Functional Avidity: A Measure to Predict the Efficacy of Effector T Cells?

Epitope targeting and viral inoculum are determinants of Nef-mediated immune evasion of HIV-1 from cytotoxic T lymphocytes

(2012) D. Y. Chen et al.   BLOOD

Immunotherapy of cancer in 2012

(2012) John M. Kirkwood et al.   CA-A CANCER JOURNAL FOR CLINICIANS

TCR signaling requirements for activating T cells and for generating memory

(2012) Dietmar Zehn et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanisms behind Functional Avidity Maturation in T Cells

(2012) Marina Rode von Essen et al.   Clinical & Developmental Immunology

TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection

(2012) Huabiao Chen et al.   NATURE IMMUNOLOGY

CTL Responses of High Functional Avidity and Broad Variant Cross-Reactivity Are Associated with HIV Control

(2012) Beatriz Mothe et al.   PLoS One

Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression

(2011) A. R. Hersperger et al.   BLOOD

Escape from highly effective public CD8+ T-cell clonotypes by HIV

(2011) M. C. Iglesias et al.   BLOOD

Enhanced cytotoxicity and decreased CD8 dependence of human cancer-specific cytotoxic T lymphocytes after vaccination with low peptide dose

(2011) Tanja Lövgren et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Adjuvant Combination and Antigen Targeting as a Strategy to Induce Polyfunctional and High-Avidity T-Cell Responses against Poorly Immunogenic Tumors

(2011) F. Aranda et al.   CANCER RESEARCH

Advantage of higher-avidity CTL specific for Tax against human T-lymphotropic virus-1 infected cells and tumors

(2011) Takako Kitazono et al.   CELLULAR IMMUNOLOGY

CD8+T-cell cross-competition is governed by peptide-MHC class I stability

(2011) Ian Galea et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8+ T Cell Responses of Low Antigen Affinity to Protect against Viral Variants

(2011) Klaas P.J.M. van Gisbergen et al.   IMMUNITY

CD8+ T Cells: Foot Soldiers of the Immune System

(2011) Nu Zhang et al.   IMMUNITY

The immunological synapse: a cause or consequence of T-cell receptor triggering?

(2011) Balbino Alarcón et al.   IMMUNOLOGY

Increased sensitivity to antigen in high avidity CD8+ T cells results from augmented membrane proximal T-cell receptor signal transduction

(2011) Sharad K. Sharma et al.   IMMUNOLOGY

High-avidity, high-IFNγ-producing CD8 T-cell responses following immune selection during HIV-1 infection

(2011) Niamh M Keane et al.   IMMUNOLOGY AND CELL BIOLOGY

A New Pathway of CD5 Glycoprotein-mediated T Cell Inhibition Dependent on Inhibitory Phosphorylation of Fyn Kinase

(2011) Martina Bamberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dominant Clonotypes within HIV-Specific T Cell Responses Are Programmed Death-1high and CD127low and Display Reduced Variant Cross-Reactivity

(2011) J. A. Conrad et al.   JOURNAL OF IMMUNOLOGY

Clonotype and Repertoire Changes Drive the Functional Improvement of HIV-Specific CD8 T Cell Populations under Conditions of Limited Antigenic Stimulation

(2011) L. Janbazian et al.   JOURNAL OF IMMUNOLOGY

Large TCR Diversity of Virus-Specific CD8 T Cells Provides the Mechanistic Basis for Massive TCR Renewal after Antigen Exposure

(2011) I. Miconnet et al.   JOURNAL OF IMMUNOLOGY

Virological and Immunological Factors Associated with HIV-1 Differential Disease Progression in HLA-B*58:01-Positive Individuals

(2011) D. R. Chopera et al.   JOURNAL OF VIROLOGY

Major Histocompatibility Complex-Dependent Cytotoxic T Lymphocyte Repertoire and Functional Avidity Contribute to Strain-Specific Disease Susceptibility after Murine Respiratory Syncytial Virus Infection

(2011) B. Jessen et al.   JOURNAL OF VIROLOGY

High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control

(2011) C. T. Berger et al.   JOURNAL OF VIROLOGY

Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles

(2011) Yoav Peretz et al.   VIRAL IMMUNOLOGY

Induction of systemic HIV-1-specific cellular immune responses by oral exposure in the uninfected partner of discordant couples

(2010) Carina L Pérez et al.   AIDS

Persistent viral infection in humans can drive high frequency low-affinity T-cell expansions

(2010) Naeem Khan et al.   IMMUNOLOGY

Efficacious Early Antiviral Activity of HIV Gag- and Pol-Specific HLA-B*2705-Restricted CD8+T Cells

(2010) Rebecca P. Payne et al.   JOURNAL OF VIROLOGY

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

(2010) Jun Huang et al.   NATURE

Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection

(2010) Andrej Košmrlj et al.   NATURE

The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation

(2010)   SCIENCE

Perforin Expression Directly Ex Vivo by HIV-Specific CD8+ T-Cells Is a Correlate of HIV Elite Control

(2010) Adam R. Hersperger et al.   PLoS Pathogens

Orally exposed uninfected individuals have systemic anti-HIV responses associating with partnersʼ viral load

(2009) Klara Hasselrot et al.   AIDS

Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity

(2009) J. R. Almeida et al.   BLOOD

Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired

(2009) M. Ahmadzadeh et al.   BLOOD

Dynamic regulation of T-cell costimulation through TCR-CD28 microclusters

(2009) Tadashi Yokosuka et al.   IMMUNOLOGICAL REVIEWS

HLA-Associated Viral Mutations Are Common in Human Immunodeficiency Virus Type 1 Elite Controllers

(2009) T. Miura et al.   JOURNAL OF VIROLOGY

Complete but curtailed T-cell response to very low-affinity antigen

(2009) Dietmar Zehn et al.   NATURE

An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a

(2009) Peter J R Ebert et al.   NATURE IMMUNOLOGY

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Potentially Exposed but Uninfected Individuals Produce Cytotoxic and Polyfunctional Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses Which Can Be Defined to the Epitope Level

(2008) A. L. Erickson et al.   Clinical and Vaccine Immunology

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

(2008) Jennifer D. Stone et al.   IMMUNOLOGY

Avidity maturation of memory CD8 T cells is limited by self-antigen expression

(2008) Michael J. Turner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetic and Immunologic Heterogeneity among Persons Who Control HIV Infection in the Absence of Therapy

(2008) Florencia Pereyra et al.   JOURNAL OF INFECTIOUS DISEASES

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

Phenotype and function of protective T cell immune responses in HIV

(2008) Michael R Betts et al.   Current Opinion in HIV and AIDS