A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction

Pharmacokinetics, pharmacodynamics and safety of BAY 2433334, a novel activated factor XI inhibitor, in healthy volunteers: A randomized phase 1 multiple‐dose study

(2022) Dagmar Kubitza et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacological profile of asundexian, a novel, orally bioavailable inhibitor of factor XIa

(2022) Stefan Heitmeier et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study

(2022) Jonathan P Piccini et al.   LANCET

Mortality Benefit of Rivaroxaban Plus Aspirin in Patients With Chronic Coronary or Peripheral Artery Disease

(2021) John W. Eikelboom et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

First evaluation of the safety, pharmacokinetics, and pharmacodynamics of BAY 2433334, a small molecule targeting coagulation factor XIa

(2021) Dirk Thomas et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Abelacimab for Prevention of Venous Thromboembolism

(2021) Peter Verhamme et al.   NEW ENGLAND JOURNAL OF MEDICINE

Milvexian for the Prevention of Venous Thromboembolism

(2021) Jeffrey I. Weitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Osocimab in Preventing Venous Thromboembolism Among Patients Undergoing Knee Arthroplasty

(2020) Jeffrey I. Weitz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Standardized End Point Definitions for Coronary Intervention Trials

(2018) Hector M Garcia-Garcia et al.   EUROPEAN HEART JOURNAL

Fourth Universal Definition of Myocardial Infarction (2018)

(2018) Kristian Thygesen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation

(2017) Borja Ibanez et al.   EUROPEAN HEART JOURNAL

Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease

(2017) John W. Eikelboom et al.   NEW ENGLAND JOURNAL OF MEDICINE

Statistical issues in the analysis of adverse events in time-to-event data

(2016) Arthur Allignol et al.   PHARMACEUTICAL STATISTICS

Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

(2015) Harry R. Büller et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stent Thrombosis With Second-Generation Drug-Eluting Stents Compared With Bare-Metal Stents

(2013) Femi Philip et al.   Circulation-Cardiovascular Interventions

Reduction of Stent Thrombosis in Patients With Acute Coronary Syndromes Treated With Rivaroxaban in ATLAS-ACS 2 TIMI 51

(2013) C. Michael Gibson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

2012 ACCF/AHA Focused Update of the Guideline for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction (Updating the 2007 Guideline and Replacing the 2011 Focused Update)

(2012) et al.   CIRCULATION

2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction

(2012) Patrick T. O'Gara et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Standardized Bleeding Definitions for Cardiovascular Clinical Trials

(2011) Roxana Mehran et al.   CIRCULATION

RUBY-1: a randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome

(2011) Ph. Gabriel Steg et al.   EUROPEAN HEART JOURNAL

Dabigatran vs. placebo in patients with acute coronary syndromes on dual antiplatelet therapy: a randomized, double-blind, phase II trial

(2011) J. Oldgren et al.   EUROPEAN HEART JOURNAL

Apixaban with Antiplatelet Therapy after Acute Coronary Syndrome

(2011) John H. Alexander et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rivaroxaban in Patients with a Recent Acute Coronary Syndrome

(2011) Jessica L. Mega et al.   NEW ENGLAND JOURNAL OF MEDICINE

Strategies to Reduce Bleeding Among Patients with Ischemic Heart Disease Treated with Antiplatelet Therapies

(2009) Sunil V. Rao   AMERICAN JOURNAL OF CARDIOLOGY

Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes

(2009) Lars Wallentin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improving clinical outcomes by reducing bleeding in patients with non-ST-elevation acute coronary syndromes

(2008) A. Budaj et al.   EUROPEAN HEART JOURNAL