FOXOs and Sirtuins in Vascular Growth, Maintenance, and Aging

Key transcriptional regulators of the vasoprotective effects of shear stress

(2018) R. A. Boon et al.   Hamostaseologie

dSir2 and Dmp53 interact to mediate aspects of CR-dependent life span extension in D. melanogaster

(2016) Johannes H. Bauer et al.   Aging-US

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

(2016) Angela V. Hafner et al.   Aging-US

Identification of a Mechanism Underlying Regulation of the Anti-Angiogenic Forkhead Transcription Factor FoxO1 in Cultured Endothelial Cells and Ischemic Muscle

(2011) Malgorzata Milkiewicz et al.   AMERICAN JOURNAL OF PATHOLOGY

SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity

(2011) Hyun-Seok Kim et al.   CANCER CELL

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

A Hormone-Dependent Module Regulating Energy Balance

(2011) Biao Wang et al.   CELL

Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis

(2011) Maria M. Mihaylova et al.   CELL

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Dissociation of the Glucose and Lipid Regulatory Functions of FoxO1 by Targeted Knockin of Acetylation-Defective Alleles in Mice

(2011) Alexander S. Banks et al.   Cell Metabolism

Fine Tuning Our Cellular Factories: Sirtuins in Mitochondrial Biology

(2011) Lei Zhong et al.   Cell Metabolism

The Logic Linking Protein Acetylation and Metabolism

(2011) Leonard Guarente   Cell Metabolism

Proatherogenic Abnormalities of Lipid Metabolism in SirT1 Transgenic Mice Are Mediated through Creb Deacetylation

(2011) Li Qiang et al.   Cell Metabolism

Repression of P66Shc Expression by SIRT1 Contributes to the Prevention of Hyperglycemia-Induced Endothelial Dysfunction

(2011) Shuang Zhou et al.   CIRCULATION RESEARCH

Expression pattern of the FoxO1 gene during mouse embryonic development

(2011) Barbara Villarejo-Balcells et al.   GENE EXPRESSION PATTERNS

Hypoxia Increases Sirtuin 1 Expression in a Hypoxia-inducible Factor-dependent Manner

(2011) Rui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A SIRT1-LSD1 Corepressor Complex Regulates Notch Target Gene Expression and Development

(2011) Peter Mulligan et al.   MOLECULAR CELL

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes

(2011) Mohan Viswanathan et al.   NATURE

Longevity hits a roadblock

(2011) David B. Lombard et al.   NATURE

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

(2011) Camilla Burnett et al.   NATURE

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase

(2011) Virginia Guarani et al.   NATURE

Adhesion molecule signalling: not always a sticky business

(2011) Ugo Cavallaro et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular control of endothelial cell behaviour during blood vessel morphogenesis

(2011) Shane P. Herbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sirtuins, Aging, and Medicine

(2011) Leonard Guarente   NEW ENGLAND JOURNAL OF MEDICINE

The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor

(2011) V M Renault et al.   ONCOGENE

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

The Evolutionarily Conserved Longevity Determinants HCF-1 and SIR-2.1/SIRT1 Collaborate to Regulate DAF-16/FOXO

(2011) Gizem Rizki et al.   PLoS Genetics

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Integrating Opposing Signals Toward Forkhead Box O

(2010) Maaike C.W. van den Berg et al.   ANTIOXIDANTS & REDOX SIGNALING

Forkhead Box O as a Sensor, Mediator, and Regulator of Redox Signaling

(2010) Peter L.J. de Keizer et al.   ANTIOXIDANTS & REDOX SIGNALING

MicroRNA-34a regulation of endothelial senescence

(2010) Takashi Ito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse

(2010) X. Ou et al.   BLOOD

RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10

(2010) Gizem Donmez et al.   CELL

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

Metabolic Networks of Longevity

(2010) Riekelt H. Houtkooper et al.   CELL

SIRT1 Promotes Proliferation and Prevents Senescence Through Targeting LKB1 in Primary Porcine Aortic Endothelial Cells

(2010) Yi Zu et al.   CIRCULATION RESEARCH

Arterial aging: a journey into subclinical arterial disease

(2010) Mingyi Wang et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

SIRT1—a metabolic sensor that controls blood vessel growth

(2010) Virginia Guarani et al.   CURRENT OPINION IN PHARMACOLOGY

LKB1 Deficiency in Tie2-Cre-expressing Cells Impairs Ischemia-induced Angiogenesis

(2010) Koji Ohashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FOXO3 Modulates Endothelial Gene Expression and Function by Classical and Alternative Mechanisms

(2010) Tobias Czymai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in Mitochondria

(2010) Katia Aquilano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 contributes to telomere maintenance and augments global homologous recombination

(2010) Jose A. Palacios et al.   JOURNAL OF CELL BIOLOGY

Mechanisms of Vascular Aging: New Perspectives

(2010) Z. Ungvari et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Linking functional decline of telomeres, mitochondria and stem cells during ageing

(2010) Ergün Sahin et al.   NATURE

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

(2010) Ying Zhao et al.   NATURE CELL BIOLOGY

Shear stress, SIRT1, and vascular homeostasis

(2010) Z. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Axon Guidance Molecules in Vascular Patterning

(2010) R. H. Adams et al.   Cold Spring Harbor Perspectives in Biology

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

(2010) Daniel Herranz et al.   Nature Communications

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity

(2009) Ludmila Pawlikowska et al.   AGING CELL

The Role of Sirtuins in the Control of Metabolic Homeostasis

(2009) Jiujiu Yu et al.   Annals of the New York Academy of Sciences

Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype

(2009) J. Gracia-Sancho et al.   CARDIOVASCULAR RESEARCH

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

(2009) Takashi Nakagawa et al.   CELL

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

P53 negatively regulates the transcriptional activity of FOXO3a under oxidative stress

(2009) Yasuo Miyaguchi et al.   CELL BIOLOGY INTERNATIONAL

FXR Acetylation Is Normally Dynamically Regulated by p300 and SIRT1 but Constitutively Elevated in Metabolic Disease States

(2009) Jongsook Kim Kemper et al.   Cell Metabolism

MicroRNA 217 Modulates Endothelial Cell Senescence via Silent Information Regulator 1

(2009) Rossella Menghini et al.   CIRCULATION

Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes

(2009) Shweta Rane et al.   CIRCULATION RESEARCH

Angiogenesis: A Team Effort Coordinated by Notch

(2009) L.-K. Phng et al.   DEVELOPMENTAL CELL

Regulation of Angiogenesis by Oxygen and Metabolism

(2009) Peter Fraisl et al.   DEVELOPMENTAL CELL

Different roles of Foxo1 and Foxo3 in the control of endothelial cell morphology

(2009) Mai Matsukawa et al.   GENES TO CELLS

MDM2 Acts Downstream of p53 as an E3 Ligase to Promote FOXO Ubiquitination and Degradation

(2009) Wei Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutual Dependence of Foxo3a and PGC-1α in the Induction of Oxidative Stress Genes

(2009) Yolanda Olmos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity

(2009) Tobias B Dansen et al.   Nature Chemical Biology

Association ofFOXO3Avariation with human longevity confirmed in German centenarians

(2009) Friederike Flachsbart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of the FOXO3A Locus with Extreme Longevity in a Southern Italian Centenarian Study

(2009) Chiara Viviani Anselmi et al.   REJUVENATION RESEARCH

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

(2009) E. M. Dioum et al.   SCIENCE

Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice

(2008) Gyeong-Min Do et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice

(2008) Q.-j. Zhang et al.   CARDIOVASCULAR RESEARCH

SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice

(2008) Alexander S. Banks et al.   Cell Metabolism

Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

(2008) Olesya Vakhrusheva et al.   CIRCULATION RESEARCH

FoxO transcription factors in the maintenance of cellular homeostasis during aging

(2008) Dervis AM Salih et al.   CURRENT OPINION IN CELL BIOLOGY

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL

Regulation of WRN Protein Cellular Localization and Enzymatic Activities by SIRT1-mediated Deacetylation

(2008) Kai Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling networks in aging

(2008) Eric L. Greer et al.   JOURNAL OF CELL SCIENCE

Biochemical and Structural Characterization of an Intramolecular Interaction in FOXO3a and Its Binding with p53

(2008) Feng Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

(2008) Zoltan Arany et al.   NATURE

Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5

(2008) Andrea Taddei et al.   NATURE CELL BIOLOGY

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

FOXO3A genotype is strongly associated with human longevity

(2008) B. J. Willcox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-34a repression of SIRT1 regulates apoptosis

(2008) M. Yamakuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular aging: insights from studies on cellular senescence, stem cell aging and progeroid syndromes

(2008) Tohru Minamino et al.   Nature clinical practice. Cardiovascular medicine