Article
Medicine, General & Internal
Francesco Luzza, Rosalba De Sarro, Roberto Licordari, Pasquale Crea, Pietro Pugliatti, Giuseppe Certo, Lorenzo Pistelli, Francesca Campanella, Maria Claudia Lo Nigro, Matteo Casale, Michele Correale, Giuseppe Dattilo
Summary: QT interval varies with heart rate and needs to be corrected. Atrial fibrillation (AF) is associated with elevated heart rate and beat-to-beat variation. The study aims to find the best correlation between QTc in AF and restored sinus rhythm (SR) and determine the best correction formula and method for determining QTc in AF. The results show that Bazzett's formula is the least accurate in estimating QTc during AF.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Multidisciplinary Sciences
Sebastien Theriault, Medea Imboden, Mary L. Biggs, Thomas R. Austin, Stefanie Aeschbacher, Emmanuel Schaffner, Jennifer A. Brody, Traci M. Bartz, Martin Risch, Kirsten Grossmann, Henry J. Lin, Elsayed Z. Soliman, Wendy S. Post, Lorenz Risch, Jose E. Krieger, Alexandre C. Pereira, Susan R. Heckbert, Nona Sotoodehnia, Nicole M. Probst-Hensch, David Conen
Summary: This study identified a significant genetic locus at the SCN5A gene associated with PAC frequency. Additionally, there was a significant concordance of effect between PAC frequency and genetic variants previously associated with AF. However, not all AF risk loci were associated with PAC frequency.
Article
Medicine, General & Internal
Ming-Chuan Lee, Yu-Tsang Wang, Yu-Ju Li, Ching-Yi Tsai, Su-Te Chen, Wun-Jyun Jhuang, Meng-Chi Chang, Mei-Yu Chien, Hsiang -Chun Lee
Summary: The study found that AF risk in patients with MetS phenotypes can be reflected by QTc quartiles.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Arwa Younis, Nofrat Nehoray, Michael Glikson, Christopher Bodurian, Eyal Nof, Nicola Luigi Bragazzi, Michael Berger, Wojciech Zareba, Ilan Goldenberg, Roy Beinart
Summary: This study evaluated the changes in QTc over time following electrical cardioversion (ECV) in patients with persistent atrial fibrillation (AF), and compared the effectiveness of continuous Holter monitoring and conventional ECG follow-up. The results showed that ECV was associated with an increased transient risk of QTc prolongation in nearly half of the patients, and Holter monitoring was superior to conventional monitoring in detecting clinically significant QTc prolongation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sahej Bains, Raquel Neves, J. Martijn Bos, John R. Giudicessi, Ciorsti MacIntyre, Michael J. Ackerman
Summary: This study reveals that the main causes of overdiagnosis of Long QT syndrome (LQTS) are prolonged QTc interval due to vasovagal syncope, mistaken positive genetic test results, unrelated family history of sudden cardiac death (SCD), isolated/transient QT prolongation, and misinterpretation of QTc interval. Understanding these determinants can increase awareness and provide critical guidance to reduce the burden of overdiagnosed LQTS.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Erika N. Titus-Lay, Heather A. Jaynes, Elena Tomaselli Muensterman, Carol A. Ott, Todd A. Walroth, Gabriela Williams, Paul R. Moe, Michelle Wilbrandt, James E. Tisdale
Summary: The study aimed to assess the accuracy of a handheld smartphone ECG for QT measurement in patients on maintenance methadone therapy, showing that the iECG is accurate and moderately good for identifying patients with methadone-associated QTc prolongation.
Article
Pharmacology & Pharmacy
Xiaolin Ke, Xin Qiu
Summary: This study aimed to evaluate the diagnostic efficiency of ambulatory electrocardiography in atrial fibrillation with long RR intervals. It was found that patients with long RR intervals during sleep had more episodes and shorter intervals compared to those during non-sleep periods. Ambulatory electrocardiography enables rapid detection of causative factors and disease occurrence frequency, allowing accurate assessment of the patient's condition and implementation of appropriate therapeutic measures to effectively improve treatment outcomes.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Maria Munk Paerregaard, Sara Osted Hvidemose, Christian Pihl, Anne-Sophie Sillesen, Solmaz Bagheri Parvin, Adrian Pietersen, Kasper Karmark Iversen, Henning Bundgaard, Alex Horby Christensen
Summary: The study aimed to describe the natural history of the QT interval during the first 4 weeks of life in newborns and provide reference values. Results showed minor changes in QT intervals over time, with uncorrected intervals decreasing with increasing heart rate. Sex and infant size did not affect the QT interval, and gestational age only had an effect in extremely premature newborns.
Article
Endocrinology & Metabolism
Arnaud D. Kaze, Matthew F. Yuyun, Sebhat Erqou, Gregg C. Fonarow, Justin B. Echouffo-Tcheugui
Summary: In a large population with type 2 diabetes, severe hypoglycemia is associated with an increased risk of QTc prolongation independently of other risk factors, and the association is strongest among younger participants.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Parag Ravindra Gajendragadkar, Adam Von Ende, Maysson Ibrahim, Elsa Valdes-Marquez, Christian Fielder Camm, Federico Murgia, Alexander Stiby, Barbara Casadei, Jemma C. Hopewell
Summary: Using a mendelian randomisation approach, this study found evidence supporting a causal association between lifelong differences in ECG parameters representing longer atrial conduction times within the normal range and a lower risk of AF. These findings suggest the need for more individualised treatment strategies for AF.
Article
Engineering, Biomedical
Alba Martin-Yebra, Leif Sornmo, Pablo Laguna
Summary: This study aims to investigate new techniques for QT adaptation estimation in permanent AF. A multilead strategy based on periodic component analysis provides more accurate QT delineation and improved time lag estimation in AF. Prolonged QT adaptation time lag is associated with a high risk of sudden cardiac death (SCD).
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Medicine, General & Internal
Bianca J. J. M. Brundel, Xun Ai, Mellanie True Hills, Myrthe F. Kuipers, Gregory Y. H. Lip, Natasja M. S. de Groot
Summary: Atrial fibrillation (AF) is the most common cardiac arrhythmia and is increasing in prevalence. Understanding the molecular mechanisms underlying AF is crucial for the development of personalized diagnostic tools and mechanism-based therapies. Co-creation with patients is essential for successful management of AF.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Cardiac & Cardiovascular Systems
Jacky K. K. Tang, Simon W. Rabkin
Summary: This case report describes an 87-year-old male patient with a history of multiple diseases, leading to prolonged QT interval on his electrocardiogram. The reduction in diuretic dose and calcium supplementation improved his serum calcium levels and shortened the QT interval. Hypocalcemia likely prolongs the QT interval through a calcium-dependent inactivation mechanism on the L-type calcium channel. Hypocalcemia is an under-recognized cause of prolonged QT interval.
Article
Engineering, Electrical & Electronic
Duc Huy Nguyen, Paul C-P Chao, Chih-Chieh Chung, Ray-Hua Horng, Bhaskar Choubey
Summary: Real-time detection of atrial fibrillation is made possible through the use of a combination of one-dimensional and two-dimensional convolutional neural networks. These models can filter out low-quality data and accurately detect atrial fibrillation.
IEEE SENSORS JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Constantine Tarabanis, Robert Ronan, Mohamed Shokr, Larry Chinitz, Lior Jankelson
Summary: A convolutional neural network (CNN) was used to accurately estimate the QTc interval and rule out prolongation in atrial fibrillation (AF) electrocardiograms (ECGs).
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Renate B. Schnabel, Elena Andreassi Marinelli, Elena Arbelo, Giuseppe Boriani, Serge Boveda, Claire M. Buckley, A. John Camm, Barbara Casadei, Winnie Chua, Nikolaos Dagres, Mirko de Melis, Lien Desteghe, Soren Zoga Diederichsen, David Duncker, Lars Eckardt, Christoph Eisert, Daniel Engler, Larissa Fabritz, Ben Freedman, Ludovic Gillet, Andreas Goette, Eduard Guasch, Jesper Hastrup Svendsen, Stephane N. Hatem, Karl Georg Haeusler, Jeff S. Healey, Hein Heidbuchel, Gerhard Hindricks, F. D. Richard Hobbs, Thomas Huebner, Dipak Kotecha, Michael Krekler, Christophe Leclercq, Thorsten Lewalter, Honghuang Lin, Dominik Linz, Gregory Y. H. Lip, Maja Lisa Lochen, Wim Lucassen, Katarzyna Malaczynska-Rajpold, Steffen Massberg, Jose L. Merino, Ralf Meyer, Lluis Mont, Michael C. Myers, Lis Neubeck, Teemu Niiranen, Michael Oeff, Jonas Oldgren, Tatjana S. Potpara, George Psaroudakis, Helmut Purerfellner, Ursula Ravens, Michiel Rienstra, Lena Rivard, Daniel Scherr, Ulrich Schotten, Dipen Shah, Moritz F. Sinner, Rudiger Smolnik, Gerhard Steinbeck, Daniel Steven, Emma Svennberg, Dierk Thomas, Mellanie True Hills, Isabelle C. van Gelder, Burcu Vardar, Elena Pala, Reza Wakili, Karl Wegscheider, Mattias Wieloch, Stephan Willems, Henning Witt, Andre Ziegler, Matthias Daniel Zink, Paulus Kirchhof
Summary: This article summarizes the key outcomes of the 8th AFNET/EHRA Consensus Conference, which was held in Hamburg in October 2021 and attended by 83 international experts. The consensus paper highlights new evidence-based approaches to improve care for patients with atrial fibrillation (AF), including population-based screening, evolving management strategies, atrial cardiomyopathy characterization, cognitive function assessment, and the role of artificial intelligence (AI).
Article
Cardiac & Cardiovascular Systems
Flemming Javier Olsen, Caroline Lokke Bjerregaard, Kristoffer Grundtvig Skaarup, Mats Christian Hojbjerg Lassen, Niklas Dyrby Johansen, Daniel Modin, Gorm Boje Jensen, Peter Schnohr, Peter Sogaard, Gunnar Gislason, Jesper Hastrup Svendsen, Rasmus Mogelvang, Tor Biering-Sorensen
Summary: Different event timing modalities have an impact on myocardial work indices, with visual assessment yielding lower global work index (GWI) values compared with Doppler-based methods.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Benedikt Linz, Eva M. Hesselkilde, Mark A. Skarsfeldt, Julie N. Hertel, Stefan M. Sattler, Yannan Yan, Jacob Tfelt-Hansen, Jonas G. Diness, Bo H. Bentzen, Dominik Linz, Thomas Jespersen
Summary: Inhibition of small-conductance calcium-activated potassium channels (SK-channels) can prevent atrial fibrillation (AF) induced by obstructive sleep apnea (OSA) in a pig model without impairing ventricular electrophysiology.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lucas Yixi Xing, Soren Zoga Diederichsen, Soren Hojberg, Derk W. Krieger, Claus Graff, Ruth Frikke-Schmidt, Morten S. Olesen, Axel Brandes, Lars Kober, Ketil Jorgen Haugan, Jesper Hastrup Svendsen
Summary: This study aimed to investigate the potential of NT-proBNP as a marker for AF screening efficacy and stroke prevention. The results showed that in individuals over 70 years old with additional stroke risk factors, ILR screening was associated with a significant reduction in stroke risk among those with higher NT-proBNP levels.
Article
Cardiac & Cardiovascular Systems
Jordi Heijman, Xiaobo Zhou, Stefano Morotti, Cristina E. Molina, Issam H. Abu-Taha, Marcel Tekook, Thomas Jespersen, Yiqiao Zhang, Shokoufeh Dobrev, Hendrik Milting, Jan Gummert, Matthias Karck, Markus Kamler, Ali El-Armouche, Arnela Saljic, Eleonora Grandi, Stanley Nattel, Dobromir Dobrev
Summary: This study found that patients with atrial fibrillation (AF) have higher SK-channel current (I-SK) in their heart cells, and the antiarrhythmic drug apamin can significantly prolong the action potential of these cells. In addition, the study also found that the abundance of SK2 channel on the cell membrane is higher in AF patients. It was discovered that inhibiting the phosphatase-2A-dependent calmodulin-Thr80 dephosphorylation and promoting the trafficking and targeting of SK-channel subunits can enhance the function of SK channels.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Mikkel Ravn Dyhr, Flemming Javier Olsen, Soren Lindberg, Daniel Modin, Thomas Fritz-Hansen, Sune Pedersen, Allan Iversen, Soren Galatius, Thomas Jespersen, Rasmus Mogelvang, Tor Biering-Sorensen
Summary: Measures of left atrial function can be used to predict atrial fibrillation (AF) in patients undergoing coronary artery bypass grafting (CABG). In patients with a normal left atrial size, both the left atrial minimum volume index and the left atrial emptying fraction are significant predictors of AF.
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2023)
Article
Biochemistry & Molecular Biology
Markus Hodal Drag, Karina Poulsdottir Debes, Clara Sandkamm Franck, Mette Flethoj, Mille Kronborg Lyhne, Jacob Eifer Moller, Trine Pagh Ludvigsen, Thomas Jespersen, Lisbeth Hoier Olsen, Tuomas O. Kilpelainen
Summary: Profiling cfDNA using nanopore sequencing and tissue-specific base modifications enables the monitoring of ongoing pathophysiological processes. This study identified differentially methylated regions (DMRs) associated with obesity in Gottingen minipigs using nanopore sequencing, validated a subset of DMRs using MSP-PCR, and compared cfDNA DMRs with gDNA DMRs. The results showed 1,236 cfDNA DMRs associated with obesity, with enrichment of pathways related to adipocytokine signaling and glucose homeostasis. No DMRs intersected between cfDNA and gDNA, suggesting that cfDNA originates from body-wide shedding of DNA.
Article
Cardiac & Cardiovascular Systems
Lucas Malta Westergaard, Amna Alhakak, Rasmus Rorth, Emil L. Fosbol, Soren L. Kristensen, Jesper H. Svendsen, Claus Graff, Jonas B. Nielsen, Gunnar H. Gislason, Lars Kober, Christian Torp-Pedersen, Christina J. Y. Lee, Peter E. Weeke
Summary: This study aimed to evaluate the risk of new-onset heart failure and all-cause mortality in patients with atrial fibrillation (AF) according to ventricular rate. The results showed that patients with ventricular rates ≥100 bpm had a higher risk of new-onset heart failure and all-cause mortality compared to those with rates of 60-79 bpm. This suggests that ventricular rates ≥100 bpm may be associated with increased risk in AF patients receiving rate control drug treatment.
Article
Nanoscience & Nanotechnology
G. Nagda, D. Beznasyuk, J. Nygard, T. S. Jespersen
Summary: In-plane selective area growth of III-V nanowires is important for quantum electronics and photonics applications, but crystal quality optimization is vital. Understanding the role of mis-orientation is important for device design and interpretation of electrical performance. This study investigates the effect of mis-orientation on morphology and material incorporation in selectively grown NWs and shows that using Sb as a surfactant during growth can improve surface roughness for large misalignment.
Article
Cardiac & Cardiovascular Systems
Helena Carstensen, Sarah Dalgas Nissen, Arnela Saljic, Eva Melis Hesselkilde, Arne van Hunnik, Mathias Hohl, Stefan Michael Sattler, Cecilie Flogstad, Charlotte Hopster-Iversen, Sander Verheule, Michael Boehm, Ulrich Schotten, Thomas Jespersen, Rikke Buhl
Summary: AF is more common in athletes, and the underlying mechanisms are not fully understood. A study investigated AF inducibility and stability in trained and untrained racehorses. The trained horses showed longer AF sustainability, but no difference in AF inducibility. The untrained horses had a significant difference in AF complexity between the right and left atria, while no such difference was observed in the trained horses. There was no evidence of structural remodeling or inflammation, and left atrial dimensions were not significantly increased. Increased AF sustainability in trained horses was not related to fibrosis or inflammation.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Julie Norup Hertel, Kezia Jerltorp, Malthe Emil Hotbjerg Hansen, Jonas L. L. Isaksen, Stefan Michael Sattler, Benedikt Linz, Sevasti-Maria Chaldoupi, Thomas Jespersen, Arnela Saljic, Uffe Gang, Martin Manninger, Dominik Linz
Summary: This study proposes a standardized workflow for 3D-electroanatomical mapping guided pulmonary vein isolation in pigs. The study conducted procedures such as femoral vein puncture, blood pressure measurement, intracardiac ultrasound-guided puncture, and 3D-electroanatomical mapping of the left atrium. The results show that reproducible and safe pulmonary vein isolation can be achieved in pigs using current technologies and a step-by-step approach.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Orthopedics
Paula L. Hedley, Ulrik Lausten-Thomsen, Kristin M. Conway, Klaus Hindso, Paul A. Romitti, Michael Christiansen
Summary: This study used publicly available data to investigate the prevalence and co-occurring anomalies of clubfoot in Denmark from 1994 to 2021. The findings showed that the prevalence of nonsyndromic clubfoot remained stable during the study period, and the reduction in maternal smoking rates did not significantly impact the prevalence. These results support the suspected multifactorial etiopathogenesis of clubfoot and provide a valuable population-based resource for future investigations.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Endocrinology & Metabolism
Christian Zinck Jensen, Jonas Lynggaard Isaksen, Gustav Ahlberg, Morten Salling Olesen, Birte Nygaard, Christina Ellervik, Jorgen Kim Kanters
Summary: This study found that single-nucleotide variations in certain genes are not associated with psychological well-being, cognitive function, or cardiovascular risk factors in patients receiving levothyroxine treatment. The results do not support a gene-treatment interaction in this context.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)