Article
Health Care Sciences & Services
Eeva Kormi, Elina Peltola, Niilo Lusila, Arja Heliovaara, Junnu Leikola, Juho Suojanen
Summary: This study aims to evaluate whether non-syndromic unilateral cleft lip and palate (UCLP) patients undergoing orthognathic surgery have asymmetry of the bony orbits. The study found that UCLP patients show asymmetry of the bony orbits during orthognathic surgery, while non-cleft class III patients do not have significant asymmetry. These results suggest that the asymmetry of the bony orbits should be considered in virtual surgical planning for UCLP patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Chihiro Iwaya, Akiko Suzuki, Junichi Iwata
Summary: Cleft lip and palate is a common congenital birth defect with varied causes. Recent studies suggest that non-coding RNAs, specifically microRNAs, may play a role in the development of cleft lip and palate. This review examines the potential of microRNAs as causative mechanisms in humans and mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lucas Alvizi, Luciano Abreu Brito, Gerson Shigeru Kobayashi, Barbara Bischain, Camila Bassi Fernandes da Silva, Sofia Ligia Guimaraes Ramos, Jaqueline Wang, Maria Rita Passos-Bueno
Summary: This study explores the functional effects of epigenetic changes associated with non-syndromic cleft lip with or without cleft palate (NSCLP). The researchers found that a region in the mir152 gene is frequently hypomethylated in NSCLP patients, leading to mir152 overexpression and downregulation of certain genes. They also discovered that mir152 upregulation in zebrafish embryos impairs craniofacial cartilage. Additionally, they propose that hypoxia during embryonic development may contribute to the hypomethylation and upregulation of mir152, leading to NSCLP.
Article
Health Care Sciences & Services
Takashi Matsumura, Hitoshi Kawanabe, Naoko Nemoto, Saki Ogino, Kazunori Fukui, Akihiko Oyama, Toru Okamoto
Summary: This study compared the treatment outcomes of single-stage surgery and two-stage surgery in children with cleft lip and palate. The results showed that the single-stage surgery had a significant positive effect on maxillary growth.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Yi-Hao Lee, Chi-Yu Tsai, Ling-Chun Wang, U-Kei Lai, Jui-Pin Lai, Shiu-Shiung Lin, Yu-Jen Chang
Summary: The study compared the postoperative temporomandibular joint position changes in two groups of cleft lip and palate patients and skeletal Class III patients treated with two-jaw orthognathic surgery. The results showed that the cleft patients had significantly more changes in TMJ position postoperatively, potentially leading to greater postoperative instability.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yi-Chin Wang, Ting-Chen Lu, Ying-An Chen, Philip Kuo-Ting Chen, Yu-Fang Liao
Summary: This study investigated the outcomes of tertiary gingivoperiosteoplasty, which is a previously uninvestigated procedure. The study included 11 adults with complete cleft lip and palate who underwent segmental Le Fort I osteotomy and concomitant gingivoperiosteoplasty. The results showed a decrease in nasoalveolar fistulas and residual cleft defects posttreatment. The minimal alveolar cleft width immediately after surgery was found to be the major influencing factor of clinical success.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Julia Maffeis, Guillaume Anthony Odri, Jacques-Marie Mercier, Justine Loin, Jean-Philippe Perrin, Aline Joly, Claudia Letelier, Pierre Corre, Helios Bertin
Summary: The aim of this study was to evaluate the sagittal and vertical relapses after Le Fort 1 osteotomy in patients with bilateral cleft lip and palate. The results showed that at one year after the surgery, patients experienced a certain degree of sagittal and vertical relapse, and vertical relapse was correlated to the degree of vertical movement. Additionally, factors such as prior pharyngeal flap, associated mandibular osteotomy, and smoking habits were associated with recurrence.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2023)
Article
Cell Biology
Anna Siewert, Benedikt Reiz, Carina Krug, Julia Heggemann, Elisabeth Mangold, Henning Dickten, Kerstin U. Ludwig
Summary: Cleft lip +/- cleft palate (CL/P) is a common birth defect. Single-cell RNA sequencing (scRNA-seq) data from embryonic mice were used to study gene expression patterns and investigate CL/P candidate genes. The study demonstrates the value of scRNA-seq data in craniofacial research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Mohammad Khursheed Alam, Ahmed Ali Alfawzan, Fatema Akhter, Haytham Jamil Alswairki, Prabhat Kumar Chaudhari
Summary: This study investigated the variation between non-syndromic cleft lip and/or palate (NSCLP) and non-cleft (NC) subjects in relation to lip morphology (LM) and nasolabial angle (NLA). The results showed significant disparities in LM-1 and NLA between NSCLP and NC individuals.
APPLIED SCIENCES-BASEL
(2022)
Article
Surgery
Bahadir Sancar, Numan Dedeoglu
Summary: The study found significant differences in buccal cortex thickness and the distance of the mandibular canal to the buccal surface in patients with cleft lip palate compared to class III individuals. Surgeons should consider these differences when performing mandibular osteotomy.
JOURNAL OF CRANIOFACIAL SURGERY
(2021)
Article
Dentistry, Oral Surgery & Medicine
A. K. Sander, E. Grau, A. K. Bartella, A. Kloss-Brandstaetter, M. Neuhaus, R. Zimmerer, B. Lethaus
Summary: This study retrospectively evaluated the medical reports of 1070 patients with different types of cleft lip and/or palate (CL/P) to explore the prevalence and association of dental anomalies. The study found that dental aplasia, supernumerary teeth, and hypoplastic teeth were common in CL/P patients. The occurrence of dental anomalies significantly increased the need for orthodontic therapy and orthognathic surgery in these patients.
Article
Surgery
Leela S. Mundra, Kristen M. Lowe, David Y. Khechoyan
Summary: This review provides recommendations on the appropriate timing for orthodontic preparation and surgical correction of alveolar clefts in patients with unilateral or bilateral CLP. It highlights the current standard of care and methods for treatment, emphasizing the importance of early mixed dentition phase for grafting and the use of preoperative and postoperative orthodontics.
JOURNAL OF CRANIOFACIAL SURGERY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Robert Frederick, Amy Claire Hogan, Natalie Seabolt, Rose Mary S. Stocks
Summary: This article emphasizes the benefits of a multidisciplinary team approach in the systemic management of patients with cleft lip and cleft palate, and suggests the addition of a registered dietitian to the care team. An ideal cleft palate care team should focus on a comprehensive, collaborative, and family-centered approach. While care teams may vary depending on context and location, there are still some key principles.
Review
Dentistry, Oral Surgery & Medicine
Gabriela Fonseca-Souza, Luiza Becker de Oliveira, Leticia Maira Wambier, Rafaela Scariot, Juliana Feltrin-Souza
Summary: Individuals with orofacial clefts are more likely to have tooth abnormalities compared to those without clefts. The type and laterality of the clefts are associated with different types of tooth abnormalities. However, the quality of evidence in the studies is low.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Chemistry, Multidisciplinary
Natalia Kaczorowska, Marcin Mikulewicz
Summary: This paper examines cephalometric parameters in patients with cleft lip and palate and cleft lip, and compares the differences between these patient groups. The results show that cleft palate surgery has an effect on the forward growth of the maxilla.
APPLIED SCIENCES-BASEL
(2022)