Article
Engineering, Biomedical
Mengyue Hu, Shubin Shi, Xu Peng, Xinyun Pu, Xixun Yu
Summary: Currently, glutaraldehyde-crosslinked bioprosthetic heart valves (BHVs) lack good biocompatibility and long-term effective durability due to subacute thrombus, inflammation, calcification, tearing, and limited durability. In this study, a cooperative strategy of double crosslinking and surface modification using double-modified xanthan gum (O2CXG) was developed. The mechanical properties of the BHVs were significantly improved through the formation of Schiff base bonds and C-C bonds networks. The combination delivery of heparin and atorvastatin effectively enhanced the anticoagulation, anti-inflammatory, and pro-endothelialization properties of the BHVs. This strategy provides a valuable pattern for the multi-functionalization of blood-contacting materials.
ACTA BIOMATERIALIA
(2023)
Review
Cardiac & Cardiovascular Systems
David F. Williams, Deon Bezuidenhout, Jandre de Villiers, Paul Human, Peter Zilla
Summary: The use of bioprosthetic valves in heart valve therapy has evolved over the decades, with a focus on improving production methods to address issues like immune responses and calcification. Recent advancements in cross-linking and decellularization techniques have improved durability, but the need for even longer-lasting and safer treatments for younger patients has become a crucial clinical and social issue. Developing alternative treatment protocols focusing on tissue-protective decellularization and finely-titrated cross-linking sequences show promise for enhancing the longevity of pericardial heart valves.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Chemistry, Physical
Jiayu Wu, Zhenyuan Wu, Huajing Zeng, Desheng Liu, Zhongying Ji, Xin Xu, Xin Jia, Pan Jiang, Zengjie Fan, Xiaolong Wang, Feng Zhou
Summary: This study presents a big step towards biomechanically compatible hydrogel heart valves using RAFT-3D printing technology. These valves have favorable mechanical properties, long-term stability, and durability due to their wide and robust hydrogen-bonding networks. They also exhibit excellent biocompatibility and hemocompatibility. The hydrogel valves efficiently regulate blood flow and can withstand high levels of pressure.
CHEMISTRY OF MATERIALS
(2022)
Article
Nutrition & Dietetics
Armando Pena, Micah L. Olson, Stephanie L. Ayers, Dorothy D. Sears, Sonia Vega-Lopez, Abigail T. Colburn, Gabriel Q. Shaibi
Summary: Obesity is linked to chronic inflammation and may increase the risk of type 2 diabetes in youth. This study investigated the relationship between inflammatory biomarkers and insulin sensitivity, beta-cell function, and response to lifestyle intervention in Latino youth with obesity. The findings showed that obesity-related inflammatory mediators were associated with T2D risk factors but were not affected by lifestyle intervention in Latino youth.
Article
Materials Science, Biomaterials
Xiaotong Chen, Tao Yu, Qunshou Kong, Hong Xu, Zhiyu Zhao, Gaocan Li, Haojun Fan, Yunbing Wang
Summary: Heart valve replacement has become the optimal choice for treating severe heart valve disease. However, current commercial bioprosthetic heart valves (BHVs) made from porcine or bovine pericardium treated with glutaraldehyde suffer from poor biocompatibility, calcification, coagulation risk, and difficulty in endothelialization. In this study, a functional BHV material OX-CA-PP has been developed, which exhibits superior anti-inflammation, improved anti-coagulation, minimal calcification, and promoted proliferation of endothelial cells. This non-glutaraldehyde functional strategy has great potential for BHVs and other implanted biomaterials.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Biotechnology & Applied Microbiology
Xiaoke Qi, Zhenlin Jiang, Mingzhe Song, Zhenjie Tang, Xinlong Xie, Yuhong Liu, Qiying Wu, Zhongshi Wu
Summary: In this study, a novel crosslinking method using ribose was applied to transcatheter heart valves (THV) for the first time, which showed potential in reducing calcification, enhancing extracellular matrix stability, increasing biomechanical properties, resistance to enzymatic degradation, and cellular compatibility in THV. The ribose-cross-linked materials exhibited better anti-calcification potential and improved durability of THV compared to glutaraldehyde-cross-linked materials.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Genetics & Heredity
Markus Toelle, Cornelia Henkel, Jaqueline Herrmann, Christoph Daniel, Milen Babic, Mengdi Xia, Anna M. Schulz, Kerstin Amann, Markus van der Giet, Mirjam Schuchardt
Summary: This study evaluated an adenine-based uremic mouse model to study medial vessel calcification and senescence-associated secretory phenotype (SASP) changes, providing a basis for understanding molecular pathogenesis and potential therapeutic interventions.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Multidisciplinary Sciences
Erlinda The, Dennis M. de Graaf, Yufeng Zhai, Qingzhou Yao, Lihua Ao, David A. Fullerton, Charles A. Dinarello, Xianzhong Meng
Summary: This study found that IL-38 levels are lower in aortic valve interstitial cells (AVICs) from patients with calcific aortic valve disease (CAVD) compared to those without CAVD. Recombinant IL-38 suppressed inflammation and calcium deposition in AVICs. IL-38 also reduced the production of inflammatory mediators and inhibited the NLRP3 inflammasome and caspase-1 activation in AVICs. These findings suggest that IL-38 has therapeutic potential for preventing CAVD progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, General & Internal
Ana P. Silva, Carla S. B. Viegas, Patricia Guilherme, Nelson Tavares, Carolina Dias, Fatima Rato, Nelio Santos, Marilia Faisca, Edgar de Almeida, Pedro L. Neves, Dina C. Simes
Summary: Accelerated and premature cardiovascular calcification is common in chronic kidney disease patients, with valvular calcification being a critical indicator of cardiovascular disease. Low levels of Gla-rich protein (GRP) and magnesium, along with high levels of phosphate, are associated with mitral and aortic valves calcification. The diagnostic value of GRP may be potentially useful in assessing cardiovascular risk in this population.
Article
Engineering, Biomedical
Alix Whelan, Elizabeth Williams, Emma Fitzpatrick, Bruce P. Murphy, Paul S. Gunning, David O'Reilly, Caitriona Lally
Summary: The study revealed that mechanical damage drives calcification of glutaraldehyde-fixed bovine pericardial (GLBP) leaflets in bioprosthetic heart valves. Specimens with lower fatigue life were associated with higher calcification, and collagen fiber architecture influences both the mechanical performance and calcification potential of GLBP in patient BHVs.
ACTA BIOMATERIALIA
(2021)
Article
Cardiac & Cardiovascular Systems
Yejin Mok, Frances Wang, Shoshana H. Ballew, Steve Menez, Kenneth R. Butler, Lynne Wagenknecht, Sanaz Sedaghat, Josef Coresh, Michael J. Blaha, Kunihiro Matsushita
Summary: We comprehensively evaluated the association of kidney and bone-mineral metabolism markers with coronary artery calcification (CAC) and extra-coronary calcification (ECC) and found that only serum phosphorus demonstrated robust associations with both CAC and ECC, supporting a key role of phosphorus in the pathophysiology of vascular calcification.
Article
Biochemistry & Molecular Biology
Anja Feldmann, Yvonne Nitschke, Franziska Linss, Dennis Mulac, Sina Stuecker, Jessica Bertrand, Insa Buers, Klaus Langer, Frank Rutsch
Summary: This study combined controlled drug delivery by nanoparticles and active targeting by antibody conjugation to effectively dissolve aortic valve calcifications. This method holds promising clinical applications for treating aortic valve stenosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yin Tintut, Henry M. Honda, Linda L. Demer
Summary: Vascular calcification is a complex biological process regulated similarly to skeletal bone at the molecular and cellular levels, affected by metabolic, hormonal, and inflammatory stimuli. Calcium deposits in the vessel wall introduce different stress effects at different edges, influencing the risk of plaque rupture.
Article
Engineering, Biomedical
Adi Morany, Karin Lavon, Rotem Halevi, Nora Haj-Ali, Danny Bluestein, Ehud Raanani, Ashraf Hamdan, Rami Haj-Ali
Summary: This study investigates the calcification development and routes of type-1 bicuspid aortic valves based on CT scans and analyzes the impact of the unique geometrical shapes of calcium deposits on their fragmentation under balloon valvuloplasty procedures. It introduces a reverse calcification technique to predict calcification progression and identifies two main calcification patterns. Additionally, a calcification fragmentation biomechanical model is proposed to study the effect of balloon valvuloplasty on different calcification patterns.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Qi Tong, Ao Sun, Zhengjie Wang, Tao Li, Xinye He, Yongjun Qian, Zhiyong Qian
Summary: With the aging population, valvular heart disease has become a major threat to human health. The current bioprosthetic heart valves prepared with xenograft or glutaraldehyde crosslinking have limitations such as thrombosis and calcification. In this study, hydrogel hybrid heart valves with improved anti-calcification and re-endothelialization were prepared using decellularized porcine heart valves and zwitterionic monomers. The results showed that the hydrogel-coated hybrid heart valve exhibited excellent collagen stability, biocompatibility, and re-endothelialization potential, with less calcification deposition and immune response compared to the glutaraldehyde-crosslinked heart valve.
MATERIALS TODAY BIO
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Norman Mangner, Utz Kappert, Axel Linke
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Vassili Panagides, David Del Val, Mohamed Abdel-Wahab, Norman Mangner, Eric Durand, Nikolaj Ihlemann, Marina Urena, Costanza Pellegrini, Francesco Giannini, Piotr Scislo, Zenon Huczek, Martin Landt, Vincent Auffret, Jan Malte Sinning, Asim N. Cheema, Luis Nombela-Franco, Chekrallah Chamandi, Francisco Campelo-Parada, Erika Munoz-Garcia, Howard C. Herrmann, Luca Testa, Won-Keun Kim, Juan Carlos Castillo, Alberto Alperi, Didier Tchetche, Antonio L. Bartorelli, Samir Kapadia, Stefan Stortecky, Ignacio Amat-Santos, Harindra C. Wijeysundera, John Lisko, Enrique Gutierrez-Ibanes, Vicenc Serra, Luisa Salido, Abdullah Alkhodair, Ugolino Livi, Tarun Chakravarty, Stamatios Lerakis, Victoria Vilalta, Ander Regueiro, Rafael Romaguera, Utz Kappert, Marco Barbanti, Jean-Bernard Masson, Frederic Maes, Claudia Fiorina, Antonio Miceli, Susheel Kodali, Henrique B. Ribeiro, Jose Armando Mangione, Fabio Sandoli de Brito Jr, Guglielmo Mario Actis Dato, Francesco Rosato, Maria-Cristina Ferreira, Valter Correia de Lima, Alexandre Siciliano Colafranceschi, Alexandre Abizaid, Marcos Antonio Marino, Vinicius Esteves, Julio Andrea, Roger R. Godinho, Fernando Alfonso, Helene Eltchaninoff, Lars Sondergaard, Dominique Himbert, Oliver Husser, Azeem Latib, Herve Le Breton, Clement Servoz, Isaac Pascual, Saif Siddiqui, Paolo Olivares, Rosana Hernandez-Antolin, John G. Webb, Sandro Sponga, Raj Makkar, Annapoorna S. Kini, Marouane Boukhris, Philippe Gervais, Axel Linke, Lisa Crusius, David Holzhey, Josep Rodes-Cabau
Summary: This multicenter study investigates the incidence, characteristics, management, and outcomes of mitral valve infective endocarditis after transcatheter aortic valve implantation. The study finds that the use of self-expanding valves and the presence of aortic regurgitation are associated with mitral valve infective endocarditis. Patients with mitral valve infective endocarditis have lower surgical management rates and poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Bruno Scheller, Tuomas T. Rissanen, Ahmed Farah, Marc-Alexander Ohlow, Norman Mangner, Jochen Woehrle, Sven Moebius-Winkler, Daniel Weilenmann, Gregor Leibundgut, Florim Cuculi, Nicole Gilgen, Michael Coslovsky, Felix Mahfoud, Raban Jeger
Summary: This analysis investigated the difference in the effectiveness of DCB versus DES in patients with and without HBR undergoing percutaneous coronary intervention. It found that DCBs were as safe and effective as DES in treating small coronary arteries, regardless of bleeding risk. Patients treated with DCB had a lower risk of severe bleeding events at 3 years.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Suleman Aktaa, Gorav Batra, Stefan K. James, Daniel J. Blackman, Peter F. Ludman, Mamas A. Mamas, Mohamed Abdel-Wahab, Gianni D. Angelini, Martin Czerny, Victoria Delgado, Giuseppe De Luca, Agricola Eustachio, Dan Foldager, Christian W. Hamm, Bernard Iung, Norman Mangner, Julinda Mehilli, Gavin J. Murphy, Darren Mylotte, Radoslaw Parma, Anna Sonia Petronio, Bodgan A. Popescu, Lars Sondergaard, Rui C. Teles, Manel Sabate, Christian J. Terkelsen, Luca Testa, Jianhua Wu, Aldo P. Maggioni, Lars Wallentin, Barbara Casadei, Chris P. Gale
Summary: The EuroHeart project aims to create pan-European data standards for cardiovascular diseases and interventions, including TAVI, to quantify quality of care and patient outcomes.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Immunology
Norman Mangner, Vassili Panagides, David del Val, Mohamed Abdel-Wahab, Lisa Crusius, Eric Durand, Nikolaj Ihlemann, Marina Urena, Costanza Pellegrini, Francesco Giannini, Tomasz Gasior, Wojtek Wojakowski, Martin Landt, Vincent Auffret, Jan-Malte Sinning, Asim N. Cheema, Luis Nombela-Franco, Chekrallah Chamandi, Francisco Campelo-Parada, Erika Munoz-Garcia, Howard C. Herrmann, Luca Testa, Won-Keun Kim, Helene Eltchaninoff, Lars Sondergaard, Dominique Himbert, Oliver Husser, Azeem Latib, Herve Le Breton, Clement Servoz, Philippe Gervais, Melanie Cote, Holger Thiele, David Holzhey, Axel Linke, Josep Rodes-Cabau
Summary: In transcatheter aortic valve related infective endocarditis (IE), absent echocardiographic signs of IE were associated with the same prognosis as evident echocardiographic signs, highlighting the need for early treatment initiation in high-risk patients presenting with positive blood cultures and symptoms of infection after TAVI.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Benedikt Schrage, Jonas Sundermeyer, Stefan Blankenberg, Pascal Colson, Dennis Eckner, Matthias Eden, Ingo Eitel, Derk Frank, Norbert Frey, Tobias Graf, Paulus Kirchhof, Danny Kupka, Ulf Landmesser, Axel Linke, Nicolas Majunke, Norman Mangner, Octavian Maniuc, Johannes Mierke, Sven Moebius-Winkler, David A. Morrow, Marc Mourad, Peter Nordbeck, Martin Orban, Federico Pappalardo, Sandeep M. Patel, Matthias Pauschinger, Vittorio Pazzanese, Darko Radakovic, P. Christian Schulze, Clemens Scherer, Robert H. G. Schwinger, Carsten Skurk, Holger Thiele, Anubodh Varshney, Lukas Wechsler, Dirk Westermann
Summary: This study evaluates the association between timing of active left ventricular (LV) unloading and implantation of VA-ECMO with outcomes in patients with cardiogenic shock (CS). The results show that early active LV unloading is associated with a lower risk of 30-day mortality and a higher likelihood of successful weaning from ventilation, without increasing complications.
JACC-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Benedikt Schrage, Jonas Sundermeyer, Benedikt Norbert Beer, Letizia Bertoldi, Alexander Bernhardt, Stefan Blankenberg, Jeroen Dauw, Zouhir Dindane, Dennis Eckner, Ingo Eitel, Tobias Graf, Patrick Horn, Paulus Kirchhof, Stefan Kluge, Axel Linke, Ulf Landmesser, Peter Luedike, Enzo Luesebrink, Norman Mangner, Octavian Maniuc, Sven Moebius Winkler, Peter Nordbeck, Martin Orban, Federico Pappalardo, Matthias Pauschinger, Michal Pazdernik, Alastair Proudfoot, Matthew Kelham, Tienush Rassaf, Hermann Reichenspurner, Clemens Scherer, Paul Christian Schulze, Robert H. G. Schwinger, Carsten Skurk, Marek Sramko, Guido Tavazzi, Holger Thiele, Luca Villanova, Nuccia Morici, Antonia Wechsler, Ralf Westenfeld, Ephraim Winzer, Dirk Westermann
Summary: This study aimed to evaluate the use of mechanical circulatory support (MCS) for the treatment of non-ischaemic cardiogenic shock (CS). The results showed that the use of MCS was associated with a lower 30-day mortality rate in patients with non-ischaemic CS. However, MCS treatment was also associated with more complications.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Medicine, General & Internal
Tomasz Gasior, Felix J. Woitek, Antonia Schroth, Mohamed Abdel-Wahab, Lisa Crusius, Stephan Haussig, Philipp Kiefer, Piotr Scislo, Zenon Huczek, Maciej Dabrowski, Adam Witkowski, Anna Olasinska-Wisniewska, Marek Grygier, Marcin Protasiewicz, Damian Hudziak, Utz Kappert, David Holzhey, Wojtek Wojakowski, Axel Linke, Norman Mangner
Summary: This study compared the clinical characteristics and outcomes of patients with enterococci infective endocarditis (EC-IE) and staphylococci infective endocarditis (SC-IE) following transcatheter aortic valve implantation. The results showed that EC-IE was associated with lower morbidity and mortality compared to SC-IE.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
B. E. Stahli, F. Varbella, A. Linke, B. Schwarz, S. B. Felix, M. Seiffert, R. Kesterke, P. Nordbeck, B. Witzenbichler, I. M. Lang, M. Kessler, C. Valina, A. Dibra, M. Rohla, M. Moccetti, M. Vercellino, L. Gaede, L. Bott-Flugel, P. Jakob, J. Stehli, A. Candreva, C. Templin, M. Schindler, M. Wischnewsky, G. Zanda, G. Quadri, N. Mangner, A. Toma, G. Magnani, P. Clemmensen, T. F. Luscher, T. Munzel, P. C. Schulze, K. -L. Laugwitz, W. Rottbauer, K. Huber, F. -J. Neumann, S. Schneider, F. Weidinger, S. Achenbach, G. Richardt, A. Kastrati, I. Ford, W. Maier, F. Ruschitzka
Summary: This study investigated the timing of complete revascularization in patients with STEMI and multivessel coronary artery disease. The findings suggest that immediate multivessel PCI is as effective as staged PCI.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Norman Mangner, Ephraim B. Winzer, Axel Linke, Volker Adams
Summary: This review provides a contemporary summary of the clinical and molecular alterations in the skeletal muscles of heart failure patients, with a focus on the effects on locomotor and respiratory muscles, particularly the diaphragm. It also discusses current and future therapeutic options, mainly focusing on the effects of exercise training.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Correction
Cardiac & Cardiovascular Systems
Suleman Aktaa, Gorav Batra, Stefan K. James, Daniel J. Blackman, Peter F. Ludman, Mamas A. Mamas, Mohamed Abdel-Waha, Gianni D. Angelini, Martin Czerny, Victoria Delgado, Giuseppe De Luca, Eustachio Agricola, Dan Foldage, Christian W. Hamm, Bernard Iung, Norman Mangner, Julinda Mehilli, Gavin J. Murphy, Darren Mylotte, Radoslaw Parma, Anna Sonia Petronio, Bodgan A. Popescu, Lars Sondergaard, Rui C. Teles, Manel Sabate, Christian J. Terkelsen, Luca Testa, Jianhua Wu, Aldo P. Maggioni, Lars Wallentin, Barbara Casade, Chris P. Gale
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
J. Jonas Sundermeyer, F. Gustafsson, C. Kellner, B. N. Beer, S. Blankenberg, P. Kirchhof, P. Luedike, N. Mangner, P. Nordbeck, M. Orban, A. Proudfoot, G. Tavazzi, H. Thiele, D. Westermann, B. Schrage
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Norman Mangner, Miriam Brinkert, Lukas S. Keller, Noriaki Moriyama, Daniel Hagemeyer, Stephan Haussig, Lisa Crusius, Richard Kobza, Mohamed Abdel-Wahab, Mika Laine, Stefan Stortecky, Thomas Pilgrim, Fabian Nietlispach, Frank Ruschitzka, Holger Thiele, Stefan Toggweiler, Axel Linke
Summary: This study aimed to investigate the safety and effectiveness of continued non-vitamin K antagonist oral anticoagulant (NOAC) therapy compared with continued vitamin K antagonist (VKA) therapy during transcatheter aortic valve implantation (TAVI). The study found that continued NOAC therapy led to comparable outcomes to continued VKA therapy, suggesting that both drugs can be used for long-term oral anticoagulation in TAVI patients.
Article
Cardiac & Cardiovascular Systems
Mohamed Abdel-Wahab, Ines Richter, Maurizio Taramasso, Axel Unbehaun, Tanja K. Rudolph, Flavio Ribichini, Ronald Binder, Joachim Schofer, Norman Mangner, Jan-Henk Dambrink, Blanca Trejo-Velasco, Holger Thiele, Mitsunobu Kitamura, Jonas Lanz
Summary: This study evaluated the procedural and one-year outcomes of the BASILICA technique in high-risk patients undergoing TAVI. The results showed that BASILICA was feasible and effective in preventing TAVI-induced CAO, and the one-year clinical outcomes were favorable.
Meeting Abstract
Cardiac & Cardiovascular Systems
J. Sundermeyer, B. N. Beer, S. Blankenberg, R. Kirchhof, P. Luedike, N. Mangner, P. Nordbeck, M. Orban, M. Pazdernik, A. Proudfoot, P. C. Schulze, G. Tavazzi, H. Thiele, D. Westermann, B. Schrage
EUROPEAN HEART JOURNAL
(2022)