accelerates the atherosclerotic plaque progressions in ApoE−/− mice
- (2018) Jinyu Pan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming
- (2018) Anette Christ et al. CELL
- Double-Strand DNA Sensing Aim2 Inflammasome Regulates Atherosclerotic Plaque Vulnerability
- (2018) Nicole Paulin et al. CIRCULATION
- NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis
- (2018) Alena Grebe et al. CIRCULATION RESEARCH
- Trained Innate Immunity as a Novel Mechanism Linking Infection and the Development of AtherosclerosisNovelty and Significance
- (2018) Jenneke Leentjens et al. CIRCULATION RESEARCH
- Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity
- (2018) Dave Boucher et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Kawasaki Disease
- (2018) Christian M. Hedrich et al. Frontiers in Pediatrics
- New mitochondrial DNA synthesis enables NLRP3 inflammasome activation
- (2018) Zhenyu Zhong et al. NATURE
- Targeting the NLRP3 inflammasome in inflammatory diseases
- (2018) Matthew S. J. Mangan et al. NATURE REVIEWS DRUG DISCOVERY
- Inflammasome Activation Aggravates Cutaneous Xanthomatosis and Atherosclerosis in ACAT1 (Acyl-CoA Cholesterol Acyltransferase 1) Deficiency in Bone Marrow
- (2018) Tetsuji Wakabayashi et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Anti-inflammatory therapy for atherosclerosis: interpreting divergent results from the CANTOS and CIRT clinical trials
- (2018) P. M. Ridker JOURNAL OF INTERNAL MEDICINE
- PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation
- (2018) Jueqi Chen et al. NATURE
- Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes
- (2018) Stephen D. Wiviott et al. NEW ENGLAND JOURNAL OF MEDICINE
- NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway
- (2018) Iva Hafner-Bratkovič et al. Nature Communications
- Introduction to the interleukin-1 family of cytokines and receptors: Drivers of innate inflammation and acquired immunity
- (2017) Charles A. Dinarello IMMUNOLOGICAL REVIEWS
- Role of NLRP3 Inflammasomes in Atherosclerosis
- (2017) Tadayoshi Karasawa et al. Journal of Atherosclerosis and Thrombosis
- ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages
- (2017) Akira Kawashima et al. JOURNAL OF IMMUNOLOGY
- Interleukin-1 Beta as a Target for Atherosclerosis Therapy
- (2017) Peter Libby JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Activation of NLRP3 inflammasomes contributes to hyperhomocysteinemia-aggravated inflammation and atherosclerosis in apoE-deficient mice
- (2017) Renqing Wang et al. LABORATORY INVESTIGATION
- Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
- (2017) Yupeng Wang et al. NATURE
- The NLRP3 inflammasome in acute myocardial infarction
- (2017) Stefano Toldo et al. Nature Reviews Cardiology
- Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease
- (2017) Siddhartha Jaiswal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- (2017) Paul M Ridker et al. NEW ENGLAND JOURNAL OF MEDICINE
- Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice
- (2017) José J. Fuster et al. SCIENCE
- Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
- (2017) Jianjin Shi et al. TRENDS IN BIOCHEMICAL SCIENCES
- AIM2 Engages Active but Unprocessed Caspase-1 to Induce Noncanonical Activation of the NLRP3 Inflammasome
- (2017) Larissa D. Cunha et al. Cell Reports
- IL-1 Inhibition May Have an Important Role in Treating Refractory Kawasaki Disease
- (2017) Perrine Dusser et al. Frontiers in Pharmacology
- Role of Interleukin-1 Signaling in a Mouse Model of Kawasaki Disease–Associated Abdominal Aortic AneurysmSignificance
- (2016) Daiko Wakita et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- NLRP3 Inflammasome Mediates Aldosterone-Induced Vascular DamageClinical Perspective
- (2016) Thiago Bruder-Nascimento et al. CIRCULATION
- K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria
- (2016) Christina J. Groß et al. IMMUNITY
- Kawasaki Disease
- (2016) Jane W. Newburger et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Sex- and Disease-Specific Inflammasome Signatures in Circulating Blood Leukocytes of Patients with Abdominal Aortic Aneurysm
- (2016) Xiaoyu Wu et al. MOLECULAR MEDICINE
- NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
- (2016) Yuan He et al. NATURE
- NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages
- (2016) Jong-Seok Moon et al. NATURE MEDICINE
- An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells
- (2016) Ivan Zanoni et al. SCIENCE
- Trained immunity: A program of innate immune memory in health and disease
- (2016) M. G. Netea et al. SCIENCE
- Inflammasome-Independent Regulation of IL-1-Family Cytokines
- (2015) Mihai G. Netea et al. Annual Review of Immunology
- Coronary Endothelial Dysfunction Induced by Nucleotide Oligomerization Domain-Like Receptor Protein with Pyrin Domain Containing 3 Inflammasome Activation During Hypercholesterolemia: Beyond Inflammation
- (2015) Yang Zhang et al. ANTIOXIDANTS & REDOX SIGNALING
- Activation of the NLRP3 inflammasome induces vascular dysfunction in obese OLETF rats
- (2015) Penghao Liu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
- (2015) Wan-ting He et al. CELL RESEARCH
- Anti-Inflammatory and Antiatherogenic Effects of the NLRP3 Inflammasome Inhibitor Arglabin in ApoE2.Ki Mice Fed a High-Fat Diet
- (2015) A. Abderrazak et al. CIRCULATION
- Bone marrow-specific caspase-1/11 deficiency inhibits atherosclerosis development inLdlr−/−mice
- (2015) Tim Hendrikx et al. FEBS Journal
- Correlation of NLRP3 with severity and prognosis of coronary atherosclerosis in acute coronary syndrome patients
- (2015) Altaf Afrasyab et al. HEART AND VESSELS
- Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock
- (2015) Dahai Yang et al. IMMUNITY
- A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation
- (2015) Jonathan L. Schmid-Burgk et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity
- (2015) Tomonori Kimura et al. JOURNAL OF CELL BIOLOGY
- Macrophage inflammasome mediates hyperhomocysteinemia-aggravated abdominal aortic aneurysm
- (2015) Weiliang Sun et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Expression of the NLRP3 Inflammasome in Carotid Atherosclerosis
- (2015) Xin Shi et al. Journal of Stroke & Cerebrovascular Diseases
- Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
- (2015) Nobuhiko Kayagaki et al. NATURE
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- (2015) Jianjin Shi et al. NATURE
- NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component
- (2015) Hexin Shi et al. NATURE IMMUNOLOGY
- A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
- (2015) Rebecca C Coll et al. NATURE MEDICINE
- Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes
- (2015) Bernard Zinman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis
- (2015) A. Warnatsch et al. SCIENCE
- Expression of the NLRP3 Inflammasome in Carotid Atherosclerosis
- (2015) Xin Shi et al. Journal of Stroke & Cerebrovascular Diseases
- Oligomerized CARD16 promotes caspase-1 assembly and IL-1β processing
- (2015) Tadayoshi Karasawa et al. FEBS Open Bio
- Inhibition of Interleukin-1 Decreases Aneurysm Formation and Progression in a Novel Model of Thoracic Aortic Aneurysms
- (2014) W. F. Johnston et al. CIRCULATION
- Moderate Hypoxia Potentiates Interleukin-1β Production in Activated Human Macrophages
- (2014) Eduardo J. Folco et al. CIRCULATION RESEARCH
- NLRP3 Inflammasome as a Novel Player in Myocardial Infarction
- (2014) Masafumi Takahashi International Heart Journal
- NLRP3 Protein Deficiency Exacerbates Hyperoxia-induced Lethality through Stat3 Protein Signaling Independent of Interleukin-1β
- (2014) Yoshiko Mizushina et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cholesterol Crystals Induce Complement-Dependent Inflammasome Activation and Cytokine Release
- (2014) E. O. Samstad et al. JOURNAL OF IMMUNOLOGY
- NLRP3 Regulates Neutrophil Functions and Contributes to Hepatic Ischemia-Reperfusion Injury Independently of Inflammasomes
- (2014) Y. Inoue et al. JOURNAL OF IMMUNOLOGY
- High dose anakinra for treatment of severe neonatal Kawasaki disease: a case report
- (2014) Ashley Shafferman et al. Pediatric Rheumatology
- Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity
- (2014) S. Saeed et al. SCIENCE
- Genetic and Pharmacologic Disruption of Interleukin-1β Signaling Inhibits Experimental Aortic Aneurysm Formation
- (2013) William F. Johnston et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Analysis of Pfizer Compounds in EPA’s ToxCast Chemicals-Assay Space
- (2013) Falgun Shah et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Sterol Regulatory Element Binding Protein 2 Activation of NLRP3 Inflammasome in Endothelium Mediates Hemodynamic-Induced Atherosclerosis Susceptibility
- (2013) Han Xiao et al. CIRCULATION
- NLRP3 Inflammasomes Show High Expression in Aorta of Patients with Atherosclerosis
- (2013) Fei Zheng et al. Heart Lung and Circulation
- K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter
- (2013) Raúl Muñoz-Planillo et al. IMMUNITY
- Inflammation-related induction of absent in melanoma 2 (AIM2) in vascular cells and atherosclerotic lesions suggests a role in vascular pathogenesis
- (2013) Maani Hakimi et al. JOURNAL OF VASCULAR SURGERY
- Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
- (2013) Takuma Misawa et al. NATURE IMMUNOLOGY
- CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
- (2013) Frederick J Sheedy et al. NATURE IMMUNOLOGY
- Fatty acid–induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis
- (2013) Stefan Freigang et al. NATURE IMMUNOLOGY
- Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock
- (2013) J. A. Hagar et al. SCIENCE
- Caspase-11 Protects Against Bacteria That Escape the Vacuole
- (2013) Y. Aachoui et al. SCIENCE
- Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4
- (2013) N. Kayagaki et al. SCIENCE
- A child with severe relapsing Kawasaki disease rescued by IL-1 receptor blockade and extracorporeal membrane oxygenation
- (2012) Sophie Cohen et al. ANNALS OF THE RHEUMATIC DISEASES
- Critical role of caspase-1 in vascular inflammation and development of atherosclerosis in Western diet-fed apolipoprotein E-deficient mice
- (2012) Fumitake Usui et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Caspase-1 Deficiency Decreases Atherosclerosis in Apolipoprotein E-Null Mice
- (2012) Jessica Gage et al. CANADIAN JOURNAL OF CARDIOLOGY
- Proatherogenic role of interleukin-18: effects on inflammation and action on vascular cells: AUTHORS' RETROSPECTIVE
- (2012) R. Elhage et al. CARDIOVASCULAR RESEARCH
- Autophagy Links Inflammasomes to Atherosclerotic Progression
- (2012) Babak Razani et al. Cell Metabolism
- Interleukin-1β Is Crucial for the Induction of Coronary Artery Inflammation in a Mouse Model of Kawasaki Disease
- (2012) Youngho Lee et al. CIRCULATION
- Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1
- (2012) Olaf Groß et al. IMMUNITY
- Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis
- (2012) Kenichi Shimada et al. IMMUNITY
- Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction
- (2012) Chong-Shan Shi et al. NATURE IMMUNOLOGY
- Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysms
- (2011) Rebecca L. Roberts et al. ATHEROSCLEROSIS
- Macrophages in the Pathogenesis of Atherosclerosis
- (2011) Kathryn J. Moore et al. CELL
- Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis
- (2011) Stefan Freigang et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Non-canonical inflammasome activation targets caspase-11
- (2011) Nobuhiko Kayagaki et al. NATURE
- Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
- (2011) Haitao Wen et al. NATURE IMMUNOLOGY
- The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization
- (2011) Sirish K Ippagunta et al. NATURE IMMUNOLOGY
- Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome
- (2011) P Menu et al. Cell Death & Disease
- Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease
- (2010) F. Meissner et al. BLOOD
- Human NLRP3 inflammasome activation is Nox1-4 independent
- (2010) R. van Bruggen et al. BLOOD
- A role for mitochondria in NLRP3 inflammasome activation
- (2010) Rongbin Zhou et al. NATURE
- NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
- (2010) Peter Duewell et al. NATURE
- Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
- (2010) Edward A Miao et al. NATURE IMMUNOLOGY
- Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
- (2010) Kiichi Nakahira et al. NATURE IMMUNOLOGY
- Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation
- (2010) Kristiina Rajamäki et al. PLoS One
- Thioredoxin-interacting protein links oxidative stress to inflammasome activation
- (2009) Rongbin Zhou et al. NATURE IMMUNOLOGY
- Inflammatory Markers and Outcomes in Cardiovascular Disease
- (2009) Leonard Kritharides PLOS MEDICINE
- Critical Role of Bone Marrow Apoptosis-Associated Speck-Like Protein, an Inflammasome Adaptor Molecule, in Neointimal Formation After Vascular Injury in Mice
- (2008) Noriyuki Yajima et al. CIRCULATION
- Regional heterogeneity within the aorta: Relevance to aneurysm disease
- (2008) Jean Marie Ruddy et al. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
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