Review
Pathology
Yusang Dai, Zheng Shen, Lusine G. Khachatryan, Diana E. Vadiyan, Sajad Karampoor, Rasoul Mirzaei
Summary: Neurogenic hypertension is a complex cardiovascular disorder influenced by genetic, environmental, and lifestyle factors. Recent research has highlighted the role of the gut microbiome in hypertension pathogenesis and the bidirectional communication between the gut microbiota and the central nervous system. The microbiome's impact on physiological functions, such as cardiovascular health, and its association with inflammatory responses have been explored. Probiotic supplementation has shown potential in reducing chronic inflammation and hypertension associated with dysbiosis in the gut microbiota.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Carmen De Miguel, Pablo Pelegrin, Alberto Baroja-Mazo, Santiago Cuevas
Summary: Inflammasomes and pyroptosis play crucial roles in the development of hypertension, with pharmacological inhibition of inflammasomes leading to reduced blood pressure. This pathway shows potential as a future anti-hypertensive strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Panayiotis Louca, Sarah E. Berry, Kate Bermingham, Paul W. Franks, Jonathan Wolf, Tim D. Spector, Ana M. Valdes, Phil Chowienczyk, Cristina Menni
Summary: Compared to normotensive controls, hypertensive individuals have higher postprandial insulin, triglycerides, and markers of inflammation, partially mediated by visceral fat mass. Reduction of visceral fat mass should be a key focus of health interventions in hypertension.
Article
Physiology
Osman Sinen, Mehmet Bulbul
Summary: The study found that peripherally administered apelin-13 inhibits gastric and colonic motor functions through autonomic pathways, and its effect is partially mediated by the apelin receptor in circumventricular organs. This research helps to provide further insights into the mechanisms of apelin-induced inhibition of gastrointestinal motility.
EXPERIMENTAL PHYSIOLOGY
(2021)
Review
Allergy
Saptarshi Roy, Chalatip Chompunud Na Ayudhya, Monica Thapaliya, Vishwa Deepak, Hydar Ali
Summary: MRGPRX2, activated by various cationic ligands, plays a role in host defense but overactivation may lead to pseudoallergy and various skin diseases. Gain and loss-of-function missense polymorphisms have been identified in MRGPRX2, and the functionality of certain ligands has been defined. The development of small-molecule HDP mimetics that activate MRGPRX2 presents a new therapeutic approach, while MRGPRX2-specific antibodies and inhibitors could be utilized for modulation of allergic and inflammatory diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Gordana Vunjak-Novakovic, Kacey Ronaldson-Bouchard, Milica Radisic
Summary: Bioengineered human tissues exhibit enough complexity to mimic native tissues, and organs-on-a-chip are better at displaying specific organ functions compared to organoids. The key to this emerging technology lies in establishing, validating, and fully utilizing the fidelity of these models.
Review
Biochemistry & Molecular Biology
Amit Bery, Hailey M. Shepherd, Wenjun Li, Alexander S. Krupnick, Andrew E. Gelman, Daniel Kreisel
Summary: Tertiary lymphoid organs (TLOs) are immune cell collections that form in non-lymphoid tissues in response to local chronic inflammation. They have complex structures and can generate strong immune responses at sites of tissue injury. Despite our improved understanding of TLO formation and function, their role in chronic inflammatory diseases remains unclear.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Luiza Marek-Jozefowicz, Boguslaw Nedoszytko, Malgorzata Grochocka, Michal A. Zmijewski, Rafal Czajkowski, Wieslaw J. Cubala, Andrzej T. Slominski
Summary: Neurogenic inflammation is the result of nerve endings and mediators' activity in the skin, leading to inflammatory reactions. TRPV-ion channels' activation increases the release of inflammatory mediators and contributes to the maintenance of cutaneous neurogenic inflammation. Understanding the molecular mechanisms of neuropeptide and neurotransmitter receptors in cutaneous cells can aid in developing effective treatments for inflammatory skin disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Balint Botz, Gabor Kriszta, Kata Bolcskei, Adam Istvan Horvath, Attila Mocsai, Zsuzsanna Helyes
Summary: The study showed that capsaicin-sensitive peptidergic sensory nerves play a crucial anti-inflammatory role in the early phase of rheumatoid arthritis, characterized by reduced cellular and vascular inflammatory components through the release of anti-inflammatory neuropeptides. These fibers may serve as important gatekeepers in the pathogenesis of rheumatoid arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Richard Nii Lante Lamptey, Chengwen Sun, Buddhadev Layek, Jagdish Singh
Summary: Hypertension is a global health concern, and neurogenic hypertension (NH) accounts for almost half of all hypertension cases. The increased sympathetic nervous system activity mediated by angiotensin II in the brain is known to be the main cause of NH. However, traditional antihypertensive drugs lack the ability to effectively penetrate the blood-brain barrier, making it challenging to manage NH. Therefore, developing strategies for targeted delivery of antihypertensives to the brain is crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marialuisa Perrotta, Daniela Carnevale
Summary: Hypertension is a multifactorial disease with pathophysiological mechanisms involving not only classical factors but also the immune system. Studies have shown the important role of neuroimmune interactions in hypertension, with specific brain areas modulating immune responses playing a crucial role in the development of high blood pressure.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Clinical Neurology
Bei Wen, Yinbing Pan, Jianguo Cheng, Li Xu, Jijun Xu
Summary: This article reviews the role of neuroinflammation in the onset and progression of CRPS from various perspectives, providing insights for future research and development of therapeutic targets for CRPS.
JOURNAL OF PAIN RESEARCH
(2023)
Review
Neurosciences
Estela M. Munoz
Summary: Microglia in circumventricular organs (CVOs) continuously adapt to react differentially to the diverse challenges they face. This review discusses microglia heterogeneity in CVOs, including the pineal gland. Further studies are needed to better understand microglia dynamics in these unique brain areas.
Review
Physiology
Lale A. A. Ertuglu, Ashley Pitzer Mutchler, Justin Yu, Annet Kirabo
Summary: Salt-sensitivity of blood pressure is an independent risk factor for cardiovascular disease and affects approximately half of the hypertensive population. Recent research suggests that high salt intake can lead to inflammation and hypertension by activating antigen-presenting cells (APCs) and T cells through oxidative stress and NLRP3 inflammasome activation. Understanding these mechanisms could help identify potential therapeutic targets for salt-sensitive hypertension.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Immunology
Yu Fan, Do-Hee Kim, Young Seob Gwak, Danbi Ahn, Yeonhee Ryu, Suchan Chang, Bong Hyo Lee, Kyle B. Bills, Scott C. Steffensen, Chae Ha Yang, Hee Young Kim
Summary: Acupuncture, used for over 2500 years, triggers acupuncture signaling and effects through the release of neuropeptides during neurogenic inflammation, enhancing sensory afferents' responses to needling at acupoints.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Neurosciences
Snigdha Mukerjee, Eric Lazartigues
NEUROSCIENCE BULLETIN
(2019)
Article
Peripheral Vascular Disease
Jiaxi Xu, Adrien J. R. Molinas, Snigdha Mukerjee, Donald A. Morgan, Kamal Rahmouni, Andrea Zsombok, Eric Lazartigues
Article
Peripheral Vascular Disease
Snigdha Mukerjee, Hong Gao, Jiaxi Xu, Ryosuke Sato, Andrea Zsombok, Eric Lazartigues
Article
Immunology
Chhinder P. Sodhi, Jenny Nguyen, Yukihiro Yamaguchi, Adam D. Werts, Peng Lu, Mitchell R. Ladd, William B. Fulton, Mark L. Kovler, Sanxia Wang, Thomas Prindle, Yong Zhang, Eric D. Lazartigues, Michael J. Holtzman, John F. Alcorn, David J. Hackam, Hongpeng Jia
JOURNAL OF IMMUNOLOGY
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Catalin M. Filipeanu, Eric Lazartigues
CARDIOVASCULAR RESEARCH
(2020)
Article
Peripheral Vascular Disease
Joshua M. Oakes, Jiaxi Xu, Tamara M. Morris, Nicholas D. Fried, Charlotte S. Pearson, Thomas D. Lobell, Nicholas W. Gilpin, Eric Lazartigues, Jason D. Gardner, Xinping Yue
Article
Cell Biology
Jiaxi Xu, Eric Lazartigues
Summary: The recent outbreak of COVID-19 caused by the novel coronavirus SARS-CoV-2 has spread rapidly worldwide. Similar to SARS-CoV, this new coronavirus utilizes ACE2 as an entry point to cells. Growing evidence suggests that COVID-19 patients, particularly those in severe condition, exhibit neurological symptoms, indicating the potential for SARS-CoV-2 to infect and damage neurons in the central nervous system. By studying human neurons derived from pluripotent stem cells, we have demonstrated the expression of ACE2 in human neurons. This highlights the importance of considering the neuro-invasive potential of SARS-CoV-2 as both a contributing factor and a therapeutic target for the severe respiratory symptoms in critical COVID-19 cases.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Endocrinology & Metabolism
Eric Lazartigues, Mirza Muhammad Fahd Qadir, Franck Mauvais-Jarvis
Review
Pharmacology & Pharmacy
Thyago M. de Queiroz, Navya Lakkappa, Eric Lazartigues
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Cell Biology
Blessing Ogunlade, Jessie J. Guidry, Snigdha Mukerjee, Srinivas Sriramula, Eric Lazartigues, Catalin M. Filipeanu
Summary: In this study, the researchers discovered that ACE2 is internalized and degraded in lysosomes after chronic Ang-II treatment. They identified fascin-1 as an accessory protein of ACE2 that interacts with the enzyme in an Ang-II dependent manner. Overexpression of fascin-1 attenuates the effects of Ang-II on ACE2 activity, while downregulation of fascin-1 severely decreases ACE2 enzymatic activity.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Medicine, Research & Experimental
Mazher Mohammed, Clara Berdasco, Eric Lazartigues
Review
Multidisciplinary Sciences
Hongpeng Jia, Xinping Yue, Eric Lazartigues
NATURE COMMUNICATIONS
(2020)
Review
Medicine, Research & Experimental
Mona Elgazzaz, Eric Lazartigues
Summary: Cardiometabolic diseases are prevalent and high mortality diseases. The complexity of their etiology involves the intertwining of genetic and environmental factors through epigenetics, leading to diverse disease courses and outcomes among individuals. Targeting epigenetic imprints on genes like RAS can potentially impact the susceptibility to cardiometabolic dysfunction.
Article
Cardiac & Cardiovascular Systems
Juan Hong, Shubin Fu, Lie Gao, Yanhui Cai, Eric Lazartigues, Han-Jun Wang
Summary: The dysfunction of voltage-gated potassium (Kv) channels in dorsal root ganglions plays a critical role in mediating the exaggerated exercise pressor reflex and muscle afferent sensitization in chronic heart failure (CHF) patients. Manipulating Kv channels in DRG neurons could be a potential new approach to reduce sympathoexcitation and improve exercise intolerance in CHF, ultimately enhancing quality of life and reducing mortality.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Nicholas D. Fried, Anna Whitehead, Eric Lazartigues, Xinping Yue, Jason D. Gardner
Summary: This study using a bilateral ovariectomy model suggests that the cardiopulmonary protection observed in nicotine-exposed female mice may be independent of ovarian hormones.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
