Article
Oncology
Yue Liu, Joanna Pagacz, Donald J. Wolfgeher, Kenneth D. Bromerg, Jacob Gorman, Stephen J. Kron
Summary: Antigen presentation may be the limiting factor in the low immune response to radiation therapy, and combining immune checkpoint blockade does not restore cytotoxic T lymphocytes function. Therapeutic vaccines based on senescent tumor cells or SnC-activated dendritic cells have the potential to enhance immune therapies and limit recurrence or metastasis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Oncology
Hans Raskov, Adile Orhan, Jan Pravsgaard Christensen, Ismail Gogenur
Summary: The functions and interactions between the innate and adaptive immune systems play a crucial role in anticancer immunity. Cytotoxic T cells with CD8 as the most effective effectors in the anticancer immune response form the basis of successful cancer immunotherapies. Advancements in genetically modified or synthetic receptors on cytotoxic T cells are being developed for future cancer treatment. Combinatory regimens may optimize treatment effects and reduce adverse events in cancer therapy.
BRITISH JOURNAL OF CANCER
(2021)
Article
Immunology
Adele Friot, Sophia Djebali, Severine Valsesia, Peggy Parroche, Maxence Dubois, Jessica Baude, Francois Vandenesch, Jacqueline Marvel, Yann Leverrier
Summary: Staphylococcus aureus is a pathogen associated with various diseases and the emergence of antibiotic-resistant strains has raised concerns. Developing vaccines may help overcome these resistant strains, but the ability of S. aureus to internalize into cells poses a challenge. This study explores the potential of CD8(+) T cells to recognize and kill S. aureus-infected dendritic cells, paving the way for CD8(+) T cell-based therapies against S. aureus.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Immunology
Vanaja Konduri, Damilola Oyewole-Said, Jonathan Vazquez-Perez, Scott A. Weldon, Matthew M. Halpert, Jonathan M. Levitt, William K. Decker
Summary: NK1.1 and its human homolog CD161 are expressed on various immune cells and play different roles in NK cells, T cells, and NKT cells. CD161-expressing CD8(+) T cells, initially studied in viral infections, have potential implications in tumor immunology, although their exact role is not well understood.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Arne Knoerck, Gertrud Schaefer, Dalia Alansary, Josephine Richter, Lorenz Thurner, Markus Hoth, Eva C. Schwarz
Summary: This study developed a FRET-based single cell fluorescent assay to compare the cytotoxic efficiency of effector memory CD8(+) T cells (T-EM) and central memory CD8(+) T cells (T-CM). The results showed that T-EM had higher cytotoxic efficiency compared to T-CM. This could be attributed to the higher expression levels of perforin and granzyme B in T-EM, which likely mediate the higher cytotoxic efficiency.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Faye A. Camp, Tonya M. Brunetti, Michelle M. Williams, Jessica L. Christenson, Varsha Sreekanth, James C. Costello, Zachary L. Z. Hay, Ross M. Kedl, Jennifer K. Richer, Jill E. Slansky
Summary: Antigenic differences formed during epithelial to mesenchymal transition (EMT) in breast cancer cells can be altered using microRNA regulator and result in enhanced immune responses. Computational analysis identifies neoantigens derived from differentially expressed genes and alternative splicing. These neoantigens show potential to elicit T cell responses and improve immunotherapy against mesenchymal cells.
Article
Biochemistry & Molecular Biology
Marta Fortunato, Giada Amodio, Silvia Gregori
Summary: Tolerogenic dendritic cells (tolDC) play a central role in immune homeostasis and peripheral tolerance. We developed a protocol to generate genetically engineered tolDC overexpressing IL-10 (DCIL-10) and found that they can modulate cytotoxic CD8(+) T cell responses by reducing proliferation and activation, and inducing anergic CD8(+) T cells without signs of exhaustion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Xi Zhang, Tianhui He, Yuan Li, Ling Chen, Hongyu Liu, Yu Wu, Hongyan Guo
Summary: Ovarian cancer is characterized by uncertain presentation and poor outcomes, with surgery and chemotherapy being the current basis of treatment. However, there are limitations due to advanced stage at diagnosis and high recurrence rate. The use of anti-VEGF agents, PARP inhibitors, and immunotherapies are being explored to enhance treatment outcomes, but the population that can benefit from these treatments remains limited.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yana Hackler, Frank Siebenhaar, Max Loehning, Marcus Maurer, Melba Munoz
Summary: MCs play a critical role in the activation and expansion of virus-specific CD8(+) T cells through proper dendritic cell (DC) activation, and are essential for antiviral functions during viral infections. Depletion of MCs impairs CD8(+) T cell effector phenotype, antiviral cytokine production, and DC activation, resulting in increased viral loads and reduced type-I interferon levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Manuel Reithofer, Sandra Rosskopf, Judith Leitner, Claire Battin, Barbara Bohle, Peter Steinberger, Beatrice Jahn-Schmid
Summary: The translation highlights the different effects of costimulatory signals on human CD8 T-cell responses, with CD28 costimulation enhancing antigen-reactive CD8 T cells, 4-1BB costimulation inducing bystander proliferation, and CD27 signals enhancing antigen-specific CD8 T cell responses.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Cell Biology
Dorina Zoephel, Adrian Angenendt, Lea Kaschek, Keerthana Ravichandran, Chantal Hof, Sandra Janku, Markus Hoth, Annette Lis
Summary: A variety of intrinsic and extrinsic factors contribute to the altered efficiency of CTLs in elderly organisms. In this study, the cytotoxic ability of CD8(+) T cells in aging was investigated, and it was found that CD8(+) T cells from elderly mice exhibited faster killing kinetics compared to those from adult mice. Further analysis revealed that CD8(+) T cells from elderly mice had increased numbers of cells with granule fusion and higher levels of perforin and granzyme, making them very efficient killers.
Article
Oncology
Tobias Burkard, Martina Herrero San Juan, Caroline Dreis, Anastasiia Kiprina, Dmitry Namgaladze, Kai Siebenbrodt, Sebastian Luger, Christian Foerch, Josef M. Pfeilschifter, Andreas Weigert, Heinfried H. Radeke
Summary: Functionally distinct cytotoxic T lymphocytes can be identified based on their expression of CD8, playing opposing roles in the tumor microenvironment and autoimmune diseases such as multiple sclerosis. The presence of CD8(Low) T cells correlated with poor prognosis and enhanced cancer progression, while a reduced frequency of these cells was found in relapse multiple sclerosis patients compared to healthy subjects during immune cell starvation in vitro.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Engineering, Biomedical
Quoc-Viet Le, Jaiwoo Lee, Junho Byun, Gayong Shim, Yu-Kyoung Oh
Summary: In this study, artificial dendritic cell-mimicking DNA microflowers (DM-AI) were developed for programming T cell stimulation. DM-AI showed high ex vivo expansion of cytotoxic T cells and induced recruitment and expansion of T cells in tumor tissues. Treatment with DM-AI also prevented tumor recurrence and growth in mice.
BIOACTIVE MATERIALS
(2022)
Review
Immunology
Joseph S. Dolina, Natalija Van Braeckel-Budimir, Graham D. Thomas, Shahram Salek-Ardakani
Summary: Recent research has revealed the heterogeneity within the exhausted CD8(+) T cell lineage, which consists of multiple interconnected subpopulations with distinct characteristics and locations. This understanding calls for a re-focusing of cancer immunotherapies on targeting the driver mechanisms underlying CD8(+) T(ex) development to stabilize functional subsets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Ella Bhagyaraj, Hongbin Wang, Xinghong Yang, Carol Hoffman, Ali Akgul, Zakia Goodwin, David W. Pascual
Summary: znBAZ infection induces an increase and activation of lung NK cells in mice, which play a crucial role in promoting lung DC activation, migration, and the development of protective CD8(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Eri Ikeda, Takahiko Shiba, Yuichi Ikeda, Wataru Suda, Akinori Nakasato, Yasuo Takeuchi, Miyuki Azuma, Masahira Hattori, Yuichi Izumi
CLINICAL ORAL INVESTIGATIONS
(2019)
Article
Immunology
Masaaki Hashiguchi, Yuji Kashiwakura, Hidefumi Kojima, Yumiko Kanno, Tetsuji Kobata
IMMUNOLOGY LETTERS
(2019)
Article
Critical Care Medicine
Chau Tran Bao Vu, Arsa Thammahong, Hideo Yagita, Miyuki Azuma, Nattiya Hirankarn, Patcharee Ritprajak, Asada Leelahavanichkul
Article
Dentistry, Oral Surgery & Medicine
Eri Ikeda, Takahiko Shiba, Yuichi Ikeda, Wataru Suda, Akinori Nakasato, Yasuo Takeuchi, Miyuki Azuma, Masahira Hattori, Yuichi Izumi
Article
Oncology
Jose-Ignacio Rodriguez-Barbosa, Miyuki Azuma, Gennadiy Zelinskyy, Jose-Antonio Perez-Simon, Maria-Luisa del Rio
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2020)
Article
Biochemistry & Molecular Biology
Yoshihisa Kashima, Naoto Nishii, Hidetake Tachinami, Emi Furusawa, Shigenori Nagai, Hiroyuki Harada, Miyuki Azuma
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Immunology
Masaaki Hashiguchi, Yuji Kashiwakura, Yumiko Kanno, Hidefumi Kojima, Tetsuji Kobata
IMMUNOLOGY LETTERS
(2020)
Article
Immunology
Y. Kashiwakura, H. Kojima, Y. Kanno, M. Hashiguchi, T. Kobata
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Takeshi Azuma, Yujiro Sato, Tatsukuni Ohno, Miyuki Azuma, Haruki Kume
Article
Immunology
Xiang Ao, Yue Yang, Takashi Okiji, Miyuki Azuma, Shigenori Nagai
Summary: The study found that MDCs induced during sepsis contribute to immune paralysis, and the PD-1/PD-L1-mediated generation of Gr-1(hi) cells in the early phase of sepsis is crucial for the development of immune paralysis in the later stage.
INFECTION AND IMMUNITY
(2021)
Article
Biology
Tomohiro Takehara, Ei Wakamatsu, Hiroaki Machiyama, Wataru Nishi, Katsura Emoto, Miyuki Azuma, Kenzo Soejima, Koichi Fukunaga, Tadashi Yokosuka
Summary: PD-1 forms microclusters with PD-L1/2 to inhibit T cell activation, with PD-L2 competing with PD-L1 for binding to PD-1. The cluster formation affects T cell signaling and serves as a visual index for the effectiveness of PD-1/2 inhibitory therapy.
COMMUNICATIONS BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Keeratika Wongtim, Eri Ikeda, Tatsukuni Ohno, Shigenori Nagai, Shigeru Okuhara, Keitetsu Kure, Miyuki Azuma
Summary: The study found that overexpression of PD-L1 in gingival basal keratinocytes in mice reduced periodontal inflammation and alveolar bone resorption in a ligature-induced periodontitis model.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Immunology
Yue Yang, Shigenori Nagai, Siwen Kang, Yulong Xia, Yohei Kawano, Kensuke Miyake, Hajime Karasuyama, Miyuki Azuma
INTERNATIONAL IMMUNOLOGY
(2020)
Article
Ophthalmology
Tomoyuki Kunishige, Hiroko Taniguchi, Tatsukuni Ohno, Miyuki Azuma, Junko Hori
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Article
Multidisciplinary Sciences
Alastair Copland, Adam Sparrow, Peter Hart, Gil Reynolds Diogo, Mathew Paul, Miyuki Azuma, Rajko Reljic
SCIENTIFIC REPORTS
(2019)