Article
Rheumatology
Guilherme R. de Jesus, Marcela Lacerda, Bruna C. dos Rodrigues, Flavia C. Santos, Adriana P. do Nascimento, Luis Cristovao Porto, Nilson R. de Jesus, Roger A. Levy, Evandro M. Klumb
Summary: Evaluation of serum VEGF, PlGF, and sFlt-1 levels can differentiate between preeclampsia, inactive SLE, and active lupus nephritis during pregnancy. Preeclampsia patients had higher sFlt-1 and lower PlGF levels, while VEGF levels were higher in pregnant women with active lupus nephritis. The sFlt-1:PlGF ratio was significantly higher in preeclampsia patients.
ARTHRITIS CARE & RESEARCH
(2021)
Article
Biology
Lijie Zhang, Xingkun Zhang, Xiaoming Zhong, Mengya Fan, Guoliang Wang, Wei Shi, Ran Xie, Yinxiang Wei, Hailong Zhang, Xiangxu Meng, Yaohui Wang, Yuanfang Ma
Summary: In patients with acute myocardial infarction (AMI), the quantity of endothelial progenitor cells (EPCs) increases while their angiogenesis activity is inhibited by serum sFlt-1.
Article
Immunology
Rianne Nederlof, Sophia Reidel, Andre Spychala, Stefanie Goedecke, Andre Heinen, Tobias Lautwein, Patrick Petzsch, Karl Koehrer, Axel Goedecke
Summary: IGF1 treatment induces an anti-inflammatory phenotype in bone marrow derived neutrophils and attenuates inflammation after myocardial infarction (MI). The effect of IGF1 is mediated through the JAK2/STAT6 pathway rather than the canonical Ras/Raf/ERK or PI3K/AKT pathway. Single cell sequencing analysis shows that IGF1 treatment downregulates pro-inflammatory genes and upregulates anti-inflammatory genes in neutrophils and macrophages after MI.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Peripheral Vascular Disease
Francesca Gaccioli, Ulla Sovio, Sungsam Gong, Emma Cook, D. Stephen Charnock-Jones, Gordon C. S. Smith
Summary: This study aimed to investigate the relationship between protein levels of sFLT1 and PlGF in maternal serum and placental tissue lysates. The findings showed that the sFLT1:PlGF ratio is increased in both preeclampsia and FGR, but in preeclampsia, it is primarily driven by increased placental sFLT1 levels, while in FGR, it is primarily driven by decreased placental PlGF levels.
Article
Medicine, General & Internal
Iris I. Mueller, Martina Schneider, Karin A. L. Mueller, Oleg Lunov, Oliver Borst, Thomas Simmet, Meinrad Gawaz
Summary: Gremlin-1 is expressed in myocardial tissue and infiltrating cells after transient myocardial ischaemia and colocalizes with the pro-fibrotic cytokine transforming growth factor-beta. Gremlin-1 reduces TGF-beta-induced collagen production in myocardial fibroblasts and administration of mGremlin-1-Fc significantly reduces infarct size.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, General & Internal
Vasileios Vittoros, Evdoxia Kyriazopoulou, Malvina Lada, Iraklis Tsangaris, Ioannis M. Koutelidakis, Evangelos J. Giamarellos-Bourboulis
Summary: This study examined the diagnostic and prognostic value of biomarkers including PCT, PlGF, and s-Flt-1 for sepsis in critically ill patients. It found that s-Flt-1 and PCT provide additional information for sepsis diagnosis and prognosis, which can aid in predicting unfavorable outcomes and preventing sepsis-associated death.
Article
Cardiac & Cardiovascular Systems
Yu Huang, Liangpeng Li, Hongmei Chen, Qiao Liao, Xiaoli Yang, Dezhong Yang, Xuewei Xia, Hongyong Wang, Wei Eric Wang, Lianglong Chen, Chunyu Zeng
Summary: YY1 expression in the heart was significantly stimulated following myocardial infarction. Overexpression of YY1 improved survival rate, cardiac function, scar size, and left ventricular volume in mice, while silencing YY1 had the opposite effects. YY1 alleviated cardiac apoptosis and fibrosis, promoted angiogenesis, T helper 2 cytokine production, M2 macrophage polarization, and enhanced endothelial cell tube formation and migration ability. Enhanced Akt phosphorylation and vascular endothelial growth factor production were observed in the presence of YY1 overexpression. These effects suggest YY1 as a potential therapeutic target for myocardial infarction.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Robert D. Hume, Tejas Deshmukh, Tram Doan, Woo Jun Shim, Shaan Kanagalingam, Vikram Tallapragada, Fairooj Rashid, Maria Marcuello, Daniel Blessing, Dinesh Selvakumar, Kalyan Raguram, Faraz Pathan, Dinny Graham, Samir Ounzain, Eddy Kizana, Richard P. Harvey, Nathan J. Palpant, James J. H. Chong
Summary: After myocardial infarction, platelet-derived growth factors (PDGFs) inhibit fibroblast differentiation into myofibroblasts, reducing fibrosis and improving heart function.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Rongrong Wu, Wangxing Hu, Huan Chen, Yingchao Wang, Qingju Li, Changchen Xiao, Lin Fan, Zhiwei Zhong, Xiaoying Chen, Kaiqi Lv, Shuhan Zhong, Yanna Shi, Jinghai Chen, Wei Zhu, Jianyi Zhang, Xinyang Hu, Jian'an Wang
Summary: Angiogenesis is essential for vascular development, and the role of regulatory long noncoding RNAs in this process is underexplored. This study identifies a novel lncRNA, SCDAL, enriched in human embryonic stem cell-derived mesenchymal stem cells, which plays a crucial role in angiogenesis by regulating the GDF6 pathway. Targeting the SCDAL-GDF6 pathway may hold potential as a therapy for ischemic heart diseases.
Article
Pharmacology & Pharmacy
Alexandre Paccalet, Claire Crola Da Silva, Laura Mechtouff, Camille Amaz, Yvonne Varillon, Charles de Bourguignon, Regine Cartier, Cyril Prieur, Danka Tomasevic, Nathalie Genot, Simon Leboube, Francois Derimay, Gilles Rioufol, Eric Bonnefoy-Cudraz, Nathan Mewton, Michel Ovize, Gabriel Bidaux, Thomas Bochaton
Summary: The circulating concentrations of sTNFR1 and sTNFR2 are inflammatory markers of morphological and functional injury after STEMI, and can predict clinical outcomes in patients. Patients with higher levels of sTNFR1 or sTNFR2 are more likely to experience adverse events within 24 months after suffering from STEMI. Soluble TNFR1 is an independent predictor of major adverse cardiovascular events and outperforms troponin I in predicting outcomes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Peripheral Vascular Disease
Rugina Neuman, Langeza Saleh, Koen Verdonk, Anton H. van den Meiracker, Henk Russcher, Herold J. Metselaar, Willy Visser, A. H. Jan Danser
Summary: The study indicates that PlGF production is significantly upregulated in AFLP patients, mainly originating from the placenta. Compared to other disease groups, AFLP patients have significantly elevated levels of PlGF, which rapidly decline postpartum.
Article
Cardiac & Cardiovascular Systems
Nihar Masurkar, Marion Bouvet, Damien Logeart, Charlene Jouve, Fatou Drame, Olivier Claude, Maguelonne Roux, Clement Delacroix, Damien Bergerot, Jean-Jacques Mercadier, Marc Sirol, Barnabas Gellen, Marine Livrozet, Antoine Fayol, Estelle Robidel, David-Alexandre Tregouet, Giovanna Marazzi, David Sassoon, Mariana Valente, Jean-Sebastien Hulot
Summary: After myocardial infarction, the secretion of GDF3 by cardiac stromal cells promotes fibroblast proliferation, leading to adverse fibrotic remodeling.
Article
Pharmacology & Pharmacy
Meifang Wu, Yanguang Guo, Ying Wu, Kaizu Xu, Liming Lin
Summary: Sacubitril/valsartan has a significant improvement on cardiac function and fibrosis in rats after experimental myocardial infarction, by inhibiting collagen synthesis in myocardial fibroblasts through the suppression of the TGF/Smads signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Polymer Science
Wei Hu, Cui Yang, Xiaodan Guo, Yihong Wu, Xian Jun Loh, Zibiao Li, Yun-Long Wu, Caisheng Wu
Summary: Myocardial infarction is a serious disease and traditional treatment methods have limitations. Recent research has shown that injectable hydrogels can improve heart function and prognosis, providing new treatment strategies for MI.
Article
Cardiac & Cardiovascular Systems
Sunil Rao, Bodo Kirsch, Deepak L. Bhatt, Andrzej Budaj, Rosa Coppolecchia, John Eikelboom, Stefan K. James, W. Schuyler Jones, Bela Merkely, Lars Keller, Renicus S. Hermanides, Gianluca Campo, Jose Luis Ferreiro, Taro Shibasaki, Hardi Mundl, John H. Alexander
Summary: This study investigated the pharmacodynamics, safety, and efficacy of the oral FXIa inhibitor asundexian for secondary prevention after acute myocardial infarction (MI). The results showed that asundexian effectively inhibited coagulation activity without increasing the risk of bleeding or ischemic events.
Article
Cardiac & Cardiovascular Systems
Akihiro Nakajima, Makoto Araki, Osamu Kurihara, Yoshiyasu Minami, Tsunenari Soeda, Taishi Yonetsu, Filippo Crea, Masamichi Takano, Takumi Higuma, Tsunekazu Kakuta, Tom Adriaenssens, Hang Lee, Sunao Nakamura, Ik-Kyung Jang
Summary: The study demonstrated that eruptive calcified nodules are associated with higher incidence of stent edge dissection and incomplete stent apposition, while superficial calcific sheets are associated with a smaller minimal stent area and higher rate of periprocedural myocardial infarction.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Osamu Kurihara, Masamichi Takano, Tsunekazu Kakuta, Tsunenari Soeda, Filippo Crea, Tom Adriaenssens, Holger M. Nef, Niklas F. Boeder, Erika Yamamoto, Hyung Oh Kim, Michele Russo, Iris McNulty, Makoto Araki, Akihiro Nakajima, Hang Lee, Kyoichi Mizuno, Ik -Kyung Jang
Summary: The study found that factors such as older age, hyperlipidemia, lack of antiplatelet therapy, higher LDL cholesterol levels, and specific plaque characteristics were associated with an increased probability of STEMI following plaque rupture. Conversely, lack of dual antiplatelet therapy and statin therapy were associated with a higher probability of STEMI following plaque erosion. Antiplatelet therapy was found to be effective in reducing the incidence of STEMI in both plaque rupture and plaque erosion, while statin therapy was particularly beneficial in cases of plaque erosion presenting as ACS.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Cardiac & Cardiovascular Systems
Makoto Araki, Taishi Yonetsu, Osamu Kurihara, Akihiro Nakajima, Hang Lee, Tsunenari Soeda, Yoshiyasu Minami, Iris McNulty, Shiro Uemura, Tsunekazu Kakuta, Ik-Kyung Jang
Summary: Lipid-rich plaques, thin-cap fibroatheroma (TCFA), and layered plaques were identified as predictors of subsequent rapid plaque progression. A new layer was detected in more than half of the lesions with rapid progression at follow-up.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Atsushi Kyodo, Makoto Watanabe, Akihiko Okamura, Saki Iwai, Azusa Sakagami, Kazutaka Nogi, Daisuke Kamon, Yukihiro Hashimoto, Tomoya Ueda, Tsunenari Soeda, Hiroyuki Okura, Yoshihiko Saito
Summary: This study revealed that patients with stent thrombosis (ST) had significantly higher rates of incomplete stent apposition, irregular protrusion, and thrombus in post-stent optical coherence tomography (OCT) findings. Furthermore, a large arc of irregular protrusion was identified as a significant feature associated with ST in these patients.
CIRCULATION JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Kazutaka Nogi, Tsunenari Soeda, Masahiko Hara, Hajime Iwama, Nozomi Toyokawa, Satoshi Sakai, Hiroki Yano, Atsushi Iwai, Yukihiro Hashimoto, Hajime Fujimoto, Megumi Suzuki, Takehito Nakai, Naofumi Doi, Yoshihiko Saito
Summary: The study found that the 4-Fr catheter system can lead to aortic waveform distortion during invasive functional assessment of coronary artery stenosis. Adequate saline flush can help reduce this distortion and its impact on iFR measurements.
Article
Multidisciplinary Sciences
Tomoya Ueda, Rika Kawakami, Kazutaka Nogi, Maki Nogi, Satomi Ishihara, Yasuki Nakada, Tomoya Nakano, Yukihiro Hashimoto, Hitoshi Nakagawa, Taku Nishida, Kenji Onoue, Tsunenari Soeda, Satoshi Okayama, Makoto Watanabe, Yoshihiko Saito
Summary: In patients with acute decompensated HF, low serum iron level at discharge was identified as an independent predictor of poor prognosis, regardless of hemoglobin or ferritin levels. This suggests a new concept that iron may play a role in the pathophysiology of ADHF through non-hematopoietic mechanisms.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Akihiro Nakajima, Yoshiyasu Minami, Makoto Araki, Osamu Kurihara, Tsunenari Soeda, Taishi Yonetsu, Zhao Wang, Iris McNulty, Hang Lee, Sunao Nakamura, Ik-Kyung Jang
Summary: This study identified three optical coherence tomography predictors for a favorable vascular response to statin therapy: large thin-cap area, high macrophage index, and layered plaque. Favorable vascular response to statin was correlated with signs of decreased inflammation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Akihiro Nakajima, Makoto Araki, Osamu Kurihara, Yoshiyasu Minami, Tsunenari Soeda, Taishi Yonetsu, Takumi Higuma, Tsunekazu Kakuta, Iris McNulty, Hang Lee, Rajeev Malhotra, Sunao Nakamura, Ik-Kyung Jang
Summary: This study identifies diabetes mellitus, chronic kidney disease, lipid-rich plaque, and macrophages as independent predictors for rapid progression of coronary calcification. The rapid progression of calcification is associated with a reduction of inflammatory features, suggesting a relationship between baseline vascular inflammation and the progression of calcification.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Daisuke Kamon, Yu Sugawara, Tsunenari Soeda, Akihiko Okamura, Yasuki Nakada, Yukihiro Hashimoto, Tomoya Ueda, Taku Nishida, Kenji Onoue, Satoshi Okayama, Makoto Watanabe, Rika Kawakami, Yoshihiko Saito
Summary: This study retrospectively analyzed 1055 patients with AMI and found that the predominant subtypes of HF after AMI were HF with mid-range ejection fraction and preserved ejection fraction, or HF with non-reduced ejection fraction. The occurrence of HF was associated with left ventricular ejection fraction, with a significant proportion of HF patients having abnormal LVEF values during follow-up.
Article
Cardiac & Cardiovascular Systems
Tomoya Nakano, Kenji Onoue, Ayako Seno, Satomi Ishihara, Yasuki Nakada, Hitoshi Nakagawa, Tomoya Ueda, Taku Nishida, Tsunenari Soeda, Makoto Watanabe, Rika Kawakami, Kinta Hatakeyama, Yasuhiro Sakaguchi, Chiho Ohbayashi, Yoshihiko Saito
Summary: The study analyzed the clinical and pathological features of patients with reduced cardiac function in the UCM and DCM groups, finding that the percentage of interstitial fibrosis area in UCM patients was greater than in DCM patients. UCM patients had higher levels of CD68-positive macrophages and MCP-1 expression in the myocardium compared to other groups. Additionally, UCM patients had lower levels of soluble Flt-1 but higher levels of PlGF and MCP-1 compared to DCM patients.
Article
Cardiac & Cardiovascular Systems
Akihiro Nakajima, Makoto Araki, Yoshiyasu Minami, Tsunenari Soeda, Taishi Yonetsu, Iris McNulty, Hang Lee, Sunao Nakamura, Ik-Kyung Jang
Summary: The study found that the layer index was greater in multilayer pattern, interrupted layer phenotype, at culprit plaque, lipid-rich plaque, and in cases with culprit plaque rupture.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Makoto Araki, Taishi Yonetsu, Osamu Kurihara, Akihiro Nakajima, Hang Lee, Tsunenari Soeda, Yoshiyasu Minami, Takumi Higuma, Shigeki Kimura, Masamichi Takano, Bryan P. Yan, Tom Adriaenssens, Niklas F. Boeder, Holger M. Nef, Chong Jin Kim, Iris McNulty, Filippo Crea, Tsunekazu Kakuta, Ik-Kyung Jang
Summary: The study found that the prevalence of lipid-rich plaques, cholesterol crystals, and calcifications increases with age in patients with plaque erosion. Younger patients were more likely to experience ST-segment-elevation myocardial infarction, while older patients were more likely to have larger diameter stenosis, lipid-rich plaques, and calcifications.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Lena Marie Seegers, Makoto Araki, Akihiro Nakajima, Taishi Yonetsu, Yoshiyasu Minami, Junya Ako, Tsunenari Soeda, Osamu Kurihara, Takumi Higuma, Shigeki Kimura, Tom Adriaenssens, Holger M. Nef, Hang Lee, Iris McNulty, Tomoyo Sugiyama, Tsunekazu Kakuta, Ik-Kyung Jang
Summary: This study revealed age-related sex differences in culprit plaque morphology and vulnerability in patients with acute coronary syndrome. Compared to men, women showed a significant increase in plaque rupture and vulnerability with age. This finding is important for further understanding the pathogenesis of acute coronary syndrome.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Lena Marie Seegers, Doreen DeFaria Yeh, Taishi Yonetsu, Tomoyo Sugiyama, Yoshiyasu Minami, Tsunenari Soeda, Makoto Araki, Akihiro Nakajima, Haruhito Yuki, Daisuke Kinoshita, Keishi Suzuki, Takayuki Niida, Hang Lee, Iris McNulty, Sunao Nakamura, Tsunekazu Kakuta, Valentin Fuster, Ik-Kyung Jang
Summary: Optical coherence tomography can identify layered plaques in vivo. This study found that layered plaques in men are more likely to exhibit features of vascular inflammation and vulnerability, as well as evidence of previous plaque rupture, compared to women.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Hiroyuki Okura, Makoto Watanabe, Akihiro Miura, Muneo Kurokawa, Tomoya Ueda, Tsunenari Soeda, Yoshihiko Saito
Summary: This study assessed the compatibility of two different IVUS catheters and consoles for quantitative measurements of coronary arteries through in vitro and in vivo experiments. The results showed good correlation between the two IVUS consoles as well as two IVUS catheters in both settings.
CARDIOVASCULAR INTERVENTION AND THERAPEUTICS
(2022)
