Glucocorticoid-Induced TNFR-Related (GITR) Protein and Its Ligand in Antitumor Immunity: Functional Role and Therapeutic Modulation

Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy

(2010) David Coe et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Therapeutic Glucocorticoid-Induced TNF Receptor-Mediated Amplification of CD4 + T Cell Responses Enhances Antiparasitic Immunity

(2010) Ashraful Haque et al.   JOURNAL OF IMMUNOLOGY

Stimulation of glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) induces inflammatory activation of microglia in culture

(2010) Heehong Hwang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Immune Rejection of Mouse Tumors Expressing Mutated Self

(2009) F. Duan et al.   CANCER RESEARCH

Glucocorticoid-Induced Tumor Necrosis Factor Receptor-Related Protein Ligand Subverts Immunosurveillance of Acute Myeloid Leukemia in Humans

(2009) T. Baessler et al.   CANCER RESEARCH

Glucocorticoid-induced tumor necrosis factor receptor stimulation enhances the multifunctionality of adoptively transferred tumor antigen-specific CD8+T cells with tumor regression

(2009) Naoko Imai et al.   CANCER SCIENCE

The GITRL–GITR system alters TLR-4 expression on DC during fungal infection

(2009) Anna Vecchiarelli et al.   CELLULAR IMMUNOLOGY

GITR Triggering Induces Expansion of Both Effector and Regulatory CD4+ T Cells In Vivo

(2009) R. W. van Olffen et al.   JOURNAL OF IMMUNOLOGY

Key Role of the GITR/GITRLigand Pathway in the Development of Murine Autoimmune Diabetes: A Potential Therapeutic Target

(2009) Sylvaine You et al.   PLoS One

GITR ligand-costimulation activates effector and regulatory functions of CD4+ T cells

(2008) Hanna Igarashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neutralization of tumor-derived soluble Glucocorticoid-Induced TNFR-Related Protein ligand increases NK cell anti-tumor reactivity

(2008) K. M. Baltz et al.   BLOOD

Localized expression of GITR-L in the tumor microenvironment promotes CD8+ T cell dependent anti-tumor immunity

(2008) John S. Cho et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Regulatory T Cell-Resistant CD8+ T Cells Induced by Glucocorticoid-Induced Tumor Necrosis Factor Receptor Signaling

(2008) H. Nishikawa et al.   CANCER RESEARCH

Construction and Preclinical Characterization of Fc-mGITRL for the Immunotherapy of Cancer

(2008) P. Hu et al.   CLINICAL CANCER RESEARCH

Co-inhibitory roles for glucocorticoid-induced TNF receptor in CD1d-dependent natural killer T cells

(2008) Shuming Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Enhancement of T-cell-mediated anti-tumour immunity via the ectopically expressed glucocorticoid-induced tumour necrosis factor receptor-related receptor ligand (GITRL) on tumours

(2008) Jinhua Piao et al.   IMMUNOLOGY

In vivo expansion of CD4+Foxp3+ regulatory T cells mediated by GITR molecules

(2008) Tomohisa Nishioka et al.   IMMUNOLOGY LETTERS

Glucocorticoid-induced Tumor Necrosis Factor Receptor Negatively Regulates Activation of Human Primary Natural Killer (NK) Cells by Blocking Proliferative Signals and Increasing NK Cell Apoptosis

(2008) Baoying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD4+CD25+ T-cell populations expressing CD134 and GITR are associated with disease activity in patients with Wegener's granulomatosis

(2008) B. Wilde et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Structural basis for ligand-mediated mouse GITR activation

(2008) Z. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of GITRL immune function: Murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily

(2008) K. Chattopadhyay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states

(2008) Z. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reverse signaling initiated from GITRL induces NF-κB activation through ERK in the inflammatory activation of macrophages

(2007) Eun Mi Bae et al.   MOLECULAR IMMUNOLOGY