Article
Biochemical Research Methods
Gaoping Cui, Ying Qing, Minghui Li, Liya Sun, Juan Zhang, Lei Feng, Jing Li, Tianlu Chen, Jijun Wang, Chunling Wan
Summary: Metabolomics analysis showed disrupted metabolism pathways in schizophrenia patients, potentially originating from dysbiotic salivary microbiota and affecting peripheral inflammatory responses, highlighting the importance of the oral-brain connection in the pathogenesis of the disease.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xue Fan, Ke Li, Xin Guo, Shengyou Liao, Qi Zhang, Yangkai Xu, Hongtu Cui, Lemin Zheng, Mingguo Xu
Summary: In this study, metabolic alterations in Kawasaki disease (KD) were investigated, and it was found that amino acid, lipid, and tryptophan metabolism were significantly disturbed. Changes in tryptophan metabolites were consistent in both patients and a mouse model of KD. Furthermore, analysis of RNA sequencing data revealed the potential involvement of Aryl hydrocarbon receptor in KD. These findings suggest that metabolic indicators could serve as novel diagnostic and therapeutic biomarkers for KD.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Nutrition & Dietetics
Guangsu Zhu, Min Guo, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen
Summary: Alzheimer's disease is characterized by global metabolic alterations, leading to cognitive impairment. This study found that B. breve CCFM1025 intervention can restore the metabolic changes induced by Aβ injection, particularly in amino acid metabolism.
Article
Nutrition & Dietetics
Nipun Saini, Manjot S. Virdee, Kaylee K. Helfrich, Sze Ting Cecilia Kwan, Sandra M. Mooney, Susan M. Smith
Summary: Prenatal alcohol exposure can cause fetal growth restrictions. Alcohol affects maternal metabolism, limiting glucose availability and resulting in changes in metabolic products, which may impact fetal weight.
Article
Plant Sciences
Feng Zhou, Xu-Yang Liu, Lin -Lin Liu, Yan Hou, Zisheng Han, Liang Zhang
Summary: By conducting a metabolomics analysis, sensory evaluation, and transcriptomic analysis on tea leaves with and without mistletoe, it was found that mistletoe affects the secondary metabolites and gene expression in tea leaves, leading to a decrease in catechin content but an increase in free amino acid content.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Forestry
Qunfeng Zhang, Meiya Liu, Roland Mumm, Ric C. H. Vos, Jianyun Ruan
Summary: This study provides insights into the spatial effects of shading on tea plants, highlighting the potential for improving tea quality through cultivation measures that enhance plant shading. By analyzing the metabolome in different parts of tea shoots under shading conditions, it was found that shading led to changes in the ratio of polyphenols to amino acids and levels of galloylated catechins, with differential responses observed among various metabolites in the young shoot tissues. The study also revealed spatial redistribution of carbon and nitrogen resources within the plant in response to shading treatments.
Article
Pharmacology & Pharmacy
Hong Wan, Xiaojun Xu, Xiaowei Yang, Angqing Li, Xiaopeng Ma, Aman Xu, Xiao Yuan, Wenbin Wang, Tao Guo, Guangtao Luo, Xiaobo He, Wang Li, Zhaorui Wang, Qiang Sun, Jing Pei, Yongzhen Guo, Yong Zhu
Summary: This study utilized an untargeted metabolomics approach to investigate the impact of SST treatment on the metabolism of breast cancer patients, revealing significant alterations in glucose, fatty acid, bile acid, and amino acid metabolism. Particularly, SST treatment was found to reduce levels of potential tumor neoantigen short peptides, shedding light on the mechanism underlying SST's interaction with base-line chemotherapy in affecting metabolic pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Reproductive Biology
Ling Hong, Yuan Chang Zhu, Su Liu, Tonghua Wu, Yuye Li, Lijun Ye, Lianghui Diao, Yong Zeng
Summary: The deterioration of the endometrial environment is a major cause of recurrent miscarriage (RM). Studies have shown alterations in metabolite profiles, increased levels of autophagy-related proteins, and significant crosstalk between amino acid metabolism and autophagy in RM. These findings suggest a potential link between aberrant crosstalk between amino acid metabolism and autophagy and the impaired endometrial microenvironment in RM.
BIOLOGY OF REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Susama Chokesuwattanaskul, Michele Fresneda Alarcon, Sangeetha Mangalakumaran, Rudi Grosman, Andrew L. Cross, Elinor A. Chapman, David Mason, Robert J. Moots, Marie M. Phelan, Helen L. Wright
Summary: This study investigates the role of altered energy metabolism in neutrophils in rheumatoid arthritis and the effects of different JAK inhibitors on neutrophil metabolism. JAK inhibitors effectively inhibit ROS production and decrease NET production in neutrophils without impairing bacterial killing.
Article
Pharmacology & Pharmacy
Hao- Xiong, Hui-Tao Zhang, Hong-Wen Xiao, Chun-Lan Huang, Mei-Zhou Huang
Summary: The study found that metabolomic analysis can better differentiate different types and states of leukemia based on existing clinical diagnostic techniques. The metabolism of choline and betaine may be significantly related to the patient's blood lipid profile. The main enrichment pathways for distinguishing differential metabolites are amino acid metabolism and fatty acid metabolism.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Giacomo Lazzarino, Romina Pallisco, Gabriele Bilotta, Ilaria Listorti, Renata Mangione, Miriam Wissam Saab, Giuseppe Caruso, Angela Maria Amorini, Maria Violetta Brundo, Giuseppe Lazzarino, Barbara Tavazzi, Pasquale Bilotta
Summary: The study analyzed metabolites in follicular fluid and identified 27 low molecular weight compounds with significantly different values in infertile females compared to control subjects. These compounds were used to calculate a Biomarker Score that effectively discriminated between control and infertile groups, indicating their potential as infertility biomarkers. Additionally, the Biomarker Score values correlated with various outcome measures of assisted reproduction techniques, suggesting a strong influence of follicular fluid metabolism on IVF success and embryonic development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Ou Sheng, Zhibin Yin, Wenjie Huang, Mengyu Chen, Mingyi Du, Qian Kong, Alisdair R. Fernie, Ganjun Yi, Shijuan Yan
Summary: This study provides a comprehensive understanding of genotype-associated carotenoid accumulation in bananas and highlights the impact of genotype on the levels of carotenoids and amino acids. These findings have important implications for the breeding of future high carotenoid banana cultivars.
Article
Biochemistry & Molecular Biology
Shaoyong Peng, Yingjie Li, Meijin Huang, Guannan Tang, Yumo Xie, Daici Chen, Yumin Hu, Tiantian Yu, Jian Cai, Zixu Yuan, Huaiming Wang, Hui Wang, Yanxin Luo, Xiaoxia Liu
Summary: This study investigates the role of cancer-associated fibroblasts (CAFs) in peritoneal metastasis (PM) of colorectal cancer (CRC) and identifies a potential therapeutic target for the treatment of PM-CRC. The study shows that the abundance of phosphatidylcholine (PC) with unsaturated acyl chains is increased in clinical PM-CRC specimens. It also reveals that CAFs are present at a higher relative abundance in primary PM-CRC tumors and that incubation with CAF-conditioned medium (CM) increases the membrane fluidity in CRC cells. The study suggests that elevated membrane fluidity enhances glucose uptake and metabolism in CRC cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lei Liu, Taiping Li, Hui Dong, Xijun Wang
Summary: The mechanism of action and potential targets of Paeoniae Radix Alba (Baishao, B) in the treatment of adjuvant-induced arthritis (AIA) rats were explained using metabolomics and network pharmacology techniques, enriching the research evidence for the development of anti-rheumatoid arthritis (RA) drugs.
Article
Medicine, Research & Experimental
Arnaud Germain, Ludovic Giloteaux, Geoffrey E. Moore, Susan M. Levine, John K. Chia, Betsy A. Keller, Jared Stevens, Carl J. Franconi, Xiangling Mao, Dikoma C. Shungu, Andrew Grimson, Maureen R. Hanson
Summary: Post-exertional malaise (PEM) is a prominent symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). By monitoring plasma metabolites, this study found significant differences in metabolic response and recovery pattern between ME/CFS patients and healthy control participants after two maximal exercise tests. Glutamate metabolism was identified as a crucial factor in the metabolic disruptions that lead to PEM.
Article
Biochemistry & Molecular Biology
Flaubert Alexis Perez-Noriega, Citlaltepetl Salinas-Lara, Carlos Sanchez-Garibay, Jose Jiram Torres-Ruiz, Jose Luis Maravillas-Montero, Mauricio Castanon-Arreola, Maria Elena Hernandez-Campos, Cesar Rodriguez-Balderas, Beatriz Victoria Basurto-Lopez, Carlos Penafiel-Salgado, Ana Paola Espinosa-Garcia, Jose Alberto Choreno-Parra, Martha Lilia Tena-Suck, Luis O. Soto-Rojas, Elsa Y. Leon-Marroquin, Jose Pablo Romero-Lopez, Manuel Castillejos-Lopez
Summary: In this study, a murine experimental model of immune complex-mediated brain vasculitis induced by cell wall antigens of Mycobacterium tuberculosis (Mtb) was established. The results showed that high levels of immune complexes were formed and deposited in the brain, lung, and kidneys, leading to vascular inflammation and meningitis. This suggests a significant role of immune complexes in the pathogenesis of tuberculosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Yair Alvarez-Ricardo, William Meza-Morales, Marco A. Obregon-Mendoza, Ruben A. Toscano, Francisco Nunez-Zarur, Juan M. German-Acacio, Nicolas Puentes-Diaz, Jorge Ali-Torres, Antonino Arenaza-Corona, Maria Teresa Ramirez-Apan, David Morales-Morales, Raul G. Enriquez
Summary: This study investigated the benzylation reaction of curcumin and tetrahydrocurcumin with benzyl bromide and potassium carbonate in acetone. It was found that curcumin undergoes O-alkylation first, followed by C-1 substitution, while THC undergoes these reactions in reverse order. The antioxidant and cytotoxic activities of the benzylated derivatives were studied, and the C-dibenzylated curcuminoid showed superior activity compared to the tribenzylated and tetrabenzylated derivatives. DFT calculations and docking calculations on a DNA fragment were conducted to explain the experimental results and the preferences for nucleophilic attack.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Infectious Diseases
Jiram Torres-Ruiz, Julieta Lomelin-Gascon, Jaquelin Lira Luna, Ana Sofia Vargas- Castro, Alfredo Perez-Fragoso, Miroslava Nunez-Aguirre, Beatriz Alcala-Carmona, Abdiel Absalon-Aguilar, Jennifer T. Balderas-Miranda, Jose Luis Maravillas-Montero, Nancy R. Mejia-Dominguez, Carlos Nunez-Alvarez, Luis Llorente, Sandra Romero-Ramirez, Victor Andres Sosa-Hernandez, Rodrigo Cervantes-Diaz, Guillermo Juarez-Vega, David Meza-Sanchez, Marina Rull-Gabayet, Luis Alberto Martinez-Juarez, Linda Morales, Lizeth Naomi Lopez-Lopez, Jose Adrian Negrete-Trujillo, Jorge Abelardo Falcon-Lezama, Rafael Ricardo Valdez-Vazquez, Hector Gallardo-Rincon, Roberto Tapia-Conyer, Diana Gomez-Martin
Summary: This study aimed to investigate the features associated with the persistence of post-COVID-19 syndrome. A cohort study of 102 COVID-19 patients was conducted, and it was found that obesity, pro-inflammatory state, and increased cellular senescence are independently associated with the persistence of post-COVID-19 syndrome. These findings have important implications for understanding and preventing post-COVID-19 syndrome.
INFECTIOUS DISEASES
(2023)
Article
Immunology
Sandra Romero-Ramirez, Victor A. Sosa-Hernandez, Rodrigo Cervantes-Diaz, Daniel A. Carrillo-Vazquez, David E. Meza-Sanchez, Carlos Nunez-Alvarez, Jiram Torres-Ruiz, Diana Gomez-Martin, Jose L. Maravillas-Montero
Summary: This study investigated the levels of IgA in the saliva of SLE patients and found that total IgA and IgA1 levels were significantly elevated in saliva of SLE patients. Furthermore, salivary IgA levels, particularly IgA2, positively correlated with anti-dsDNA IgG antibody titers. Additionally, the presence of salivary anti-nucleosome IgA antibodies in SLE patients, not previously reported elsewhere, was also detected. According to the results, characterization of IgA in saliva could be a potentially helpful tool in the clinical care of SLE patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
M. Fernanda Munoz Tecocoatzi, Jose C. Paez-Franco, Kenneth Rubio-Carrasco, Alejandra Nunez-Pineda, Alejandro Dorazco-Gonzalez, Ines Fuentes-Noriega, Alfredo R. Vilchis-Nestor, Lilian I. Olvera, David Morales-Morales, Juan Manuel German-Acacio
Summary: Ball-milling using neat grinding or liquid-assisted grinding with different solvents allowed the formation of various solid forms of pioglitazone hydrochloride (PGZ·HCl) and rosuvastatin calcium (RSV). By adjusting the molar ratios of the reactants, coamorphous forms with different stoichiometries were obtained. In addition, mixtures of solid forms coexisted with the coamorphous forms when the drug ratio was not stoichiometric. The dissolution profiles of these solid forms were evaluated, and a synchronized release of both drugs was observed. The coamorphous 2:1 form showed an improved dissolution rate compared to pure PGZ·HCl, which may be attributed to pH changes caused by the degradation processes of RSV.
Article
Microbiology
Carla M. Roman-Montes, Saul Bojorges-Aguilar, Ever Arturo Corral-Herrera, Andrea Rangel-Cordero, Paulette Diaz-Lomeli, Axel Cervantes-Sanchez, Bernardo A. Martinez-Guerra, Sandra Rajme-Lopez, Karla Maria Tamez-Torres, Rosa Areli Martinez-Gamboa, Maria Fernanda Gonzalez-Lara, Alfredo Ponce-de-Leon, Jose Sifuentes-Osornio
Summary: This study describes the prevalence, related factors, and outcomes of Invasive Fungal Infections (IFI) in critically ill patients with COVID-19. The overall prevalence of IFI was 9.3%, with 5.6% being COVID-19-associated pulmonary aspergillosis (CAPA) and 2.5% being invasive candidiasis (IC). Factors related to IFI included higher SOFA scores and empiric antibiotic use for COVID-19. CAPA was the most frequent type of IFI.
Article
Chemistry, Medicinal
Marco Villeda-Villegas, Jose C. Paez-Franco, Guadalupe Coyote-Dotor, Alejandra Nunez-Pineda, Alejandro Dorazco-Gonzalez, Ines Fuentes-Noriega, Kenneth Rubio-Carrasco, Helen Toledo P. Jaldin, David Morales-Morales, Juan Manuel German-Acacio
Summary: A coamorphous salt in a 1:1 ratio of Fluvastatin sodium (FLV) and Pioglitazone hydrochloride (PGZ center dot HCl) can be prepared by ball milling through neat grinding (NG), while the salt-cocrystal continuum is preferably formed by liquid-assisted grinding (LAG) using ethanol (EtOH). Attempts to prepare the coamorphous salt from the salt-cocrystal continuum by neat grinding were unsuccessful. Ball milling by NG or LAG can access a great variety of solid forms (PGZ center dot HCl-FLV 1:1): coamorphous with hexane; physical mixture with ethyl acetate; salt-cocrystal continuum with EtOH; and immiscible components with water.
Article
Chemistry, Physical
Juan Manuel German Acacio, Simon Hernandez-Ortega, Everardo Jaime-Adan, Jesus Valdes-Martinez
Summary: To test the hypothesis, we synthesized and determined the crystal structure of the compound [PtCl3(4-HoxpyH)], 1, which shows that the ligand HoxpyH coordinates through the nitrogen atom of the oxime group and forms the expected H-bonds. In the crystal, six molecules interact through hydrogen bonds and O center dot center dot center dot Cl interactions, forming rings that extend into two-dimensional structures. These 2D structures are stacked on top of each other through Pt center dot center dot center dot pyH and Pt-Cl center dot center dot center dot pyH interactions, without interpenetrating or forming channels.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Immunology
Norma Hernandez-Pedro, Marisol Arroyo-Hernandez, Pedro Barrios-Bernal, Eunice Romero-Nunez, Victor A. Sosa-Hernandez, Santiago avila-Rios, Jose Luis Maravillas-Montero, Rogelio Perez-Padilla, Diego de Miguel-Perez, Christian Rolfo, Oscar Arrieta
Summary: Immune dysregulation and cancer treatment may affect the protection of SARS-CoV-2 vaccination. NSCLC patients undergoing oncological treatment, especially chemotherapy and tyrosine kinase inhibitors, have impaired antibody generation after receiving the vaccine. Patients receiving immunotherapy did not generate antibodies.
Article
Microbiology
Karla M. Tamez-Torres, Norma Mongua-Rodriguez, Leticia Ferreyra-Reyes, Pedro Torres-Gonzalez, Guadalupe Delgado-Sanchez, Maribel Martinez-Hernandez, Miriam Bobadilla-del-Valle, Velma Y. Jasso-Sosa, Priscila del S. Lopez-Castillo, Elizabeth Ferreira-Guerrero, Luis Pablo Cruz-Hervert, Jose Sifuentes-Osornio, Carlos A. Aguilar-Salinas, Lourdes Garcia-Garcia, Alfredo Ponce-de-Leon
Summary: Tuberculosis (TB) associated with diabetes mellitus (DM) is a growing problem, particularly in low- and medium-resource countries. However, the use of isoniazid (INH) or rifampicin (RIF) for TB preventive treatment (TPT) in people with type 2 DM is not safe enough to be considered a universal indication.
Article
Microbiology
Fabian Rojas-Larios, Bernardo Alfonso Martinez-Guerra, Luis Esau Lopez-Jacome, Enrique Bolado-Martinez, Maria del Rosario Vazquez-Larios, Maria del Consuelo Velazquez-Acosta, Daniel Romero-Romero, Christian Daniel Mireles-Davalos, Sandra Quintana-Ponce, Jose Manuel Feliciano-Guzman, Jose Miguel Perez-Hernandez, Yoselin Paola Correa-Leon, Eduardo Lopez-Gutierrez, Eduardo Rodriguez-Noriega, Esteban Gonzalez-Diaz, Elena Victoria Choy-Chang, Juan Pablo Mena-Ramirez, Victor Antonio Monroy-Colin, Alfredo Ponce-de-Leon-Garduno, Margarita Alcaraz-Espejel, Laura Karina Aviles-Benitez, Luis Javier Quintanilla-Cazares, Eloisa Ramirez-Alanis, Juan Manuel Barajas-Magallon, Cecilia Padilla-Ibarra, Maria Bertha Ballesteros-Silva, Noe Antonio Atanacio-Sixto, Cecilia Teresita Morales-de-la-Pena, Mario Galindo-Mendez, Talia Perez-Vicelis, Guillermo Jacobo-Baca, Martha Irene Moreno-Mendez, Maria de la Luz Mora-Pacheco, Maricruz Gutierrez-Brito, Xochitl Yadira Sanchez-Godinez, Norberta Vianey Navarro-Vargas, Luz Elena Mercado-Bravo, Alejandro Delgado-Barrientos, Maria Asuncion Santiago-Calderon, Ismelda Lopez-Ovilla, Alejandro Molina-Chavarria, Joaquin Rincon-Zuno, Rafael Franco-Cendejas, Sandra Miranda-Mauricio, Isabel Cristina Marquez-Avalos, Maribel Lopez-Garcia, Lizbeth Soraya Duarte-Miranda, Carlos Miguel Cetina-Umana, Irma Elena Barroso-Herrera-y-Cairo, Laura Isabel Lopez-Moreno, Elvira Garza-Gonzalez
Summary: We analyzed antimicrobial resistance (AMR) data of clinical isolates from 43 centers in Mexico, including Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterococcus faecium, and Staphylococcus aureus. The study investigated the site of care, patient age, and clinical specimen type to determine AMR patterns. The findings revealed that ICU patients had the highest AMR in E. coli, K. pneumoniae, and P. aeruginosa isolates, while non-ICU patients had higher AMR in A. baumannii isolates. The oldest age group showed the highest AMR in E. coli, E. faecium, and S. aureus, while the 19-59 age group had the highest AMR in A. baumannii and P. aeruginosa. Additionally, higher AMR was observed in E. coli, K. pneumoniae, and P. aeruginosa isolates from blood specimens, and the most frequently detected carbapenemase-encoding gene in E. coli was blaNDM (84%).
Article
Infectious Diseases
Hector Orlando Rivera-Villegas, Bernardo Alfonso Martinez-Guerra, Rosalia Garcia-Couturier, Luis Fernando Xancal-Salvador, Veronica Esteban-Kenel, Ricardo Antonio Jaimes-Aquino, Miguel Mendoza-Rojas, Axel Cervantes-Sanchez, Steven Mendez-Ramos, Jorge Eduardo Alonso-Montoya, Diana Munguia-Ramos, Karla Maria Tamez-Torres, Carla Marina Roman-Montes, Sandra Rajme-Lopez, Areli Martinez-Gamboa, Miriam Bobadilla-del-Valle, Maria Fernanda Gonzalez-Lara, Jose Sifuentes-Osornio, Alfredo Ponce-de-Leon
Summary: This study aimed to identify factors associated with 90-day all-cause mortality in patients with CR-GNB infections. The results showed that age, immunosuppression, and septic shock at diagnosis were independently associated with death within 90 days after CR-GNB infection. Additionally, receiving antibiogram-guided appropriate treatment was independently associated with a lower risk of death. These findings have important implications for clinical practice and addressing the problem of carbapenem resistance.
Article
Infectious Diseases
Fernando Solis-Huerta, Bernardo Alfonso Martinez-Guerra, Carla Marina Roman-Montes, Karla Maria Tamez-Torres, Sandra Rajme-Lopez, Narciso Ortiz-Conchi, Norma Irene Lopez-Garcia, Guadalupe Yvonne Villalobos-Zapata, Andrea Rangel-Cordero, Janet Santiago-Cruz, Luis Fernando Xancal-Salvador, Steven Mendez-Ramos, Eric Ochoa-Hein, Arturo Galindo-Fraga, Alfredo Ponce-de-Leon, Maria Fernanda Gonzalez-Lara, Jose Sifuentes-Osornio
Summary: This retrospective cohort study identified several risk factors for hospital-acquired infections (HAI) in patients with severe COVID-19, including early mechanical ventilation, chronic kidney disease, use of corticosteroids and tocilizumab, age ≥60 years, male sex, and obesity.
Review
Biology
Manuel Adrian Velazque-Cervantes, Yazmin Rocio Benitez-Zeferino, Arturo Flores-Pliego, Addy Cecilia Helguera-Repetto, David Eduardo Meza-Sanchez, Jose Luis Maravillas-Montero, Guadalupe Leon-Reyes, Javier Mancilla-Ramirez, Jorge Francisco Cerna-Cortes, Maria Isabel Baeza-Ramirez, Moises Leon-Juaarez
Summary: Cellular communication relies on vesicular systems, especially exosomes, which transport cargo influenced by various molecular signals and proteins involved in exosome biogenesis. Viruses can recruit exosomes to transport viral factors, and the late domains in viral proteins are crucial for exosomal selection and biogenesis.
