Article
Medicine, General & Internal
Andrea Matteucci, Michela Bonanni, Marco Centioni, Federico Zanin, Francesco Geuna, Gianluca Massaro, Giuseppe Sangiorgi
Summary: The COVID-19 pandemic led to changes in the in-hospital management of patients with CIEDs, with routine controls being shifted to remote home monitoring. The study found a decrease in arrhythmic events and hospital admissions in 2020 compared to 2019, while heart failure alarm activations increased. The combination of home monitoring and telemedicine has proved effective in ensuring surveillance of CIED patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Eric J. Hall, Soumojit Pal, Michael S. Glennon, Puneeth Shridhar, Sidney L. Satterfield, Beth Weber, Qinkun Zhang, Guy Salama, Hind Lal, Jason R. Becker
Summary: Cardiac natriuretic peptides play a crucial role in regulating cardiovascular physiology. Deficiency in either atrial natriuretic peptide (ANP) or B-type natriuretic peptide (BNP) can cause adverse effects on the structure and function of the heart. This study shows that ANP and BNP exert non-redundant functions in maintaining myocardial cGMP levels, which in turn regulate the activity of cardiomyocyte p38 mitogen-activated protein kinase (p38 MAPK) and cAMP response element-binding protein (CREB). Deficiency in cardiac natriuretic peptides increases the risk of stress-induced ventricular arrhythmias.
CARDIOVASCULAR RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Caitlin Hall, Katja Gehmlich, Chris Denning, Davor Pavlovic
Summary: Cardiac fibroblasts play a crucial role in providing support to the heart and are involved in physiological signaling processes, but excessive activation can lead to pathological remodeling. Research is expanding our understanding of cardiac fibroblast activation and their interactions with cardiac myocytes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Cardiac & Cardiovascular Systems
Riccardo Scirpa, Edoardo Cittadini, Lorenzo Mazzocchi, Giacomo Tini, Matteo Sclafani, Domitilla Russo, Andrea Imperatrice, Alessandro Tropea, Camillo Autore, Beatrice Musumeci
Summary: Transthyretin related cardiac amyloidosis (TTR-CA) is increasingly recognized due to a non-invasive diagnostic algorithm. The disease has two stages - presymptomatic and symptomatic, with the need to diagnose in the first stage becoming more urgent. Risk stratification is important to identify patients at higher risk of cardiovascular events and death, with proposed prognostic scores based on biomarkers and laboratory findings. A multiparametric approach combining information from various tests may be necessary for comprehensive risk prediction and management.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Dena Esfandyari, Bio Maria Gheo Idrissou, Konstantin Hennis, Petros Avramopoulos, Anne Dueck, Ibrahim El-Battrawy, Laurenz Grueter, Melanie Annemarie Meier, Anna Christina Naeger, Deepak Ramanujam, Tatjana Dorn, Thomas Meitinger, Christian Hagl, Hendrik Milting, Martin Borggrefe, Stefanie Fenske, Martin Biel, Andreas Dendorfer, Yassine Sassi, Alessandra Moretti, Stefan Engelhardt
Summary: MicroRNA-365 regulates human cardiac action potential by modulating key cardiac repolarizing channels.
NATURE COMMUNICATIONS
(2022)
Review
Multidisciplinary Sciences
John C. Wood
Summary: Thalassemias are common hereditary diseases due to their protective effect against malarial infection. Patients with thalassemia exhibit imbalanced hemoglobin formation, oxidative stress, and apoptosis of red cell precursors. The cardiovascular consequences of thalassemia have changed significantly over time due to advancements in treatment.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Medicine, General & Internal
Igor Diemberger, Alessandro Vicentini, Giuseppe Cattafi, Matteo Ziacchi, Saverio Iacopino, Giovanni Morani, Ennio Pisano, Giulio Molon, Tiziana Giovannini, Antonio Dello Russo, Giuseppe Boriani, Emanuele Bertaglia, Mauro Biffi, Maria Grazia Bongiorni, Roberto Rordorf, Giulio Zucchelli
Summary: A prospective analysis of data from Italian patients with implantable defibrillators and/or cardiac resynchronization devices during COVID-19 lockdown restrictions revealed a significant impact on patients' activity levels, heart rate variability, and arrhythmic burden. There was a marked decrease in physical activity and increase in atrial and ventricular arrhythmias during the lockdown period, which improved slightly post-lockdown. COVID-19 infection prevalence did not have a significant impact on these findings.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Thassio Mesquita, Rui Zhang, Jae Hyung Cho, Rui Zhang, Yen-Nien Lin, Lizbeth Sanchez, Joshua Goldhaber, Joseph K. Yu, Jialiu A. Liang, Weixin Liu, Natalia A. Trayanova, Eugenio Cingolani
Summary: Chronotropic incompetence and sinoatrial node (SAN) dysfunction are common problems in patients with heart failure, but the underlying mechanisms are not yet fully understood. This study identified intrinsic abnormalities in SAN structure and function as the cause of chronotropic incompetence in heart failure patients with preserved ejection fraction (HFpEF).
Review
Cell Biology
Sander Verheule, Ulrich Schotten
Summary: Fibrosis is recognized as a key determinant of conduction disturbances in both atria and ventricles, with different forms such as replacement, endomysial, perimysial, perivascular, endocardial, and epicardial fibrosis. The impact on conduction depends on how the patterns of electrical connections between myocytes are altered. Evaluating cardiac fibrosis should exclude fibrous tissue that does not affect conduction and differentiate between different types.
Review
Cardiac & Cardiovascular Systems
Andres G. Griborio-Guzman, Olexiy Aseyev, Hyder Shah, Masoud Sadreddini
Summary: Cardiac myxomas are the most common primary cardiac tumors in adults, with a low incidence rate, typically presenting as undifferentiated atrial masses that require prompt surgical resection. Patients may exhibit various symptoms, and diagnosis is established based on clinical, imaging, and histopathology features, with a favorable prognosis following surgical resection.
Article
Multidisciplinary Sciences
Sheng-an Su, Yuhao Zhang, Wudi Li, Yutao Xi, Yunrui Lu, Jian Shen, Yuankun Ma, Yaping Wang, Yimin Shen, Lan Xie, Hong Ma, Yao Xie, Meixiang Xiang
Summary: Ventricular arrhythmogenesis is a key cause of sudden cardiac death following myocardial infarction (MI). Increased mechanical stress, specifically through the activation of Piezo1, plays a significant role in ventricular arrhythmias. Activation of Piezo1 impairs intracellular calcium homeostasis and leads to the enhancement of cardiac arrhythmias. Targeting Piezo1 may be a promising therapeutic approach for the treatment of sudden cardiac death and heart failure.
Article
Medicine, Research & Experimental
Al -Hassan J. Dajani, Michael B. Liu, Michael A. Olaopa, Lucian Cao, Carla Valenzuela-Ripoll, Timothy J. Davis, Megan D. Poston, Elizabeth H. Smith, Jaime Contreras, Marissa Pennino, Christopher M. Waldmann, Donald B. Hoover, Jason T. Lee, Patrick Y. Jay, Ali Javaheri, Roger Slavik, Zhilin Qu, Olujimi A. Ajijola
Summary: Ventricular arrhythmias in heart failure are enhanced by sympathoexcitation. However, radiotracer studies suggest that reduced cardiac sympathetic innervation may actually increase the risk of VAs in failing hearts. This study found that in a murine model of dilated cardiomyopathy, there was global hypoinnervation in the ventricular myocardium. Interestingly, even though sympathetic innervation was reduced, there were transmural gradients present, with the endocardium lacking sympathetic nerve fibers. This pattern was also observed in human left ventricular wall samples from DCM patients. Further investigations using computational models showed that arrhythmogenesis increased as heterogeneity in sympathetic innervation worsened. Overall, this study suggests that heterogeneous innervation gradients in DCM play a role in promoting arrhythmogenesis and restoration of homogeneous sympathetic innervation may reduce VAs.
Article
Cardiac & Cardiovascular Systems
M. Scott Binder, Lisa R. Yanek, Wanjun Yang, Barbara Butcher, Sanaz Norgard, Joseph E. Marine, Aravindan Kolandaivelu, Jonathan Chrispin, Neal S. Fedarko, Hugh Calkins, Brian O'Rourke, Katherine C. Wu, Gordon F. Tomaselli, Andreas S. Barth
Summary: Heart failure (HF) is increasing in prevalence, and there is a need for better biomarkers to predict and prognosticate the condition. GDF-15 (growth differentiation factor-15) is a novel biomarker associated with HF mortality, but there have been no serial studies on GDF-15. This study investigated the association between GDF-15 levels over time and the occurrence of ventricular arrhythmias, HF hospitalizations, and all-cause mortality.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Christoph Maack, Jil C. Tardiff
Summary: Heart failure is a systemic disease that can impair cardiac function through neuroendocrine activation, inflammation, and metabolic changes. Additionally, genetic variants in sarcomeric protein genes can predispose individuals to develop heart failure. The 2022 Gordon Research Conference aims to identify novel treatment targets for complex cardiac disorders through high-resolution approaches.
NATURE REVIEWS CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Gokhan Aksan, Ahmet Yanik, Osman Can Yontar, Omer Gedikli, Ugur Arslan, Korhan Soylu
Summary: This study revealed a significant relationship between AHRE and CS galectin-3 levels, indicating that high CS galectin-3 levels can predict the development of AHRE in CRT patients.
JOURNAL OF INVESTIGATIVE MEDICINE
(2021)
Review
Clinical Neurology
Nicholas E. Lim, Benjamin Chia, Max K. Bulsara, Mark Parsons, Graeme J. Hankey, Andrew Bivard
Summary: The study aimed to determine whether automated CT perfusion (CTP) is accurate in predicting the irreversible infarct core in acute ischemic stroke. Through a systematic review and meta-analysis, the study found insufficient evidence and significant heterogeneity in the accuracy of CTP prediction compared to DWI or FLAIR in infarct core.
CEREBROVASCULAR DISEASES
(2023)
Article
Psychology, Clinical
Osvaldo P. Almeida, Graeme J. Hankey, Bu B. Yeap, Jonathan Golledge, Christopher Etherton-Beer, Suzanne Robinson, Leon Flicker
Summary: Cancer is associated with a lower risk of dementia, although methodological issues raise concerns about this relationship. A long-term study of 31,080 men aged 65-85 years found that the hazard ratio of dementia associated with cancer was 1.13, but dropped to 0.85 when excluding participants who developed dementia within 2 years. The diagnosis of cancer seems to facilitate the early detection of dementia cases.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Varinder Kaur Randhawa, Sean van Diepen, Benjamin Hibbert, Andre Denault, Warwick Butt, Rakesh Arora
Summary: From the 1960s to the present, coronary care units (CCUs) have undergone advancements in technology and treatment protocols, resulting in improved care for patients with complex cardiovascular disease. The establishment of systems-of-care and referral networks has shifted the demographics and management of critically ill cardiovascular patients. Patients now have access to timely interventions and support devices, such as defibrillation, pacers, thrombolysis, and temporary mechanical circulatory support.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Christopher B. Fordyce, Andreas H. Kramer, Craig Ainsworth, Jim Christenson, Gary Hunter, Julie Kromm, Carmen Lopez Soto, Damon C. Scales, Mypinder Sekhon, Sean van Diepen, Laura Dragoi, Colin Josephson, Jim Kutsogiannis, Michel R. Le May, Christopher B. Overgaard, Martin Savard, Gregory Schnell, Graham C. Wong, Emilie Belley-Cote, Tadeu A. Fantaneanu, Christopher B. Granger, Adriana Luk, Rebecca Mathew, Victoria McCredie, Laurel Murphy, Jeanne Teitelbaum
Summary: Cardiac arrest (CA) has a low survival rate with favorable neurologic recovery. Withdrawal of life-sustaining measures after successful resuscitation is the most common cause of death, based on perceived poor neurologic prognosis due to underlying brain injury. Neuro-prognostication is complex and challenging, with limited evidence. This position statement provides recommendations for neuroprognostication in various domains and highlights the need for a systematic, multimodal approach.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Timothy D. Henry, Demetri Yannopoulos, Sean van Diepen
Article
Cardiac & Cardiovascular Systems
Andrew Kochan, Terry Lee, Nima Moghaddam, Grace Milley, Joel Singer, John A. Cairns, Graham C. Wong, Jacob C. Jentzer, Sean van Diepen, Carlos Alviar, Christopher B. Fordyce
Summary: This study analyzed the association between the time from first medical contact to percutaneous coronary angiography and mortality and major adverse cardiovascular events in patients with ST-segment-elevation myocardial infarction (STEMI) with and without cardiogenic shock (CS). The results showed that delays in reperfusion were associated with worse outcomes in patients with STEMI complicated by CS. Therefore, strategies are needed to reduce the time from first medical contact to device for these patients.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Clinical Neurology
Christine Eileen Mc Carthy, Salim Yusuf, Conor Judge, Alberto Alvarez-Iglesias, Graeme J. Hankey, Shahram Oveisgharan, Albertino Damasceno, Helle Klingenberg Iversen, Annika Rosengren, Alvaro Avezum, Patricio Lopez-Jaramillo, Denis Xavier, Xingyu Wang, Sumathy Rangarajan, Martin O'Donnell
Summary: Sleep disturbance symptoms are associated with a graded increased risk of stroke. Short sleep, long sleep, impaired quality of sleep, difficulty getting to sleep, difficulty maintaining sleep, unplanned napping, snoring, snorting, and breathing cessation are all significantly associated with an increased odds of acute stroke.
Article
Hematology
Ross I. Baker, Grace Gilmore, Vivien Chen, Laura Young, Eileen Merriman, Jennifer Curnow, Joanne Joseph, Jim Y. Tiao, Jun Chih, Simon McRae, Paul Harper, Chee W. Tan, Timothy Brighton, Gordon Royle, Amanda Hugman, Graeme J. Hankey, Helen Crowther, Jirping Boey, Alexander Gallus, Philip Campbell, Huyen Tran
Summary: This study observed the difference in urgent hemostatic management between patients on VKA and those on DOACs. The results showed that in DOAC patients, the frequency of measuring DOAC plasma levels was low, the time for the coagulation sample to reach the laboratory varied widely, and some patients had insufficient plasma DOAC concentrations.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Medicine, General & Internal
Ross J. Marriott, Kevin Murray, Robert J. Adams, Leen Antonio, Christie M. Ballantyne, Douglas C. Bauer, Shalender Bhasin, Mary L. Biggs, Peggy M. Cawthon, David J. Couper, Adrian S. Dobs, Leon Flicker, David J. Handelsman, Graeme J. Hankey, Anke Hannemann, Robin Haring, Benjumin Hsu, Magnus Karlsson, Sean A. Martin, Alvin M. Matsumoto, Dan Mellstroem, Claes Ohlsson, Terence W. O'Neill, Eric S. Orwoll, Matteo Quartagno, Molly M. Shores, Antje Steveling, Asa Tivesten, Thomas G. Travison, Dirk Vanderschueren, Gary A. Wittert, Frederick C. W. Wu, Bu B. Yeap
Summary: The study found that various factors, including age, obesity, marital status, physical activity, smoking, hypertension, cardiovascular disease, cancer, and diabetes, are associated with variations in male testosterone, SHBG, and LH concentrations. Reduced testosterone and increased LH concentrations may indicate impaired testicular function in men older than 70 years.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Psychiatry
Osvaldo P. Almeida, Graeme J. Hankey, Bu B. Yeap, Jonathan Golledge, Christopher Etherton-Beer, Suzanne Robinson, Leon Flicker
Summary: This study examined the prevalence of common mental disorders among older Australian men and found that the rates of depressive and anxiety disorders increase with age, especially among the older old, which is different from the results of the NSMHW conducted in 2020-2021.
AUSTRALASIAN PSYCHIATRY
(2023)
Article
Clinical Neurology
Karly Zacharia, Emily Ramage, Margaret Galloway, Meredith Burke, Graeme J. Hankey, Elizabeth Lynch, Catherine M. Said, Coralie English, Amanda Patterson, Lesley Macdonald-Wicks
Summary: This study examined the dietary intake and quality of Australian stroke survivors. The findings indicate that the diet quality of stroke survivors is poor, with inadequate intake of nutrients important for reducing recurrent stroke risk. Further research is needed to develop effective interventions to improve diet quality.
CEREBROVASCULAR DISEASES
(2023)
Article
Rehabilitation
J. Kim, G. Sookram, E. Godecke, E. Brogan, E. Armstrong, F. Ellery, T. Rai, M. L. Rose, N. Ciccone, S. Middleton, A. Holland, G. J. Hankey, J. Bernhardt, D. A. Cadilhac
Summary: This study aimed to estimate costs in patients with aphasia after stroke by comparing different therapies. The results showed that there were no significant differences in costs and outcomes among the different treatment options for patients with aphasia after stroke.
TOPICS IN STROKE REHABILITATION
(2023)
Review
Endocrinology & Metabolism
Yanning Xu, Arash Derakhshan, Ola Hysaj, Lea Wildisen, Till Ittermann, Alessandro Pingitore, Nazanin Abolhassani, Marco Medici, Lambertus A. L. M. Kiemeney, Niels P. Riksen, Robin P. F. Dullaart, Stella Trompet, Marcus Doerr, Suzanne J. Brown, Boerge Schmidt, Dagmar Fuehrer-Sakel, Mark P. J. Vanderpump, Axel Muendlein, Heinz Drexel, Howard A. Fink, M. Kamran Ikram, Maryam Kavousi, Connie M. Rhee, Isabela M. Bensenor, Fereidoun Azizi, Graeme J. Hankey, Massimo Iacoviello, Misa Imaizumi, Graziano Ceresini, Luigi Ferrucci, Jose A. Sgarbi, Douglas C. Bauer, Nick Wareham, Kristien Boelaert, Stephan J. L. Bakker, J. Wouter Jukema, Bert Vaes, Giorgio Iervasi, Bu B. Yeap, Rudi G. J. Westendorp, Tim I. M. Korevaar, Henry Voelzke, Salman Razvi, Jacobijn Gussekloo, John P. Walsh, Anne R. Cappola, Nicolas Rodondi, Robin P. Peeters, Layal Chaker
Summary: This study aimed to define the optimal healthy ranges of TSH and FT4 based on the risk of cardiovascular disease and mortality. The study found that the 20-40th percentiles of FT4 and the 60-80th percentiles of TSH could represent the optimal healthy ranges of thyroid function.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
David Berg, Erin Ann Bohula, Sean Van Diepen, Jason Neil Katz, David A. Morrow
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)