Article
Obstetrics & Gynecology
Serhat Ege, Muhammet Hanifi Bademkiran, Nurullah Peker, Selami Erdem, Rusen Koceroglu, Ozcan Erel
Summary: This study found that serum IMA levels were significantly higher in CC-resistant PCOS patients, indicating more oxidative stress in this group. IMA may serve as a valuable indicator for guiding management of CC-resistant PCOS patients.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Arduino A. Mangoni, Angelo Zinellu
Summary: This study conducted a systematic review and meta-analysis on the serum concentrations of ischaemia-modified albumin (IMA) in patients with acute ischaemic stroke (AIS), intracerebral haemorrhage (ICH), and subarachnoid haemorrhage (SAH). The results showed significantly higher IMA concentrations in these patients, suggesting that IMA concentrations might be useful in diagnosing stroke and distinguishing between different types of stroke.
Article
Multidisciplinary Sciences
Seok-In Hong, Youn-Jung Kim, Yeon Joo Cho, Jin Won Huh, Sang-Bum Hong, Won Young Kim
Summary: Combining pre-arrest serum albumin levels with the GO-FAR score improved the predictive performance for neurological outcomes in in-hospital cardiac arrest patients. Patients were divided into quartiles based on albumin levels and scored accordingly, leading to an enhancement in predictive ability in the albumin-added model. This study demonstrated a significant improvement in predictive performance by incorporating pre-arrest albumin levels into the original GO-FAR score.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Paolo Caraceni, Manuel Tufoni, Giacomo Zaccherini, Oliviero Riggio, Paolo Angeli, Carlo Alessandria, Sergio Neri, Francesco G. Foschi, Fabio Levantesi, Aldo Airoldi, Loredana Simone, Gianluca Svegliati-Baroni, Stefano Fagiuoli, Giacomo Laffi, Raffaele Cozzolongo, Vito Di Marco, Vincenzo Sangiovanni, Filomena Morisco, Pierluigi Toniutto, Antonio Gasbarrini, Rosanna De Marco, Salvatore Piano, Silvia Nardelli, Chiara Elia, Andrea Roncadori, Maurizio Baldassarre, Mauro Bernardi
Summary: Baseline serum albumin concentration closely correlates with 18-month mortality in untreated patients; on-treatment serum albumin levels are strongly associated with outcomes, especially at 1 month after treatment. Long-term albumin administration improves patient survival even if the serum albumin level does not normalize.
JOURNAL OF HEPATOLOGY
(2021)
Article
Oncology
Teruhisa Sakamoto, Teppei Sunaguchi, Keisuke Goto, Masaki Morimoto, Yuki Murakami, Kozo Miyatani, Takehiko Hanaki, Yuji Shishido, Kyoichi Kihara, Tomoyuki Matsunaga, Manabu Yamamoto, Naruo Tokuyasu, Yoshiyuki Fujiwara
Summary: The modified nutritional geriatric risk index (mGNRI) may be more useful than the original GNRI in predicting the prognosis of patients with pancreatic cancer. When combined with psoas muscle volume (PMV), the mGNRI may provide more accurate prognostic outcomes.
Article
Multidisciplinary Sciences
Li Chen, Chunlei Tan, Qingwen Li, Zhibo Ma, Meng Wu, Xiaosheng Tan, Tiangen Wu, Jinwen Liu, Jing Wang
Summary: This study investigated the prognostic value of albumin-bilirubin (ALBI) score in breast cancer patients with liver metastasis after surgery. The results showed that patients with low ALBI score had better survival outcomes. ALBI score can be used to identify high-risk patients with liver metastasis.
Article
Multidisciplinary Sciences
Jose C. Paez-Franco, Jiram Torres-Ruiz, Victor A. Sosa-Hernandez, Rodrigo Cervantes-Diaz, Sandra Romero-Ramirez, Alfredo Perez-Fragoso, David E. Meza-Sanchez, Juan Manuel German-Acacio, Jose L. Maravillas-Montero, Nancy R. Mejia-Dominguez, Alfredo Ponce-de-Leon, Alfredo Ulloa-Aguirre, Diana Gomez-Martin, Luis Llorente
Summary: Using gas chromatography coupled to mass spectrometry, we identified significant changes in serum metabolites associated with severe and mild COVID-19 patients, particularly in altered amino acid catabolism. The study found that three alpha-hydroxyl acids of amino acid origin increased with disease severity, correlating with changes in oxygen saturation levels and clinical markers of lung damage. The conversion of alpha-keto acids to alpha-hydroxyl acids is suggested to play a role in maintaining NAD recycling in patients with altered oxygen levels during SARS-CoV-2 infection, highlighting the potential importance of amino acid supplementation.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Zheng Zhao, Lin Cai, Si Zhang, Heng Zhang, Xiaoyang Liu, Chenglong Li, Yan Zhao, Jianzhong Zhang
Summary: This study found that patients with psoriasis have higher serum uric acid levels and a higher prevalence of hyperuricemia compared to healthy controls. Treatment with secukinumab successfully decreased serum uric acid levels in patients with psoriasis, while adalimumab had no significant effect on serum uric acid levels.
CHINESE MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Xiu-Min Chen, Dan-Ni Yao, Mao-Jie Wang, Xiao-Dong Wu, Jing-Wen Deng, Hao Deng, Run-Yue Huang, Chuan-Jian Lu
Summary: Psoriasis is a common chronic skin disease that requires long-term treatment. This study identifies serum exosomal miRNAs as potential biomarkers and therapeutic targets for psoriasis, providing new possibilities for clinical diagnosis and treatment.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Cihan Adanas, Sezai Ozkan, Canan Demir
Summary: In patients with osteomyelitis, the level of ischaemia modified albumin was significantly higher compared to healthy controls, and there was a significant correlation between ischaemia modified albumin and C-reactive protein levels.
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
(2021)
Article
Gastroenterology & Hepatology
Serkan Ipek, Hulya Yalcin, Burak Toprak
Summary: The study found that IMA levels are associated with disease activity in ulcerative colitis patients and can be a useful parameter for assessing disease activity.
GASTROENTEROLOGY REVIEW-PRZEGLAD GASTROENTEROLOGICZNY
(2022)
Article
Biochemistry & Molecular Biology
Muberra Acar, Havva Sayhan Kaplan, Ali F. Erdem, Yakup Tomak, Gupse Turan, Mehmet Ozdin
Summary: This study investigated the effect of dexmedetomidine on the oxidant-antioxidant (thiol/disulphide) balance. The results showed a minimal decrease in thiol-disulphide levels in the group treated with dexmedetomidine. Additionally, dexmedetomidine was found to reduce tubular damage and necrosis in the kidneys.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Review
Oncology
Long-Bin Jeng, Wen-Ling Chan, Chiao-Fang Teng
Summary: This review summarizes the prognostic significance of serum albumin (ALB) level and ALB-based mono- and combination biomarkers in predicting the prognosis of hepatocellular carcinoma (HCC) patients after different therapies. It emphasizes the importance of developing valuable and independent prognostic biomarkers for early prediction of poor prognosis in HCC patients. The review also highlights the diverse biological functions of ALB and its common use as a biomaterial and therapeutic agent in clinical settings.
Article
Clinical Neurology
Ling Chen, Yang Jin, Ling Wang, Kai Wei, Xin Li, Tao Jiang, Xiangyang Cao, Liujun Xue, Qiantao Cheng
Summary: This study investigated the impact of human serum albumin (HSA) levels on symptomatic cerebral vasospasm (SCVS) in patients with aneurysmal subarachnoid hemorrhage (aSAH). The results showed that HSA levels lower than the average and lowest levels were associated with the occurrence of SCVS, and the lowest HSA level was a better predictor for SCVS.
NEUROLOGICAL SCIENCES
(2023)
Article
Dermatology
Efsun Tanacan, Aynure Oztekin, Unsal Savci, Engin Senel, Coskun Oztekin, Salim Neselioglu, Ozcan Erel
Summary: This study investigates the role of ischemia-modified albumin (IMA) and IMA/albumin levels in patients with AA. The results show significant differences in the mean values of IMA and IMA/albumin ratio between the study and control groups. However, these findings suggest that IMA and IMA/albumin may not be useful in predicting the severity of AA in patients.
DERMATOLOGY PRACTICAL & CONCEPTUAL
(2023)