Enhanced Ca 2+ -Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation

Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it

(2021) Stanley Nattel et al.   CARDIOVASCULAR RESEARCH

Small Conductance Ca2 +-Activated K+ (SK) Channel mRNA Expression in Human Atrial and Ventricular Tissue: Comparison Between Donor, Atrial Fibrillation and Heart Failure Tissue

(2021) Elisa Darkow et al.   Frontiers in Physiology

Trigger-Specific Remodeling of KCa2 Potassium Channels in Models of Atrial Fibrillation

(2021) Ann-Kathrin Rahm et al.   Pharmacogenomics & Personalized Medicine

Effective termination of atrial fibrillation by SK channel inhibition is associated with a sudden organization of fibrillatory conduction

(2021) Giulia Gatta et al.   EUROPACE

Differential regulation of K Ca 2.1 ( KCNN1 ) K + channel expression by histone deacetylases in atrial fibrillation with concomitant heart failure

(2021) Ann‐Kathrin Rahm et al.   Physiological Reports

Genetic inhibition of nuclear factor of activated T-cell c2 prevents atrial fibrillation in CREM transgenic mice

(2021) Li Ni et al.   CARDIOVASCULAR RESEARCH

The KCa2 Channel Inhibitor AP30663 Selectively Increases Atrial Refractoriness, Converts Vernakalant-Resistant Atrial Fibrillation and Prevents Its Reinduction in Conscious Pigs

(2020) Jonas Goldin Diness et al.   Frontiers in Pharmacology

Mechanisms of Action of the KCa2-Negative Modulator AP30663, a Novel Compound in Development for Treatment of Atrial Fibrillation in Man

(2020) Bo Hjorth Bentzen et al.   Frontiers in Pharmacology

Molecular Basis of Atrial Fibrillation Pathophysiology and Therapy

(2020) Stanley Nattel et al.   CIRCULATION RESEARCH

Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Post-Operative Atrial Fibrillation

(2020) Jordi Heijman et al.   CIRCULATION RESEARCH

First Clinical Study with AP30663 ‐ a K Ca 2 Channel Inhibitor in Development for Conversion of Atrial Fibrillation

(2020) Pim Gal et al.   CTS-Clinical and Translational Science

2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS)

(2020) Gerhard Hindricks et al.   EUROPEAN HEART JOURNAL

Early Rhythm-Control Therapy in Patients with Atrial Fibrillation

(2020) Paulus Kirchhof et al.   NEW ENGLAND JOURNAL OF MEDICINE

Atria-selective antiarrhythmic drugs in need of alliance partners

(2019) Rémi Peyronnet et al.   PHARMACOLOGICAL RESEARCH

A computational model of induced pluripotent stem‐cell derived cardiomyocytes incorporating experimental variability from multiple data sources

(2019) Divya C. Kernik et al.   JOURNAL OF PHYSIOLOGY-LONDON

Multi-ethnic genome-wide association study for atrial fibrillation

(2018) Carolina Roselli et al.   NATURE GENETICS

Catheter Ablation for Atrial Fibrillation with Heart Failure

(2018) Nassir F. Marrouche et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) Increases Small-Conductance Ca2+-Activated K+ Current in Patients with Chronic Atrial Fibrillation

(2018) Xuehui Fan et al.   MEDICAL SCIENCE MONITOR

Development of a High-Throughput Flow Cytometry Assay to Monitor Defective Trafficking and Rescue of Long QT2 Mutant hERG Channels

(2018) Scott A. Kanner et al.   Frontiers in Physiology

Inhibition of Small Conductance Calcium-Activated Potassium (SK) Channels Prevents Arrhythmias in Rat Atria During β-Adrenergic and Muscarinic Receptor Activation

(2018) Lasse Skibsbye et al.   Frontiers in Physiology

Coupling of SK channels, L-type Ca2+ channels, and ryanodine receptors in cardiomyocytes

(2018) Xiao-Dong Zhang et al.   Scientific Reports

Profibrotic, Electrical, and Calcium-Handling Remodeling of the Atria in Heart Failure Patients With and Without Atrial Fibrillation

(2018) Cristina E. Molina et al.   Frontiers in Physiology

Small conductance calcium-activated potassium current and the mechanism of atrial arrhythmia in mice with dysfunctional melanocyte-like cells

(2016) Wei-Chung Tsai et al.   HEART RHYTHM

Distinct subcellular mechanisms for the enhancement of the surface membrane expression of SK2 channel by its interacting proteins, α-actinin2 and filamin A

(2016) Zheng Zhang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Nucleoside Diphosphate Kinase B–Activated Intermediate Conductance Potassium Channels Are Critical for Neointima Formation in Mouse Carotid ArteriesSignificance

(2015) Xiao-Bo Zhou et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Upregulation of K2P3.1 K+Current Causes Action Potential Shortening in Patients With Chronic Atrial FibrillationCLINICAL PERSPECTIVE

(2015) Constanze Schmidt et al.   CIRCULATION

Pharmacologic inhibition of small-conductance calcium-activated potassium (SK) channels by NS8593 reveals atrial antiarrhythmic potential in horses

(2015) Maria Mathilde Haugaard et al.   HEART RHYTHM

Methods for isolating atrial cells from large mammals and humans

(2015) Niels Voigt et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Alterations in the Interactome of Serine/Threonine Protein Phosphatase Type-1 in Atrial Fibrillation Patients

(2015) David Y. Chiang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Small-conductance calcium-activated potassium (SK) channels contribute to action potential repolarization in human atria

(2014) Lasse Skibsbye et al.   CARDIOVASCULAR RESEARCH

Cellular and Molecular Electrophysiology of Atrial Fibrillation Initiation, Maintenance, and Progression

(2014) Jordi Heijman et al.   CIRCULATION RESEARCH

Tachycardia-induced silencing of subcellular Ca2+ signaling in atrial myocytes

(2014) Maura Greiser et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional interaction with filamin A and intracellular Ca2+enhance the surface membrane expression of a small-conductance Ca2+-activated K+(SK2) channel

(2014) Sassan Rafizadeh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of KCNN3 results in sudden cardiac death

(2013) Saagar Mahida et al.   CARDIOVASCULAR RESEARCH

Role of Small-Conductance Calcium-Activated Potassium Channels in Atrial Electrophysiology and Fibrillation in the Dog

(2013) Xiao-Yan Qi et al.   CIRCULATION

Cellular and Molecular Mechanisms of Atrial Arrhythmogenesis in Patients With Paroxysmal Atrial Fibrillation

(2013) Niels Voigt et al.   CIRCULATION

Proarrhythmic effect of blocking the small conductance calcium activated potassium channel in isolated canine left atrium

(2013) Chia-Hsiang Hsueh et al.   HEART RHYTHM

Impaired Na+-dependent regulation of acetylcholine-activated inward-rectifier K+ current modulates action potential rate dependence in patients with chronic atrial fibrillation

(2013) Niels Voigt et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Bisoprolol reversed small conductance calcium-activated potassium channel (SK) remodeling in a volume-overload rat model

(2013) Yajuan Ni et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Enhanced Sarcoplasmic Reticulum Ca 2+ Leak and Increased Na + -Ca 2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial Fibrillation

(2012) Niels Voigt et al.   CIRCULATION

Palmitoylation and Membrane Association of the Stress Axis Regulated Insert (STREX) Controls BK Channel Regulation by Protein Kinase C

(2012) Xiaobo Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small-Conductance Calcium-Activated Potassium Channel and Recurrent Ventricular Fibrillation in Failing Rabbit Ventricles

(2011) Su-Kiat Chua et al.   CIRCULATION RESEARCH

Human Atrial Action Potential and Ca 2+ Model

(2011) Eleonora Grandi et al.   CIRCULATION RESEARCH

Effects on Atrial Fibrillation in Aged Hypertensive Rats by Ca 2+ -Activated K + Channel Inhibition

(2011) Jonas G. Diness et al.   HYPERTENSION

Decreased expression of small-conductance Ca2+-activated K+ channels SK1 and SK2 in human chronic atrial fibrillation

(2011) Tao Yu et al.   LIFE SCIENCES

CaMKII-Dependent Diastolic SR Ca 2+ Leak and Elevated Diastolic Ca 2+ Levels in Right Atrial Myocardium of Patients With Atrial Fibrillation

(2010) Stefan Neef et al.   CIRCULATION RESEARCH

Inhibition of Small-Conductance Ca 2+ -Activated K + Channels Terminates and Protects Against Atrial Fibrillation

(2010) Jonas Goldin Diness et al.   Circulation-Arrhythmia and Electrophysiology

In Humans, Chronic Atrial Fibrillation Decreases the Transient Outward Current and Ultrarapid Component of the Delayed Rectifier Current Differentially on Each Atria and Increases the Slow Component of the Delayed Rectifier Current in Both

(2010) Ricardo Caballero et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Parameter Sensitivity Analysis in Electrophysiological Models Using Multivariable Regression

(2009) Eric A. Sobie   BIOPHYSICAL JOURNAL

Ablation of a Ca2+-activated K+channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation

(2009) Ning Li et al.   JOURNAL OF PHYSIOLOGY-LONDON

 -Actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel)

(2009) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Signaling Underlying Atrial Tachycardia Remodeling of L-type Calcium Current

(2008) Xiao Yan Qi et al.   CIRCULATION RESEARCH

Modulation of SK Channel Trafficking by Beta Adrenoceptors Enhances Excitatory Synaptic Transmission and Plasticity in the Amygdala

(2008) E. S. L. Faber et al.   JOURNAL OF NEUROSCIENCE